Papers by KARTHICK RAJA R
The crops world wide are damaged economically because of insect infestation. Chemical insecticide... more The crops world wide are damaged economically because of insect infestation. Chemical insecticides are used for their control but their use comes with certain issues like development of resistant populations, environmental and health hazards. Hence research on alternatives for chemical pesticides has gained importance. Plant and microbial compounds are effectively assessed for their insecticidal activities as they are compounds of natural origin.In this context, insecticidal activity of methanol and ethyl acetate extracts of Fusarium venenatum against Sf-21 insect cell line has been studied. The crude extracts obtained from the fungus were found to show noticeable cytotoxicity in Sf-21 cells. Among them maximum cytotoxicity activity was observed with methanol extracts with IC50value being 125µg/mL compared to that of ethyl acetate extract (IC 50 value250µg/ml).
Blood, 2011
2870 Background: Regulatory T (Treg) cells are one of the master regulators in maintaining tolera... more 2870 Background: Regulatory T (Treg) cells are one of the master regulators in maintaining tolerance and immune homeostasis. Several studies in hematological and non-hematological malignancies revealed that increased level of Treg cells significantly impede the anti-tumor responses. Moreover, in non-hematological malignancies Treg cells correlate inversely with patient's survival (Beyer et al, 2006, Blood). Here in this study we evaluated the prognostic significance of Treg cells in multiple myeloma (MM) patients and influence of chemotherapies on Treg cells. Patients and Method: In this study a cohort of 74 newly diagnosed MM patients were recruited and all patients gave informed consent. Median age of the patient cohort was 67 years (range: 38–88). According to international staging system (ISS) patients were characterized as ISS1=20(27%), ISS2=27(36%), ISS3=25(34%) and undetermined=2(3%). Patients were treated with following treatment regimens: low or high dose combination of...
Blood, 2010
4998 Background. Monoclonal gammopathy of undetermined significance (MGUS) is the most common pla... more 4998 Background. Monoclonal gammopathy of undetermined significance (MGUS) is the most common plasma cell disorder which can eventually progress into malignant multiple myeloma (MM). Plasma cells (PCs) are the terminal stadium of B cells differentiation, but it is still unclear which population is the source of pathological PCs with malignant transformation and which population is involved in and may give rise to clonogenic myeloma stem cells. Aims. Phenotypic analysis of CD19+ cell subpopulations in monoclonal gammopathy patients and healthy volunteers to asses their frequency and to find differences on cellular level. Methods. Total of 38 samples was analyzed (16 newly diagnosed untreated MM patients, 12 untreated MGUS persons and 10 healthy donors). CD19+ cells were analyzed for surface expression of CD24, CD27, CD38, and IgD by 5-colors immunophenotyping. Subpopulations of pre-plasma cells consist of transitional B cells (CD24+CD38+), naïve B cells (CD38-IgD+), activated B cell...
Blood, 2009
2819 Poster Board II-795 Introduction: T regulatory (T reg) cells play an important role in maint... more 2819 Poster Board II-795 Introduction: T regulatory (T reg) cells play an important role in maintenance of self-tolerance, control of immune functions and regulation of homeostasis of T cell populations. T reg cells also influence immune responses against infectious agents and tumor cells. Several recent studies have demonstrated increased counts of T reg cells in patients with solid tumors and hematological malignancies. Monoclonal gammopathies (MGs) are associated with abnormal immune functions, mainly immunoparesis. Abnormal T cell functions have also been reported. We have evaluated the frequency of T reg cells in MG patients in different stages of disease. Patients and Methods: A total of 69 patients (pts) with MGs were enrolled in this pilot study (16% \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(1169\) \end{document} with MGUS, 7% \batchmode \documentclass[fleqn,1...
Multiple Myeloma - A Quick Reflection on the Fast Progress, 2013
Flow cytometry is an inevitable tool in clinical diagnosis of various pathological conditions. Re... more Flow cytometry is an inevitable tool in clinical diagnosis of various pathological conditions. Recently, its application plays a significant role in monitoring of several immune suppressor cells in patients with cancer and autoimmune disorders. Regulatory T cells (Treg cells) are immune cells which help in maintaining immune homeostasis in physiological conditions by patrolling unwanted immune responses; however, in cancers and autoimmune diseases, Treg cell numbers and function are significantly altered. In this chapter, we focus and update the information regarding Treg cells and their subsets, and application of flow cytometry in phenotyping and functional characterization of various immune regulatory and suppressor cells in multiple myeloma patients.
Oncoimmunology, 2013
Multiple myeloma (MM) patients exhibit consistent degrees of immune dysfunction. Regulatory T cel... more Multiple myeloma (MM) patients exhibit consistent degrees of immune dysfunction. Regulatory T cells contribute to the establishment of an immunosuppressive status in MM patients, hence favoring disease progression.
Multiple Myeloma - An Overview, 2012
Leukemia & Lymphoma, 2012
Cytometry Part B: Clinical Cytometry, 2013
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Papers by KARTHICK RAJA R