Post-tetanic events were recorded in isolated, superfused, epididymal and prostatic halves of the... more Post-tetanic events were recorded in isolated, superfused, epididymal and prostatic halves of the rat vas deferens. Increasing the frequency of nerve stimulation from 0.15 to 15 Hz (1 30 s) and then back to 0.15 Hz produced a post-tetanic potentiation (PTP) of the muscular responses in the epididymal end but a posttetanic inhibitory response (PTI) in the prostatic half. Both efl'ects were abolished by tetrodotoxin or animal pretreatment with 6-hydroxy dopamine (6-OHDA). PTP was markedly reduced by reserpine treatment or tissue incubation with prazosin. PTI was not altered by adrenergic drugs but partially reduced by tissue application of bicuculline or strychnine, revealing that 7-aminobutyric acid (GABA) may modulate the motor transmission towards the prostatic half of the rat ductus.
Post-tetanic events were recorded in isolated, superfused, epididymal and prostatic halves of the... more Post-tetanic events were recorded in isolated, superfused, epididymal and prostatic halves of the rat vas deferens. Increasing the frequency of nerve stimulation from 0.15 to 15 Hz (1 30 s) and then back to 0.15 Hz produced a post-tetanic potentiation (PTP) of the muscular responses in the epididymal end but a posttetanic inhibitory response (PTI) in the prostatic half. Both efl'ects were abolished by tetrodotoxin or animal pretreatment with 6-hydroxy dopamine (6-OHDA). PTP was markedly reduced by reserpine treatment or tissue incubation with prazosin. PTI was not altered by adrenergic drugs but partially reduced by tissue application of bicuculline or strychnine, revealing that 7-aminobutyric acid (GABA) may modulate the motor transmission towards the prostatic half of the rat ductus.
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