Papers by José Algaba Moreno
Selecciones Avicolas, 2006
Frontiers in immunology, 2017
Antigen processing for presentation by major histocompatibility complex class II (MHCII) molecule... more Antigen processing for presentation by major histocompatibility complex class II (MHCII) molecules requires the latter to travel through the endocytic pathway together with its chaperons: the invariant chain (Ii) and DM. Nevertheless, the nature of the compartments where MHCII molecules travel to acquire peptides lacks definition regarding molecules involved in intracellular vesicular trafficking, such as Rab small GTPases. We aimed to define which Rab proteins are present during the intracellular transport of MHCII, DM, and Ii through the endocytic pathway on their route to the cell surface during dendritic cell (DC) maturation. We examined, by means of three-color confocal microscopy, the association of MHCII, DM, and Ii with Rab5, Rab7, Rab9, and Rab11 during the maturation of bone marrow-derived or spleen DC in response to LPS as an inflammatory stimulus. Prior to the stage of immature DC, MHCII migrated from diffuse small cytoplasmic vesicles, predominantly Rab5+Rab7- and Rab5+...
Journal of Ovarian Research, 2013
Background Studies of alternative mRNA splicing (AS) in health and disease have yet to yield the ... more Background Studies of alternative mRNA splicing (AS) in health and disease have yet to yield the complete picture of protein diversity and its role in physiology and pathology. Some forms of cancer appear to be associated to certain alternative mRNA splice variants, but their role in the cancer development and outcome is unclear. Methods We examined AS profiles by means of whole genome exon expression microarrays (Affymetrix GeneChip 1.0) in ovarian tumors and ovarian cancer-derived cell lines, compared to healthy ovarian tissue. Alternatively spliced genes expressed predominantly in ovarian tumors and cell lines were confirmed by RT-PCR. Results Among several significantly overexpressed AS genes in malignant ovarian tumors and ovarian cancer cell lines, the most significant one was that of the zinc finger protein ZNF695, with two previously unknown mRNA splice variants identified in ovarian tumors and cell lines. The identity of ZNF695 AS variants was confirmed by cloning and seque...
Revista Ingenieria Uc, 2013
Sensors (Basel, Switzerland), Jan 31, 2018
Different tools are being implemented in order to improve the water management in agricultural ir... more Different tools are being implemented in order to improve the water management in agricultural irrigated areas of semiarid environments. Thermography has been progressively introduced as a promising technique for irrigation scheduling and the assessing of crop-water status, especially when deficit irrigation is being implemented. However, an important limitation is related to the cost of the actual cameras, this being a severe limitation to its practical usage by farmers and technicians. This work evaluates the potential and the robustness of a thermal imaging camera that is connected to smartphone (Flir One) recently developed by Flir Systems Inc. as a first step to assess the crop water status. The trial was developed in mature almond ( Mill.) trees that are subjected to different irrigation treatments. Thermal information obtained by the Flir One camera was deal with the thermal information obtained with a conventional Thermal Camera (Flir SC660) with a high resolution, and subse...
I+D Tecnológico
El ransomware es una de las nuevas amenazas a las que estamos expuestos, enfocándose principalmen... more El ransomware es una de las nuevas amenazas a las que estamos expuestos, enfocándose principalmente en los sistemas operativos de escritorio Windows, sin dejar de lado a los dispositivos móviles y microcomputadores que también están expuestos de igual manera al robo, fuga de información y secuestro de los datos, poniendo en riesgo la seguridad personal. El ransomware ha evolucionado a través de la implementación de técnicas criptográficas que utilizan algoritmos de cifrado asimétrico. Además, utiliza la ingeniería social como principal método de propagación de malware, en este trabajo se presenta el análisis del ransomware hidden tear, los lineamientos de detección y prevención, además de buenas prácticas y recomendaciones.
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Papers by José Algaba Moreno