An anaphylactic reaction was provoked in pigs by two intravenous injections of chicken egg albumi... more An anaphylactic reaction was provoked in pigs by two intravenous injections of chicken egg albumin given approx. 2 weeks apart; some of the animals were in a state of vitamin E deficiency. The second injection of albumin was followed by vomiting, forced respiration, severe cyanosis and distinct edema in the stomach, larynx and gall bladder. These pathomorphological changes are in accordance with those regarded as typical for edema disease. Both the clinical symptoms and the pathomorphological alterations were most evident in animals with vitamin E supplementation, whereas vitamin E deficient animals showed a more moderate response. The anaphylactic reaction was not accompanied by evident changes resembling Mulberry heart disease, either in normal pigs or in vitamin E deficient animals.
Most of the experiments to determine the requirements of calcium and phosphorus in pigs of age 2 ... more Most of the experiments to determine the requirements of calcium and phosphorus in pigs of age 2 to 9 weeks, have shown that optimal weight gain and feed conversion are obtained by giving 0.4 % of calcium in the feed with a calcium-phosphorus ratio of about 1. An increase of the calcium and phosphorus contents to 0.8 and 0.6 %, respectively, has resulted in an increased calcification and breaking strength of the bones, without any significant influence on weight gain and feed conversion (Miller et al. 1962, 1964a, b, ZimmermaIJ et al. 1963, Rutledge et al. 1961). Other authors, however, (Combs et al. 1962, Combs & Wallace 1962) have s.fated that by increasing the calcium content from 0.40 to 0.88 % an approximate linear decrase in daily weight gain and a decreased feed conversion were obtained. No effect was observed on weight gain and feed conversion by changing the phosphorus content from 0.24 to 0. 77 %. Increased amounts of phosphorus in the diet resulted in higher ash content of the bones. Chapman et al. (1962) have studied the calcium and phosphorus requirements of pigs weighing 12 to 90 kg. Highes.t daily weight gain and maximal breaking strength of the bones were obtained by 0.8 % of calcium and 0.6 % of phosphorus in the
Twenty-four conventionally reared pigs were divided into four equal groups and fed a basic ration... more Twenty-four conventionally reared pigs were divided into four equal groups and fed a basic ration deficient in vitamin E and selenium. One group was given a supplement of vitamin E and selenium. One group was given a supplement of vitamin E, another received selenium and a third received both nutrients. No supplement was given to the control group. After the pigs had been fed the different diets for 59 days they were inoculated with a pure culture of Treponema hyodysenteriae They were subsequently observed for 22 days. The inoculation resulted in outbreaks of swine dysentery in all groups. The results indicated that the administration of vitamin E supplement alone to the pigs reduced the clinical effects of T hyodysenteriae only to a minor degree. On the other hand, supplementation with selenium, either alone or with vitamin E, had a more positive effect which was most clearly illustrated by a greater weight gain during the postinoculation period.
ABSTRACT Six young horses presented with a rapidly expanding maxillary mass with concurrent nasal... more ABSTRACT Six young horses presented with a rapidly expanding maxillary mass with concurrent nasal discharge. All horses had a nonpainful firm unilateral facial swelling centred over the maxillary sinuses, accompanied by mucopurulent nasal discharge. Diagnostic imaging revealed an infiltrative nasomaxillary mass with cheek tooth involvement, diagnosed as odontogenic myxoma. The tooth involvement included missing, malformed and/or displaced dental precursors or unerupted teeth. Due to the rapid expansion and extent of the masses, and the poor prognosis reported for surgical excision, euthanasia was recommended and performed in all cases. Macroscopically, a soft oedematous tissue with a grey to green colour was seen in the regions of missing, malformed or displaced dental precursors or unerupted teeth. Histologically, this tissue consisted of spindle shaped cells surrounded by an abundant homogenous pale stroma, rich in acid mucopolysaccharides. Immunohistochemistry was positive for actin and the mesenchymal marker vimentin. The cheek tooth involvement identified in the described cases resembled what is previously reported in odontogenic myxoma in children and young adults. Even in man, maxillary odontogenic myxoma represents a therapeutic challenge due to the invasiveness of the lesions and radical surgical excision is recommended. Treatment is further complicated by sinonasal involvement. Surgery was not attempted in the cases presented here due to the extent of the lesions and the risk of recurrence. Clinicians should be aware of this rare condition when presented with young horses with sinonasal neoplasia.
TEIGE, JON jr., KNUT NORDSTOGA, MORTEN FJ0LSTAD and Il'\GER NAFST AD: The generalized Sluoartznum... more TEIGE, JON jr., KNUT NORDSTOGA, MORTEN FJ0LSTAD and Il'\GER NAFST AD: The generalized Sluoartznum reaction in pigs in duced by diet and single injection of disintegrated cells or partially purified endotoxin from Escherichia coli. Acta vet. scand. 1973, 14, 92-106.-Two experiments (Exps. I and II) were performed in pigs to test the effect of disintegrated cells and partially purified endotoxin derived from E. coli. The pigs were fed a diet supplemented with cod liver oil in one group, cod liver oil plus vitamin E in another group, and only commercial pig food in a third group. After one injection of disintegrated cells in Exp. I, lesions characteristic for generalized Shwartzman reaction (GSR), including hemorrhagic necrosis of the skin developed in the two groups given cod liver oil. A single case was also recorded among the control pigs after injection of a large dose. One injection of partially purified endotoxin in Exp. II gave almost similar results as in Exp. I. These two experiments show that pigs fed relatively high amounts of unsaturated fat are predisposed for the GSR and that vitamin E may, to a certain extent, protect against the development of the reaction. generalized Shwartzman reaction; pig; endotoxin; Escherichia coli; unsaturated fat; vi tam i n E.
In these studies, either conventional or specific-pathogen-free pigs were used. In the present st... more In these studies, either conventional or specific-pathogen-free pigs were used. In the present study, 2 approximately 8 weeks old conventional pigs (Nos. 1 and 2) were purchased and fed the same basic ration as used by Teige et al. (1977). In addition, 10 % cod liver oil was incor
... heiene@ nvh. no * Presented by NSAVA (Norway) REPRINT PAPER (N) Chronic kidney disease with o... more ... heiene@ nvh. no * Presented by NSAVA (Norway) REPRINT PAPER (N) Chronic kidney disease with oxalate-like nephrosis in Ragdoll cats R. Heiene (1), G. Rumsby (3), M. Ziener (4), SA Dahl (5), C. Tims (3), Jon Teige (2), N. Ottesen (1) Page 37. ... [2] lorenzo V, Alvarez A ...
Twenty-four conventionally reared pigs divided into 4 groups were fed a basic ration deficient in... more Twenty-four conventionally reared pigs divided into 4 groups were fed a basic ration deficient in selenium. The following daily supplement of selenium was given per pig; Group 1: none, group 2: 0.2 mg, group 3: 0.4 mg and group 4: 0.8 mg. After 51 days all pigs were inoculated orally with a pure culture of Treponema hyodysenteriae, and subsequently observed for 26 days. Clinical signs of swine dysentery were seen in all 4 groups. Criteria such as morbidity rate, incubation time and weight gain showed that the non-supplemented pigs suffered more severely from swine dysentery than the supplemented ones. Best protection was found among the pigs given a daily supplement of 0.4 mg selenium, whereas a supplement of 0.8 mg had a negative influence on the resistance to swine dysentery. The results indicate that selenium plays a more complex role in mucosal defence mechanisms than hitherto anticipated. swine dysentery ; selenium s u p p l e m e n t a t i o n ; T rep 0 n e m a h y 0 d Ysen t e ria e.
TEIGE, JON jr. and HANS GAMLEM: The generalized Shwartzman reaction in association with E.coli en... more TEIGE, JON jr. and HANS GAMLEM: The generalized Shwartzman reaction in association with E.coli enterotoxemia in a pig. Acta vet. scand. 1977, 18, 316-322.-A _Pig at the age of app•rox. 10 weeks died after four days of illness. Distmot necrotic changes were found both in the skin and the cortex of the kidneys. The histological examination revealed fibrinoid thrombi in skin vessels. In the kidneys similar thrombi were observed in capillaries of the glomeruli and in their afferent arterioles and i•n the interlobular arteries. In these vessels there were also a fibrinoid mural necrosis. These changes were in accordance with those expected to occur in the generalized Shwar.tzman reaction (GSR). The diagnosis of Escherichia coli enterotoxemia was based on the pathomorphological changes in the alimentary tract. The E. coli enterotoxemia was considered the cause of the GSRchanrges. genera 1 i zed Sh wart z man reaction; pig; E. coli enter o toxemia; edema disease; bi 1atera1 co rt i ca 1 necrosis.
An anaphylactic reaction was provoked in pigs by two intravenous injections of chicken egg albumi... more An anaphylactic reaction was provoked in pigs by two intravenous injections of chicken egg albumin given approx. 2 weeks apart; some of the animals were in a state of vitamin E deficiency. The second injection of albumin was followed by vomiting, forced respiration, severe cyanosis and distinct edema in the stomach, larynx and gall bladder. These pathomorphological changes are in accordance with those regarded as typical for edema disease. Both the clinical symptoms and the pathomorphological alterations were most evident in animals with vitamin E supplementation, whereas vitamin E deficient animals showed a more moderate response. The anaphylactic reaction was not accompanied by evident changes resembling Mulberry heart disease, either in normal pigs or in vitamin E deficient animals.
Most of the experiments to determine the requirements of calcium and phosphorus in pigs of age 2 ... more Most of the experiments to determine the requirements of calcium and phosphorus in pigs of age 2 to 9 weeks, have shown that optimal weight gain and feed conversion are obtained by giving 0.4 % of calcium in the feed with a calcium-phosphorus ratio of about 1. An increase of the calcium and phosphorus contents to 0.8 and 0.6 %, respectively, has resulted in an increased calcification and breaking strength of the bones, without any significant influence on weight gain and feed conversion (Miller et al. 1962, 1964a, b, ZimmermaIJ et al. 1963, Rutledge et al. 1961). Other authors, however, (Combs et al. 1962, Combs & Wallace 1962) have s.fated that by increasing the calcium content from 0.40 to 0.88 % an approximate linear decrase in daily weight gain and a decreased feed conversion were obtained. No effect was observed on weight gain and feed conversion by changing the phosphorus content from 0.24 to 0. 77 %. Increased amounts of phosphorus in the diet resulted in higher ash content of the bones. Chapman et al. (1962) have studied the calcium and phosphorus requirements of pigs weighing 12 to 90 kg. Highes.t daily weight gain and maximal breaking strength of the bones were obtained by 0.8 % of calcium and 0.6 % of phosphorus in the
Twenty-four conventionally reared pigs were divided into four equal groups and fed a basic ration... more Twenty-four conventionally reared pigs were divided into four equal groups and fed a basic ration deficient in vitamin E and selenium. One group was given a supplement of vitamin E and selenium. One group was given a supplement of vitamin E, another received selenium and a third received both nutrients. No supplement was given to the control group. After the pigs had been fed the different diets for 59 days they were inoculated with a pure culture of Treponema hyodysenteriae They were subsequently observed for 22 days. The inoculation resulted in outbreaks of swine dysentery in all groups. The results indicated that the administration of vitamin E supplement alone to the pigs reduced the clinical effects of T hyodysenteriae only to a minor degree. On the other hand, supplementation with selenium, either alone or with vitamin E, had a more positive effect which was most clearly illustrated by a greater weight gain during the postinoculation period.
ABSTRACT Six young horses presented with a rapidly expanding maxillary mass with concurrent nasal... more ABSTRACT Six young horses presented with a rapidly expanding maxillary mass with concurrent nasal discharge. All horses had a nonpainful firm unilateral facial swelling centred over the maxillary sinuses, accompanied by mucopurulent nasal discharge. Diagnostic imaging revealed an infiltrative nasomaxillary mass with cheek tooth involvement, diagnosed as odontogenic myxoma. The tooth involvement included missing, malformed and/or displaced dental precursors or unerupted teeth. Due to the rapid expansion and extent of the masses, and the poor prognosis reported for surgical excision, euthanasia was recommended and performed in all cases. Macroscopically, a soft oedematous tissue with a grey to green colour was seen in the regions of missing, malformed or displaced dental precursors or unerupted teeth. Histologically, this tissue consisted of spindle shaped cells surrounded by an abundant homogenous pale stroma, rich in acid mucopolysaccharides. Immunohistochemistry was positive for actin and the mesenchymal marker vimentin. The cheek tooth involvement identified in the described cases resembled what is previously reported in odontogenic myxoma in children and young adults. Even in man, maxillary odontogenic myxoma represents a therapeutic challenge due to the invasiveness of the lesions and radical surgical excision is recommended. Treatment is further complicated by sinonasal involvement. Surgery was not attempted in the cases presented here due to the extent of the lesions and the risk of recurrence. Clinicians should be aware of this rare condition when presented with young horses with sinonasal neoplasia.
TEIGE, JON jr., KNUT NORDSTOGA, MORTEN FJ0LSTAD and Il'\GER NAFST AD: The generalized Sluoartznum... more TEIGE, JON jr., KNUT NORDSTOGA, MORTEN FJ0LSTAD and Il'\GER NAFST AD: The generalized Sluoartznum reaction in pigs in duced by diet and single injection of disintegrated cells or partially purified endotoxin from Escherichia coli. Acta vet. scand. 1973, 14, 92-106.-Two experiments (Exps. I and II) were performed in pigs to test the effect of disintegrated cells and partially purified endotoxin derived from E. coli. The pigs were fed a diet supplemented with cod liver oil in one group, cod liver oil plus vitamin E in another group, and only commercial pig food in a third group. After one injection of disintegrated cells in Exp. I, lesions characteristic for generalized Shwartzman reaction (GSR), including hemorrhagic necrosis of the skin developed in the two groups given cod liver oil. A single case was also recorded among the control pigs after injection of a large dose. One injection of partially purified endotoxin in Exp. II gave almost similar results as in Exp. I. These two experiments show that pigs fed relatively high amounts of unsaturated fat are predisposed for the GSR and that vitamin E may, to a certain extent, protect against the development of the reaction. generalized Shwartzman reaction; pig; endotoxin; Escherichia coli; unsaturated fat; vi tam i n E.
In these studies, either conventional or specific-pathogen-free pigs were used. In the present st... more In these studies, either conventional or specific-pathogen-free pigs were used. In the present study, 2 approximately 8 weeks old conventional pigs (Nos. 1 and 2) were purchased and fed the same basic ration as used by Teige et al. (1977). In addition, 10 % cod liver oil was incor
... heiene@ nvh. no * Presented by NSAVA (Norway) REPRINT PAPER (N) Chronic kidney disease with o... more ... heiene@ nvh. no * Presented by NSAVA (Norway) REPRINT PAPER (N) Chronic kidney disease with oxalate-like nephrosis in Ragdoll cats R. Heiene (1), G. Rumsby (3), M. Ziener (4), SA Dahl (5), C. Tims (3), Jon Teige (2), N. Ottesen (1) Page 37. ... [2] lorenzo V, Alvarez A ...
Twenty-four conventionally reared pigs divided into 4 groups were fed a basic ration deficient in... more Twenty-four conventionally reared pigs divided into 4 groups were fed a basic ration deficient in selenium. The following daily supplement of selenium was given per pig; Group 1: none, group 2: 0.2 mg, group 3: 0.4 mg and group 4: 0.8 mg. After 51 days all pigs were inoculated orally with a pure culture of Treponema hyodysenteriae, and subsequently observed for 26 days. Clinical signs of swine dysentery were seen in all 4 groups. Criteria such as morbidity rate, incubation time and weight gain showed that the non-supplemented pigs suffered more severely from swine dysentery than the supplemented ones. Best protection was found among the pigs given a daily supplement of 0.4 mg selenium, whereas a supplement of 0.8 mg had a negative influence on the resistance to swine dysentery. The results indicate that selenium plays a more complex role in mucosal defence mechanisms than hitherto anticipated. swine dysentery ; selenium s u p p l e m e n t a t i o n ; T rep 0 n e m a h y 0 d Ysen t e ria e.
TEIGE, JON jr. and HANS GAMLEM: The generalized Shwartzman reaction in association with E.coli en... more TEIGE, JON jr. and HANS GAMLEM: The generalized Shwartzman reaction in association with E.coli enterotoxemia in a pig. Acta vet. scand. 1977, 18, 316-322.-A _Pig at the age of app•rox. 10 weeks died after four days of illness. Distmot necrotic changes were found both in the skin and the cortex of the kidneys. The histological examination revealed fibrinoid thrombi in skin vessels. In the kidneys similar thrombi were observed in capillaries of the glomeruli and in their afferent arterioles and i•n the interlobular arteries. In these vessels there were also a fibrinoid mural necrosis. These changes were in accordance with those expected to occur in the generalized Shwar.tzman reaction (GSR). The diagnosis of Escherichia coli enterotoxemia was based on the pathomorphological changes in the alimentary tract. The E. coli enterotoxemia was considered the cause of the GSRchanrges. genera 1 i zed Sh wart z man reaction; pig; E. coli enter o toxemia; edema disease; bi 1atera1 co rt i ca 1 necrosis.
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