French medicine in the second half of the 19th century includes the seminal contributions of Clau... more French medicine in the second half of the 19th century includes the seminal contributions of Claude Bernard, Lasèque, Trousseau, Jaccoud and Charcot, and counted among the most notable representatives is Professor Charles Robert Richet, Nobel Prize Winner for Medicine and Physiology in 1913, for the discovery of anaphylaxis. With his versatile personality he was involved in many different fields. His investigative work included diverse themes such as respiration, digestion, epilepsy and the regulation of body heat. To him we owe three new words, and as such, three new concepts: anaphylaxis, polypnea and zoomotherapy. Richet also excelled as a bacteriologist, pathologist, medical statistician, poet, novelist, playwright, historian, psychologist, parapsychologist, pacifist, philosopher and bibliographer. Especially interested in telepathy, and in general, extrasensory perception phenomena, he contributed decisively to the creation of a new science, metapsychics.
... A los 81 años, la noche del pasado viernes 13 de junio de 2003, ha fallecido en St. ... Arthu... more ... A los 81 años, la noche del pasado viernes 13 de junio de 2003, ha fallecido en St. ... Arthur C. Guyton (cortesía de su nuera, Susan Guyton). 304 ... a compren-der las intimidades de la fisiología a nivel celular y subcelular como, por ejemplo, el AMP cícli-co de Earl Sutherland que ...
Biophysicist whose research transformed our understanding of the nervous system. He was awarded a... more Biophysicist whose research transformed our understanding of the nervous system. He was awarded a Nobel Prize in 1970 for development of the quantal theory of acetylcholine release at the neuromuscular junction. His research on how acetylcholine was stored in nerve terminals and released by neural impulses was one of the foundation stones of psychopharmacology.
Revista Española de Sanidad Penitenciaria, Jun 1, 2013
This article reviews the main aspects of chronic hepatitis C (epidemiological, genomic related to... more This article reviews the main aspects of chronic hepatitis C (epidemiological, genomic related to enhanced molecular understanding of the life cycle of the hepatitis C virus, HCV) especially standard therapy with pegylated interferon a and ribavirin. Emphasis is also placed on the immune response of the liver to HCV and the assessment of liver fibrosis via transient elastography.
Revista Española de Sanidad Penitenciaria, Feb 26, 2013
This article reviews the main aspects of chronic hepatitis C (epidemiological, genomic related to... more This article reviews the main aspects of chronic hepatitis C (epidemiological, genomic related to enhanced molecular understanding of the life cycle of the hepatitis C virus, HCV) especially standard therapy with pegylated interferon a and ribavirin. Emphasis is also placed on the immune response of the liver to HCV and the assessment of liver fibrosis via transient elastography.
Book Reviews razzmatazz quackery hardly developed before the rapid expansion of commerce, adverti... more Book Reviews razzmatazz quackery hardly developed before the rapid expansion of commerce, advertising, communications and the press after the 1740s. Benes also shows that, at least up to the War of Independence, many of the showbiz-style quacks were paying brief visits to Europe, including the pioneer electro-therapist and sex-therapist, James Graham. In one final way, this volume documents the different course taken by New World medicine, by exploring the intimate links between healing, holiness-and business! American religious sects, it is well known, continually begat new medical doctrines, including the powerful Thomsonian movement. What is less well known, though intriguingly revealed in two absorbing papers on the Shakers (David Richards' 'Medicine and healing among the Maine Shakers, 1784-1854', and Margaret Moody Stier's 'Blood, sweat and herbs: health and medicine at the Harvard Shaker community, 1820-1855') is the development of the manufacture and sale of medicinal herbs as an early form of highly profitable agri-business. Now that pre-industrial community healing practices are being better understood, it is time that their comparative history was more fully explored, so that common elements and local diversities can be appreciated. It is on the basis of admirable collections of research papers like Medicine and healing that it will soon be possible to investigate such parallels.
Journal of the History of Medicine and Allied Sciences, May 15, 2012
F RANCISCO Guerra Pérez-Carral passed away on November 25, 2011, aged ninety-five, after an engag... more F RANCISCO Guerra Pérez-Carral passed away on November 25, 2011, aged ninety-five, after an engaged and fruitful life. Born at Torrelavega (Cantabria) on November 19, 1916, he had virtually finished medical studies in London at the outbreak of the Spanish Civil War. Committed to the Republican side, he left Spain in 1939 and established himself abroad as a pharmacologist, first at the National University of Mexico. Here, during the decade of the 1940s, in a laboratory on the second floor of the School of Medicine in Mexico City, he showed the effect of cardiac glycosides on ox myocardial myosin, increasing contractile strength by stimulating the release of phosphorus (Arch. Inst. Cardiol. Mex., 1946, 16, 449); his two collaborators, A. Veerkam and P. L. Eberstadt, curiously a Jew and a German anti-Semite, purified the myosin using a technique that Dr. Guerra had learned from the Spanish pharmacologist Tomas Alday Redonnet. He also investigated, among other things, the action of sodium salicylate inhibiting hyaluronidase (Duran Reynals’s spreading factor) in rheumatic fever, and the effects of hallucinogenic drugs and benzol in the mechanisms of regulation of the central nervous system. Two of his books were of particular importance in this period, Métodos de Farmacologı́a Experimental (1946) and Manual de Farmacologı́a (1951); with the latter, he became the first author in Mexico to describe the new antibiotics and sulfa drugs and helped bring about the gradual decline in infant mortality in Mexico. In addition, he personally advised Mao Tse Tung in the organization and planning of hospitals
pacientes y los profesionales en atención primaria Revisiones Revisión al documento de consenso p... more pacientes y los profesionales en atención primaria Revisiones Revisión al documento de consenso para la determinación e informe del perfil lipídico en laboratorios clínicos españoles El diseño observacional larvario Clínica cotidiana Cavernoma cervical alto (C1-C2): una presentación infrecuente Cuando unos edemas no son lo que parecen Dolor en la cara anterior del cuello con odinofagia de dos meses de evolución Síndrome de hiperémesis cannabinoide Anetodermia primaria Menos vista, más oído Carta al Editor El operón Lac de Escherichia coli y el nacimiento de la genética molecular www.mgyf.org Incluida en el IBECS Incluida en MEDES www.mgyf.org medicina general y de familia edición digital
... Recuerda en muchos aspectos al también Nobel de Química Linus Pauling al que cita reiteradame... more ... Recuerda en muchos aspectos al también Nobel de Química Linus Pauling al que cita reiteradamente en la obra, al igual que a Sir Peter Brian Medawar, Leo Szilard, François Jacob, Hans Adolf Krebs ya tantos y tantos otros, protagonistas de un siglo paradigmatico en las ...
The regulation of interleukin-2 receptor a chain (IL2Ra) expression and nuclear factor (NF) activ... more The regulation of interleukin-2 receptor a chain (IL2Ra) expression and nuclear factor (NF) activation by protein kinase C (PKC) in resting T cells, has been studied. Treatment of human resting T cells with phorbol esters strongly induced the expression of IL-2Ra and the activation of NF-ICB. This activation was due to the translocation of p65 and c-Re1 NFwB proteins from cytoplasmic stores to the nucleus, where they bound the ICB sequence of the ILdRa promoter either as ~ 5 0 . ~ 6 5 or as p50.c-Rel heterodimers. Interestingly, all of those events were largely indirect and mediated by endogenously secreted tumor necrosis factor a (TNFa), as they were strongly inhibited by a neutralizing anti-TNFa monoclonal ntibody. Furthermore, cyclosporin A, which blocked TNFa production induced by PKC, strongly inhibited IL-2Ra and NF-KB activation. The addition of either TNFa or IL-2 partially recovered cyclosporin A-induced IL-2Ra inhibition, but only TNFa completely recovered NF.& activation....
Biophysicist whose research transformed our understanding of the nervous system. He was awarded a... more Biophysicist whose research transformed our understanding of the nervous system. He was awarded a Nobel Prize in 1970 for development of the quantal theory of acetylcholine release at the neuromuscular junction. His research on how acetylcholine was stored in nerve terminals and released by neural impulses was one of the foundation stones of psychopharmacology.
French medicine in the second half of the 19th century includes the seminal contributions of Clau... more French medicine in the second half of the 19th century includes the seminal contributions of Claude Bernard, Lasèque, Trousseau, Jaccoud and Charcot, and counted among the most notable representatives is Professor Charles Robert Richet, Nobel Prize Winner for Medicine and Physiology in 1913, for the discovery of anaphylaxis. With his versatile personality he was involved in many different fields. His investigative work included diverse themes such as respiration, digestion, epilepsy and the regulation of body heat. To him we owe three new words, and as such, three new concepts: anaphylaxis, polypnea and zoomotherapy. Richet also excelled as a bacteriologist, pathologist, medical statistician, poet, novelist, playwright, historian, psychologist, parapsychologist, pacifist, philosopher and bibliographer. Especially interested in telepathy, and in general, extrasensory perception phenomena, he contributed decisively to the creation of a new science, metapsychics.
... A los 81 años, la noche del pasado viernes 13 de junio de 2003, ha fallecido en St. ... Arthu... more ... A los 81 años, la noche del pasado viernes 13 de junio de 2003, ha fallecido en St. ... Arthur C. Guyton (cortesía de su nuera, Susan Guyton). 304 ... a compren-der las intimidades de la fisiología a nivel celular y subcelular como, por ejemplo, el AMP cícli-co de Earl Sutherland que ...
Biophysicist whose research transformed our understanding of the nervous system. He was awarded a... more Biophysicist whose research transformed our understanding of the nervous system. He was awarded a Nobel Prize in 1970 for development of the quantal theory of acetylcholine release at the neuromuscular junction. His research on how acetylcholine was stored in nerve terminals and released by neural impulses was one of the foundation stones of psychopharmacology.
Revista Española de Sanidad Penitenciaria, Jun 1, 2013
This article reviews the main aspects of chronic hepatitis C (epidemiological, genomic related to... more This article reviews the main aspects of chronic hepatitis C (epidemiological, genomic related to enhanced molecular understanding of the life cycle of the hepatitis C virus, HCV) especially standard therapy with pegylated interferon a and ribavirin. Emphasis is also placed on the immune response of the liver to HCV and the assessment of liver fibrosis via transient elastography.
Revista Española de Sanidad Penitenciaria, Feb 26, 2013
This article reviews the main aspects of chronic hepatitis C (epidemiological, genomic related to... more This article reviews the main aspects of chronic hepatitis C (epidemiological, genomic related to enhanced molecular understanding of the life cycle of the hepatitis C virus, HCV) especially standard therapy with pegylated interferon a and ribavirin. Emphasis is also placed on the immune response of the liver to HCV and the assessment of liver fibrosis via transient elastography.
Book Reviews razzmatazz quackery hardly developed before the rapid expansion of commerce, adverti... more Book Reviews razzmatazz quackery hardly developed before the rapid expansion of commerce, advertising, communications and the press after the 1740s. Benes also shows that, at least up to the War of Independence, many of the showbiz-style quacks were paying brief visits to Europe, including the pioneer electro-therapist and sex-therapist, James Graham. In one final way, this volume documents the different course taken by New World medicine, by exploring the intimate links between healing, holiness-and business! American religious sects, it is well known, continually begat new medical doctrines, including the powerful Thomsonian movement. What is less well known, though intriguingly revealed in two absorbing papers on the Shakers (David Richards' 'Medicine and healing among the Maine Shakers, 1784-1854', and Margaret Moody Stier's 'Blood, sweat and herbs: health and medicine at the Harvard Shaker community, 1820-1855') is the development of the manufacture and sale of medicinal herbs as an early form of highly profitable agri-business. Now that pre-industrial community healing practices are being better understood, it is time that their comparative history was more fully explored, so that common elements and local diversities can be appreciated. It is on the basis of admirable collections of research papers like Medicine and healing that it will soon be possible to investigate such parallels.
Journal of the History of Medicine and Allied Sciences, May 15, 2012
F RANCISCO Guerra Pérez-Carral passed away on November 25, 2011, aged ninety-five, after an engag... more F RANCISCO Guerra Pérez-Carral passed away on November 25, 2011, aged ninety-five, after an engaged and fruitful life. Born at Torrelavega (Cantabria) on November 19, 1916, he had virtually finished medical studies in London at the outbreak of the Spanish Civil War. Committed to the Republican side, he left Spain in 1939 and established himself abroad as a pharmacologist, first at the National University of Mexico. Here, during the decade of the 1940s, in a laboratory on the second floor of the School of Medicine in Mexico City, he showed the effect of cardiac glycosides on ox myocardial myosin, increasing contractile strength by stimulating the release of phosphorus (Arch. Inst. Cardiol. Mex., 1946, 16, 449); his two collaborators, A. Veerkam and P. L. Eberstadt, curiously a Jew and a German anti-Semite, purified the myosin using a technique that Dr. Guerra had learned from the Spanish pharmacologist Tomas Alday Redonnet. He also investigated, among other things, the action of sodium salicylate inhibiting hyaluronidase (Duran Reynals’s spreading factor) in rheumatic fever, and the effects of hallucinogenic drugs and benzol in the mechanisms of regulation of the central nervous system. Two of his books were of particular importance in this period, Métodos de Farmacologı́a Experimental (1946) and Manual de Farmacologı́a (1951); with the latter, he became the first author in Mexico to describe the new antibiotics and sulfa drugs and helped bring about the gradual decline in infant mortality in Mexico. In addition, he personally advised Mao Tse Tung in the organization and planning of hospitals
pacientes y los profesionales en atención primaria Revisiones Revisión al documento de consenso p... more pacientes y los profesionales en atención primaria Revisiones Revisión al documento de consenso para la determinación e informe del perfil lipídico en laboratorios clínicos españoles El diseño observacional larvario Clínica cotidiana Cavernoma cervical alto (C1-C2): una presentación infrecuente Cuando unos edemas no son lo que parecen Dolor en la cara anterior del cuello con odinofagia de dos meses de evolución Síndrome de hiperémesis cannabinoide Anetodermia primaria Menos vista, más oído Carta al Editor El operón Lac de Escherichia coli y el nacimiento de la genética molecular www.mgyf.org Incluida en el IBECS Incluida en MEDES www.mgyf.org medicina general y de familia edición digital
... Recuerda en muchos aspectos al también Nobel de Química Linus Pauling al que cita reiteradame... more ... Recuerda en muchos aspectos al también Nobel de Química Linus Pauling al que cita reiteradamente en la obra, al igual que a Sir Peter Brian Medawar, Leo Szilard, François Jacob, Hans Adolf Krebs ya tantos y tantos otros, protagonistas de un siglo paradigmatico en las ...
The regulation of interleukin-2 receptor a chain (IL2Ra) expression and nuclear factor (NF) activ... more The regulation of interleukin-2 receptor a chain (IL2Ra) expression and nuclear factor (NF) activation by protein kinase C (PKC) in resting T cells, has been studied. Treatment of human resting T cells with phorbol esters strongly induced the expression of IL-2Ra and the activation of NF-ICB. This activation was due to the translocation of p65 and c-Re1 NFwB proteins from cytoplasmic stores to the nucleus, where they bound the ICB sequence of the ILdRa promoter either as ~ 5 0 . ~ 6 5 or as p50.c-Rel heterodimers. Interestingly, all of those events were largely indirect and mediated by endogenously secreted tumor necrosis factor a (TNFa), as they were strongly inhibited by a neutralizing anti-TNFa monoclonal ntibody. Furthermore, cyclosporin A, which blocked TNFa production induced by PKC, strongly inhibited IL-2Ra and NF-KB activation. The addition of either TNFa or IL-2 partially recovered cyclosporin A-induced IL-2Ra inhibition, but only TNFa completely recovered NF.& activation....
Biophysicist whose research transformed our understanding of the nervous system. He was awarded a... more Biophysicist whose research transformed our understanding of the nervous system. He was awarded a Nobel Prize in 1970 for development of the quantal theory of acetylcholine release at the neuromuscular junction. His research on how acetylcholine was stored in nerve terminals and released by neural impulses was one of the foundation stones of psychopharmacology.
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