Papers by Hussain Hussain
Cureus
Incremental changes in the diagnosis of breast cancer leave drastic impacts on patients. There ar... more Incremental changes in the diagnosis of breast cancer leave drastic impacts on patients. There are detrimental shifts in cost, psychological disorders in terms of depression, and morbidities. Stage IV breast cancer has a high mortality rate and was afflicting our patient who was diagnosed with metastatic breast cancer estrogen receptor/progesterone receptor (ER/PR) positive, human epidermal growth factor receptor 2 (HER-2) neo negative, and low Ki-67. Among the various management modalities and effective treatments, capecitabine was selected because of its benefits; however, there are several commonly known adverse effects when using capecitabine including non-immune hemolytic anemia, a very rare and unexpected side effect despite the many research and clinical trials performed. Immune mediate or Coombs positive hemolytic anemia was reported with the usage of capecitabine, but this patient developed Coombs negative or non-immune hemolytic anemia. Capecitabine, a form of fluoropyrimidine, hypothetically affects the erythrocyte membrane structure resulting in the destruction of these cells. Additionally, discontinuation of capecitabine in the patient led to the resolution of the condition; this made us more aware of the precise diagnosis, also considering that the bone marrow biopsy came back negative.
Cureus, 2020
Myopericarditis remains a prominent infectious inflammatory disorder throughout a patient's lifet... more Myopericarditis remains a prominent infectious inflammatory disorder throughout a patient's lifetime. Moreover, viral pathogens have been proven to be the leading contributors to myopericarditis in the pediatric and adult populations. Despite the current comprehensive knowledge of myocardial injury in viral and post-viral myopericarditis, the cellular and molecular mechanisms of SARS-CoV-2-induced myopericarditis are poorly understood. This report presents a case of coronavirus (COVID-19) fulminant myopericarditis and acute respiratory distress syndrome (ARDS) in a middle-aged male patient: a 51-yearold man with a history of hypertension who arrived to the emergency department with a dry cough, fatigue, dyspnea, and a fever. A real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay confirmed a diagnosis of COVID-19 infection, resulting in the patient's admission to the airborne isolation unit for clinical observation. When his condition began to deteriorate, the patient was transferred to the cardiac care unit after electrocardiography detected cardiac injury, demonstrating diffuse ST-segment elevation. Laboratory evaluations revealed elevated troponin T and BNP, with an echocardiogram indicating global left ventricular hypokinesia and a reduced ejection fraction. The patient was treated with hydroxychloroquine, azithromycin, dobutamine, remdesivir, and ventilatory support. This specific case highlights the severity and complications that may arise as a direct result of COVID-19 infection.
Cureus, 2020
Malignant hypertension (hypertensive emergency), is an extreme elevation of blood pressure under ... more Malignant hypertension (hypertensive emergency), is an extreme elevation of blood pressure under certain conditions that can lead to organ damage and other serious consequences. It is a common condition that affects about one in three Americans, according to the Centers for Disease Control and Prevention. An elevation of systolic blood pressure above 180 mmHg and diastolic blood pressure above 120 mmHg is considered a hypertensive emergency. This article addresses the case of a 61-year-old female patient who presented to the ER with a semicomatose and gasping condition and response to painful stimuli with an unclear voice. She also had unstable vital signs, with a blood pressure of 370/200 mmHg, a pulse rate of 115, a respiratory rate of 22, and a pulse oximetry of 96%, but no fever. Her son provided a brief history and reported that a stressful condition had occurred at home one hour before; she had begun to scream and been brought to the ER by ambulance in the condition described above. Cardiac monitoring and an electrocardiograph were performed and indicated a normal condition besides the unstable vital signs. Oxygen was administered via a nasal cannula with 20 mg of intravenous hydralazine, and the patient's blood pressure improved progressively. Moreover, she regained consciousness with no end-organ damage. A hypertensive emergency is usually associated with end-organ damage, such as heart, kidney, eye, or brain damage. However, in this case, despite the extreme elevation of her blood pressure, the patient suffered no organ damage. It is essential to manage the extreme elevation of blood pressure as soon as possible and monitor the patient for consequences.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2020
A 26-year-old female presented with frequent prolonged gaze, mild anxiety, insomnia, poor concent... more A 26-year-old female presented with frequent prolonged gaze, mild anxiety, insomnia, poor concentration and a decrease in attention span that generally lasted for two to three minutes. The patient immigrated to the United States at the age of 16 and noted similar symptoms of mild inattentive spells throughout her childhood that were not as profound. The patient reported ten traffic violations and eight motor vehicle accidents, which resulted in frequent hospitalisations. The medical, surgical history, prenatal and neonatal history was non-contributory. Furthermore, there was no family history of similar symptoms or relevant conditions. An assessment of the neurological, mental status, cardiac, respiratory, gastrointestinal systems provided normal findings. Additionally, normal diagnostic results were obtained from the electroencephalogram, magnetic resonance imaging, electrolytes, complete blood count, iron panel, serum ceruloplasmin, urine copper level, urinalysis, liver, renal function, thyroid function, and antinuclear antibody tests. The differential diagnosis thought of was, sluggish cognitive tempo, hepatolenticular disease, lead poisoning, and absent seizure. The sluggish cognitive tempo is the term for a syndrome now called as "concentration deficit disorder" [1]. The causes for the phenomenon are unknown, and the patient typically presents with daydreaming, mental fogginess, hypoactivity, and slow processing speed [Table/Fig-1] [2].
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Papers by Hussain Hussain