Papers by Ines Perez Marin
Recent reports in oncological and non-oncological experimental setups provide strong evidence tha... more Recent reports in oncological and non-oncological experimental setups provide strong evidence that senescent cells are under the surveillance of CD8 T cell-mediated adaptive immunity. These new data also shed light on the mechanisms that sensitize senescent cells to CD8 T cell-dependent killing, as well as those that enable senescent cells to evade CD8 T cell immunosurveillance. Understanding the interplay between cellular senescence and the adaptive immune system may open new strategies to ameliorate aging and aging-associated diseases.
Cancer Discovery, Oct 27, 2022
Cellular senescence is a stress response that activates innate immune cells, but little is known ... more Cellular senescence is a stress response that activates innate immune cells, but little is known about its interplay with the adaptive immune system. Here, we show that senescent cells combine several features that render them highly efficient in activating dendritic cells (DC) and antigen-specific CD8 T cells. This includes the release of alarmins, activation of IFN signaling, enhanced MHC class I machinery, and presentation of senescence-associated self-peptides that can activate CD8 T cells. In the context of cancer, immunization with senescent cancer cells elicits strong antitumor protection mediated by DCs and CD8 T cells. Interestingly, this protection is superior to immunization with cancer cells undergoing immunogenic cell death. Finally, the induction of senescence in human primary cancer cells also augments their ability to activate autologous antigen-specific tumor-infiltrating CD8 lymphocytes. Our study indicates that senescent cancer cells can be exploited to develop efficient and protective CD8-dependent antitumor immune responses. SIGNIFICANCE: Our study shows that senescent cells are endowed with a high immunogenic potentialsuperior to the gold standard of immunogenic cell death. We harness these properties of senescent cells to trigger efficient and protective CD8-dependent antitumor immune responses. See related article by Chen et al., p. 432.
bioRxiv (Cold Spring Harbor Laboratory), Jun 6, 2022
Cellular senescence is a stress response that activates innate immunity. However, the interplay b... more Cellular senescence is a stress response that activates innate immunity. However, the interplay between senescent cells and the adaptive immune system remains largely unexplored. Here, we show that senescent cells display enhanced MHC class I (MHC-I) antigen processing and presentation. Immunization of mice with senescent syngeneic fibroblasts generates CD8 T cells reactive against both normal and senescent fibroblasts, some of them targeting senescence-associated MHC-I-peptides. In the context of cancer, we demonstrate that senescent cancer cells trigger strong anti-tumor protection mediated by antigen-presenting cells and CD8 T cells. This response is superior to the protection elicited by cells undergoing immunogenic cell death. Finally, induction of senescence in patient-derived cancer cells exacerbates the activation of autologous tumor-reactive CD8 tumor-infiltrating lymphocytes (TILs) with no effect on non-reactive TILs. Our study indicates that immunization with senescent cancer cells strongly activates anti-tumor immunity, and this can be exploited for cancer therapy. STATEMENT OF SIGNIFICANCE Our study shows that senescent cells are endowed with a high immunogenic potential, superior to the gold standard of immunogenic cell death. The induction of senescence in cancer cells can be exploited to develop efficient and protective CD8-dependent anti-tumor immune responses. .
Aging Cell, Sep 10, 2022
This is an open access article under the terms of the Creative Commons Attribution License, which... more This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Localización: Contenidos y mercado en la regulación de la comunicación audiovisual: El nuevo marc... more Localización: Contenidos y mercado en la regulación de la comunicación audiovisual: El nuevo marco de la ley 7/2010 General de Comunicación Audiovisual/coord. por Beatriz Belando Garín, Gonzalo Montiel Roig, 2011, ISBN 978-84-9876-958-6, págs. 113-138
Anti-cancer therapies often result in a subset of surviving cancer cells that undergo therapy-ind... more Anti-cancer therapies often result in a subset of surviving cancer cells that undergo therapy-induced senescence (TIS). Senescent cancer cells strongly modify the intratumoural microenvironment favoring immunosuppression and, thereby, tumour growth. An emerging strategy to optimise current therapies is to combine them with treatments that eliminate senescent cells. To this end, we undertook an unbiased proteomics approach to identify surface markers contributing to senescent cells immune evasion. Through this approach, we discovered that the immune checkpoint inhibitor PD-L2, but not PD-L1, is upregulated across multiple senescent human and murine cells. Importantly, blockade of PD-L2 strongly synergises with genotoxic chemotherapy, causing remission of solid tumours in mice. We show that PD-L2 inhibition prevents the persistence of chemotherapy-induced senescent cells, which exert cell-extrinsic immunomodulatory actions. In particular, upon chemotherapy, tumours deficient in PD-L2 ...
E.T.S.I. Agrónomos (UPM), May 4, 2022
Plant proteolysis is a metabolic process where specific enzymes called peptidases degrade protein... more Plant proteolysis is a metabolic process where specific enzymes called peptidases degrade proteins. In plants, this complex process involves broad metabolic networks and different sub-cellular compartments. Several types of peptidases take part in the proteolytic process, mainly cysteine-, serine-, aspartyl-and metallo-peptidases. Among the cysteine-peptidases, the papain-like or C1A peptidases (family C1, clan CA) are extensively present in land plants and are classified into catepsins L-, B-, Hand Flike. The catalytic mechanism of these C1A peptidases is highly conserved and involves
La serie “Amar en tiempos revueltos” emitida, desde septiembre de 2005, por La 1 de TVE y produci... more La serie “Amar en tiempos revueltos” emitida, desde septiembre de 2005, por La 1 de TVE y producida por Diagonal TV, nos traslada directamente a los anos de la guerra civil espanola y a los anos de la dictadura franquista. “Amar en tiempos revueltos” retrata con una fidelidad extraordinaria y al detalle cual fue la situacion personal y social de las personas que vivieron y sufrieron las consecuencias de la guerra, sirva de ejemplo, la escasez de todo tipo de materias por los anos del bloqueo que la comunidad internacional impuso al regimen franquista y las consiguientes cartillas de racionamiento de la postguerra. A pesar de estas circunstancias historicas, la serie muestra mujeres de vanguardia y precursoras de la mujer actual. Por tanto, pretendemos realizar un analisis de la mujer en la sociedad espanola a traves de las historias de sus protagonistas, mostrando el lado mas positivo y los valores que se traslucen de sus personajes: la solidaridad de las mujeres, la amistad, la col...
Contenidos y mercado en la regulación de la …, 2011
Localización: Contenidos y mercado en la regulación de la comunicación audiovisual: El nuevo marc... more Localización: Contenidos y mercado en la regulación de la comunicación audiovisual: El nuevo marco de la ley 7/2010 General de Comunicación Audiovisual/coord. por Beatriz Belando Garín, Gonzalo Montiel Roig, 2011, ISBN 978-84-9876-958-6, págs. 113-138
El Levantamiento Del Velo Las Mujeres En El Derecho Privado 2011 Isbn 978 84 9985 026 9 Pags 983 1016, 2011
"Este arttículo muestra un recorrido histórico de la evolución de la doc... more "Este arttículo muestra un recorrido histórico de la evolución de la doctrinal del Jurado de Autocontrol desde el año 1996 hasta el año 2009 referente a las resoluciones por publicidad sexista sobre la mujer. De esta investigación se deduce como la modificación del artículo 3.a) de la Ley 34/1988, de 11 de noviembre, General de Publicidad por la Ley Orgánica 1/2004, de 28 de diciembre, de Medidas de Protección Integral contra la Violencia de Género, ha supuesto un avance, ya que a partir del año 2005 el número de resoluciones estimadas por el Jurado de autocontrol por cosifiacación aumentó con respecto a la época anterior a la modificación del mismo (art. 3.a) LGP)"
Derecho y (des) igualdad por razón de género: …, 2011
Información del artículo ¿Mujer, objeto publicitario?
This research arose from the need to consolidate a meaningful bilingual methodology for children ... more This research arose from the need to consolidate a meaningful bilingual methodology for children from three to five years of age from low socioeconomic backgrounds belonging to the public education system, where they could begin learning English and Spanish by means of a bilingual methodology that provides them with the same opportunities as middle to upper class children. Its aim is to implement an Early Sequential Bilingual Methodology Model in a public Early Childhood Development Center-ECDC (Centro de Desarrollo Infantil-CDI), and to collect data from class observations, student's responses, early childhood teachers' and English teachers' views as well as parents' perceptions towards its methodology and implementation in order to consolidate the model. Likewise, it will provide children with new opportunities to develop higher cognitive and high order thinking skills that can maximize their academic performance throughout their school years. This present Early Sequential Bilingual Model is a descriptive case study funded by a public university in Colombia and was implemented in a public ECDC (CDI) in Pereira (Risaralda-Colombia) based on the bilingual methodological proposals portrayed by Rodao (2011) and Arias et al. (2015). This research project depicts and systematizes the most predominant methodological techniques employed when teaching English at public ECDCs (CDIs) and interprets their effectiveness based on the data collected from 1
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Papers by Ines Perez Marin