J.-f. Nicolas
Professor Jean-François Nicolas
Dermatology, Allergology & Clinical Immunology
Past & Present
Jean-François Nicolas is head of the Allergology and Clinical Immunology Department of Lyon University Hospital. He is dermatologist, professor of Immunology and PI of a research team in INSERM Unit 1111-CIRI (co-PI Marc Vocanson).
The main research themes concern immunodermatology and more precisely the pathophysiology of skin inflammation.
JF Nicolas received his MD from Lyon University Medical School in 1983. His dermatology speciality degree was obtained through specific training in immunodermatology (Professor Jean Thivolet). He obtained a PhD in 1990, having trained at Scripps Clinic and the University of California, San-Diego (Dr Jacques Chiller) and having been a recipient of an INSERM young investigator award. He then entered INSERM as Research Director and worked successively in Dermatology (U 209 and U 346, 1990-1992) and Immunology (U80, U999 and U503, 1992-1998) Inserm Research Units.
JF Nicolas was appointed Professor of Immunology - Hospital Practitioner in 1998 in Lyon University Hospital where he developed a skin inflammation/drug allergy clinical unit that became in 2005 the department of Allergology and Clinical Immunology (Co-Head Pr F Bérard).
Scientific summary
JF Nicolas’s research activities concern the Skin Immune System, and especially the study of cellular and molecular signals that lead to immune responses or tolerance to cutaneous antigens and allergens. Research projects are directed to the understanding of the immune mechanisms leading to inflammatory skin diseases (eczemas, psoriasis and drug allergy) using both clinical, translational and fundamental studies in pre-clinical mouse models of these diseases. In addition, the team works on cutaneous routes of vaccination to improve the overall efficacy of vaccines.
Important contributions include: i) the demonstration that CD8+ cytotoxic T cells are major effector cells of several antigen/allergen specific skin diseases including eczemas (allergic contact dermatitis and atopic eczema) and T cell-mediated drug allergies; ii) the characterization of different subsets of CD4+ Treg cells able to prevent (tolerance) or limit (regulation) the skin inflammation.
JF Nicolas is very much involved in teaching/training of medical students especially in the field of allergy, skin biology, immunodermatology and clinical immunology.
JF Nicolas has authored or co-authored over 150 research papers and book chapters. He is the Co-Editor of the European Journal of Dermatology that he founded with Jean Thivolet in 1990.
More info on:
Annual report on the activities of the department of Allergology & Clinical Immunology Lyon:
http://allergo.lyon.inserm.fr/affiches/Rapport_activite_2015.pdf
Fundamental & Translationnal research activities: http://ciri.inserm.fr/les-equipes/toutes-nos-equipes/immunologie-de-lallergie-cutanee-et-vaccination/themes-de-recherches/
Dermatology, Allergology & Clinical Immunology
Past & Present
Jean-François Nicolas is head of the Allergology and Clinical Immunology Department of Lyon University Hospital. He is dermatologist, professor of Immunology and PI of a research team in INSERM Unit 1111-CIRI (co-PI Marc Vocanson).
The main research themes concern immunodermatology and more precisely the pathophysiology of skin inflammation.
JF Nicolas received his MD from Lyon University Medical School in 1983. His dermatology speciality degree was obtained through specific training in immunodermatology (Professor Jean Thivolet). He obtained a PhD in 1990, having trained at Scripps Clinic and the University of California, San-Diego (Dr Jacques Chiller) and having been a recipient of an INSERM young investigator award. He then entered INSERM as Research Director and worked successively in Dermatology (U 209 and U 346, 1990-1992) and Immunology (U80, U999 and U503, 1992-1998) Inserm Research Units.
JF Nicolas was appointed Professor of Immunology - Hospital Practitioner in 1998 in Lyon University Hospital where he developed a skin inflammation/drug allergy clinical unit that became in 2005 the department of Allergology and Clinical Immunology (Co-Head Pr F Bérard).
Scientific summary
JF Nicolas’s research activities concern the Skin Immune System, and especially the study of cellular and molecular signals that lead to immune responses or tolerance to cutaneous antigens and allergens. Research projects are directed to the understanding of the immune mechanisms leading to inflammatory skin diseases (eczemas, psoriasis and drug allergy) using both clinical, translational and fundamental studies in pre-clinical mouse models of these diseases. In addition, the team works on cutaneous routes of vaccination to improve the overall efficacy of vaccines.
Important contributions include: i) the demonstration that CD8+ cytotoxic T cells are major effector cells of several antigen/allergen specific skin diseases including eczemas (allergic contact dermatitis and atopic eczema) and T cell-mediated drug allergies; ii) the characterization of different subsets of CD4+ Treg cells able to prevent (tolerance) or limit (regulation) the skin inflammation.
JF Nicolas is very much involved in teaching/training of medical students especially in the field of allergy, skin biology, immunodermatology and clinical immunology.
JF Nicolas has authored or co-authored over 150 research papers and book chapters. He is the Co-Editor of the European Journal of Dermatology that he founded with Jean Thivolet in 1990.
More info on:
Annual report on the activities of the department of Allergology & Clinical Immunology Lyon:
http://allergo.lyon.inserm.fr/affiches/Rapport_activite_2015.pdf
Fundamental & Translationnal research activities: http://ciri.inserm.fr/les-equipes/toutes-nos-equipes/immunologie-de-lallergie-cutanee-et-vaccination/themes-de-recherches/
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