Biochemical and Biophysical Research Communications, 1997
highly metastatic cells have been shown to express For clarification of the functions of ganglios... more highly metastatic cells have been shown to express For clarification of the functions of gangliosides on complex gangliosides more than poorly metastatic cells tumor metastasis, examination was made of the gangli-(5-7), whereas Zebda et al. observed the expression of oside patterns of poorly metastatic FBJ-S1 and highly complex gangliosides to decrease in metastatic melametastatic FBJ-LL cells. FBJ-S1 cells expressed GM3 noma cells (8). In all these studies, changes in ganglioand GD1a, whereas FBJ-LL cells expressed GM3 and side patterns associated with metastatic ability were slightly expressed GD1a. The capacity for FBJ-LL cells shown not to be simple. That the metastasis involves to migrate was ten times that of FBJ-S1 cells, but dea series of complex processes including detachment of creased by a half by pretreatment with GD1a. GD1b or cells from the primary tumor, invasion into sur-GT1b had the same effect as GD1a, and synthetic sialyl rounding stroma, intravasation into and extravasation compounds to a lesser extent, suggesting that gangliofrom blood vessels, and growth at the metastatic site sides contain more than two sialyl residues to inhibit may be the reason for this. The effects of individual the migration of FBJ-LL cells. ᭧ 1997 Academic Press gangliosides should thus be examined for respective metastatic processes. Therefore, study was made here to determine the role in cell migration of ganglioside Gangliosides, sialic acid-containing glycosphingoli-GD1a differing in expression in poorly and highly metapids, are considered to be present on the outer leaflet static cells. of the lipid bilayer of the plasma membrane and partici-We indicated GD1a ganglioside higly expressed in pate in cell growth, cell adhesion, differentiation, and poorly metastatic FBJ-S1 cells to suppress the migratumorigenesis (1, 2). Gangliosides may also participate tion of higly metastatic FBJ-LL cells whose capacity in tumor metastasis. Ganglioside content has been refor migration would have been ten times that of FBJported to increase in highly metastatic cells (3,4) and S1 cells.
Biochemical and Biophysical Research Communications, 1997
highly metastatic cells have been shown to express For clarification of the functions of ganglios... more highly metastatic cells have been shown to express For clarification of the functions of gangliosides on complex gangliosides more than poorly metastatic cells tumor metastasis, examination was made of the gangli-(5-7), whereas Zebda et al. observed the expression of oside patterns of poorly metastatic FBJ-S1 and highly complex gangliosides to decrease in metastatic melametastatic FBJ-LL cells. FBJ-S1 cells expressed GM3 noma cells (8). In all these studies, changes in ganglioand GD1a, whereas FBJ-LL cells expressed GM3 and side patterns associated with metastatic ability were slightly expressed GD1a. The capacity for FBJ-LL cells shown not to be simple. That the metastasis involves to migrate was ten times that of FBJ-S1 cells, but dea series of complex processes including detachment of creased by a half by pretreatment with GD1a. GD1b or cells from the primary tumor, invasion into sur-GT1b had the same effect as GD1a, and synthetic sialyl rounding stroma, intravasation into and extravasation compounds to a lesser extent, suggesting that gangliofrom blood vessels, and growth at the metastatic site sides contain more than two sialyl residues to inhibit may be the reason for this. The effects of individual the migration of FBJ-LL cells. ᭧ 1997 Academic Press gangliosides should thus be examined for respective metastatic processes. Therefore, study was made here to determine the role in cell migration of ganglioside Gangliosides, sialic acid-containing glycosphingoli-GD1a differing in expression in poorly and highly metapids, are considered to be present on the outer leaflet static cells. of the lipid bilayer of the plasma membrane and partici-We indicated GD1a ganglioside higly expressed in pate in cell growth, cell adhesion, differentiation, and poorly metastatic FBJ-S1 cells to suppress the migratumorigenesis (1, 2). Gangliosides may also participate tion of higly metastatic FBJ-LL cells whose capacity in tumor metastasis. Ganglioside content has been refor migration would have been ten times that of FBJported to increase in highly metastatic cells (3,4) and S1 cells.
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