Proceedings of Spie the International Society For Optical Engineering, Mar 13, 2001
Biosensor, ELISA, and frog embryo teratogenesis assay: Xenopus (FETAX) analysis of water associat... more Biosensor, ELISA, and frog embryo teratogenesis assay: Xenopus (FETAX) analysis of water associated with frog malformations in Minnesota. [Proceedings of SPIE 4206, 147 (2001)]. Eric AE Garber, Judith L. Erb, James G. Downward ...
Advances In Experimental Medicine And Biology, 2008
A novel evanescent-based biosensor (Endotect, ThreeFold Sensors, Inc.) was developed with laser-b... more A novel evanescent-based biosensor (Endotect, ThreeFold Sensors, Inc.) was developed with laser-based fiber optics using fluorescent dye-labeled recombinant human estrogen receptor-alpha (rhERalpha) and hERbeta as probes. A three-tiered approach evaluating various steps in the formation of the estrogen-receptor complex and its subsequent activity was developed for instrument calibration to detect estrogen mimics in biological samples, water and soil. Using this approach, binding affinities and activities of certain known estrogen mimics were determined for their use as calibrator molecules. Results indicated rhERalpha and rhERbeta may be employed as probes to distinguish estrogen mimics with a broad range of affinities. In addition, application of the biosensor for detecting DNA-binding proteins in human tissue extracts was demonstrated. The later studies suggest the biosensor may be used as a clinical laboratory tool for assessing tumor marker proteins.
Proceedings of Spie the International Society For Optical Engineering, Mar 13, 2001
Biosensor, ELISA, and frog embryo teratogenesis assay: Xenopus (FETAX) analysis of water associat... more Biosensor, ELISA, and frog embryo teratogenesis assay: Xenopus (FETAX) analysis of water associated with frog malformations in Minnesota. [Proceedings of SPIE 4206, 147 (2001)]. Eric AE Garber, Judith L. Erb, James G. Downward ...
Advances In Experimental Medicine And Biology, 2008
A novel evanescent-based biosensor (Endotect, ThreeFold Sensors, Inc.) was developed with laser-b... more A novel evanescent-based biosensor (Endotect, ThreeFold Sensors, Inc.) was developed with laser-based fiber optics using fluorescent dye-labeled recombinant human estrogen receptor-alpha (rhERalpha) and hERbeta as probes. A three-tiered approach evaluating various steps in the formation of the estrogen-receptor complex and its subsequent activity was developed for instrument calibration to detect estrogen mimics in biological samples, water and soil. Using this approach, binding affinities and activities of certain known estrogen mimics were determined for their use as calibrator molecules. Results indicated rhERalpha and rhERbeta may be employed as probes to distinguish estrogen mimics with a broad range of affinities. In addition, application of the biosensor for detecting DNA-binding proteins in human tissue extracts was demonstrated. The later studies suggest the biosensor may be used as a clinical laboratory tool for assessing tumor marker proteins.
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Papers by Judith Erb