This study deals with the pressure-dependence of porous rock deformation, the permeability change... more This study deals with the pressure-dependence of porous rock deformation, the permeability changes associated with this deformation, and the consequent effects of fluid flow during the CO 2 injection phase in different configurations of deep saline aquifers. The study is approached from the standpoint of critical state soil mechanics, analyzing the effect exerted by different aspects that influence the geomechanical behaviour of porous rocks during CO 2 storage. Through the study of the hydromechanical response of the environment, this paper shows how to assess the advisability of the use of CO 2 storage, also identifying those cases and environments that would be less likely to lead to the creation or reopening of potential leakage paths.
Febrile neutropenia (FN) is associated with disruption of planned chemotherapy and increased mana... more Febrile neutropenia (FN) is associated with disruption of planned chemotherapy and increased management costs. However, the economic impact of FN in Spanish clinical practice has not been documented hitherto. A multicenter, retrospective chart review of adults with breast or lung cancer or non-Hodgkin's lymphoma (NHL) who had > or = 1 FN episode during chemotherapy. Resource use, direct costs, and FN effect on planned chemotherapy were assessed. 238 episodes of FN were analyzed in 194 patients. The mean + or - SD length of FN-related hospitalization was 8.7 + or - 6.9 days (median [p(25)-p(75)] = 7 [5-11] days). At least one transfusion was needed in 77 (32.3%) FN episodes, blood tests were done in 233 (97.9%) and blood cultures in 207 (87.0%). Antibiotics were used in all episodes (100%), other drugs in 186 (78.2%) episodes and the granulocyte colony-stimulating factor (G-CSF) in 161 (67.7%) episodes. The distribution of costs per episode of FN were: hospitalization 79%, antibiotics 10%, G-CSF 5%, complementary tests 4%; other drugs 1%, blood transfusions 1%. The estimated mean (95% CI) cost per FN episode was euro3841 (95% CI: euro3476-4206). FN management was costlier in NHL patients euro4514 (95% CI: euro3805-5223) than in breast or lung cancer patients (euro3519 [95% CI: euro2976-4061] and euro3311 [95% CI: euro2817-3805] respectively) (P…
Trees growing close to buildings in urban landscapes may change the soil moisture around foundati... more Trees growing close to buildings in urban landscapes may change the soil moisture around foundations, producing shrinkage and swelling. This paper presents a numerical solver to estimate the movements resulting from these volumetric strains. This tool will be of assistance in both designing the footings of new buildings and in the analysis of damage associated with buildings that have already been constructed. The conceptual model used is based on current knowledge of the hydro-mechanical behaviour of unsaturated soils. Its numerical implementation is simple, making it easy for users to make changes as they see fit. The program has been verified, validated, and applied in a real stabilization problem.
Parameter identification is one of the key elements in the construction of models in geosciences.... more Parameter identification is one of the key elements in the construction of models in geosciences. However inherent difficulties such as the instability of ill-posed problems or the presence of multiple local optima may impede the execution of this task. Regularization methods and Bayesian formulations, such as the maximum a posteriori estimation approach, have been used to overcome those complications. Nevertheless, in some instances, a more in-depth analysis of the inverse problem is advisable before obtaining estimates of the optimal parameters. The Markov Chain Monte Carlo (MCMC) methods used in Bayesian inference have been applied in the last 10 years in several fields of geosciences such as hydrology, geophysics or reservoir engineering. In the present paper a compilation of basic tools for
This study deals with the pressure-dependence of porous rock deformation, the permeability change... more This study deals with the pressure-dependence of porous rock deformation, the permeability changes associated with this deformation, and the consequent effects of fluid flow during the CO 2 injection phase in different configurations of deep saline aquifers. The study is approached from the standpoint of critical state soil mechanics, analyzing the effect exerted by different aspects that influence the geomechanical behaviour of porous rocks during CO 2 storage. Through the study of the hydromechanical response of the environment, this paper shows how to assess the advisability of the use of CO 2 storage, also identifying those cases and environments that would be less likely to lead to the creation or reopening of potential leakage paths.
Febrile neutropenia (FN) is associated with disruption of planned chemotherapy and increased mana... more Febrile neutropenia (FN) is associated with disruption of planned chemotherapy and increased management costs. However, the economic impact of FN in Spanish clinical practice has not been documented hitherto. A multicenter, retrospective chart review of adults with breast or lung cancer or non-Hodgkin's lymphoma (NHL) who had > or = 1 FN episode during chemotherapy. Resource use, direct costs, and FN effect on planned chemotherapy were assessed. 238 episodes of FN were analyzed in 194 patients. The mean + or - SD length of FN-related hospitalization was 8.7 + or - 6.9 days (median [p(25)-p(75)] = 7 [5-11] days). At least one transfusion was needed in 77 (32.3%) FN episodes, blood tests were done in 233 (97.9%) and blood cultures in 207 (87.0%). Antibiotics were used in all episodes (100%), other drugs in 186 (78.2%) episodes and the granulocyte colony-stimulating factor (G-CSF) in 161 (67.7%) episodes. The distribution of costs per episode of FN were: hospitalization 79%, antibiotics 10%, G-CSF 5%, complementary tests 4%; other drugs 1%, blood transfusions 1%. The estimated mean (95% CI) cost per FN episode was euro3841 (95% CI: euro3476-4206). FN management was costlier in NHL patients euro4514 (95% CI: euro3805-5223) than in breast or lung cancer patients (euro3519 [95% CI: euro2976-4061] and euro3311 [95% CI: euro2817-3805] respectively) (P…
Trees growing close to buildings in urban landscapes may change the soil moisture around foundati... more Trees growing close to buildings in urban landscapes may change the soil moisture around foundations, producing shrinkage and swelling. This paper presents a numerical solver to estimate the movements resulting from these volumetric strains. This tool will be of assistance in both designing the footings of new buildings and in the analysis of damage associated with buildings that have already been constructed. The conceptual model used is based on current knowledge of the hydro-mechanical behaviour of unsaturated soils. Its numerical implementation is simple, making it easy for users to make changes as they see fit. The program has been verified, validated, and applied in a real stabilization problem.
Parameter identification is one of the key elements in the construction of models in geosciences.... more Parameter identification is one of the key elements in the construction of models in geosciences. However inherent difficulties such as the instability of ill-posed problems or the presence of multiple local optima may impede the execution of this task. Regularization methods and Bayesian formulations, such as the maximum a posteriori estimation approach, have been used to overcome those complications. Nevertheless, in some instances, a more in-depth analysis of the inverse problem is advisable before obtaining estimates of the optimal parameters. The Markov Chain Monte Carlo (MCMC) methods used in Bayesian inference have been applied in the last 10 years in several fields of geosciences such as hydrology, geophysics or reservoir engineering. In the present paper a compilation of basic tools for
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Papers by Juan Alonso