Journal of health sciences and medicine, Oct 22, 2020
Background: The interatrial block (IAB) is a condition that occurs due to the delay of conduction... more Background: The interatrial block (IAB) is a condition that occurs due to the delay of conduction in the right atrium to the left atrium, and can be partial (pIAB) or advanced (aIAB), and also is associated with atrial arrhythmia. Diastolic dysfunction (DD) is an important condition frequently encountered in most healthy middle-aged individuals and plays a role in the development of many cardiovascular diseases. It is noteworthy that frequent paroxysmal atrial fibrillation (PAF) attacks are observed especially in individuals with DD in clinical life, and its relationship with the presence of interatrial block is still unclear in these patients. Our aim in this study was to evaluate the relationship between the presence of DD and the development of interatrial block and PAF. Material and Method: A total of 146; 92 patients with DD and 54 control (proven by echocardiography) were enrolled in this cross-sectional and prospectively study. The properties of the P wave were evaluated in leads D2-3 aVF and V1. Echocardiography and electrocardiography results of the two groups were compared. Results: The mean age of the DD and the control group was (62.3±0.74 and 61.2±0.61 years, p=0.481) respectively. The frequency of IAB was significantly higher in the DD than the control group (37%-46.7%-16.3%, 77.8%-18.5%-3.7%, and none-pIAB-aIAB, respectively). In the correlation analysis, there was a strong correlation between the presence of DD and IAB (r: 0.439, p<0.001), and the history of PAF and IAB (r: 0.458, p<0.001). Conclusion: In our study, the frequency of IAB was significantly higher in the DD group. We think that it may be beneficial to evaluate P waves more carefully to determine the risky individuals among those who have DD in clinical life.
International Journal of the Cardiovascular Academy, 2021
Obstructive sleep apnea (OSA) is a syndrome characterized by recurrent apnea and hypopnea episode... more Obstructive sleep apnea (OSA) is a syndrome characterized by recurrent apnea and hypopnea episodes during sleep, primarily affecting the middle-aged population. [1] Global estimates suggest that 936 million people worldwide have mild-to-moderate OSA, and 425 million have moderate-to-severe OSA. [2] In some observational studies, the prevalence of OSA may be as high as 50% among patients with heart failure. OSA can play a crucial role in heart failure by causing repetitive hypoxia and apnea episodes, hormonal and metabolic impairment, systemic inflammation, and mechanical hemodynamic disturbances. Extensive research has shown the link between OSA and cardiac remodeling causing heart failure. For example, Borrelli et al. found a 62% prevalence of OSA in heart failure. [3] Though, these results were based on basic echocardiographic parameters. Most of the studies have focused on left ventricular (LV) hypertrophy, decreased LV ejection fraction (EF), and LV diastolic dysfunction in the presence of OSA and heart failure. [3-5] The strain is a measure of myocardial deformation. Furthermore, strain analysis is defined as a current LV function index method in recent echocardiography guidelines.
Numerous studies have shown an association between patent foramen ovale (PFO) and cryptogenic str... more Numerous studies have shown an association between patent foramen ovale (PFO) and cryptogenic stroke suggesting that paradoxical emboli may be an important cause of stroke. In addition, some authors have proposed that platelet activation is present in PFO patients and this might be the cause of the stroke. The aim of this study was to assess the mean platelet volume (MPV), an indicator of platelet activation and/or reactivity in patients with PFO. The study group consisted of 77 patients with PFO. An age, sex, BMI-matched control group was composed of 43 healthy volunteers. We measured serum MPV values in patients and controls. MPV was significantly higher among PFO patients when compared with control group (9.0 W 0.8 vs. 8.3 W 0.9 fl, respectively; P < 0.001). We have shown that MPV was significantly elevated in patients with PFO compared with controls.
Dünya Sağlık Örgütünün(DSÖ) tanımlamasında; vücut kitle indeksi (VKİ) 25 ve üzeri olanları hafif ... more Dünya Sağlık Örgütünün(DSÖ) tanımlamasında; vücut kitle indeksi (VKİ) 25 ve üzeri olanları hafif kilolu, 30 ve üzeri olanları obez olarak sınıflandırmıştır ve obezitenin dünya genelinde prevalansı giderek artmaktadır. Obezite, artık epidemi ve önemli bir halk sağlığı problemi haline gelmiştir. Çalışmamızda kronik inflamatuvar ve epidemik bir hastalık olan obezitenin yeni inflamasyon ve kardiyovasküler hastalık risk belirteci olarak tanımlanmış nötrofil/lenfosit oranı (NLR), monosit düşük yoğunluklu lipoprotein (HDL) oranı (MHR) ve plazma aterojenik indeksi (PAI) parametreleriyle ilişkisini araştırmak amaçlanmıştır. GEREÇ VE YÖNTEM: Birinci basamak sağlık merkezine 01.12.2018 ile 31.04.2019 tarihleri arasında ardışık başvuran toplam 536 hasta retrospektif kesitsel tasarımla değerlendirildi. Hastaların demografik özellikleri, kronik hastalık karakterleri ve laboratuvar, boy, kilo, bel ve kalça çevreleri hasta kayıt veri tabanından temin edildi. Başvuran hastalar, VKİ'ne göre normal kilolu (18,5-24,9), hafif kilolu(25-29,9), obez (30-34,9) ve morbid obez(35 ve üzeri) olarak dört gruba ayrıldı. Gruplar arası değişkenler değerlendirildi. BULGULAR: Çalışmada yaş ortalaması 34 (IQR 25-42)'tü ve %84,5'i(452) kadın cinsiyetteydi. Çalışma popülasyonunun %18(97)'si normal kilolu, %26,5 (142)'si hafif kilolu, %27,5(147)'si obez, %28,2 (151)'si morbid obezdi. Obezite derecesi arttıkça yaş (p<0.001), hipertansiyon öyküsü(p=0.003) anlamlı olarak artmaktaydı. Laboratuvar parametreleri incelendiğinde, açlık kan şekeri düzeyi, insülin direnci,C-reaktif protein (CRP), ferritin düzeyleri obezite derecesi ile artmıştı (p<0.001) ancak HDL kolesterol azalmıştı (p<0.001). NLR, MHR ve PAI de obeziteyle artış gösterdi ancak istatistiksel anlamlılığa sadece PAI ulaştı (p<0.001). Hemoglobin, platelet, D vitamini, B12 vitamini değişkenlerinde obezite grupları arasında anlamlı farklılık yoktu. Lineer regresyon modelinde obezite ile yaş, CRP ve PAI arasında kuvvetli ilişki saptandı. SONUÇ: Araştırdığımız parameterlerden PAI, obez hastalarda kardiyovasküler hastalık riski değerlendirmek için ucuz ve pratik bir belirteç olarak klinik pratikte kullanılabilir. NLR ve MHR obezite ile artmış ancak istatiksel anlamlılığa ulaşmamıştır.
Abstract Objective: Mitral valve prolapse (MVP) is the most common cause of mitral regurgitation ... more Abstract Objective: Mitral valve prolapse (MVP) is the most common cause of mitral regurgitation in developed countries. The role of inflammation in the pathogenesis of MVP is still not clear. In this study, we aimed to investigate how inflammatory markers such as monocyte/high-density lipoprotein ratio (MHR), lymphocyte/monocyte ratio (LMR), neutrophil/lymphocyte ratio (NLR), and platelet/neutrophil ratio (PLR) are affected in MVP patients. Methods: In this retrospective study, we included 461 patients with MVP and 459 normal echocardiographic patients, matched with gender and age. Inflammatory markers and all variables were compared between the two groups. Results: There were no statistically significant differences in age, sex, or body mass index between the two groups. Neutrophil counts (4,960 [3,900-6,780]. 4,200 [3,800-5,600], p < 0.001), NLR (2.488 [1.72-4.51], 1.857 [1.49-2.38], p < 0.001), MHR (14.9 [11.9-18.6], 12.2 [9.4-17.3], p = 0.003), PLR (122.4 [85-171], 104.4 [85-130], p < 0.001), and CRP (0.71 ± 0.50, 0.67 ± 0.33 p < 0.001) were significantly higher, and LMR (3.75 [2.75-5.09], 4.06 [3.12-4.83] p = 0.016) was significantly lower in the MVP group than the control group, respectively. In logistic regression analysis, NLR (odds ratio [OR]: 1.058 [1.047-1.072]; p < 0.001), LMR (OR: 1.560 [1.211-2.522]; p = 0.027), and PLR (OR: 1.015 [1.012-1.019]; p = 0.003) were found to be independent predictors for MVP presence. Conclusions: These parameters can be used as a simple, low-cost, practical tool to detect inflammation in MVP.
Şizofreni hastalari genel topluma gore daha yuksek oranlarda metabolik sistem sorunlarina sahipti... more Şizofreni hastalari genel topluma gore daha yuksek oranlarda metabolik sistem sorunlarina sahiptirler. Bu hastalarin olum nedenleri arasinda kardiyak hastaliklar onemli bir yer tutmaktadir. Wolf Parkinson White sendromu dogumsal bir kalp hastaligidir ve ozellikle ventikuler aritmilere yol acmasi sebebiyle yasami tehdit edebilmektedir. Insanlardan zarar gorecegi korkusu ile basvuran 33 yasinda erkek hastada isitsel halusinasyonlar ve persekutif hezeyanlari siddetli olup hastane yatakli unitesinde tedaviye alindi. Fiziksel muayenesinde, EKG anormalligi saptanan hastada, kardiyoloji birimi ile degerlendirilerek Wolff Parkinson White sendromu tanisi saptandi. Bu olguda; Şizofreni ve Wolff Parkinson White sendromu birlikteliginde haloperidol ve aripiprazol tedavisi ile dort aylik klinik izleminde kardiyak yan etki gozlenmedigi sunulmaktadir. Şizofreni hastalarinin rutin kardiak muayenesi ve Şizofreni-Wolff Parkinson White sendromu birlikteliginde antipsikotik secimi onemlilik arz etmekte...
Patients with schizophrenia has higher rates of metabolic system problems than general population... more Patients with schizophrenia has higher rates of metabolic system problems than general population. Cardiac diseases is an important cause of death in these patients. Wolf Parkinson White syndrome is a congenital heart disease, that particularly it can life threatening due to ventricular arrhythmias. Thirty three year-old, male patient admitted with complaints of the fear of humans are going damage of him and the patient admitted to the psychiatry inpatient unit with severe hallucinations and delusions. In his physical examination, abnormal ECG was detected and evaluated with cardiology department, and Wolf Parkinson White syndome was diagnosed. In this case, we reported a patient with schizophrenia and wolf Parkinson white syndrome treated with haloperidol and aripiprazole and any cardiac side effect was not observed during the four months of follow up. It has important to routine cardiac examination in patients with schizophrenia and choose of antipsychotics in the comorbidity of s...
International Journal of the Cardiovascular Academy, 2021
Background: Rehospitalizations with acute coronary syndromes (ACSs) have declined over the last y... more Background: Rehospitalizations with acute coronary syndromes (ACSs) have declined over the last years, but there is a remaining need for potential further reduction of rehospitalization after ACS to determine the most predominant predictors that can guide strategies to reduce re-hospitalizations burden. Aim: This multi-center study aimed to evaluate the demographic, clinical characteristics, and medications of rehospitalized patients who suffered a new cardiac event in 12 months after admission due to ACS. Material and Methods: Patients age >18 years who have been hospitalized between November 1 2017, and April 1 2018, for ACS within12 months before the readmission for a new acute coronary event were enrolled. Results: The present study included a total of 628 (65.9% from Turkey) consecutive patients rehospitalized with ACS (ST-elevation myocardial infarction [STEMI], 23.0%; ACS without ST-elevation [NSTE-ACS], 76.9%) from 15 different countries. The majority of the rehospitalize...
Acute kidney injury (AKI) is a very common and important complication of cardiac surgery. It is a... more Acute kidney injury (AKI) is a very common and important complication of cardiac surgery. It is associated with severe complications including mortality. Cardiac surgery may induce oxidative stress and inflammation and both of these processes may be associated with AKI. N-acetyl cysteine (NAC) is a mucolytic agent and it has antioxidant and anti-inflammatory properties. Although positive results have been obtained in animal studies, however; no significant beneficial effects of NAC on AKI have been found in randomized studies and meta-analyses. Currently available data do not support to recommend NAC for the prevention of AKI after cardiac surgery.
GIRIŞ ve AMAC Literaturde kardiyovaskuler sisteme etkili ilaclarin depresif etkilerini inceleyen ... more GIRIŞ ve AMAC Literaturde kardiyovaskuler sisteme etkili ilaclarin depresif etkilerini inceleyen calismalar bulunmaktadir. Bu calismalarda birbirinden farkli bulgular yer almakta ve lipofilik beta bloker ilaclarin tedavinin ilk aylarinda depresif belirtilere neden olabildigi, beta blokerlerin genel olarak depresyon riskini artirmadigi, kardiyovaskuler hastaligi olan bireylerde statin kullaniminin depresif belirtileri ve depresyon gelisme riskini azalttigi bildirilmektedir. Bu arastirmanin amaci bir universite hastanesi kardiyoloji poliklinigine basvuran bireylerde depresyon durumunun belirlenmesi ve kullanilan kalp ilaclari ile arasindaki iliskinin incelenmesidir. GEREC ve YONTEM Bu arastirma, 2013 yilinda bir universite hastanesinin kardiyoloji poliklinigine basvuran bireylere(n:707) gozetim altinda anket uygulanarak yapildi. Anket; sosyodemografik ozellikleri, kalp hastaliklari ve depresyon ile iliskili faktorleri sorgulayan 39 sorudan ve Beck ve arkadaslari tarafindan gelistiril...
Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2021
OBJECTIVE Hypertension is a challenging problem in the older population because of poor drug adhe... more OBJECTIVE Hypertension is a challenging problem in the older population because of poor drug adherence (DA). We aimed to determine the DA and examine the drug interaction index (DII) on DA in older patients with hypertension. METHODS In this cross-sectional, observational study, we enrolled 418 eligible patients aged ≥ 65 years between 1 February 2020 and 30 September 2020 in a tertiary hospital outpatient cardiology clinic. We prepared a questionnaire to record sociodemographic characteristics, morbidities, and drugs used by the population. The Morisky Medication Adherence Scale-8 (MMAS-8) was used for DA assessment. We identified drug interactions using the Lexicomp application. We calculated the DII from a ratio of clinically relevant interaction to total interaction. Descriptive tests and multiple linear regression analyses were performed to find independent factors on DA. RESULTS The mean age (± standard deviation [SD]) was 72.91 (±6.47), and 272/146 were female/male in the study population. The most frequent comorbid disease was diabetes mellitus (23.5%). The percentage of patients having polypharmacy was 39.5, and the mean daily drug (±SD) use was 4.27 (±2.57). The most prescribed antihypertensive drugs were thiazide/derivates (29.8%) and angiotensin receptor blockers (24.8%). The mean MMAS-8 (±SD) was 4.55±0.98, and 321 (76.8%) participants had a poor DA. A total of 33.4% of patients had significant drug interaction. The mean DII (±SD) was 0.345±0.017. The area under the receiver operating characteristic (ROC) curve for DII was 0.616 (95% confidence interval [CI]: 0.547-0.686). CONCLUSION We defined a new index for drug interaction intensity. Furthermore, the DII may be a useful tool to study aspects of DA in older patients with hypertension.
Background: The interatrial block (IAB) is a condition that occurs due to the delay of conduction... more Background: The interatrial block (IAB) is a condition that occurs due to the delay of conduction in the right atrium to the left atrium, and can be partial (pIAB) or advanced (aIAB), and also is associated with atrial arrhythmia. Diastolic dysfunction (DD) is an important condition frequently encountered in most healthy middle-aged individuals and plays a role in the development of many cardiovascular diseases. It is noteworthy that frequent paroxysmal atrial fibrillation (PAF) attacks are observed especially in individuals with DD in clinical life, and its relationship with the presence of interatrial block is still unclear in these patients. Our aim in this study was to evaluate the relationship between the presence of DD and the development of interatrial block and PAF. Material and Method: A total of 146; 92 patients with DD and 54 control (proven by echocardiography) were enrolled in this cross-sectional and prospectively study. The properties of the P wave were evaluated in leads D2-3 aVF and V1. Echocardiography and electrocardiography results of the two groups were compared. Results: The mean age of the DD and the control group was (62.3±0.74 and 61.2±0.61 years, p=0.481) respectively. The frequency of IAB was significantly higher in the DD than the control group (37%-46.7%-16.3%, 77.8%-18.5%-3.7%, and none-pIAB-aIAB, respectively). In the correlation analysis, there was a strong correlation between the presence of DD and IAB (r: 0.439, p<0.001), and the history of PAF and IAB (r: 0.458, p<0.001). Conclusion: In our study, the frequency of IAB was significantly higher in the DD group. We think that it may be beneficial to evaluate P waves more carefully to determine the risky individuals among those who have DD in clinical life.
Journal of health sciences and medicine, Oct 22, 2020
Background: The interatrial block (IAB) is a condition that occurs due to the delay of conduction... more Background: The interatrial block (IAB) is a condition that occurs due to the delay of conduction in the right atrium to the left atrium, and can be partial (pIAB) or advanced (aIAB), and also is associated with atrial arrhythmia. Diastolic dysfunction (DD) is an important condition frequently encountered in most healthy middle-aged individuals and plays a role in the development of many cardiovascular diseases. It is noteworthy that frequent paroxysmal atrial fibrillation (PAF) attacks are observed especially in individuals with DD in clinical life, and its relationship with the presence of interatrial block is still unclear in these patients. Our aim in this study was to evaluate the relationship between the presence of DD and the development of interatrial block and PAF. Material and Method: A total of 146; 92 patients with DD and 54 control (proven by echocardiography) were enrolled in this cross-sectional and prospectively study. The properties of the P wave were evaluated in leads D2-3 aVF and V1. Echocardiography and electrocardiography results of the two groups were compared. Results: The mean age of the DD and the control group was (62.3±0.74 and 61.2±0.61 years, p=0.481) respectively. The frequency of IAB was significantly higher in the DD than the control group (37%-46.7%-16.3%, 77.8%-18.5%-3.7%, and none-pIAB-aIAB, respectively). In the correlation analysis, there was a strong correlation between the presence of DD and IAB (r: 0.439, p<0.001), and the history of PAF and IAB (r: 0.458, p<0.001). Conclusion: In our study, the frequency of IAB was significantly higher in the DD group. We think that it may be beneficial to evaluate P waves more carefully to determine the risky individuals among those who have DD in clinical life.
International Journal of the Cardiovascular Academy, 2021
Obstructive sleep apnea (OSA) is a syndrome characterized by recurrent apnea and hypopnea episode... more Obstructive sleep apnea (OSA) is a syndrome characterized by recurrent apnea and hypopnea episodes during sleep, primarily affecting the middle-aged population. [1] Global estimates suggest that 936 million people worldwide have mild-to-moderate OSA, and 425 million have moderate-to-severe OSA. [2] In some observational studies, the prevalence of OSA may be as high as 50% among patients with heart failure. OSA can play a crucial role in heart failure by causing repetitive hypoxia and apnea episodes, hormonal and metabolic impairment, systemic inflammation, and mechanical hemodynamic disturbances. Extensive research has shown the link between OSA and cardiac remodeling causing heart failure. For example, Borrelli et al. found a 62% prevalence of OSA in heart failure. [3] Though, these results were based on basic echocardiographic parameters. Most of the studies have focused on left ventricular (LV) hypertrophy, decreased LV ejection fraction (EF), and LV diastolic dysfunction in the presence of OSA and heart failure. [3-5] The strain is a measure of myocardial deformation. Furthermore, strain analysis is defined as a current LV function index method in recent echocardiography guidelines.
Numerous studies have shown an association between patent foramen ovale (PFO) and cryptogenic str... more Numerous studies have shown an association between patent foramen ovale (PFO) and cryptogenic stroke suggesting that paradoxical emboli may be an important cause of stroke. In addition, some authors have proposed that platelet activation is present in PFO patients and this might be the cause of the stroke. The aim of this study was to assess the mean platelet volume (MPV), an indicator of platelet activation and/or reactivity in patients with PFO. The study group consisted of 77 patients with PFO. An age, sex, BMI-matched control group was composed of 43 healthy volunteers. We measured serum MPV values in patients and controls. MPV was significantly higher among PFO patients when compared with control group (9.0 W 0.8 vs. 8.3 W 0.9 fl, respectively; P < 0.001). We have shown that MPV was significantly elevated in patients with PFO compared with controls.
Dünya Sağlık Örgütünün(DSÖ) tanımlamasında; vücut kitle indeksi (VKİ) 25 ve üzeri olanları hafif ... more Dünya Sağlık Örgütünün(DSÖ) tanımlamasında; vücut kitle indeksi (VKİ) 25 ve üzeri olanları hafif kilolu, 30 ve üzeri olanları obez olarak sınıflandırmıştır ve obezitenin dünya genelinde prevalansı giderek artmaktadır. Obezite, artık epidemi ve önemli bir halk sağlığı problemi haline gelmiştir. Çalışmamızda kronik inflamatuvar ve epidemik bir hastalık olan obezitenin yeni inflamasyon ve kardiyovasküler hastalık risk belirteci olarak tanımlanmış nötrofil/lenfosit oranı (NLR), monosit düşük yoğunluklu lipoprotein (HDL) oranı (MHR) ve plazma aterojenik indeksi (PAI) parametreleriyle ilişkisini araştırmak amaçlanmıştır. GEREÇ VE YÖNTEM: Birinci basamak sağlık merkezine 01.12.2018 ile 31.04.2019 tarihleri arasında ardışık başvuran toplam 536 hasta retrospektif kesitsel tasarımla değerlendirildi. Hastaların demografik özellikleri, kronik hastalık karakterleri ve laboratuvar, boy, kilo, bel ve kalça çevreleri hasta kayıt veri tabanından temin edildi. Başvuran hastalar, VKİ'ne göre normal kilolu (18,5-24,9), hafif kilolu(25-29,9), obez (30-34,9) ve morbid obez(35 ve üzeri) olarak dört gruba ayrıldı. Gruplar arası değişkenler değerlendirildi. BULGULAR: Çalışmada yaş ortalaması 34 (IQR 25-42)'tü ve %84,5'i(452) kadın cinsiyetteydi. Çalışma popülasyonunun %18(97)'si normal kilolu, %26,5 (142)'si hafif kilolu, %27,5(147)'si obez, %28,2 (151)'si morbid obezdi. Obezite derecesi arttıkça yaş (p<0.001), hipertansiyon öyküsü(p=0.003) anlamlı olarak artmaktaydı. Laboratuvar parametreleri incelendiğinde, açlık kan şekeri düzeyi, insülin direnci,C-reaktif protein (CRP), ferritin düzeyleri obezite derecesi ile artmıştı (p<0.001) ancak HDL kolesterol azalmıştı (p<0.001). NLR, MHR ve PAI de obeziteyle artış gösterdi ancak istatistiksel anlamlılığa sadece PAI ulaştı (p<0.001). Hemoglobin, platelet, D vitamini, B12 vitamini değişkenlerinde obezite grupları arasında anlamlı farklılık yoktu. Lineer regresyon modelinde obezite ile yaş, CRP ve PAI arasında kuvvetli ilişki saptandı. SONUÇ: Araştırdığımız parameterlerden PAI, obez hastalarda kardiyovasküler hastalık riski değerlendirmek için ucuz ve pratik bir belirteç olarak klinik pratikte kullanılabilir. NLR ve MHR obezite ile artmış ancak istatiksel anlamlılığa ulaşmamıştır.
Abstract Objective: Mitral valve prolapse (MVP) is the most common cause of mitral regurgitation ... more Abstract Objective: Mitral valve prolapse (MVP) is the most common cause of mitral regurgitation in developed countries. The role of inflammation in the pathogenesis of MVP is still not clear. In this study, we aimed to investigate how inflammatory markers such as monocyte/high-density lipoprotein ratio (MHR), lymphocyte/monocyte ratio (LMR), neutrophil/lymphocyte ratio (NLR), and platelet/neutrophil ratio (PLR) are affected in MVP patients. Methods: In this retrospective study, we included 461 patients with MVP and 459 normal echocardiographic patients, matched with gender and age. Inflammatory markers and all variables were compared between the two groups. Results: There were no statistically significant differences in age, sex, or body mass index between the two groups. Neutrophil counts (4,960 [3,900-6,780]. 4,200 [3,800-5,600], p < 0.001), NLR (2.488 [1.72-4.51], 1.857 [1.49-2.38], p < 0.001), MHR (14.9 [11.9-18.6], 12.2 [9.4-17.3], p = 0.003), PLR (122.4 [85-171], 104.4 [85-130], p < 0.001), and CRP (0.71 ± 0.50, 0.67 ± 0.33 p < 0.001) were significantly higher, and LMR (3.75 [2.75-5.09], 4.06 [3.12-4.83] p = 0.016) was significantly lower in the MVP group than the control group, respectively. In logistic regression analysis, NLR (odds ratio [OR]: 1.058 [1.047-1.072]; p < 0.001), LMR (OR: 1.560 [1.211-2.522]; p = 0.027), and PLR (OR: 1.015 [1.012-1.019]; p = 0.003) were found to be independent predictors for MVP presence. Conclusions: These parameters can be used as a simple, low-cost, practical tool to detect inflammation in MVP.
Şizofreni hastalari genel topluma gore daha yuksek oranlarda metabolik sistem sorunlarina sahipti... more Şizofreni hastalari genel topluma gore daha yuksek oranlarda metabolik sistem sorunlarina sahiptirler. Bu hastalarin olum nedenleri arasinda kardiyak hastaliklar onemli bir yer tutmaktadir. Wolf Parkinson White sendromu dogumsal bir kalp hastaligidir ve ozellikle ventikuler aritmilere yol acmasi sebebiyle yasami tehdit edebilmektedir. Insanlardan zarar gorecegi korkusu ile basvuran 33 yasinda erkek hastada isitsel halusinasyonlar ve persekutif hezeyanlari siddetli olup hastane yatakli unitesinde tedaviye alindi. Fiziksel muayenesinde, EKG anormalligi saptanan hastada, kardiyoloji birimi ile degerlendirilerek Wolff Parkinson White sendromu tanisi saptandi. Bu olguda; Şizofreni ve Wolff Parkinson White sendromu birlikteliginde haloperidol ve aripiprazol tedavisi ile dort aylik klinik izleminde kardiyak yan etki gozlenmedigi sunulmaktadir. Şizofreni hastalarinin rutin kardiak muayenesi ve Şizofreni-Wolff Parkinson White sendromu birlikteliginde antipsikotik secimi onemlilik arz etmekte...
Patients with schizophrenia has higher rates of metabolic system problems than general population... more Patients with schizophrenia has higher rates of metabolic system problems than general population. Cardiac diseases is an important cause of death in these patients. Wolf Parkinson White syndrome is a congenital heart disease, that particularly it can life threatening due to ventricular arrhythmias. Thirty three year-old, male patient admitted with complaints of the fear of humans are going damage of him and the patient admitted to the psychiatry inpatient unit with severe hallucinations and delusions. In his physical examination, abnormal ECG was detected and evaluated with cardiology department, and Wolf Parkinson White syndome was diagnosed. In this case, we reported a patient with schizophrenia and wolf Parkinson white syndrome treated with haloperidol and aripiprazole and any cardiac side effect was not observed during the four months of follow up. It has important to routine cardiac examination in patients with schizophrenia and choose of antipsychotics in the comorbidity of s...
International Journal of the Cardiovascular Academy, 2021
Background: Rehospitalizations with acute coronary syndromes (ACSs) have declined over the last y... more Background: Rehospitalizations with acute coronary syndromes (ACSs) have declined over the last years, but there is a remaining need for potential further reduction of rehospitalization after ACS to determine the most predominant predictors that can guide strategies to reduce re-hospitalizations burden. Aim: This multi-center study aimed to evaluate the demographic, clinical characteristics, and medications of rehospitalized patients who suffered a new cardiac event in 12 months after admission due to ACS. Material and Methods: Patients age >18 years who have been hospitalized between November 1 2017, and April 1 2018, for ACS within12 months before the readmission for a new acute coronary event were enrolled. Results: The present study included a total of 628 (65.9% from Turkey) consecutive patients rehospitalized with ACS (ST-elevation myocardial infarction [STEMI], 23.0%; ACS without ST-elevation [NSTE-ACS], 76.9%) from 15 different countries. The majority of the rehospitalize...
Acute kidney injury (AKI) is a very common and important complication of cardiac surgery. It is a... more Acute kidney injury (AKI) is a very common and important complication of cardiac surgery. It is associated with severe complications including mortality. Cardiac surgery may induce oxidative stress and inflammation and both of these processes may be associated with AKI. N-acetyl cysteine (NAC) is a mucolytic agent and it has antioxidant and anti-inflammatory properties. Although positive results have been obtained in animal studies, however; no significant beneficial effects of NAC on AKI have been found in randomized studies and meta-analyses. Currently available data do not support to recommend NAC for the prevention of AKI after cardiac surgery.
GIRIŞ ve AMAC Literaturde kardiyovaskuler sisteme etkili ilaclarin depresif etkilerini inceleyen ... more GIRIŞ ve AMAC Literaturde kardiyovaskuler sisteme etkili ilaclarin depresif etkilerini inceleyen calismalar bulunmaktadir. Bu calismalarda birbirinden farkli bulgular yer almakta ve lipofilik beta bloker ilaclarin tedavinin ilk aylarinda depresif belirtilere neden olabildigi, beta blokerlerin genel olarak depresyon riskini artirmadigi, kardiyovaskuler hastaligi olan bireylerde statin kullaniminin depresif belirtileri ve depresyon gelisme riskini azalttigi bildirilmektedir. Bu arastirmanin amaci bir universite hastanesi kardiyoloji poliklinigine basvuran bireylerde depresyon durumunun belirlenmesi ve kullanilan kalp ilaclari ile arasindaki iliskinin incelenmesidir. GEREC ve YONTEM Bu arastirma, 2013 yilinda bir universite hastanesinin kardiyoloji poliklinigine basvuran bireylere(n:707) gozetim altinda anket uygulanarak yapildi. Anket; sosyodemografik ozellikleri, kalp hastaliklari ve depresyon ile iliskili faktorleri sorgulayan 39 sorudan ve Beck ve arkadaslari tarafindan gelistiril...
Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2021
OBJECTIVE Hypertension is a challenging problem in the older population because of poor drug adhe... more OBJECTIVE Hypertension is a challenging problem in the older population because of poor drug adherence (DA). We aimed to determine the DA and examine the drug interaction index (DII) on DA in older patients with hypertension. METHODS In this cross-sectional, observational study, we enrolled 418 eligible patients aged ≥ 65 years between 1 February 2020 and 30 September 2020 in a tertiary hospital outpatient cardiology clinic. We prepared a questionnaire to record sociodemographic characteristics, morbidities, and drugs used by the population. The Morisky Medication Adherence Scale-8 (MMAS-8) was used for DA assessment. We identified drug interactions using the Lexicomp application. We calculated the DII from a ratio of clinically relevant interaction to total interaction. Descriptive tests and multiple linear regression analyses were performed to find independent factors on DA. RESULTS The mean age (± standard deviation [SD]) was 72.91 (±6.47), and 272/146 were female/male in the study population. The most frequent comorbid disease was diabetes mellitus (23.5%). The percentage of patients having polypharmacy was 39.5, and the mean daily drug (±SD) use was 4.27 (±2.57). The most prescribed antihypertensive drugs were thiazide/derivates (29.8%) and angiotensin receptor blockers (24.8%). The mean MMAS-8 (±SD) was 4.55±0.98, and 321 (76.8%) participants had a poor DA. A total of 33.4% of patients had significant drug interaction. The mean DII (±SD) was 0.345±0.017. The area under the receiver operating characteristic (ROC) curve for DII was 0.616 (95% confidence interval [CI]: 0.547-0.686). CONCLUSION We defined a new index for drug interaction intensity. Furthermore, the DII may be a useful tool to study aspects of DA in older patients with hypertension.
Background: The interatrial block (IAB) is a condition that occurs due to the delay of conduction... more Background: The interatrial block (IAB) is a condition that occurs due to the delay of conduction in the right atrium to the left atrium, and can be partial (pIAB) or advanced (aIAB), and also is associated with atrial arrhythmia. Diastolic dysfunction (DD) is an important condition frequently encountered in most healthy middle-aged individuals and plays a role in the development of many cardiovascular diseases. It is noteworthy that frequent paroxysmal atrial fibrillation (PAF) attacks are observed especially in individuals with DD in clinical life, and its relationship with the presence of interatrial block is still unclear in these patients. Our aim in this study was to evaluate the relationship between the presence of DD and the development of interatrial block and PAF. Material and Method: A total of 146; 92 patients with DD and 54 control (proven by echocardiography) were enrolled in this cross-sectional and prospectively study. The properties of the P wave were evaluated in leads D2-3 aVF and V1. Echocardiography and electrocardiography results of the two groups were compared. Results: The mean age of the DD and the control group was (62.3±0.74 and 61.2±0.61 years, p=0.481) respectively. The frequency of IAB was significantly higher in the DD than the control group (37%-46.7%-16.3%, 77.8%-18.5%-3.7%, and none-pIAB-aIAB, respectively). In the correlation analysis, there was a strong correlation between the presence of DD and IAB (r: 0.439, p<0.001), and the history of PAF and IAB (r: 0.458, p<0.001). Conclusion: In our study, the frequency of IAB was significantly higher in the DD group. We think that it may be beneficial to evaluate P waves more carefully to determine the risky individuals among those who have DD in clinical life.
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Papers by İbrahim Ersoy