Introduction: Gestational Diabetes Mellitus (GDM) is a condition potentially occurring during pre... more Introduction: Gestational Diabetes Mellitus (GDM) is a condition potentially occurring during pregnancy. It is associated with adverse foetal and maternal outcomes and is particularly prevalent in South Asian women who comprised this study sample. Aim: To provide a critical analysis of the information on GDM risk that can be identified from screening using the Oral Glucose Challenge Test (OGCT-50 g). Materials and Methods: A prospective cohort study was conducted over eight months. Purposive sampling was used to collect demographic and clinical data {age; Body mass Index (BMI); parity; history of Diabetes Mellitus (DM) in a first degree relative and histories of GDM, polyhydramnious, macrosomia, birth congenital abnormalities and still birth} from 300 South Asian women in mid-trimester pregnancy who consented to undertake an OGCT-50g. Excluded were primigravidas, women with DM or other medical conditions, and women who were unwilling or unable to give informed written consent. Descriptive, comparative and multivariate logistic analyses were used to investigate strengths of correlation between OGCT outcomes and clinical/historical risk factors. Results: The OGCT were 107 (35.7%) positive and 193 (64.3%) negative. The threshold for body mass risk was identified as 27.5 kg/m2. Women with two or more risk factors were OGCT positive on 72.9% occasions whereas women with one or no risk factor were OGCT negative on 81.9% occasions. Approximately, 50% of women had a family history of DM as their only risk factor and 24% of them were OGCT positive. Conclusion: The BMI was the strongest determinant of a positive OGCT result. The logistic regression analysis demonstrated that using the lower BMI threshold of 27.5 compared to 30.0 [as per National Institute for Health and Care Excellence (NICE) guideline] improved agreement between risk factors profile was assessed and OGCT results.
Journal of cardiology and cardiovascular sciences, May 1, 2019
Background: The applicability of the Short Form (SF36) questionnaire to disparate populations led... more Background: The applicability of the Short Form (SF36) questionnaire to disparate populations led us to use this tool to investigate how health-related quality-of-life (HRQoL) for patients who underwent coronary artery bypass grafting (CABG) is related to gender, age and survival. Method: SF36 data and the presence of cardiac symptoms were collected from 44 women and 166 men prior to surgery and from consenting survivors at one and eight-year follow-ups. Survival data were collected from government records for 18 years post operation. Paired t-tests, Pearson correlation coefficients, chi-squared tests and the log-rank test were used to investigate connections between HRQoL and age, presence of angina/breathlessness and survival within and across genders. Results: HRQoL improved significantly for males and females in almost all health domains at the one year follow-up. At the eight year follow-up most female domain scores showed further improvement whereas the majority of male domain scores declined. Cardiac symptoms were present in 75.8% of women and 68.3% of men (χ2=0.7120, p=0.3988) at the one-year follow-up, and 84.2% of women and 70.2% of men at the eight-year follow-up. Male long term survival (53.6% after 18 years) depended significantly on retaining post-operative improvements in HRQoL to the medium term (p<0.002 in 4 of 8 domains). Female long term survival (40.9%) was significantly less than male survival (p=0.0108) and depended on maintaining a steady upward trend in HRQoL over the medium term. Age was not a determinant in HRQoL following CABG. Long term male and female survival was not significantly different and approached those of age and gender matched samples from the general population. Conclusion: Strategies to improve HRQoL in women may support improved survival by reducing excess short term female mortality, but the effectiveness of the same strategy for men is less apparent.
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Introduction Coronavirus disease 2019 (COVID-19) pandemic has continued relentlessly for over one... more Introduction Coronavirus disease 2019 (COVID-19) pandemic has continued relentlessly for over one and half years now, causing a threat to life, fear of falling sick, helplessness, anxiety, depression and, pessimism about the future. There has been an increasing concern over student mental health in higher education. Our study was designed to measure current mental health status and its relationship with sociodemographic variables and level of knowledge about COVID-19 in Saudi Arabia. Method A cross-sectional survey was conducted among laboratory medicine students of Makkah city, Saudi Arabia from October, 2020 to January, 21. A semi-structured questionnaire was circulated through mail and What’s App. Data collected included sociodemographic details and level of knowledge towards the COVID-19 among the students. Depression anxiety and stress-21 item (DASS 21) was used to assess psychological status. Result Our study reported 51.4% depressive symptoms, 57.9% anxiety symptoms, and 48.5...
Background: Postpartum bleeding (PPB) and its clinical management (i.e., skin-to-skin contact and... more Background: Postpartum bleeding (PPB) and its clinical management (i.e., skin-to-skin contact and breastfeeding) are the essential parameters in which healthcare services are mandatory to promote maternal and fetal well-being. Aim: The researcher aims to investigate the broader perspectives regarding immediate skin-to-skin initial contact between baby and mother. Besides, breastfeeding significance would encourage the development of clinical outcomes' well-being. Across various institutions and globally, several integrative practices are established to promote and preserve maternal and fetal mortality and morbidity. Hence, comprehensive literature aimed to probe the cause-and-effect relationship association. Methods: The literature search was adopted using appropriate keywords and followed a standard scientific data search system. The search included PubMed and Google Scholar databases. All publications associated with immediate newborn care and bonding with mothers were the hig...
Background The coronavirus disease 2019 pandemic has shown a significant impact on the psychologi... more Background The coronavirus disease 2019 pandemic has shown a significant impact on the psychological well-being of health care workers. The aim of the study was to evaluate the impact of the COVID-19 pandemic on the psychological health of health care workers in the Kingdom of Saudi Arabia. During the months of November and December, 283 health care workers completed a survey containing measures of depression, anxiety and stress (using Depression Anxiety and Stress-21 scale [DASS-21]) and questions regarding potential predictors such as the role of COVID-19 perception, availability of mental health support and work-related factors. Pearson X2 test revealed factors associated with the presence of significant psychiatric symptoms. Result Among the participants, 17.3% screened positive for depression, 26.2% for anxiety and 17.3% for stress. Nurses reported significantly more depression, anxiety and stress than doctors. Those who received mental health support reported significantly les...
Angiotensin-converting enzyme (ACE) regulates several biological functions besides its vital role... more Angiotensin-converting enzyme (ACE) regulates several biological functions besides its vital role in immune functions. ACE is elevated in immune cells in inflammatory diseases including atherosclerosis, granuloma, chronic kidney disease, and also autoimmune diseases, like multiple sclerosis, rheumatoid arthritis, and type I diabetes. No significant information prevails in the literature regarding the isolation, identification, and profiling of potential ACE inhibitory peptides. In the present study, indigenous crop varieties like seeds (peanut, corn, oat, sunflower, chickpea, parsley, cottonseed, papaya, sesame, and flaxseed) were used to evaluate their ACE inhibition activity. Variables including hydrolysis time, enzyme-to-substrate ratio (E/S), pH, and temperature were standardized to acquire the most suitable and optimum ACE inhibition activity. Seeds of cotton, chickpea, and peanuts displayed remarkably maximum ACE inhibition activity than other plants. The study disclosed that ...
Molecules isolated and identified from plant origin are used to manufacture most chemotherapeutic... more Molecules isolated and identified from plant origin are used to manufacture most chemotherapeutic drugs for cancer treatment. We assumed that these plant extracts contain prolific bioactive compounds with potent antiproliferative activities and could be effective against different human cancer cells. Ethanolic extracts were prepared from Chelidonium majus, Myrica cerifera, Fumaria indica, Nigella sativa, and Silybum marianum, and the antiproliferative assay was performed in HepG2 and HeLa human cancer cell lines. All plants extract exhibited antiproliferative potential against studied cancer cell lines in the dose and time-dependent manner. Chelidonium majus and Silybum marianum have shown promising results against HepG2 and HeLa cells, respectively, followed by Myrica cerifera, Fumaria indica, and Nigella sativa. Results indicated that utilization of whole plant extract as anticancer compounds could be of great value in generating novel chemotherapeutic drugs.
Primary dysmenorrhea is one of the most prevalent debilitating problems in reproductive ages. A g... more Primary dysmenorrhea is one of the most prevalent debilitating problems in reproductive ages. A general lack of understanding about the particular needs of Indian adolescents, specifically adolescent girls, persists in India and the wider global community. Adolescence group is viewed as an opportune time to practice healthy living habits and prevent future health complication. Aim of the study: This study was aimed to identify the effect of reflexology on the relief of dysmenorrhea with premenstrual syndrome. Research design: True experimental research design was adopted and the study sample was chosenby simple random sampling technique. Study population was the students studying in P.D.B. Government Higher Secondary School, Krishnagiri District and P.B.A.Government Girls High School, Tamilnadu.Dysmenorrhea symptoms scale was used to assess the symptoms among adolescent girls. The data was collected after obtaining the permission from concerned administrative personnel of the School...
International Journal of Trend in Scientific Research and Development, 2019
The success of any educational institution is measured by its academic performance or how well st... more The success of any educational institution is measured by its academic performance or how well students meet the standards set out. This study aimed to determine the factors affecting the academic performance of second and third year student nurses in Saudi Arabia. Academic success is important because it is strongly linked to the positive outcomes we value… Academic success is important because working people will need higher levels of education to tackle the technologically demanding occupations of the future. This study may benefit the students by allowing them to understand better the factors that can affect their academic performance. A quantitative descriptive design was utilized. Selfreporting course survey questionnaire was the main method used for data gathering. Average weighted mean and proportions were used to determine the level of impact of the different factors affecting student nurses' academic performance. The items on "What happened during the course" found to be of high impact. Meanwhile few items in the same category fell in the low range and rated related to their grading as moderate. In the aspect of course evaluation, the first item on "what I learnt in this course is important and will be useful to me" was determined to have the greatest impact among the course related items. Among the five domains, the item related to their overall evaluation "Satisfied with the quality of the course" fall behind the teacher related factors. Based from the findings, it was concluded that several factors pose high impact on the academic performance of student nurses, with teacher related factors topping the list.
Introduction: Gestational Diabetes Mellitus (GDM) is a condition potentially occurring during pre... more Introduction: Gestational Diabetes Mellitus (GDM) is a condition potentially occurring during pregnancy. It is associated with adverse foetal and maternal outcomes and is particularly prevalent in South Asian women who comprised this study sample. Aim: To provide a critical analysis of the information on GDM risk that can be identified from screening using the Oral Glucose Challenge Test (OGCT-50 g). Materials and Methods: A prospective cohort study was conducted over eight months. Purposive sampling was used to collect demographic and clinical data {age; Body mass Index (BMI); parity; history of Diabetes Mellitus (DM) in a first degree relative and histories of GDM, polyhydramnious, macrosomia, birth congenital abnormalities and still birth} from 300 South Asian women in mid-trimester pregnancy who consented to undertake an OGCT-50g. Excluded were primigravidas, women with DM or other medical conditions, and women who were unwilling or unable to give informed written consent. Descr...
Introduction: Gestational Diabetes Mellitus (GDM) is a condition potentially occurring during pre... more Introduction: Gestational Diabetes Mellitus (GDM) is a condition potentially occurring during pregnancy. It is associated with adverse foetal and maternal outcomes and is particularly prevalent in South Asian women who comprised this study sample. Aim: To provide a critical analysis of the information on GDM risk that can be identified from screening using the Oral Glucose Challenge Test (OGCT-50 g). Materials and Methods: A prospective cohort study was conducted over eight months. Purposive sampling was used to collect demographic and clinical data {age; Body mass Index (BMI); parity; history of Diabetes Mellitus (DM) in a first degree relative and histories of GDM, polyhydramnious, macrosomia, birth congenital abnormalities and still birth} from 300 South Asian women in mid-trimester pregnancy who consented to undertake an OGCT-50g. Excluded were primigravidas, women with DM or other medical conditions, and women who were unwilling or unable to give informed written consent. Descriptive, comparative and multivariate logistic analyses were used to investigate strengths of correlation between OGCT outcomes and clinical/historical risk factors. Results: The OGCT were 107 (35.7%) positive and 193 (64.3%) negative. The threshold for body mass risk was identified as 27.5 kg/m2. Women with two or more risk factors were OGCT positive on 72.9% occasions whereas women with one or no risk factor were OGCT negative on 81.9% occasions. Approximately, 50% of women had a family history of DM as their only risk factor and 24% of them were OGCT positive. Conclusion: The BMI was the strongest determinant of a positive OGCT result. The logistic regression analysis demonstrated that using the lower BMI threshold of 27.5 compared to 30.0 [as per National Institute for Health and Care Excellence (NICE) guideline] improved agreement between risk factors profile was assessed and OGCT results.
Journal of cardiology and cardiovascular sciences, May 1, 2019
Background: The applicability of the Short Form (SF36) questionnaire to disparate populations led... more Background: The applicability of the Short Form (SF36) questionnaire to disparate populations led us to use this tool to investigate how health-related quality-of-life (HRQoL) for patients who underwent coronary artery bypass grafting (CABG) is related to gender, age and survival. Method: SF36 data and the presence of cardiac symptoms were collected from 44 women and 166 men prior to surgery and from consenting survivors at one and eight-year follow-ups. Survival data were collected from government records for 18 years post operation. Paired t-tests, Pearson correlation coefficients, chi-squared tests and the log-rank test were used to investigate connections between HRQoL and age, presence of angina/breathlessness and survival within and across genders. Results: HRQoL improved significantly for males and females in almost all health domains at the one year follow-up. At the eight year follow-up most female domain scores showed further improvement whereas the majority of male domain scores declined. Cardiac symptoms were present in 75.8% of women and 68.3% of men (χ2=0.7120, p=0.3988) at the one-year follow-up, and 84.2% of women and 70.2% of men at the eight-year follow-up. Male long term survival (53.6% after 18 years) depended significantly on retaining post-operative improvements in HRQoL to the medium term (p<0.002 in 4 of 8 domains). Female long term survival (40.9%) was significantly less than male survival (p=0.0108) and depended on maintaining a steady upward trend in HRQoL over the medium term. Age was not a determinant in HRQoL following CABG. Long term male and female survival was not significantly different and approached those of age and gender matched samples from the general population. Conclusion: Strategies to improve HRQoL in women may support improved survival by reducing excess short term female mortality, but the effectiveness of the same strategy for men is less apparent.
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Introduction Coronavirus disease 2019 (COVID-19) pandemic has continued relentlessly for over one... more Introduction Coronavirus disease 2019 (COVID-19) pandemic has continued relentlessly for over one and half years now, causing a threat to life, fear of falling sick, helplessness, anxiety, depression and, pessimism about the future. There has been an increasing concern over student mental health in higher education. Our study was designed to measure current mental health status and its relationship with sociodemographic variables and level of knowledge about COVID-19 in Saudi Arabia. Method A cross-sectional survey was conducted among laboratory medicine students of Makkah city, Saudi Arabia from October, 2020 to January, 21. A semi-structured questionnaire was circulated through mail and What’s App. Data collected included sociodemographic details and level of knowledge towards the COVID-19 among the students. Depression anxiety and stress-21 item (DASS 21) was used to assess psychological status. Result Our study reported 51.4% depressive symptoms, 57.9% anxiety symptoms, and 48.5...
Background: Postpartum bleeding (PPB) and its clinical management (i.e., skin-to-skin contact and... more Background: Postpartum bleeding (PPB) and its clinical management (i.e., skin-to-skin contact and breastfeeding) are the essential parameters in which healthcare services are mandatory to promote maternal and fetal well-being. Aim: The researcher aims to investigate the broader perspectives regarding immediate skin-to-skin initial contact between baby and mother. Besides, breastfeeding significance would encourage the development of clinical outcomes' well-being. Across various institutions and globally, several integrative practices are established to promote and preserve maternal and fetal mortality and morbidity. Hence, comprehensive literature aimed to probe the cause-and-effect relationship association. Methods: The literature search was adopted using appropriate keywords and followed a standard scientific data search system. The search included PubMed and Google Scholar databases. All publications associated with immediate newborn care and bonding with mothers were the hig...
Background The coronavirus disease 2019 pandemic has shown a significant impact on the psychologi... more Background The coronavirus disease 2019 pandemic has shown a significant impact on the psychological well-being of health care workers. The aim of the study was to evaluate the impact of the COVID-19 pandemic on the psychological health of health care workers in the Kingdom of Saudi Arabia. During the months of November and December, 283 health care workers completed a survey containing measures of depression, anxiety and stress (using Depression Anxiety and Stress-21 scale [DASS-21]) and questions regarding potential predictors such as the role of COVID-19 perception, availability of mental health support and work-related factors. Pearson X2 test revealed factors associated with the presence of significant psychiatric symptoms. Result Among the participants, 17.3% screened positive for depression, 26.2% for anxiety and 17.3% for stress. Nurses reported significantly more depression, anxiety and stress than doctors. Those who received mental health support reported significantly les...
Angiotensin-converting enzyme (ACE) regulates several biological functions besides its vital role... more Angiotensin-converting enzyme (ACE) regulates several biological functions besides its vital role in immune functions. ACE is elevated in immune cells in inflammatory diseases including atherosclerosis, granuloma, chronic kidney disease, and also autoimmune diseases, like multiple sclerosis, rheumatoid arthritis, and type I diabetes. No significant information prevails in the literature regarding the isolation, identification, and profiling of potential ACE inhibitory peptides. In the present study, indigenous crop varieties like seeds (peanut, corn, oat, sunflower, chickpea, parsley, cottonseed, papaya, sesame, and flaxseed) were used to evaluate their ACE inhibition activity. Variables including hydrolysis time, enzyme-to-substrate ratio (E/S), pH, and temperature were standardized to acquire the most suitable and optimum ACE inhibition activity. Seeds of cotton, chickpea, and peanuts displayed remarkably maximum ACE inhibition activity than other plants. The study disclosed that ...
Molecules isolated and identified from plant origin are used to manufacture most chemotherapeutic... more Molecules isolated and identified from plant origin are used to manufacture most chemotherapeutic drugs for cancer treatment. We assumed that these plant extracts contain prolific bioactive compounds with potent antiproliferative activities and could be effective against different human cancer cells. Ethanolic extracts were prepared from Chelidonium majus, Myrica cerifera, Fumaria indica, Nigella sativa, and Silybum marianum, and the antiproliferative assay was performed in HepG2 and HeLa human cancer cell lines. All plants extract exhibited antiproliferative potential against studied cancer cell lines in the dose and time-dependent manner. Chelidonium majus and Silybum marianum have shown promising results against HepG2 and HeLa cells, respectively, followed by Myrica cerifera, Fumaria indica, and Nigella sativa. Results indicated that utilization of whole plant extract as anticancer compounds could be of great value in generating novel chemotherapeutic drugs.
Primary dysmenorrhea is one of the most prevalent debilitating problems in reproductive ages. A g... more Primary dysmenorrhea is one of the most prevalent debilitating problems in reproductive ages. A general lack of understanding about the particular needs of Indian adolescents, specifically adolescent girls, persists in India and the wider global community. Adolescence group is viewed as an opportune time to practice healthy living habits and prevent future health complication. Aim of the study: This study was aimed to identify the effect of reflexology on the relief of dysmenorrhea with premenstrual syndrome. Research design: True experimental research design was adopted and the study sample was chosenby simple random sampling technique. Study population was the students studying in P.D.B. Government Higher Secondary School, Krishnagiri District and P.B.A.Government Girls High School, Tamilnadu.Dysmenorrhea symptoms scale was used to assess the symptoms among adolescent girls. The data was collected after obtaining the permission from concerned administrative personnel of the School...
International Journal of Trend in Scientific Research and Development, 2019
The success of any educational institution is measured by its academic performance or how well st... more The success of any educational institution is measured by its academic performance or how well students meet the standards set out. This study aimed to determine the factors affecting the academic performance of second and third year student nurses in Saudi Arabia. Academic success is important because it is strongly linked to the positive outcomes we value… Academic success is important because working people will need higher levels of education to tackle the technologically demanding occupations of the future. This study may benefit the students by allowing them to understand better the factors that can affect their academic performance. A quantitative descriptive design was utilized. Selfreporting course survey questionnaire was the main method used for data gathering. Average weighted mean and proportions were used to determine the level of impact of the different factors affecting student nurses' academic performance. The items on "What happened during the course" found to be of high impact. Meanwhile few items in the same category fell in the low range and rated related to their grading as moderate. In the aspect of course evaluation, the first item on "what I learnt in this course is important and will be useful to me" was determined to have the greatest impact among the course related items. Among the five domains, the item related to their overall evaluation "Satisfied with the quality of the course" fall behind the teacher related factors. Based from the findings, it was concluded that several factors pose high impact on the academic performance of student nurses, with teacher related factors topping the list.
Introduction: Gestational Diabetes Mellitus (GDM) is a condition potentially occurring during pre... more Introduction: Gestational Diabetes Mellitus (GDM) is a condition potentially occurring during pregnancy. It is associated with adverse foetal and maternal outcomes and is particularly prevalent in South Asian women who comprised this study sample. Aim: To provide a critical analysis of the information on GDM risk that can be identified from screening using the Oral Glucose Challenge Test (OGCT-50 g). Materials and Methods: A prospective cohort study was conducted over eight months. Purposive sampling was used to collect demographic and clinical data {age; Body mass Index (BMI); parity; history of Diabetes Mellitus (DM) in a first degree relative and histories of GDM, polyhydramnious, macrosomia, birth congenital abnormalities and still birth} from 300 South Asian women in mid-trimester pregnancy who consented to undertake an OGCT-50g. Excluded were primigravidas, women with DM or other medical conditions, and women who were unwilling or unable to give informed written consent. Descr...
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