Background T-cell lymphoblastic lymphoma (T-LBL) is an aggressive neoplasm closely related to T-c... more Background T-cell lymphoblastic lymphoma (T-LBL) is an aggressive neoplasm closely related to T-cell acute lymphoblastic leukaemia (T-ALL). Despite their similarities, and contrary to TALL , studies on pediatric T-LBL are scarce and, therefore, its molecular landscape has not been fully elucidated yet. Procedure To characterize the genetic and molecular heterogeneity of paediatric T-LBL, 33 patients were analyzed using an integrated approach, including targeted next generation sequencing, RNA-sequencing transcriptome analysis and copy-number arrays. Results Copy number and mutational analyses allowed the detection of recurrent homozygous deletions of 9p/CDKN2A (78%), trisomy 20 (19%) and gains of 17q24-q25 (16%), as well as frequent mutations of NOTCH1 (62%), followed by BCL11B (23%), WT1 (19%) and FBXW7, PHF6 and RPL10 genes (15%, respectively). This genetic profile did not differ to that described in TALL in terms of mutation incidence and global genomic complexity level but unveiled virtually exclusive 17q25 gains and trisomy 20 in T-LBL. Additionally, we identified novel gene fusions in paediatric T-LBL including NOTCH1-IKZF2, RNGTT-SNAP91 and DDX3X-MLLT10, the latter being the only one previously described in TALL. Moreover, clinical correlations highlighted the presence of Notch pathway alterations as a factor related to favorable outcome. Conclusions In summary, the genomic landscape of paediatric T-LBL is similar to that observed in TALL and Notch signaling pathway deregulation remains the cornerstone in its pathogenesis, including not only mutations but fusion genes targeting NOTCH1.
Pre-carboniferous Evolution of the San Rafael Block, Argentina, 2017
The Rio Seco de los Castanos Formation (RSC) is one of the ‘pre-Carboniferous units’ outcropping ... more The Rio Seco de los Castanos Formation (RSC) is one of the ‘pre-Carboniferous units’ outcropping within the San Rafael Block assigned to Upper Silurian–Lower Devonian age. We review the provenance data obtained by petrography and geochemical-isotope analyses as well as the U–Pb detrital zircon ages. Comparison with La Horqueta Formation is also discussed. The main components of this marine fine-grained siliciclastic platform are sandstones and mudstones. The conglomerates are restricted to channel fill deposits developed mainly at the Lomitas Negras location. A low anchizone for the RSC was indicated by illite crystallinity index. From the geochemical proxies described above (Manassero et al. in Devonian Change: Case studies in Palaeogeography and Palaeoecology. Geological Society, 2009) a provenance from an unrecycled crust with an average composition similar to depleted compared with average Upper Continental Crust is suggested. TDM ages are within the range of the Mesoproterozoic basement and Palaeozoic supracrustal rocks of the Precordillera-Cuyania terrane. eNd values of the RSC are similar to those from sedimentary rocks from the Lower Palaeozoic carbonate-siliciclastic platform of the San Rafael Block. These data suggest an Early Carboniferous (Mississipian) low-metamorphic (anchizone) event for the unit. It is correlated with the ‘Chanic’ tectonic phase that affected the Precordillera-Cuyania terrane and also linked to the collision of the Chilenia terrane in the western pre-Andean Gondwana margin. As final remarks we can comment that the studied RSC samples show dominant source derivation from Famatinian (Late Cambrian-Devonian) and Pampean-Brasiliano (Neoproterozoic-Early Cambrian) cycles. Detritus derived from the Mesoproterozoic basement are scarce. U–Pb data constrain the maximum sedimentation age of the RSC to the Silurian–Early Devonian.
Pre-carboniferous Evolution of the San Rafael Block, Argentina, 2017
In this contribution we describe fossil plant remains from Río Seco de los Castaños Formation, at... more In this contribution we describe fossil plant remains from Río Seco de los Castaños Formation, at San Rafael Block, Mendoza Province, Argentina. The fossil plants comprise non-forked and forked axes without or with delicate lateral expansions, which are assigned to Bowerophylloides cf. mendozaensis and Hostinella sp. We refer them to primitive land plants and discuss about their systematic affiliation. Furthermore, we mention the presence of a diverse acritarch assemblage present in the same lithostratigraphic unit. On the basis of the taxonomical information and stratigraphic correlation, we could infer that Río Seco de
En esta tesis se estudia los fenomenos de la recristalizacion y la precipitacion de Fe (hierro) q... more En esta tesis se estudia los fenomenos de la recristalizacion y la precipitacion de Fe (hierro) que se producen, en el tratamiento de recocido final, de las hojas finas de aluminio de pureza comercial 1050 A, fabricadas con dos tipos de materia prima. Una de ellas es la banda obtenida por colada continua. La otra es la banda que se obtiene por laminacion en caliente. Se analizan los fenomenos de la recristalizacion y la precipitacion previa o simultanea del Fe y sus consecuencias, por las diferencias de calidad entre las hojas finas obtenidas con una u otra materia prima. Los costes de obtencion de la banda de colada continua son menores que los que comporta la fabricacion de esta por laminacion en caliente, si bien la calidad de las hojas finas obtenidas con banda continua no es la adecuada para algunas de las aplicaciones. Se ha investigado, con resultados satisfactorios, la introduccion en el proceso de tratamientos termicos, para hacer de la banda de colada continua un material ...
The Itacurubi Group is a siliciclastic Silurian sequence exposed in eastern Paraguay (Parana Basi... more The Itacurubi Group is a siliciclastic Silurian sequence exposed in eastern Paraguay (Parana Basin). It includes from bottom to top the Eusebio Ayala, Vargas Pena and Cariy formations. The entire sedimentary group has yielded a rich association of invertebrates, ichnofossils and palynomorphs. The low-diversity graptolite fauna found within the uppermost beds of the Vargas Pena Formation is described herein. The monograptids comprising this fauna are Stimulograptus aff. sedgwickii (PORTLOCK), Monograptus aff. priodon (BRONN) and ?Demirastrites sp. These taxa confirm the presence of late Aeronian-early Telychian deposits. The accompanying fossil assemblage also suggests a Mid-Llandovery age for this unit. The recognized graptolite biozones allow us to correlate the Vargas Pena Formation with other Silurian units in South America. From the palaeoenvironmental point of view this sector of the Parana Basin reflects a shallow shelf with high tolerance to oxygen invertebrates association.
We carried out a sedimentary provenance analysis of the Devonian Gualilán Group, Central Precordi... more We carried out a sedimentary provenance analysis of the Devonian Gualilán Group, Central Precordillera of western Argentina, focusing on the siliciclastic record of the Talacasto (Lower Devonian) and the Punta Negra (Lower-Middle Devonian) formations. Provenance is determined based on petrography, heavy minerals, whole-rock geochemistry, Sm-Nd isotopes, and U-Pb detrital zircon dating. Sandstones are composed of quartz, feldspar, and metamorphic and plutonic lithoclasts. The Gualilán Group underwent moderate weathering indicated by CIA values and Th/U ratios below 76 and 4.9, respectively. Th/Sc, Zr/Sc, Cr/V and La/Th ratios, negative Eu-anomalies and REE patterns point to felsic source compositions. The heavy minerals and zircon morphologies indicate that high-grade metamorphic and igneous rocks provided the bulk of detritus. T DM ages between 1.40 and 1.46 Ga and ε Nd(t) values ranging from − 9.21 to − 11.13 constrain the signature of the sources. U-Pb detrital zircon ages for the Talacasto Formation are equally distributed between the Famatinian (Late Cambrian-Late Devonian), Pampean-Brazilian (Neoproterozoic-Early Cambrian) and Grenvillian-Sunsas (Mesoproterozoic) orogenic cycles. Detrital zircon ages of the Punta Negra Formation were dominantly supplied from Mesoproterozoic rocks, linked to the Grenvillian-Sunsas orogeny. The data indicate a provenance from rocks located eastwards of the basin represented by the basement of the Pampean Ranges. The peripheral foreland basin developed during the post-collisional regime that followed the accretion of Cuyania against Gondwana. Whereas eastern and western Pampean Ranges provided detritus to the Talacasto Formation, the Punta Negra Formation was sourced by the western Pampean Ranges, implying exhumation and erosion of such basement during the Devonian.
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
3247 Background: Ph+ALL is a rare subgroup of pediatric ALL with very high risk of treatment fail... more 3247 Background: Ph+ALL is a rare subgroup of pediatric ALL with very high risk of treatment failure and reported long-term overall survival (OS) of only 30–40%. Standard treatment includes allogeneic SCT in first complete remission (CR1). Imatinib has been lately incorporated to first-line treatment regimens. In a recent study with pediatric Ph+ALL patients, imatinib given continuously at a dose of 340 mg/m2/day in combination with chemotherapy resulted in a significant improvement in early outcome (Schultz KR et al, J Clin Oncol 2009). Aim: to describe the Spanish Cooperative Group SHOP results in Ph+ALL with imatinib given continuously at an intermediate dose in combination with intensive chemotherapy and compare the toxicities and outcome of patients treated in the imatinib cohort -SHOP 05- with those treated without imatinib -SHOP 94 and SHOP 99- (historical controls). Patients and Methods: children with Ph+ALL aged 1–18 years treated in 39 institutions in Spain were enrolled i...
Ascocerid cephalopods are described for the first time from high paleolatitudes of Gondwana. Stud... more Ascocerid cephalopods are described for the first time from high paleolatitudes of Gondwana. Studied material was collected from the Hirnantian?–Llandovery strata of the Eusebio Ayala and Vargas Peña formations, Paraná Basin, southeastern Paraguay. The specimens are poorly preserved and were questionably assigned to the subfamily Probillingsitinae Flower, 1941, being undetermined at genus and species rank because diagnostic characters are not visible. A particular feature seen in our material is the presence of both parts of the ascocerid conch (the juvenile or cyrtocone and the mature or brevicone) joined together, which is a very rare condition in the known paleontological record. The specimens are interpreted as at a subadult stage of development because fully grown ascocerids would have lost the juvenile shell. A planktonic vertical migrant mode of life with a subvertical attitude is proposed for the juvenile, and a horizontal demersal nektonic mode for the adult form, as has be...
One of the 'pre-Carboniferous units' from the San Rafael Block is the sedimentary Río Seco de los... more One of the 'pre-Carboniferous units' from the San Rafael Block is the sedimentary Río Seco de los Castaños Formation, which is distributed in isolated outcrops within the Block. At the Rodeo de la Bordalesa area two small intrusives in the mentioned unit were mapped, composed of tonalitic rocks, lamprophyre ('spessartite-kersantite') and aplite dykes. We present in this paper, geochemical and isotopic data from the gray tonalitic rocks with abundant mafic enclaves and late magmatic aplite veins. The country rocks are a folded sequence of feldspathic sandstones, wackes, and shales. The Rodeo de la Bordalesa tonalite dykes are characterized by high to medium potassium concentration, with metaluminous composition and I-type calc-alkaline signature. The 401 ± 4 Ma U-Pb zircon age corresponds to the emplacement time and it is confirmed by the K-Ar biotite age.
The ‘El Nihuil Mafic Unit’ is exposed at the Loma Alta region northwards of the El Nihuil dam. Th... more The ‘El Nihuil Mafic Unit’ is exposed at the Loma Alta region northwards of the El Nihuil dam. This igneous body consists mainly of mafic rocks assigned to the Precambrian and Lower Paleozoic according to different authors. The mafic unit shows an elongated shape with a NNE–SSW orientation on the western side of the San Rafael Block (SRB), developed for a length of 17.5 km and with a maximum width of 4.2 km and is composed of deformed gabbros, amphibolites, and tonalites that represent the Mesoproterozoic continental crust, and dykes and sills of undeformed Lower Paleozoic porphyritic dolerites. We present the petrology, geochemistry, isotope data, and determinations of emplacement conditions of the dolerites that could represent a sliver of Cuyania-Chilenia terranes suture. The dolerites show classical porphyritic texture, with elongated subhedral plagioclase (andesine) and clinopyroxene phenocrysts. Geochemical analyses of El Nihuil Dolerite samples indicate that the rocks are MORB-type basalts. In the P2O5 versus Zr diagram, the dolerites plot in the tholeiitic field similarly to western Cuyania basalts, and in the Th–Hf/3–Ta tectonic discrimination diagram the dolerite dykes plot mainly as E-MORB. Dolerite samples were dated by K–Ar (whole rock) systematic and the ages are 448.5 ± 10 and 434.2 ± 10 Ma (Upper Ordovician and close to the Lower Silurian boundary). The dolerites represent the unique Lower Paleozoic mafic rock outcrops within the SRB. Nd(TDM) ages are in between 0.51 and 0.80 Ga; eNd(0) record positive values ranging from +3.85 and +7.84; eNd(t) record +4.27 to +12.42. 87Sr/86Sr ratios are in between 0.7032 and 0.7050 in agreement with values for ocean ridge tholeiites. These mafic rocks are interpreted as a part of a dismembered ‘Famatinian ophiolite belt’ emplaced during the Lower Paleozoic extensional environment within a thinned Mesoproterozoic continental crust on western Cuyania terrane.
Revista De La Asociacion Geologica Argentina, Jun 1, 2012
En el sur de la Precordillera mendocina, aflora el plutón de Cacheuta formado por un borde de tip... more En el sur de la Precordillera mendocina, aflora el plutón de Cacheuta formado por un borde de tipo monzonítico a granodiorítico (Boca del Río) gris-verdoso y otro posterior de mayor superficie aflorante de composición granítica y tonos rosadosrojizos. Se ofrecen en este trabajo nuevos datos geoquímicos sobre las rocas monzoníticas y el análisis geocronológico por el método U/Pb (LA-ICP-MS) sobre 25 cristales de circones extraídos de tres muestras. Las rocas monzoníticas analizadas son de características subalcalinas, metaaluminosas y presentan enriquecimiento en LREE, diseño plano o ligeramente inclinado de HREE y leve anomalía negativa de Eu. La signatura geoquímica es de rocas calco-alcalinas de arco magmático. El análisis geocronológico por U/Pb permitió definir un histograma con una moda principal de edades entre 253-258 Ma correspondiente al Pérmico Tardío. Luego los datos isotópicos se extienden entre el Carbonífero Tardío con 302 Ma para un circón de una de las muestras como registro más antiguo y otra que presenta la edad de 249 Ma correspondiendo ya al Triásico más bajo. Con estos datos se confirma que el magmatismo del plutón de Cacheuta pertenece al ciclo gondwánico, resultando coetáneo con parte de la actividad volcánica del Grupo Choiyoi.
Si des psychologues et des concepts psychologiques ont ete decisifs pour la comprehension du comp... more Si des psychologues et des concepts psychologiques ont ete decisifs pour la comprehension du comportement humain dans les entreprises et pour l'optimisation des schemes organisationnels, les psychologues sont peu presents actuellement dans les entreprises espagnoles. Il s'agirait d'une situation de colonisation, par l'economie, de ce champ. De plus, deux difficultes majeures se presentent au psychologue qui voudrait travailler en entreprise. L'une tient a la distinction entre la demande explicite et celle que le psychologue peut (et doit) percevoir comme demande reelle du client. L'autre tient a sa formation, centree principalement sur l'etude de conduites individuelles. Neanmoins, trois voies peuvent constituer des apports specifiques du psychologue a l'entreprise : 1) concilier la norme de sante mentale des personnes avec la norme et les necessites de l'organisation; 2) diriger la gestion de la culture; 3) redefinir l'environnement mental des Ressources Humaines dans la perspective de la creation de valeur pour les personnes
A succession of Devonian cover rocks occurs in outcrop and in the subsurface of central-northern ... more A succession of Devonian cover rocks occurs in outcrop and in the subsurface of central-northern Uruguay where they were deposited in an intracratonic basin. This Durazno Group comprises three distinct stratigraphic units, namely the Cerrezuelo, Cordob es and La Paloma formations. The Durazno Group does not exceed 300 m of average thickness and preserves a transgressive-regressive cycle within a shallow-marine siliciclastic shelf platform, and is characterized by an assemblage of invertebrate fossils of Malvinokaffric affinity especially within the Lower Devonian Cordob es shales. The sedimentary provenance of the Durazno Group was determined using petrography, geochemistry, and morphological studies of detrital zircons as well as their UePb ages. Sandstone petrography of Cerrezuelo and La Paloma sequences shows that they have a dominantly quartz-feldspathic composition with a minor contribution of other minerals. Whole-rock geochemical data indicate that alteration was strong in each of the three formations studied; chondritic-normalized REE patterns essentially parallel to PAAS, the presence of a negative Eu-anomaly, and Th/Sc and La/Hf ratios point to an average source composition similar to UCC or slightly more felsic. Within the Cerrezuelo Formation, recycling of older volcano-metasedimentary sources is interpreted from Zr/Sc ratios and high Hf, Zr, and REE concentrations. UePb detrital zircon age populations of the Cerrezuelo and La Paloma formations indicate that the principal source terranes are of Neoproterozoic age, but include also minor populations derived from Mesoproterozoic and Archean-Paleoproterozoic rocks. A provenance from the Cuchilla Dionisio-Dom Feliciano, Nico P erez and Piedra Alta terranes of Uruguay and southern Brazil is likely. This study establishes an intracratonic extensional tectonic setting during Durazno time. Considering provenance age sources, regional paleocurrent distributions and the established orogenic history recorded in SW Gondwana, we suggest that the basin fill was derived from paleohighs located in what is currently SE Uruguay.
Early Silurian trilobites and graptolites from the Vargas Peña Formation of the western Paraná Ba... more Early Silurian trilobites and graptolites from the Vargas Peña Formation of the western Paraná Basin are described. The studied material comes from two successions (San Fernando and Galeano quarries) on the southwestern flank of the Ypacaraí graben, about 30 km southeast of Asunción city, eastern Paraguay. The faunas include Calymene boettneri Harrington, C. harringtoni Tortello sp. nov., Trimerus sp., Dalmanites ypacarayensis (Baldis & Hansen), Dalmanites sp., Guaranites paraguayensis Baldis & Hansen, Eophacops sp., Normalograptus cf. ajjeri (Legrand), N. aff. rectangularis (McCoy), Metaclimacograptus cf. asejradi Legrand, Paraclimacograptus innotatus (Nicholson), and P. brasiliensis (Ruedemann). The taxa recognized suggest a ?late Rhuddanian to late Aeronian/early Telychian age for the Vargas Peña Formation. The graptolites constitute a low diversity, oxygen tolerant fauna that would be indicative of shallow water conditions, an environment that is also supported by the occurrence...
Resumen Este artículo revisa la bibliografía existente sobre los problemas que la banda de colada... more Resumen Este artículo revisa la bibliografía existente sobre los problemas que la banda de colada continua, laminada en frío, presenta en su recristalización. Se examinan los impedimentos que presenta la precipitación de elementos de aleación o impurezas, previa o simultánea a la recristalización, para la nucleación de la recristalización y por tanto para ésta. Se explica el uso de las curvas TTT (Temperatura, Tiempo, Transformación) para la determinación de temperatura y velocidad de calentamiento críticas para llegar a la recristalización sin pasar por la zona de precipitación. Se explica también la obtención de curvas CTT (Concentración, Tiempo, Transformación) y "diagramas de tamaño de grano" para aleaciones Al-Mn en función de la velocidad de calentamiento y contenido de manganeso en solución sólida. Palabras clave Banda de aluminio de colada continua. Precipitación. Nucleación. Recristalización. Pretratamiento.
Clinical Investigation nature publishing group Background: Evidence for an inherited genetic risk... more Clinical Investigation nature publishing group Background: Evidence for an inherited genetic risk for pediatric acute lymphoblastic leukemia has been provided in several studies. Most of them focused on coding regions. However, those regions represent only 1.5% of the entire genome. In acute lymphoblastic leukemia (ALL), it has been suggested that the expression of microRNAs (miRNAs) is dysregulated, which suggests that they may have a role in ALL risk. Changes in miRNA function may occur through single-nucleotide polymorphisms (SNPs). Therefore, the aim of this study was to evaluate whether polymorphisms in pre-miRNAs, and/or miRNA-processing genes, contribute to a predisposition for childhood ALL. Methods: In this study, we analyzed 118 SNPs in pre-miRNAs and miRNA-processing genes in 213 B-cell ALL patients and 387 controls. results: We found 11 SNPs significantly associated with ALL susceptibility. These included three SNPs present in miRNA genes (miR-612, miR-499, and miR-449b) and eight SNPs present in six miRNA biogenesis pathway genes (TNRC6B, DROSHA, DGCR8, EIF2C1, CNOT1, and CNOT6). Among the 118 SNPs analyzed, rs12803915 in mir-612 and rs3746444 in mir-499 exhibited a more significant association, with a P value <0.01. conclusion: The results of this study indicate that SNP rs12803915 located in pre-mir-612, and SNP rs3746444 located in pre-mir-499, may represent novel markers of B-cell ALL susceptibility.
FIGURE 1. High-resolution CT series at level of middle lobe bronchus. (A) Day 35: bronchopneumoni... more FIGURE 1. High-resolution CT series at level of middle lobe bronchus. (A) Day 35: bronchopneumonia alveolar pattern in middle lobe, posterior segment of right lower lobe, and lingula. (B) Day 65: minimal changes in lung pattern. (C) Day 260: total resolution of alveolar diffuse pattern.
Background T-cell lymphoblastic lymphoma (T-LBL) is an aggressive neoplasm closely related to T-c... more Background T-cell lymphoblastic lymphoma (T-LBL) is an aggressive neoplasm closely related to T-cell acute lymphoblastic leukaemia (T-ALL). Despite their similarities, and contrary to TALL , studies on pediatric T-LBL are scarce and, therefore, its molecular landscape has not been fully elucidated yet. Procedure To characterize the genetic and molecular heterogeneity of paediatric T-LBL, 33 patients were analyzed using an integrated approach, including targeted next generation sequencing, RNA-sequencing transcriptome analysis and copy-number arrays. Results Copy number and mutational analyses allowed the detection of recurrent homozygous deletions of 9p/CDKN2A (78%), trisomy 20 (19%) and gains of 17q24-q25 (16%), as well as frequent mutations of NOTCH1 (62%), followed by BCL11B (23%), WT1 (19%) and FBXW7, PHF6 and RPL10 genes (15%, respectively). This genetic profile did not differ to that described in TALL in terms of mutation incidence and global genomic complexity level but unveiled virtually exclusive 17q25 gains and trisomy 20 in T-LBL. Additionally, we identified novel gene fusions in paediatric T-LBL including NOTCH1-IKZF2, RNGTT-SNAP91 and DDX3X-MLLT10, the latter being the only one previously described in TALL. Moreover, clinical correlations highlighted the presence of Notch pathway alterations as a factor related to favorable outcome. Conclusions In summary, the genomic landscape of paediatric T-LBL is similar to that observed in TALL and Notch signaling pathway deregulation remains the cornerstone in its pathogenesis, including not only mutations but fusion genes targeting NOTCH1.
Pre-carboniferous Evolution of the San Rafael Block, Argentina, 2017
The Rio Seco de los Castanos Formation (RSC) is one of the ‘pre-Carboniferous units’ outcropping ... more The Rio Seco de los Castanos Formation (RSC) is one of the ‘pre-Carboniferous units’ outcropping within the San Rafael Block assigned to Upper Silurian–Lower Devonian age. We review the provenance data obtained by petrography and geochemical-isotope analyses as well as the U–Pb detrital zircon ages. Comparison with La Horqueta Formation is also discussed. The main components of this marine fine-grained siliciclastic platform are sandstones and mudstones. The conglomerates are restricted to channel fill deposits developed mainly at the Lomitas Negras location. A low anchizone for the RSC was indicated by illite crystallinity index. From the geochemical proxies described above (Manassero et al. in Devonian Change: Case studies in Palaeogeography and Palaeoecology. Geological Society, 2009) a provenance from an unrecycled crust with an average composition similar to depleted compared with average Upper Continental Crust is suggested. TDM ages are within the range of the Mesoproterozoic basement and Palaeozoic supracrustal rocks of the Precordillera-Cuyania terrane. eNd values of the RSC are similar to those from sedimentary rocks from the Lower Palaeozoic carbonate-siliciclastic platform of the San Rafael Block. These data suggest an Early Carboniferous (Mississipian) low-metamorphic (anchizone) event for the unit. It is correlated with the ‘Chanic’ tectonic phase that affected the Precordillera-Cuyania terrane and also linked to the collision of the Chilenia terrane in the western pre-Andean Gondwana margin. As final remarks we can comment that the studied RSC samples show dominant source derivation from Famatinian (Late Cambrian-Devonian) and Pampean-Brasiliano (Neoproterozoic-Early Cambrian) cycles. Detritus derived from the Mesoproterozoic basement are scarce. U–Pb data constrain the maximum sedimentation age of the RSC to the Silurian–Early Devonian.
Pre-carboniferous Evolution of the San Rafael Block, Argentina, 2017
In this contribution we describe fossil plant remains from Río Seco de los Castaños Formation, at... more In this contribution we describe fossil plant remains from Río Seco de los Castaños Formation, at San Rafael Block, Mendoza Province, Argentina. The fossil plants comprise non-forked and forked axes without or with delicate lateral expansions, which are assigned to Bowerophylloides cf. mendozaensis and Hostinella sp. We refer them to primitive land plants and discuss about their systematic affiliation. Furthermore, we mention the presence of a diverse acritarch assemblage present in the same lithostratigraphic unit. On the basis of the taxonomical information and stratigraphic correlation, we could infer that Río Seco de
En esta tesis se estudia los fenomenos de la recristalizacion y la precipitacion de Fe (hierro) q... more En esta tesis se estudia los fenomenos de la recristalizacion y la precipitacion de Fe (hierro) que se producen, en el tratamiento de recocido final, de las hojas finas de aluminio de pureza comercial 1050 A, fabricadas con dos tipos de materia prima. Una de ellas es la banda obtenida por colada continua. La otra es la banda que se obtiene por laminacion en caliente. Se analizan los fenomenos de la recristalizacion y la precipitacion previa o simultanea del Fe y sus consecuencias, por las diferencias de calidad entre las hojas finas obtenidas con una u otra materia prima. Los costes de obtencion de la banda de colada continua son menores que los que comporta la fabricacion de esta por laminacion en caliente, si bien la calidad de las hojas finas obtenidas con banda continua no es la adecuada para algunas de las aplicaciones. Se ha investigado, con resultados satisfactorios, la introduccion en el proceso de tratamientos termicos, para hacer de la banda de colada continua un material ...
The Itacurubi Group is a siliciclastic Silurian sequence exposed in eastern Paraguay (Parana Basi... more The Itacurubi Group is a siliciclastic Silurian sequence exposed in eastern Paraguay (Parana Basin). It includes from bottom to top the Eusebio Ayala, Vargas Pena and Cariy formations. The entire sedimentary group has yielded a rich association of invertebrates, ichnofossils and palynomorphs. The low-diversity graptolite fauna found within the uppermost beds of the Vargas Pena Formation is described herein. The monograptids comprising this fauna are Stimulograptus aff. sedgwickii (PORTLOCK), Monograptus aff. priodon (BRONN) and ?Demirastrites sp. These taxa confirm the presence of late Aeronian-early Telychian deposits. The accompanying fossil assemblage also suggests a Mid-Llandovery age for this unit. The recognized graptolite biozones allow us to correlate the Vargas Pena Formation with other Silurian units in South America. From the palaeoenvironmental point of view this sector of the Parana Basin reflects a shallow shelf with high tolerance to oxygen invertebrates association.
We carried out a sedimentary provenance analysis of the Devonian Gualilán Group, Central Precordi... more We carried out a sedimentary provenance analysis of the Devonian Gualilán Group, Central Precordillera of western Argentina, focusing on the siliciclastic record of the Talacasto (Lower Devonian) and the Punta Negra (Lower-Middle Devonian) formations. Provenance is determined based on petrography, heavy minerals, whole-rock geochemistry, Sm-Nd isotopes, and U-Pb detrital zircon dating. Sandstones are composed of quartz, feldspar, and metamorphic and plutonic lithoclasts. The Gualilán Group underwent moderate weathering indicated by CIA values and Th/U ratios below 76 and 4.9, respectively. Th/Sc, Zr/Sc, Cr/V and La/Th ratios, negative Eu-anomalies and REE patterns point to felsic source compositions. The heavy minerals and zircon morphologies indicate that high-grade metamorphic and igneous rocks provided the bulk of detritus. T DM ages between 1.40 and 1.46 Ga and ε Nd(t) values ranging from − 9.21 to − 11.13 constrain the signature of the sources. U-Pb detrital zircon ages for the Talacasto Formation are equally distributed between the Famatinian (Late Cambrian-Late Devonian), Pampean-Brazilian (Neoproterozoic-Early Cambrian) and Grenvillian-Sunsas (Mesoproterozoic) orogenic cycles. Detrital zircon ages of the Punta Negra Formation were dominantly supplied from Mesoproterozoic rocks, linked to the Grenvillian-Sunsas orogeny. The data indicate a provenance from rocks located eastwards of the basin represented by the basement of the Pampean Ranges. The peripheral foreland basin developed during the post-collisional regime that followed the accretion of Cuyania against Gondwana. Whereas eastern and western Pampean Ranges provided detritus to the Talacasto Formation, the Punta Negra Formation was sourced by the western Pampean Ranges, implying exhumation and erosion of such basement during the Devonian.
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
3247 Background: Ph+ALL is a rare subgroup of pediatric ALL with very high risk of treatment fail... more 3247 Background: Ph+ALL is a rare subgroup of pediatric ALL with very high risk of treatment failure and reported long-term overall survival (OS) of only 30–40%. Standard treatment includes allogeneic SCT in first complete remission (CR1). Imatinib has been lately incorporated to first-line treatment regimens. In a recent study with pediatric Ph+ALL patients, imatinib given continuously at a dose of 340 mg/m2/day in combination with chemotherapy resulted in a significant improvement in early outcome (Schultz KR et al, J Clin Oncol 2009). Aim: to describe the Spanish Cooperative Group SHOP results in Ph+ALL with imatinib given continuously at an intermediate dose in combination with intensive chemotherapy and compare the toxicities and outcome of patients treated in the imatinib cohort -SHOP 05- with those treated without imatinib -SHOP 94 and SHOP 99- (historical controls). Patients and Methods: children with Ph+ALL aged 1–18 years treated in 39 institutions in Spain were enrolled i...
Ascocerid cephalopods are described for the first time from high paleolatitudes of Gondwana. Stud... more Ascocerid cephalopods are described for the first time from high paleolatitudes of Gondwana. Studied material was collected from the Hirnantian?–Llandovery strata of the Eusebio Ayala and Vargas Peña formations, Paraná Basin, southeastern Paraguay. The specimens are poorly preserved and were questionably assigned to the subfamily Probillingsitinae Flower, 1941, being undetermined at genus and species rank because diagnostic characters are not visible. A particular feature seen in our material is the presence of both parts of the ascocerid conch (the juvenile or cyrtocone and the mature or brevicone) joined together, which is a very rare condition in the known paleontological record. The specimens are interpreted as at a subadult stage of development because fully grown ascocerids would have lost the juvenile shell. A planktonic vertical migrant mode of life with a subvertical attitude is proposed for the juvenile, and a horizontal demersal nektonic mode for the adult form, as has be...
One of the 'pre-Carboniferous units' from the San Rafael Block is the sedimentary Río Seco de los... more One of the 'pre-Carboniferous units' from the San Rafael Block is the sedimentary Río Seco de los Castaños Formation, which is distributed in isolated outcrops within the Block. At the Rodeo de la Bordalesa area two small intrusives in the mentioned unit were mapped, composed of tonalitic rocks, lamprophyre ('spessartite-kersantite') and aplite dykes. We present in this paper, geochemical and isotopic data from the gray tonalitic rocks with abundant mafic enclaves and late magmatic aplite veins. The country rocks are a folded sequence of feldspathic sandstones, wackes, and shales. The Rodeo de la Bordalesa tonalite dykes are characterized by high to medium potassium concentration, with metaluminous composition and I-type calc-alkaline signature. The 401 ± 4 Ma U-Pb zircon age corresponds to the emplacement time and it is confirmed by the K-Ar biotite age.
The ‘El Nihuil Mafic Unit’ is exposed at the Loma Alta region northwards of the El Nihuil dam. Th... more The ‘El Nihuil Mafic Unit’ is exposed at the Loma Alta region northwards of the El Nihuil dam. This igneous body consists mainly of mafic rocks assigned to the Precambrian and Lower Paleozoic according to different authors. The mafic unit shows an elongated shape with a NNE–SSW orientation on the western side of the San Rafael Block (SRB), developed for a length of 17.5 km and with a maximum width of 4.2 km and is composed of deformed gabbros, amphibolites, and tonalites that represent the Mesoproterozoic continental crust, and dykes and sills of undeformed Lower Paleozoic porphyritic dolerites. We present the petrology, geochemistry, isotope data, and determinations of emplacement conditions of the dolerites that could represent a sliver of Cuyania-Chilenia terranes suture. The dolerites show classical porphyritic texture, with elongated subhedral plagioclase (andesine) and clinopyroxene phenocrysts. Geochemical analyses of El Nihuil Dolerite samples indicate that the rocks are MORB-type basalts. In the P2O5 versus Zr diagram, the dolerites plot in the tholeiitic field similarly to western Cuyania basalts, and in the Th–Hf/3–Ta tectonic discrimination diagram the dolerite dykes plot mainly as E-MORB. Dolerite samples were dated by K–Ar (whole rock) systematic and the ages are 448.5 ± 10 and 434.2 ± 10 Ma (Upper Ordovician and close to the Lower Silurian boundary). The dolerites represent the unique Lower Paleozoic mafic rock outcrops within the SRB. Nd(TDM) ages are in between 0.51 and 0.80 Ga; eNd(0) record positive values ranging from +3.85 and +7.84; eNd(t) record +4.27 to +12.42. 87Sr/86Sr ratios are in between 0.7032 and 0.7050 in agreement with values for ocean ridge tholeiites. These mafic rocks are interpreted as a part of a dismembered ‘Famatinian ophiolite belt’ emplaced during the Lower Paleozoic extensional environment within a thinned Mesoproterozoic continental crust on western Cuyania terrane.
Revista De La Asociacion Geologica Argentina, Jun 1, 2012
En el sur de la Precordillera mendocina, aflora el plutón de Cacheuta formado por un borde de tip... more En el sur de la Precordillera mendocina, aflora el plutón de Cacheuta formado por un borde de tipo monzonítico a granodiorítico (Boca del Río) gris-verdoso y otro posterior de mayor superficie aflorante de composición granítica y tonos rosadosrojizos. Se ofrecen en este trabajo nuevos datos geoquímicos sobre las rocas monzoníticas y el análisis geocronológico por el método U/Pb (LA-ICP-MS) sobre 25 cristales de circones extraídos de tres muestras. Las rocas monzoníticas analizadas son de características subalcalinas, metaaluminosas y presentan enriquecimiento en LREE, diseño plano o ligeramente inclinado de HREE y leve anomalía negativa de Eu. La signatura geoquímica es de rocas calco-alcalinas de arco magmático. El análisis geocronológico por U/Pb permitió definir un histograma con una moda principal de edades entre 253-258 Ma correspondiente al Pérmico Tardío. Luego los datos isotópicos se extienden entre el Carbonífero Tardío con 302 Ma para un circón de una de las muestras como registro más antiguo y otra que presenta la edad de 249 Ma correspondiendo ya al Triásico más bajo. Con estos datos se confirma que el magmatismo del plutón de Cacheuta pertenece al ciclo gondwánico, resultando coetáneo con parte de la actividad volcánica del Grupo Choiyoi.
Si des psychologues et des concepts psychologiques ont ete decisifs pour la comprehension du comp... more Si des psychologues et des concepts psychologiques ont ete decisifs pour la comprehension du comportement humain dans les entreprises et pour l'optimisation des schemes organisationnels, les psychologues sont peu presents actuellement dans les entreprises espagnoles. Il s'agirait d'une situation de colonisation, par l'economie, de ce champ. De plus, deux difficultes majeures se presentent au psychologue qui voudrait travailler en entreprise. L'une tient a la distinction entre la demande explicite et celle que le psychologue peut (et doit) percevoir comme demande reelle du client. L'autre tient a sa formation, centree principalement sur l'etude de conduites individuelles. Neanmoins, trois voies peuvent constituer des apports specifiques du psychologue a l'entreprise : 1) concilier la norme de sante mentale des personnes avec la norme et les necessites de l'organisation; 2) diriger la gestion de la culture; 3) redefinir l'environnement mental des Ressources Humaines dans la perspective de la creation de valeur pour les personnes
A succession of Devonian cover rocks occurs in outcrop and in the subsurface of central-northern ... more A succession of Devonian cover rocks occurs in outcrop and in the subsurface of central-northern Uruguay where they were deposited in an intracratonic basin. This Durazno Group comprises three distinct stratigraphic units, namely the Cerrezuelo, Cordob es and La Paloma formations. The Durazno Group does not exceed 300 m of average thickness and preserves a transgressive-regressive cycle within a shallow-marine siliciclastic shelf platform, and is characterized by an assemblage of invertebrate fossils of Malvinokaffric affinity especially within the Lower Devonian Cordob es shales. The sedimentary provenance of the Durazno Group was determined using petrography, geochemistry, and morphological studies of detrital zircons as well as their UePb ages. Sandstone petrography of Cerrezuelo and La Paloma sequences shows that they have a dominantly quartz-feldspathic composition with a minor contribution of other minerals. Whole-rock geochemical data indicate that alteration was strong in each of the three formations studied; chondritic-normalized REE patterns essentially parallel to PAAS, the presence of a negative Eu-anomaly, and Th/Sc and La/Hf ratios point to an average source composition similar to UCC or slightly more felsic. Within the Cerrezuelo Formation, recycling of older volcano-metasedimentary sources is interpreted from Zr/Sc ratios and high Hf, Zr, and REE concentrations. UePb detrital zircon age populations of the Cerrezuelo and La Paloma formations indicate that the principal source terranes are of Neoproterozoic age, but include also minor populations derived from Mesoproterozoic and Archean-Paleoproterozoic rocks. A provenance from the Cuchilla Dionisio-Dom Feliciano, Nico P erez and Piedra Alta terranes of Uruguay and southern Brazil is likely. This study establishes an intracratonic extensional tectonic setting during Durazno time. Considering provenance age sources, regional paleocurrent distributions and the established orogenic history recorded in SW Gondwana, we suggest that the basin fill was derived from paleohighs located in what is currently SE Uruguay.
Early Silurian trilobites and graptolites from the Vargas Peña Formation of the western Paraná Ba... more Early Silurian trilobites and graptolites from the Vargas Peña Formation of the western Paraná Basin are described. The studied material comes from two successions (San Fernando and Galeano quarries) on the southwestern flank of the Ypacaraí graben, about 30 km southeast of Asunción city, eastern Paraguay. The faunas include Calymene boettneri Harrington, C. harringtoni Tortello sp. nov., Trimerus sp., Dalmanites ypacarayensis (Baldis & Hansen), Dalmanites sp., Guaranites paraguayensis Baldis & Hansen, Eophacops sp., Normalograptus cf. ajjeri (Legrand), N. aff. rectangularis (McCoy), Metaclimacograptus cf. asejradi Legrand, Paraclimacograptus innotatus (Nicholson), and P. brasiliensis (Ruedemann). The taxa recognized suggest a ?late Rhuddanian to late Aeronian/early Telychian age for the Vargas Peña Formation. The graptolites constitute a low diversity, oxygen tolerant fauna that would be indicative of shallow water conditions, an environment that is also supported by the occurrence...
Resumen Este artículo revisa la bibliografía existente sobre los problemas que la banda de colada... more Resumen Este artículo revisa la bibliografía existente sobre los problemas que la banda de colada continua, laminada en frío, presenta en su recristalización. Se examinan los impedimentos que presenta la precipitación de elementos de aleación o impurezas, previa o simultánea a la recristalización, para la nucleación de la recristalización y por tanto para ésta. Se explica el uso de las curvas TTT (Temperatura, Tiempo, Transformación) para la determinación de temperatura y velocidad de calentamiento críticas para llegar a la recristalización sin pasar por la zona de precipitación. Se explica también la obtención de curvas CTT (Concentración, Tiempo, Transformación) y "diagramas de tamaño de grano" para aleaciones Al-Mn en función de la velocidad de calentamiento y contenido de manganeso en solución sólida. Palabras clave Banda de aluminio de colada continua. Precipitación. Nucleación. Recristalización. Pretratamiento.
Clinical Investigation nature publishing group Background: Evidence for an inherited genetic risk... more Clinical Investigation nature publishing group Background: Evidence for an inherited genetic risk for pediatric acute lymphoblastic leukemia has been provided in several studies. Most of them focused on coding regions. However, those regions represent only 1.5% of the entire genome. In acute lymphoblastic leukemia (ALL), it has been suggested that the expression of microRNAs (miRNAs) is dysregulated, which suggests that they may have a role in ALL risk. Changes in miRNA function may occur through single-nucleotide polymorphisms (SNPs). Therefore, the aim of this study was to evaluate whether polymorphisms in pre-miRNAs, and/or miRNA-processing genes, contribute to a predisposition for childhood ALL. Methods: In this study, we analyzed 118 SNPs in pre-miRNAs and miRNA-processing genes in 213 B-cell ALL patients and 387 controls. results: We found 11 SNPs significantly associated with ALL susceptibility. These included three SNPs present in miRNA genes (miR-612, miR-499, and miR-449b) and eight SNPs present in six miRNA biogenesis pathway genes (TNRC6B, DROSHA, DGCR8, EIF2C1, CNOT1, and CNOT6). Among the 118 SNPs analyzed, rs12803915 in mir-612 and rs3746444 in mir-499 exhibited a more significant association, with a P value <0.01. conclusion: The results of this study indicate that SNP rs12803915 located in pre-mir-612, and SNP rs3746444 located in pre-mir-499, may represent novel markers of B-cell ALL susceptibility.
FIGURE 1. High-resolution CT series at level of middle lobe bronchus. (A) Day 35: bronchopneumoni... more FIGURE 1. High-resolution CT series at level of middle lobe bronchus. (A) Day 35: bronchopneumonia alveolar pattern in middle lobe, posterior segment of right lower lobe, and lingula. (B) Day 65: minimal changes in lung pattern. (C) Day 260: total resolution of alveolar diffuse pattern.
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