The present invention includes compositions and methods for treating and delivering medicinal for... more The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.
The current study sought to explore how language use pertaining to time and well-being practices ... more The current study sought to explore how language use pertaining to time and well-being practices could be an indicator of perceptions of stress, hope, and well-being outcomes. Using social media as a sampling platform, this mixed-method study involved 323 participants in the general population answering a time-orientation prompt concerning wellness and well-being practices. Participants were categorized into Finders, Makers, and Takers based on self-selected language use, and a qualitative content analysis of findings was conducted. Quantitatively, Finders reported higher perceptions of stress, lower levels of hope (pathway thinking), and all groups scored similarly on well-being outcomes. Results support that self-selected language use for time conveys different outcomes for participants, including perception of stress and hope levels. Implications involve exploration of language use for well-being outcomes in both clinical and general populations.
Despite the increasing importance of mini-tablet for its advantages as pediatric formulations and... more Despite the increasing importance of mini-tablet for its advantages as pediatric formulations and in modified-release applications, its popularity is limited due to the lack of formulation and processing knowledge in developing such dosage forms. In this study, common grades of microcrystalline cellulose and roller compacted granules with a range of powder properties were used to evaluate the critical material properties required for the successful manufacturing of 1.7-mm mini-tablets. It was found that blends with small particle size had poor flow properties that did not support consistent die filling and also tended to cause tooling jam and damage. While the granulation process was effective in improving blend flow properties by increasing particle size, it is imperative to avoid very large particles that could also cause inadequate flow by blocking the space within the die. Successful mini-tablet compression could be achieved by removing particles larger than roughly 1/3 of the d...
Scale-up of the Roller Compaction Process: A Practical and Dimensionless Approach Roller compacti... more Scale-up of the Roller Compaction Process: A Practical and Dimensionless Approach Roller compaction is a continuous dry granulation process commonly used in the pharmaceutical industry to improve powder flow and blend uniformity via powder densification. In the roller compaction process, powder is fed between two counter-rotating rolls. The friction between the powder and the rotating roll surface draws the powder through the gap between the rolls and maximum compaction (densification) occurs when the separation between the rolls is at its minimum. The resultant compacts, or briquettes, are then milled to achieve the desired granule size. While the roller compaction process appears simple, efforts to quantitatively model the process have proven challenging due to complex material behavior in the feeding and compaction zones. To date, implementation of roller compaction models to experimental work has been limited because these models typically require large experimental data sets or...
Highly proliferative cancer cells over express molecular markers such as epidermal growth factor ... more Highly proliferative cancer cells over express molecular markers such as epidermal growth factor receptor (EGFR). When specifically targeted gold nanoparticles bind to EGFR they tend to cluster on the cell membrane leading to an optical red-shift in the plasmon resonance frequency and an increase in absorption in the red region. These changes in optical properties provide the opportunity for photoacoustic
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2009
Nanotechnology offers unique opportunities for cancer detection, therapy and the ability to monit... more Nanotechnology offers unique opportunities for cancer detection, therapy and the ability to monitor therapeutic interventions. This potential has to be analyzed in context of challenges that need to be overcome in translation of nanoparticles to clinical applications including specific delivery in tissues and clearance from the body. Here, we will present a case study of plasmonic nanoparticles in cancer imaging and therapy.
AAPS Advances in the Pharmaceutical Sciences Series, 2011
... Production Jasmine M. Rowe and Keith P. Johnston 1 CREMPHOR EL is a registered trademark of B... more ... Production Jasmine M. Rowe and Keith P. Johnston 1 CREMPHOR EL is a registered trademark of BASF Corporation. ... 1000 10000 100000 0 100 200 300 400 500 Pressure (bar) S o lu b ility in C O 2 (µ mo l/mo l) Menthol Salicylic acid Griseofulvin Chloraphemicol α-tocopherol ...
2010 IEEE International Ultrasonics Symposium, 2010
Page 1. 1 Abstract Plasmonic nanoparticles have been widely used for various biomedical applicat... more Page 1. 1 Abstract Plasmonic nanoparticles have been widely used for various biomedical applications such as biological imaging, sensing, and cancer therapy. Specifically, gold nanospheres, nanorods, and nanoshells are ...
We present a novel method towards diagnose cancer at an early stage via a blood test. Early diagn... more We present a novel method towards diagnose cancer at an early stage via a blood test. Early diagnosis is high on the future agenda of oncologists because of significant evidence that it will result in a higher cure rate. Capture of circulating tumor cells (CTCs) which are known to escape from carcinomas at an early stage offers such an opportunity.
ABSTRACT Roads are an increasingly common feature of forest landscapes all over the world, and wh... more ABSTRACT Roads are an increasingly common feature of forest landscapes all over the world, and while information accumulates regarding the impacts of roads globally, there remains a paucity of information within tropical regions. Here we investigate the potential for biodiversity impacts from an unmarked road within a rainforest protected area in Western Amazonia. We focus on three key taxonomic groups; amphibians, butterflies and birds, each of which have been shown to be both sensitive and reliable indicators of forest disturbance. In total, 315 amphibians of 26 different species, 348 butterflies of 65 different species, 645 birds representing 77 different species were captured using mist netting and 877 bird records representing 79 different species were recorded using point counts. We provide evidence to show that the presence of a small unmarked road significantly altered levels of faunal species richness, diversity, relative abundance and community structure. This was true to a varying degree for all three taxa, up to and potentially beyond 350 m into the forest interior. Responses to the road were shown to be taxon specific. We found increasing proximity to the road had a negative effect on amphibian and understorey bird communities, whilst butterfly and overall diurnal bird communities responded positively. We show that the impact on biodiversity extends up to at least 32 % of the whole reserve area; a serious impact under any scenario. This work provides support for recently voiced calls to limit networks of unmarked roads in order to realistically and effectively preserve natural levels of tropical biodiversity.
A novel concept is presented for the formation of stable suspensions composed of low density floc... more A novel concept is presented for the formation of stable suspensions composed of low density flocs of high aspect ratio drug particles in hydrofluoroalkane (HFA) propellants, and for subdividing (templating) the flocs with aerosolized HFA droplets to achieve high fine particle fractions with a pressurized metered dose inhaler. Bovine serum albumin (BSA) nanorods, produced by thin film freezing (TFF), were added to HFA to form a suspension. Particle properties were analyzed with an Anderson cascade impactor (ACI), static and dynamic light scattering and optical microscopy. The space filling flocs in HFA were stable against settling for one year. The pMDI produced high fine particle fractions (38-47%) with an emitted dose of 0.7 mg/actuation. The atomized HFA droplets break apart, that is template, the highly open flocs. Upon evaporation of HFA, capillary forces shrink the templated flocs to produce porous particles with optimal aerodynamic diameters for deep lung delivery. Open flocs composed of nanorods, stable against settling, may be templated during actuation with a pMDI to produce optimal aerodynamic diameters and high fine particle fractions. This concept is applicable to a wide variety of drugs without the need for surfactants or cosolvents to stabilize the primary particles.
A nebulized dispersion of amorphous, high surface area, nanostructured aggregates of itraconazole... more A nebulized dispersion of amorphous, high surface area, nanostructured aggregates of itraconazole (ITZ):mannitol:lecithin (1:0.5:0.2, w/w) yielded improved bioavailability in mice. The ultra-rapid freezing (URF) technique used to produce the nanoparticles was found to molecularly disperse the ITZ with the excipients as a solid solution. Upon addition to water, ITZ formed a colloidal dispersion suitable for nebulization, which demonstrated optimal aerodynamic properties for deep lung delivery and high lung and systemic levels when dosed to mice. The ITZ nanoparticles produced supersaturation levels 27 times the crystalline solubility upon dissolution in simulated lung fluid. A dissolution/permeation model indicated that the absorption of 3 m ITZ particles is limited by the dissolution rate (BCS Class II behavior), while absorption is permeation-limited for more rapidly dissolving 230 nm particles. The predicted absorption half-life for 230 nm amorphous ITZ particles was only 15 min, as a result of the small particle size and high supersaturation, in general agreement with the in vivo results. Thus, bioavailability may be enhanced, by decreasing the particle size to accelerate dissolution and increasing permeation with (1) an amorphous morphology to raise the drug solubility, and (2) permeability enhancers.
The present invention includes compositions and methods for treating and delivering medicinal for... more The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.
The current study sought to explore how language use pertaining to time and well-being practices ... more The current study sought to explore how language use pertaining to time and well-being practices could be an indicator of perceptions of stress, hope, and well-being outcomes. Using social media as a sampling platform, this mixed-method study involved 323 participants in the general population answering a time-orientation prompt concerning wellness and well-being practices. Participants were categorized into Finders, Makers, and Takers based on self-selected language use, and a qualitative content analysis of findings was conducted. Quantitatively, Finders reported higher perceptions of stress, lower levels of hope (pathway thinking), and all groups scored similarly on well-being outcomes. Results support that self-selected language use for time conveys different outcomes for participants, including perception of stress and hope levels. Implications involve exploration of language use for well-being outcomes in both clinical and general populations.
Despite the increasing importance of mini-tablet for its advantages as pediatric formulations and... more Despite the increasing importance of mini-tablet for its advantages as pediatric formulations and in modified-release applications, its popularity is limited due to the lack of formulation and processing knowledge in developing such dosage forms. In this study, common grades of microcrystalline cellulose and roller compacted granules with a range of powder properties were used to evaluate the critical material properties required for the successful manufacturing of 1.7-mm mini-tablets. It was found that blends with small particle size had poor flow properties that did not support consistent die filling and also tended to cause tooling jam and damage. While the granulation process was effective in improving blend flow properties by increasing particle size, it is imperative to avoid very large particles that could also cause inadequate flow by blocking the space within the die. Successful mini-tablet compression could be achieved by removing particles larger than roughly 1/3 of the d...
Scale-up of the Roller Compaction Process: A Practical and Dimensionless Approach Roller compacti... more Scale-up of the Roller Compaction Process: A Practical and Dimensionless Approach Roller compaction is a continuous dry granulation process commonly used in the pharmaceutical industry to improve powder flow and blend uniformity via powder densification. In the roller compaction process, powder is fed between two counter-rotating rolls. The friction between the powder and the rotating roll surface draws the powder through the gap between the rolls and maximum compaction (densification) occurs when the separation between the rolls is at its minimum. The resultant compacts, or briquettes, are then milled to achieve the desired granule size. While the roller compaction process appears simple, efforts to quantitatively model the process have proven challenging due to complex material behavior in the feeding and compaction zones. To date, implementation of roller compaction models to experimental work has been limited because these models typically require large experimental data sets or...
Highly proliferative cancer cells over express molecular markers such as epidermal growth factor ... more Highly proliferative cancer cells over express molecular markers such as epidermal growth factor receptor (EGFR). When specifically targeted gold nanoparticles bind to EGFR they tend to cluster on the cell membrane leading to an optical red-shift in the plasmon resonance frequency and an increase in absorption in the red region. These changes in optical properties provide the opportunity for photoacoustic
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2009
Nanotechnology offers unique opportunities for cancer detection, therapy and the ability to monit... more Nanotechnology offers unique opportunities for cancer detection, therapy and the ability to monitor therapeutic interventions. This potential has to be analyzed in context of challenges that need to be overcome in translation of nanoparticles to clinical applications including specific delivery in tissues and clearance from the body. Here, we will present a case study of plasmonic nanoparticles in cancer imaging and therapy.
AAPS Advances in the Pharmaceutical Sciences Series, 2011
... Production Jasmine M. Rowe and Keith P. Johnston 1 CREMPHOR EL is a registered trademark of B... more ... Production Jasmine M. Rowe and Keith P. Johnston 1 CREMPHOR EL is a registered trademark of BASF Corporation. ... 1000 10000 100000 0 100 200 300 400 500 Pressure (bar) S o lu b ility in C O 2 (µ mo l/mo l) Menthol Salicylic acid Griseofulvin Chloraphemicol α-tocopherol ...
2010 IEEE International Ultrasonics Symposium, 2010
Page 1. 1 Abstract Plasmonic nanoparticles have been widely used for various biomedical applicat... more Page 1. 1 Abstract Plasmonic nanoparticles have been widely used for various biomedical applications such as biological imaging, sensing, and cancer therapy. Specifically, gold nanospheres, nanorods, and nanoshells are ...
We present a novel method towards diagnose cancer at an early stage via a blood test. Early diagn... more We present a novel method towards diagnose cancer at an early stage via a blood test. Early diagnosis is high on the future agenda of oncologists because of significant evidence that it will result in a higher cure rate. Capture of circulating tumor cells (CTCs) which are known to escape from carcinomas at an early stage offers such an opportunity.
ABSTRACT Roads are an increasingly common feature of forest landscapes all over the world, and wh... more ABSTRACT Roads are an increasingly common feature of forest landscapes all over the world, and while information accumulates regarding the impacts of roads globally, there remains a paucity of information within tropical regions. Here we investigate the potential for biodiversity impacts from an unmarked road within a rainforest protected area in Western Amazonia. We focus on three key taxonomic groups; amphibians, butterflies and birds, each of which have been shown to be both sensitive and reliable indicators of forest disturbance. In total, 315 amphibians of 26 different species, 348 butterflies of 65 different species, 645 birds representing 77 different species were captured using mist netting and 877 bird records representing 79 different species were recorded using point counts. We provide evidence to show that the presence of a small unmarked road significantly altered levels of faunal species richness, diversity, relative abundance and community structure. This was true to a varying degree for all three taxa, up to and potentially beyond 350 m into the forest interior. Responses to the road were shown to be taxon specific. We found increasing proximity to the road had a negative effect on amphibian and understorey bird communities, whilst butterfly and overall diurnal bird communities responded positively. We show that the impact on biodiversity extends up to at least 32 % of the whole reserve area; a serious impact under any scenario. This work provides support for recently voiced calls to limit networks of unmarked roads in order to realistically and effectively preserve natural levels of tropical biodiversity.
A novel concept is presented for the formation of stable suspensions composed of low density floc... more A novel concept is presented for the formation of stable suspensions composed of low density flocs of high aspect ratio drug particles in hydrofluoroalkane (HFA) propellants, and for subdividing (templating) the flocs with aerosolized HFA droplets to achieve high fine particle fractions with a pressurized metered dose inhaler. Bovine serum albumin (BSA) nanorods, produced by thin film freezing (TFF), were added to HFA to form a suspension. Particle properties were analyzed with an Anderson cascade impactor (ACI), static and dynamic light scattering and optical microscopy. The space filling flocs in HFA were stable against settling for one year. The pMDI produced high fine particle fractions (38-47%) with an emitted dose of 0.7 mg/actuation. The atomized HFA droplets break apart, that is template, the highly open flocs. Upon evaporation of HFA, capillary forces shrink the templated flocs to produce porous particles with optimal aerodynamic diameters for deep lung delivery. Open flocs composed of nanorods, stable against settling, may be templated during actuation with a pMDI to produce optimal aerodynamic diameters and high fine particle fractions. This concept is applicable to a wide variety of drugs without the need for surfactants or cosolvents to stabilize the primary particles.
A nebulized dispersion of amorphous, high surface area, nanostructured aggregates of itraconazole... more A nebulized dispersion of amorphous, high surface area, nanostructured aggregates of itraconazole (ITZ):mannitol:lecithin (1:0.5:0.2, w/w) yielded improved bioavailability in mice. The ultra-rapid freezing (URF) technique used to produce the nanoparticles was found to molecularly disperse the ITZ with the excipients as a solid solution. Upon addition to water, ITZ formed a colloidal dispersion suitable for nebulization, which demonstrated optimal aerodynamic properties for deep lung delivery and high lung and systemic levels when dosed to mice. The ITZ nanoparticles produced supersaturation levels 27 times the crystalline solubility upon dissolution in simulated lung fluid. A dissolution/permeation model indicated that the absorption of 3 m ITZ particles is limited by the dissolution rate (BCS Class II behavior), while absorption is permeation-limited for more rapidly dissolving 230 nm particles. The predicted absorption half-life for 230 nm amorphous ITZ particles was only 15 min, as a result of the small particle size and high supersaturation, in general agreement with the in vivo results. Thus, bioavailability may be enhanced, by decreasing the particle size to accelerate dissolution and increasing permeation with (1) an amorphous morphology to raise the drug solubility, and (2) permeability enhancers.
Uploads
Papers by Jasmine Rowe