Papers by Joanna Brydak-Godowska
PubMed, 2007
Helicoidal peripapillary chorioretinal degeneration (HCPD) is characterized by bilateral wing- sh... more Helicoidal peripapillary chorioretinal degeneration (HCPD) is characterized by bilateral wing- shaped atrophic areas in retina, radiating from the optic disc. Two cases (women: 23 and 58 years old) of this rare degeneration are presented. No changes of eye fundus and erg, eog, visual field evaluations had been noticed during 2 years follow-up.
PubMed, 2007
The aim of the study was to assess ocular manifestations in patients with systemic lupus erythema... more The aim of the study was to assess ocular manifestations in patients with systemic lupus erythematosus (SLE). The following, were included in the evaluation: clinical condition, duration of the disease and treatment used. The study was performed in 100 patients with SLE. Evaluation of the clinical condition and opththalmoscopic findings in patients with SLE demonstrated abnormal Schirmer tests in 41% patients, scleritis 2%, retinopathy 7% and neuritis 1%. Inflammatory changes in the anterior segment of the eyeball, neuritis and retinopathy occurred solely in the phase of exacerbation. Adverse events observed after treatment with chloroquine or prednisone (chloroquine maculopathy,cataract, glaucoma) are related to dosage and duration of the treatment.
PubMed, Oct 1, 2018
Objectives: Myopia is associated with increased frequency of retinal degenerative changes which a... more Objectives: Myopia is associated with increased frequency of retinal degenerative changes which are the risk factors of intra- and postpartal ophthalmological complications. Aim of this study was to analyze the degenerative lesions detected in opthalmological examination (including peripheral retinal lesions) as a potential risk factors for eyes' status in terms of delivery in myopic women. Material and methods: 254 pregnant women affected with myopia underwent opthalmological examination as a screening method to examine retina. In case of any degenerative lesions, the qualification for laser photocoagulation treatment was performed. Furthermore, study group was divided into two subgroups due to presence or absence of the retinal lesions and opthalmological outcomes compared. Follow up examination was performed in every patient from the study group between 3 and 6 months after the delivery. Results: Among 508 eyes, retinal lesions were revealed in 69 women (121 eyes) what constituted for 23.8%. In remaining 185 patients results of the opthalmological examination were normal. Average maternal age was higher in group affected with degenerative lesions (p<0.001). Myopia in women with retinal lesions ranged between -0.25 and -12 dioptries (D), while in 43 cases of degenerative lesions qualified for laser photocoagulation this value ranged between -0.5 and -12.0 D (p=ns). Postpartal follow-up examination did not reveal any abnormalities in this group, as well. Conclusion: Degenerative retinal lesions are present in one fourth of pregnant women. Both the severity and type of the lesions are not associated with severity of myopia. Among pregnant patients, retinal lesions occur in patients with more advanced maternal age. opthalmological examination remains an important prophylactic modality in retinal disorders, especially in primary retinal detachment due degenerative disorders.
Medical Science Monitor, Jul 8, 2021
Self financing During the coronavirus disease 2019 (COVID-19) pandemic, numerous reports of ocula... more Self financing During the coronavirus disease 2019 (COVID-19) pandemic, numerous reports of ocular anomalies occurring in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged. The most frequently reported pathology is conjunctivitis, which may be the first or only clinical manifestation of the disease. Involvement of SARS-CoV-2 in development of alterations in other ocular structures was suggested, including the cornea, the retina, and blood vessels. Possible mechanisms include direct activity of the viral agent, as well as systemic inflammatory response with accompanying thromboembolic complications. Genetic material of SARS-CoV-2 was detected in ocular secretions of infected individuals, including asymptomatic patients. Moreover, angiotensin-converting enzyme 2 (ACE2), a receptor protein used by the virus to enter the cell, has been found on the surface of various structures of the eye, which indicates a risk of transmission through ocular tissues. Therefore, it is crucial to use eye protection by medical professionals having contact with potentially infected patients. This paper is a review of the literature regarding ocular manifestations of SARS-CoV-2 infection and a summary of the current state of knowledge about possibility of transmission from an ophthalmology point of view. For data collection, a thorough PubMed search was performed, using the key words: "COVID ocular", "COVID eye", "SARS-CoV-2 ocular", and "SARS-CoV-2 eye". Conclusions: SARS-CoV-2 infection may manifest itself in various ocular conditions. Eye protection should not be neglected, as recent studies suggest the eye as a potential route of transmission. Further search for adequate safety measures in ophthalmology practice is required.
PubMed, 2016
Objective: To present the influence of dexamethasone intravitreal implant due to macular edema in... more Objective: To present the influence of dexamethasone intravitreal implant due to macular edema in non-infectious uveitis in the fellow eye. Patients and methods: A 25-year-old patient with a long history of juvenile arthritis with concomitant recurrent bilateral uveitis, complicated with increases of intraocular pressure and macular edema was treated with a single intravitreal dexamethasone implant into the eye with lower visual acuity. Results: During a 36-month follow-up, the patient's bilateral visual acuity improved. The retinal thickness in both maculae decreased. Conclusions: Treating macular edema in the course of recurrent uveitis accompanying a systemic disease with dexamethasone depot in vitreous may play a beneficial role also in the fellow eye, when affected. This therapeutic effect in the fellow eye may suggest that the medication can penetrate into the circulatory system and reach such other organs as the fellow eye.
Medical Science Monitor
Self financing During the coronavirus disease 2019 (COVID-19) pandemic, numerous reports of ocula... more Self financing During the coronavirus disease 2019 (COVID-19) pandemic, numerous reports of ocular anomalies occurring in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged. The most frequently reported pathology is conjunctivitis, which may be the first or only clinical manifestation of the disease. Involvement of SARS-CoV-2 in development of alterations in other ocular structures was suggested, including the cornea, the retina, and blood vessels. Possible mechanisms include direct activity of the viral agent, as well as systemic inflammatory response with accompanying thromboembolic complications. Genetic material of SARS-CoV-2 was detected in ocular secretions of infected individuals, including asymptomatic patients. Moreover, angiotensin-converting enzyme 2 (ACE2), a receptor protein used by the virus to enter the cell, has been found on the surface of various structures of the eye, which indicates a risk of transmission through ocular tissues. Therefore, it is crucial to use eye protection by medical professionals having contact with potentially infected patients. This paper is a review of the literature regarding ocular manifestations of SARS-CoV-2 infection and a summary of the current state of knowledge about possibility of transmission from an ophthalmology point of view. For data collection, a thorough PubMed search was performed, using the key words: "COVID ocular", "COVID eye", "SARS-CoV-2 ocular", and "SARS-CoV-2 eye". Conclusions: SARS-CoV-2 infection may manifest itself in various ocular conditions. Eye protection should not be neglected, as recent studies suggest the eye as a potential route of transmission. Further search for adequate safety measures in ophthalmology practice is required.
Annals of Transplantation, 2009
European Journal of Ophthalmology, 2011
Neuro endocrinology letters, 2018
OBJECTIVES Myopia is associated with increased frequency of retinal degenerative changes which ar... more OBJECTIVES Myopia is associated with increased frequency of retinal degenerative changes which are the risk factors of intra- and postpartal ophthalmological complications. Aim of this study was to analyze the degenerative lesions detected in opthalmological examination (including peripheral retinal lesions) as a potential risk factors for eyes' status in terms of delivery in myopic women. MATERIAL AND METHODS 254 pregnant women affected with myopia underwent opthalmological examination as a screening method to examine retina. In case of any degenerative lesions, the qualification for laser photocoagulation treatment was performed. Furthermore, study group was divided into two subgroups due to presence or absence of the retinal lesions and opthalmological outcomes compared. Follow up examination was performed in every patient from the study group between 3 and 6 months after the delivery. RESULTS Among 508 eyes, retinal lesions were revealed in 69 women (121 eyes) what constitut...
Annals of Transplantation, 2009
European review for medical and pharmacological sciences, 2016
OBJECTIVE To present the influence of dexamethasone intravitreal implant due to macular edema in ... more OBJECTIVE To present the influence of dexamethasone intravitreal implant due to macular edema in non-infectious uveitis in the fellow eye. PATIENTS AND METHODS A 25-year-old patient with a long history of juvenile arthritis with concomitant recurrent bilateral uveitis, complicated with increases of intraocular pressure and macular edema was treated with a single intravitreal dexamethasone implant into the eye with lower visual acuity. RESULTS During a 36-month follow-up, the patient's bilateral visual acuity improved. The retinal thickness in both maculae decreased. CONCLUSIONS Treating macular edema in the course of recurrent uveitis accompanying a systemic disease with dexamethasone depot in vitreous may play a beneficial role also in the fellow eye, when affected. This therapeutic effect in the fellow eye may suggest that the medication can penetrate into the circulatory system and reach such other organs as the fellow eye.
Klinika oczna, 2007
The aim of the study was to assess ocular manifestations in patients with systemic lupus erythema... more The aim of the study was to assess ocular manifestations in patients with systemic lupus erythematosus (SLE). The following, were included in the evaluation: clinical condition, duration of the disease and treatment used. The study was performed in 100 patients with SLE. Evaluation of the clinical condition and opththalmoscopic findings in patients with SLE demonstrated abnormal Schirmer tests in 41% patients, scleritis 2%, retinopathy 7% and neuritis 1%. Inflammatory changes in the anterior segment of the eyeball, neuritis and retinopathy occurred solely in the phase of exacerbation. Adverse events observed after treatment with chloroquine or prednisone (chloroquine maculopathy,cataract, glaucoma) are related to dosage and duration of the treatment.
Advances in Experimental Medicine and Biology, 2017
Bartonella species, vector-borne etiologic agents of many systemic or self-limited infections, ar... more Bartonella species, vector-borne etiologic agents of many systemic or self-limited infections, are responsible for a widening spectrum of diseases in humans, including inflammatory conditions of the eye. The aim of this study was to determine whether there is any relationship between uveitis and the evidence of Bartonella spp. infection in the serum, ocular fluid, and cataract mass in patients with intraocular inflammation. Polymerase chain reaction (PCR)-based tests and DNA sequencing were performed on surgery-extracted specimens of intraocular fluid and lens mass of 33 patients. Sera from 51 patients and 101 control subjects were tested for the presence of specific antibodies against Bartonella spp. Neither IgM-class antibodies against Bartonella spp. nor Bartonella spp. DNA were detected. A specific IgG-class antibody was found in 33.3% of the patients with uveitis. The rate of positive Bartonella serology was higher among the uveitis patients than that in control subjects. This high rate may in part result from unrecognized indirect mechanisms rather than the immediate presence and multiplication of Bartonella spp. in the eyeball. Nonetheless we believe that screening for Bartonella spp. should become part of the diagnostic workup in uveitis.
Klinika oczna, 2007
Systemic lupus erythematosus (SLE) is a chronic, immunologically mediated inflammatory connective... more Systemic lupus erythematosus (SLE) is a chronic, immunologically mediated inflammatory connective tissue disorder with manifestations including various body organs (joints, pleura, pericardium, kidneys, brain, skin), caused by accumulation of immune complexes. According to epidemiological data SLE affects 0.12% of the population worldwide, while in Poland the number of reported cases is c. 60 000 - 80 000. SLE may also involve the eye. Anterior segment findings include keratoconjunctivitis sicca, keratitis and scleritis. Retinal manifestations of SLE are cotton wool spots, hemorrhage and vasculitis. The ARA (American Rheumatism Association), criteria are used in establishing the diagnosis of SLE. Although the ocular symptoms are not included in the ARA criteria, they may be initial findings and precede other manifestations of SLE.
Diagnostics
Background: Focal choroidal excavation (FCE) is one of the pachychoroid spectrum diseases. It may... more Background: Focal choroidal excavation (FCE) is one of the pachychoroid spectrum diseases. It may be an isolated lesion or associated with other ophthalmological disorders. The aim of the study was to present the epidemiology, clinical features and multimodal imaging findings in FCE. Methods: This is a case series of 14 consecutive patients with a diagnosis of FCE, confirmed by multimodal imaging, from a review of the 5076 optical coherence tomography (OCT) scans in 2538 patients. Choroidal thickness (CT) was measured under the fovea and in the area of maximum choroidal thickening in the affected eye and under the fovea in the fellow eye. Results: The mean age of the subjects was 40 ± 13.58 years. FCE occurred unilaterally and was an isolated lesion in all cases. The fellow eye did not show any macular pathology in all patients. Twelve eyes presented conforming FCEs and two non–conforming FCEs. In 79% of cases, FCE was subfoveal. The mean maximum CT was 390 μm in the affected eye wi...
Ophthalmology Journal
This article is available in open access under Creative Common Attribution-Non-Commercial-No Deri... more This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially
Journal of ophthalmology, 2017
To assess the occurrence of choroidal neovascularization (CNV) secondary to chronic central serou... more To assess the occurrence of choroidal neovascularization (CNV) secondary to chronic central serous chorioretinopathy (CSCR) using optical coherence tomography angiography (OCTA) and correlate these findings with choroidal thickness (CT). This retrospective study included 25 consecutive patients (43 eyes), mean age 48.12 ± 7.8 years, diagnosed with persistent CSCR. All patients underwent a complete ophthalmic examination, fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography, and OCTA. CNV was confirmed in 18.6% of eyes using FA and ICGA and in 25.6% of eyes using OCTA. All cases of CNV were associated with irregular retinal pigment epithelial detachment. CT was increased in the affected eyes (mean 491.05 ± 91.98), but there were no statistically significant correlations between CT and CNV and PED occurrence (= 0.661 and= 0.614, resp.) and between CT and duration of the disease (= 0.940). OCTA detected CNV more frequently than other imaging ...
Ocular immunology and inflammation, Jan 8, 2018
To describe a case series of ocular complications associated with upper respiratory tract infecti... more To describe a case series of ocular complications associated with upper respiratory tract infections. Four patients aged 21-61 years (three females, one male) had confirmed ocular complications connected with a general upper respiratory tract infection with myalgia and fever. Ophthalmological examination, including a visual acuity test, a slit-lamp exam, intraocular pressure measurements, fluorescein and indocyanine green angiography, optical coherence tomography (OCT), and diagnostic tests for influenza were performed in the patients (RT-PCR, HAI). Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) was diagnosed in three patients and serous macular detachment (SME) in one. Influenza virus infection was confirmed by molecular biological methods (RT-PCR) or the hemagglutination inhibition test (HAI) in two patients. All patients were treated with systemic prednisone. A coincidence between APMPPE and SME epitheliopathy and influenza virus infection was observed in diff...
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Papers by Joanna Brydak-Godowska