Papers by Hamid Khederlou
The journal of Tehran University Heart Center./The journal of Tehran University Heart Center, May 21, 2024
Case reports in critical care, Apr 20, 2024
Background Consanguineous marriage (CM) 's impact on cardiovascular diseases, including struc... more Background Consanguineous marriage (CM) 's impact on cardiovascular diseases, including structural congenital heart diseases, has been confirmed. Although CM can affect genetics with oligogenicity and homogeneity, the relationship between CM and coronary artery disease (CAD) has not been conclusively confirmed. Therefore, this study was conducted to determine the relationship between CAD and CM. Methods We conducted a cross-sectional-prospective study from June 2021 to August 2022. Patients undergoing coronary angiography at Tehran Heart Center were included. A questionnaire was designed, including demographic and anthropometric information, past medical history, cardiovascular risk factors, results of previous angiograms, and parental kinship. Finally, 11,986 patients were analyzed regarding the relationship between CAD and CM. Results 69.9% of the patients included in this study were male. The mean age of the patients was 58.9 ± 10.7 years. Out of 11986 patients, 9083 (75.8%) ...
Journal of Clinical Ultrasound, Mar 29, 2023
Conditions other than stenosis also disturb the coronary flow. Such conditions include the corona... more Conditions other than stenosis also disturb the coronary flow. Such conditions include the coronary slow flow phenomenon, coronary artery ectasia, and coronary artery tortuosity. Evidence exists regarding myocardial dysfunction in these conditions. In this review, we present studies that have used speckle‐tracking echocardiography to determine whether coronary flow disturbances are accompanied by myocardial dysfunction. Additionally, we seek to show the gaps in knowledge concerning this issue and the dimensions that future studies should consider.
Journal of cardiovascular and thoracic research, Jun 29, 2023
Journal of Comprehensive Pediatrics, Sep 18, 2021
Multidisciplinary cardiovascular annals, Jul 24, 2020
international journal of endocrinology and metabolism, Sep 2, 2020
European Heart Journal - Case Reports
Background Lysosomal storage diseases (LSDs) are rare, progressive, multi-organ disorders caused ... more Background Lysosomal storage diseases (LSDs) are rare, progressive, multi-organ disorders caused by inherited enzyme deficiencies. Gaucher’s disease (GD) is the most prevalent form of LSDs. Case summary A 19-year-old Caucasian male presented with exertional dyspnoea. Physical examination revealed a Grade III/VI systolic diamond murmur at the heart base and a Grade IV/VI systolic murmur at the apex. Electrocardiogram showed signs of left ventricular hypertrophy (LVH). Trans-thoracic echocardiography (TTE) and trans-oesophageal echocardiography (TEE) demonstrated moderate LVH, severe aortic valve stenosis, severe supra-valvular aortic stenosis, and moderate mitral stenosis with severe degenerative mitral valve regurgitation. Bone marrow biopsy and aspiration confirmed the presence of characteristic Gaucher's cells. The patient underwent the Bentall procedure and mitral valve replacement and was discharged in good condition. Discussion Gaucher’s disease exhibits three clinical phen...
The Journal of Tehran University Heart Center
Background: Myocardial perfusion imaging (MPI) is a noninvasive method with acceptable sensitivit... more Background: Myocardial perfusion imaging (MPI) is a noninvasive method with acceptable sensitivity and specificity in diagnosing coronary artery disease (CAD) in moderate-risk patients, including those with CAD risk factors. Methods: The present cross-sectional, prospective study was conducted on 4886 patients from April 2020 through March 2023 at Chamran and Tehran Heart Center hospitals. A questionnaire regarding anthropometric variables, demographic characteristics, CAD risk factors, and MPI findings was designed. Results: Totally, 2179 patients (44.6%) had abnormal MPI. Patients with abnormal MPI were significantly older than those with normal MPI. Older age (OR, 1.64; 95% CI, 1.2 to 1.72; P<0.001), diabetes mellitus (DM) (OR, 1.36; 95% CI, 1.1 to 1.48; P=0.012), hypertension (OR, 1.24; 95% CI, 1.04 to 1.37; P=0.032), and dyslipidemia (OR, 1.54; 95% CI, 1.25 to 1.8; P<0.001) were associated with abnormal MPI independently. Patients with more CAD risk factors were more like...
The Journal of Tehran University Heart Center
Background: Ventricular arrhythmias (VAs), which result from acute myocardial infarction and reva... more Background: Ventricular arrhythmias (VAs), which result from acute myocardial infarction and revascularization, are preventable causes of sudden cardiac death. This study aimed to determine the incidence, types, and risk factors of VAs in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PCI). Methods: This cross-sectional study was conducted at the cardiology department of a tertiary care cardiac center in Zanjan, Iran. All the patients were monitored during hospitalization, and the incidence of cardiac arrhythmias and the outcomes were recorded. Result: Among 315 patients, the mean age was 62.14±10.11 years, and 76.2% were male. Male gender was significantly associated with VA occurrence (P=0.038). Among the patients, 50.5% had VAs, of which 26.4% were sustained ventricular tachycardia (sustained VT) and ventricular fibrillation (VF). Sustained VT and VF, but not total arrhythmias, were more common in anterior infarctions. Most...
Iranian Journal of Radiology
Background: Due to its non-specific symptoms, pulmonary arterial hypertension (PAH) is difficult ... more Background: Due to its non-specific symptoms, pulmonary arterial hypertension (PAH) is difficult to diagnose via non-invasive methods. Various diagnostic tests are required to evaluate PAH patients. The increased diameter of the main pulmonary artery in computed tomography (CT) imaging represents a high probability of PAH. Moreover, N-terminal pro B-type natriuretic peptide (NT-proBNP) and pro B-type natriuretic peptide (proBNP) can be considered as prognostic predictors in patients with PAH. Objectives: This study aimed to evaluate the correlation of CT-based main pulmonary artery diameter (MPAD) and the serum level of NT-proBNP (as a strong pro-inflammatory factor) with the severity of PAH in echocardiography among patients with PAH. Patients and Methods: In this cross-sectional study, a total of 63 hospitalized patients with PAH due to chronic obstructive pulmonary disease were recruited from 2019 to 2020 after initial evaluations and collection of serum NT-proBNP measurements an...
Journal of Clinical Ultrasound
Conditions other than stenosis also disturb the coronary flow. Such conditions include the corona... more Conditions other than stenosis also disturb the coronary flow. Such conditions include the coronary slow flow phenomenon, coronary artery ectasia, and coronary artery tortuosity. Evidence exists regarding myocardial dysfunction in these conditions. In this review, we present studies that have used speckle‐tracking echocardiography to determine whether coronary flow disturbances are accompanied by myocardial dysfunction. Additionally, we seek to show the gaps in knowledge concerning this issue and the dimensions that future studies should consider.
Journal of Craniomaxillofacial Research
Introduction: Due to the increasing prevalence of COVID-19 and its effects on the sense of taste ... more Introduction: Due to the increasing prevalence of COVID-19 and its effects on the sense of taste and smell, we analyzed Blood electrolyte levels and biomarkers in COVID-19 patients who have a sign of anosmia and ageusia in Zanjan, Iran, and its relationship with biochemical blood indicators. Method: The retrospective study included all hospitalized patients with confirmed COVID-19. We registered laboratory parameters. A questionnaire that validity and reliability have already been confirmed was used to assess anosmia and ageusia. Statistical analysis was evaluated using a bivariate Bayesian logistic regression in the binomial distribution. Results: A total of 450 COVID-19 patients completed the study (221 females). The mean age of the patients was 56.36±17.34 years. 31.8% and 24.9% of patients reported anosmia and ageusia. There was no significant relationship between anosmia and ageusia with age, gender, place of hospitalization, marriage status, duration of hospitalization, and CT...
European Heart Journal - Case Reports
Background Complete heart block (CHB) means a lack of association between the atrium and the vent... more Background Complete heart block (CHB) means a lack of association between the atrium and the ventricle. Hypercalcemia is an electrolyte disorder that rarely causes CHB. Case summary Hereby, we report the case of a 59-year-old male who was admitted with general weakness. The electrocardiography (ECG) changes revealed CHB, short QT interval due to short ST segment, and generalized ST elevation. The initial calcium level was 15.8 mg/dL (high), and serum levels of parathyroid hormone (PTH), vitamin D, and phosphorus were normal. A chest computed tomography scan showed a large, central mass with cavitation in the right lung. After an initial diagnosis of lung cancer and paraneoplastic hypercalcemia, the patient was treated with normal saline, calcitonin, and zoledronic acid, whose calcium levels decreased to 10.4 mg/dL after 4 days. Pathological ECG findings were also resolved after the correction of serum levels of calcium. Discussion Hypercalcemia sometimes occurs as a paraneoplastic s...
International journal of cardiovascular practice, Nov 5, 2022
International Journal of Endocrinology and Metabolism, 2020
Background: Heart failure is a pathophysiologic state in which the cardiac output is not able to ... more Background: Heart failure is a pathophysiologic state in which the cardiac output is not able to supply the body with enough oxygen and nutrients. The prevalence of heart failure has increased dramatically over the last decades. Vitamin D levels in patients with chronic heart failure are lower than healthy controls, and vitamin D deficiency has a direct relationship with mortality. Objectives: This study aimed to evaluate the effect of vitamin D on the improvement of left ventricular ejection fraction in patients with systolic heart failure. Methods: In this case-control clinical trial, 142 patients with chronic systolic heart failure were identified. Based on the inclusion and exclusion criteria, 114 patients were enrolled in the study and randomly divided into two groups. One group (n = 58) received 50,000 units of vitamin D capsules weekly for eight weeks, and the patients in the other group (n = 56) received a placebo. After excluding 15 patients from the placebo group and 17 pa...
Journal of Thoracic Disease and Cardiothoracic Surgery, 2021
Background: The COVID-19 can cause serious life-threatening complications. Vitamin D deficiency h... more Background: The COVID-19 can cause serious life-threatening complications. Vitamin D deficiency has been proposed to mediate the disease by some studies, however, there is a lack of sufficient data. Methods: In this descriptive-analytical study, 72 Iranian adult patients with COVID-19 were examined. At the beginning of hospitalization, serum levels of vitamin D were checked and patients were divided into four groups as vitamin D above normal, normal, insufficient, or deficient. The prognosis of patients has been evaluated based on serum levels of vitamin D and other underlying factors. Results: Only 30% of patients had normal vitamin D concentrations. Vitamin D status was associated with COVID-19 complications, but not with underlying diseases. In the multivariable logistic regression, COVID-19 prognosis was associated with being male, length of stay in an intensive care unit (ICU), need for intubation, acute respiratory disease syndrome (ARDS), and myocarditis. The serum vitamin D ...
Rheumatology Research, 2020
Since mid-December of 2019, an outbreak of pneumonia has been spread from Wuhan City, Hubei provi... more Since mid-December of 2019, an outbreak of pneumonia has been spread from Wuhan City, Hubei province, China, as a viralpneumonia. After virus identification and isolation, the pathogen for this pneumonia was originally called 2019 novelcoronavirus (2019-nCoV). 2019-nCoV has been associated with progressive cytokine storm leading to a hyper-inflammatorystate that this state associated with respiratory failure. We hereby reported a known case of Rheumatoid arthritis, Hypertensionand Coronary artery bypass graft that confirmed 2019-nCoV and he was associated with progressive cytokine storm leading torespiratory failure. After corticosteroid administration, respiratory failure and extremely high levels of IL6 respondeddramatically to pulse-doses of Methylprednisolone. We concluded that pulse-doses of Corticosteroids can be effective incontrolling and relieving cytokine storms and related respiratory failure.
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Papers by Hamid Khederlou