Papers by Javier Campos Perez
ChemMedChem, 2021
Enzymatic nanoreactors were obtained by galactose‐1‐phosphate uridylyl‐transferase (GALT) encapsu... more Enzymatic nanoreactors were obtained by galactose‐1‐phosphate uridylyl‐transferase (GALT) encapsulation into plant virus capsids by a molecular self‐assembly strategy. The aim of this work was to produce virus‐like nanoparticles containing GALT for an enzyme‐replacement therapy for classic galactosemia. The encapsulation efficiency and the catalytic constants of bio‐nanoreactors were determined by using different GALT and virus coat protein ratios. The substrate affinity of nanoreactors was slightly lower than that of the free enzyme; the activity rate was 16 % of the GALT free enzyme. The enzymatic nanoreactors without functionalization were internalized into different cell lines including fibroblast and kidney cells, but especially into hepatocytes. The enzymatic nanoreactors are an innovative enzyme preparation with potential use for the treatment of classic galactosemia.
Revista Hacienda Pública Espñola, 2015
In 2011 all ECB publications feature a motif taken from the €100 banknote. (Deutsche Bundesbank) ... more In 2011 all ECB publications feature a motif taken from the €100 banknote. (Deutsche Bundesbank) for providing us with data and very useful information and advises on Ireland, France and Germany, respectively. We also thank Pablo Hernández de Cos, Enrique Moral Benito and all the participants at the Working Group on Public Finance of the European System of Central Banks for fruitful suggestions and discussions. This version of the paper also benefited from comments by an anonymous anonymous referee of the ECB Working Paper Series. All the routines will be available at http: //sites.google.com /site /domdepalo
Journal of Molecular Structure: THEOCHEM, 2006
The substituent induced shifts (SIS) of a hydroxyl group at position 5a over the 13 C chemical sh... more The substituent induced shifts (SIS) of a hydroxyl group at position 5a over the 13 C chemical shifts on the A ring for some sapogenins have been calculated at B3LYP level of theory with the 6-31G** basis set within the DFT methodology with the GIAO approach. The calculated SIS at beta and gamma carbons fairly agrees with the experimental ones. The experimental anomalous deshielding SIS on several gamma carbons is well reproduced by the calculations and could be related to intramolecular hydrogen bonding.
Cuadernos de Economía y Dirección de la Empresa, 2012
analizar estas relaciones, hemos estudiado el efecto de dos grupos distintos nologías: las TIC in... more analizar estas relaciones, hemos estudiado el efecto de dos grupos distintos nologías: las TIC intraorganizativas o internas y las TIC interorganizativas o externas. Los re procedentes de una muestra de 84 proveedores de primer nivel de la industria del automóvil señalan que existe un mayor efecto de las TIC internas sobre la implantación de Lean Product las TIC externas sobre la integración electrónica de la cadena de suministro. Igualmente, se apr la relación entre TIC internas y la implantación de Lean Production es más fuerte cuando se co presencia de TIC externas. En este caso, además, se observa una relación negativa entre TIC ex implantación de Lean Production. Por último, los resultados muestran que las TIC internas no en la integración electrónica con los proveedores.
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2000
Symmetrical tilt and twist grain boundary structures have been simulated in bcc iron using a many... more Symmetrical tilt and twist grain boundary structures have been simulated in bcc iron using a many-body potential of the Finnis-Sinclair form. Initial structures were relaxed to the local minimum energy configuration using molecular dynamics. The width and relative energies of the resulting grain boundaries have been calculated. Collision cascades have been initiated in the structure by imparting initial energy to a single Fe atom and the interaction of the cascade with the grain boundary has been studied again using molecular dynamics simulations. The cascades were chosen where the primary knock-on atom (PKA) had initial energy of 1 keV and the orientation and distance of the PKA were changed in order to generate some statistical information concerning the radiation damage near the interface. The results show an increased radiation damage in the grain boundary region compared to the bulk material. The interstitials that form in the boundary region seem to be stable and do not move away from the boundary during the recrystallisation phase of the collision cascade. Clusters of interstitials are easily produced at the boundary in either structure but the defects induced near the twist boundary are more extensive that those near the tilt boundary.
El Profesional de la Informacion, 2008
Resumen: Cuanto más estructurado está un sistema científico y mayor es el grado de integración de... more Resumen: Cuanto más estructurado está un sistema científico y mayor es el grado de integración de las entidades que lo forman más eficiente puede hacerse su gestión. Los curricula vitae (CV) de los investigadores son documentos que reúnen datos de personas, instituciones y trabajos, y, vistos en su conjunto, son una privilegiada fuente potencial de información de la actividad científica de un país. Sin embargo si no están almacenados de forma adecuada no es posible explotarlos para realizar estudios sobre ellos. Por otro lado, la inexistencia de un modelo de CV único y normalizado obliga al investigador a rellenar múltiples versiones durante su ejercicio profesional. La Fundación Española para la Ciencia y la Tecnología (Fecyt), junto con las entidades pertenecientes al Sistema español de ciencia, tecnología y empresa (Secte), han puesto en marcha el proyecto Curriculum Vitae Normalizado. Este artículo describe su funcionamiento y destaca los beneficios de su implantación.
Composites Part A: Applied Science and Manufacturing, 2010
Non-isothermal crystallization behavior of poly(ε-caprolactone)/bentonite (natural and soy lecith... more Non-isothermal crystallization behavior of poly(ε-caprolactone)/bentonite (natural and soy lecithin-modified) nanocomposites was studied by means of differential scanning calorimetry (DSC). In addition, a microscopic analysis of cryofracture surface was performed by scanning electron microscopy (SEM). Experimental data show that pure bentonite (Bent) acts as retarding agent and that soy lecithin partially counteracts this effect because it accelerates the crystallization process. The soy lecithin was used as natural and cheap clay modifier that can be used in food contact applications, which is the thought application for the studied materials. Kinetic parameters, obtained by using classical methods such as Avrami and Mo models, were able to partially describe the non-isothermal crystallization behavior of the studied materials and the results are further supported by the effective activation energy calculations by iso-conversional method of Friedman. The full models, which take into account the different parameters during cooling under non-isothermal conditions, were used to construct continuous cooling transformations (CCTs) diagrams that confirm all previous results and that will be used to determine the processing conditions of studied materials.
Carbohydrate Polymers, 2010
... Javier Pérez Quiñones a , Corresponding Author Contact Information , E-mail The Corresponding... more ... Javier Pérez Quiñones a , Corresponding Author Contact Information , E-mail The Corresponding Author , E-mail The Corresponding Author , Yamilet Coll García a ... natural source (Dockal et al., 2003), the preparation conditions and the purity of samples (Mau, Yang, & Yen, 2009 ...
azoresbioportal.angra.uac.pt
Se aportan nuevos registros de Opetiopalpus bicolor (Laporte de Castelnau, 1836) (Coleoptera, Cle... more Se aportan nuevos registros de Opetiopalpus bicolor (Laporte de Castelnau, 1836) (Coleoptera, Cleridae) en lagunas de España Central, siendo citada la especie por primera vez para Cuenca y Guadalajara. Se revisan también los datos sobre su biología y distribución en la Península Ibérica.
- This work aims to evaluate the effect of crop type and density on insects' community in th... more - This work aims to evaluate the effect of crop type and density on insects' community in the Mediterra-nean region. In winter of 2004, four 35m x 10m blocks (replicates) were delimited and 24 equidistant 2m x 3m plots were marked. Seven crop types (barley, vetch, turnip, ...
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Papers by Javier Campos Perez