Papers by Julian Rodriguez
Acta Neuropathologica, 1994
We report a case of spinal cord neurocytoma in a 67-year-old man who had experienced a progressiv... more We report a case of spinal cord neurocytoma in a 67-year-old man who had experienced a progressive numbness of the left foot during the previous 4 years. Magnetic resonance imaging showed a well-defined intramedullary tumor located at the T10-Tll level. The pathological examination revealed histological characteristics described in neurocytomas. The tumor cells showed a uniform small nucleus and clear or slightly eosinophilic cytoplasm with frequent perinuclear halos, resembling the picture of oligodendroglioma. Some tumor cells exhibited mature ganglion cell appearance. Electron microscopy showed cells with microtubules and dense-core vesicles in their cytoplasm and cytoplasmic process. Immunohistochemically, the majority of tumor cells expressed synaptophysin and neuronspecific enolase. We conclude that this tumor is an exceptional case of neurocytoma located in the spinal cord, and consider that the term neurocytoma can be applied to tumors with neuronal differentiation intermediate between neuroblastoma and ganglioneuroma, even if arising in CNS outside of the intracranial ventricular system. Key words Neurocytoma 9 Spinal cord differentiation. It was first described by Hassoun et al. [8]. Since then about 100 other cases have been reported [2, 5, 7, 9, 11-13, 20], very few of which were shown to be located in parts of the brain other than in the ventricular system [7, 12]. Only four cases have been described in the cervical cord [14, 15]. In this report we present a spinal cord tumor in a 67-year-old man, with the histological, immunohistochemical and ultrastructural characteristics of a central neurocytoma.
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Papers by Julian Rodriguez