Papers by Julien Dandrieux
CRC Press eBooks, Oct 7, 2022
CRC Press eBooks, Oct 7, 2022
Veterinary Clinics of North America-small Animal Practice, 2021
In this article, we review different tests that have been researched in dogs with chronic enterop... more In this article, we review different tests that have been researched in dogs with chronic enteropathy. The usefulness of these tests either to assess etiology, to differentiate between treatment response, or to monitor treatment response is discussed. The tests are divided in those that are commercially available and those that hold promises for further development
Forensic imaging, Sep 1, 2021
Abstract Post-mortem imaging (PMI) is a rapidly expanding field in human medicine. In veterinary ... more Abstract Post-mortem imaging (PMI) is a rapidly expanding field in human medicine. In veterinary medicine the literature published on PMI is limited to a few small case series and single case reports. This retrospective study investigated the use of PMI at a university veterinary hospital over a ten-year period (January 2010 – March 2020). Imaging studies were analysed with documentation of the modality used, the cause of death and if the study was requested for medicolegal reasons. There was a five fold increase in PMI between the first five years (2010-2014) and the last five years (2015-2020). The modality with the greatest increase in use was post mortem computed tomography (PMCT) with a six-fold increase. PMI is an evolving field in veterinary radiology with rapid growth in use observed over the last 10 years.
Journal of Small Animal Practice, Jan 5, 2021
ObjectivesCytological biopsies are an integral additional test to an abdominal ultrasound when a ... more ObjectivesCytological biopsies are an integral additional test to an abdominal ultrasound when a lesion is identified, but there is little published on factors that that may impact achieving a clinically useful sample of gastrointestinal lesions obtained by ultrasound‐guided fine‐needle cytologic biopsy. This retrospective, descriptive study aimed to assess factors that may influence the clinical usefulness of submitted cytological samples collected from gastrointestinal lesions by ultrasound‐guided percutaneous fine‐needle cytologic biopsy.Material and MethodsGastrointestinal cytological samples obtained from 25 dogs and 19 cats over 2.5 years were reviewed and determined as clinically useful or clinically useless as per the cytology report. Variables dependent on the ultrasound exam that were used in the analysis included lesion location, lesion thickness, loss of gastrointestinal layering, and the number of slides submitted.ResultsThirty (30/44) of the submitted cytological samples were considered clinically useful. Factors associated with achieving a clinically useful sample in univariable models included the number of slides submitted and the thickness of the lesion. However, these two variables appear inter‐related, as a weak correlation existed between them. Where histologic biopsies were obtained, a clinically useful sample had a partial or complete agreement with histology in three of 12 and eight of 12 cases, respectively.Clinical SignificanceUltrasound‐guided fine‐needle cytological biopsies of gastrointestinal masses provided a clinically useful sample in two‐third of the cases, especially if more slides were provided to the cytologist and thicker lesions were sampled.
American Journal of Veterinary Research, Oct 1, 2008
Objective-To determine whether lymphocyte apoptosis in intestinal mucosae is more common in healt... more Objective-To determine whether lymphocyte apoptosis in intestinal mucosae is more common in healthy dogs than dogs with inflammatory bowel disease (IBD) and whether numbers of apoptotic cells increase after successful treatment of affected dogs. Animals-8 dogs with IBD (IBD dogs) and 8 healthy control dogs. Procedures-Biopsy specimens of the duodenum and colon were obtained via endoscopy from dogs with IBD before and after 10 weeks of standard treatment and compared with specimens obtained from control dogs. Expression of activated caspase 3 (Casp3), caspase-cleaved fragment p85 from poly-ADP-ribose polymerase (PARP), and B-cell leukemia/lymphoma 2 (Bcl-2) was measured in the duodenal (villous tip and base) and colonic mucosae. Results-Expression of Casp3 was greater in the duodenal villous tips of control dogs, compared with expression in similar tissues from dogs with IBD before or after treatment. Despite clinical improvement of dogs with IBD, expression of Casp3 did not increase after treatment. Expression of PARP did not differ between groups at any time point. Expression of Bcl-2 was greater at all 3 tissue sites in control dogs, compared with expression at the same sites in dogs with IBD. Furthermore, Bcl-2 expression in duodenal villous tips was higher in dogs with IBD after treatment but was not higher elsewhere. In control dogs, expression patterns for all 3 markers were similar between sites (villous tip > villous base > colon). Conclusions and Clinical Relevance-Expression of Casp3 in lymphocytes in duodenal villous tips was significantly reduced in dogs with IBD, compared with expression in healthy dogs, but no increase was detected following successful treatment of IBD. Increased expression of Bcl-2 may be a potential marker of the success of treatment.
Australian Veterinary Journal, Jul 22, 2019
Veterinary Clinical Pathology, Sep 9, 2019
This is the author manuscript accepted for publication and has undergone full peer review but has... more This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as
Journal of Small Animal Practice, Mar 1, 2013
The aim of this study was to determine canine breed predispositions for decreased serum folate or... more The aim of this study was to determine canine breed predispositions for decreased serum folate or markedly decreased cobalamin concentrations. METHODS: Retrospective analysis of samples from dogs that had serum folate and cobalamin concentrations measured, from 1990 to 2002 at the Comparative Gastroenterology Laboratory of Liverpool, were enrolled. A total of 13,069 samples were analysed. Those with trypsin-like immunoreactivity < 5•0 lg/L were excluded, and only breeds with at least 30 individuals tested were further analyzed. Breed predisposition was determined by calculating odds ratios and 95% confidence intervals for hypocobalaminaemia or decreased folate concentration. Significance was tested with a two-sided Fisher's exact test, and the level of statistical significance was set at P<0•05. RESULTS: A total of 9960 dogs fulfilled the inclusion criteria. Forty breeds contained at least 30 individuals. Predispositions for hypocobalaminaemia were identified in shar peis, Staffordshire bull terriers, German shepherd dogs and mixed breeds. Predispositions for decreased folate concentration were found in golden retrievers and boxers. CLINICAL SIGNIFICANCE: Predisposition for marked hypocobalaminaemia and decreased folate concentration differed between breeds. The shar peis had a markedly increased odds ratio for hypocobalaminaemia, as previously reported in North America, but other at-risk breeds were also identified.
Journal of Small Animal Practice, Oct 13, 2017
This is the author manuscript accepted for publication and has undergone full peer review but has... more This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as
Social Science Research Network, 2022
Journal of Feline Medicine and Surgery Open Reports, 2020
Case summary A 15-year-old male neutered domestic longhair cat was referred for investigation of ... more Case summary A 15-year-old male neutered domestic longhair cat was referred for investigation of a pancreatic nodule. Fine-needle aspiration of the nodule was performed on two occasions, 2 weeks apart, and cytology revealed pyogranulomatous inflammation and moderately dysplastic exocrine pancreatic epithelium, suspicious for neoplasia. Thoracic radiographs were unremarkable and a partial pancreatectomy was performed. On histopathology, the nodule was diagnosed as a moderately differentiated pancreatic adenocarcinoma. Two weeks after surgery, a firm subcutaneous nodule was detected on the left ventrolateral abdomen. Cytology of the nodule was suggestive of pancreatic carcinoma and needle tract seeding was suspected. With palliative treatment, the cat lived a further 136 days. Relevance and novel information To our knowledge, this represents the first report of suspected transabdominal needle tract seeding of pancreatic carcinoma following fine-needle aspiration in veterinary medicine. Veterinarians should consider this when discussing risks of pancreatic fine-needle aspiration with owners and should attempt to minimise the number of needle aspirations where possible.
Veterinary Clinics of North America-small Animal Practice, 2021
Veterinary Medicine : Research and Reports, Dec 1, 2019
In this article, the studies about the prevalence of chronic enteropathy are reviewed as well as ... more In this article, the studies about the prevalence of chronic enteropathy are reviewed as well as the information regarding short-and long-term prognosis for dogs treated with the three most common therapies; these include dietary modification, antibiotics, and immunosuppressants. Although the data available are limited, most studies support a good to excellent long-term response in dogs that have a successful food trial, whereas the response is poor with antibiotics or ongoing treatment is required to retain remission. There is a risk of antimicrobial resistance developing with inappropriate use of antimicrobials such as in these situations. The published information highlights the need for alternative strategies to antibiotic treatment to manipulate the GI microbiome, and in the final part of this article studies on the use of probiotic for the treatment of chronic enteropathy are reviewed.
Javma-journal of The American Veterinary Medical Association, Jun 15, 2013
P rotein-losing enteropathy is a syndrome characterized by loss of albumin through the intestinal... more P rotein-losing enteropathy is a syndrome characterized by loss of albumin through the intestinal wall and has been reported in many breeds including Basenji, German Shepherd Dog, Rottweiler, Soft-Coated Wheaten Terrier, and Yorkshire Terrier. 1 Various intestinal lesions can be responsible for the protein loss; primary and secondary lymphangiectesia have both been described as well as CEs characterized by inflammation of the intestines, infectious or parasitic diseases, and neoplastic diseases. 1 When PLE arises secondary to CE, it is usually considered to have a guarded prognosis because of the unpredictable response to treatment and risk of relapse. 1 Comparison of a chlorambucil-prednisolone combination with an azathioprine-prednisolone combination for treatment of chronic enteropathy with concurrent protein-losing enteropathy in dogs: 27 cases (2007-2010
Chronic enteropathy (CE) is an umbrella term used in dogs to describe a group of diseases with di... more Chronic enteropathy (CE) is an umbrella term used in dogs to describe a group of diseases with different aetiologies, characterised by chronic gastrointestinal signs. These diseases are clinically classified according to treatment response as food-responsive (FRE), antibiotic-responsive (ARE), and immunosuppressant-responsive enteropathies (IRE). The first part of this PhD thesis prospectively describes the features of CE that are commonly seen in dogs presenting to a referral centre in Australia; information that has not been available previously. We found that similar to other countries, most dogs with CE are food-responsive, followed by antibiotic-responsive with a minority of immunosuppressant-responsive. Furthermore, our study raised concerns about prolonged antibiotic treatment for dogs with ARE. Firstly, most of these dogs do not respond to treatment completely for prolonged periods (as opposed to dogs with FRE that do), raising the question about the real benefit of antibiotic treatment. Secondly, half of the dogs with ARE required long-term or pulse treatment with antibiotics, which raises concerns about development of bacterial resistance. Our findings highlight the need to find alternative treatment for dogs with ARE in view of the poor long-term outcome. Although most dogs with FRE had long-term remission, adequate dietary trials were not performed until reaching the referral setting. This indicates that better education of general veterinary practitioners about the importance of performing adequate diet trial is needed to improve early disease remission in these dogs. The next focus of the research was to evaluate the role of macrophages in CE; this was achieved by using two macrophage markers: calprotectin and cluster of differentiation 163 (CD163) in immunohistochemical examination. Both
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Papers by Julien Dandrieux