Papers by Alessia Gasparini
Physical Review Letters, Aug 10, 2007
We report the coexistence of ferromagnetic order and superconductivity in UCoGe at ambient pressu... more We report the coexistence of ferromagnetic order and superconductivity in UCoGe at ambient pressure. Magnetization measurements show that UCoGe is a weak ferromagnet with a Curie temperature TC= 3 K and a small ordered moment m0= 0.03 µB. Superconductivity is observed with a resistive transition temperature Ts = 0.8 K for the best sample. Thermal-expansion and specific-heat measurements provide solid evidence for bulk magnetism and superconductivity. The proximity to a ferromagnetic instability, the defect sensitivity of Ts, and the absence of Pauli limiting, suggest triplet superconductivity mediated by critical ferromagnetic fluctuations.
Radiotherapy and Oncology, Mar 1, 2013
S286 2nd ESTRO Forum 2013 step uses the Risk Priority Number (RPN) which is a product of relative... more S286 2nd ESTRO Forum 2013 step uses the Risk Priority Number (RPN) which is a product of relative indices of occurrence, detectability and severity. 4) Corrective redesign process re-engineering to remove stresses from the system and reduce the likelihood of recurrence. Results: A complex process map was produced and over 40 potential FM's were identified in the system. RPN analysis identified 11 FM's which were rated sufficiently highly to initiate corrective redesign. This involved major initiatives such as ensuring the process was completely paperless, conduction of staff training sessions to promote independent checking and the purchase of additional equipment to reduce the incidence of incorrect patient set up. More minor redesign initiatives involved increasing the incidence of patient identification checks and ensuring multiple assessment of pregancy status throughout the process. Conclusions: This study has indicated that FMEA can be applied in the RT setting. Although an ever evolving process FMEA has identified scope for improving the RT process, strengthened the risk management matrix and enabled the evolution of a bespoke QC programme designed on the basis of prospective analysis and quantification of risk. Much further work is required in this area such as tighter specifications of RPN's, and a reduction in the beauracratic load however it is felt FMEA is a valuable and rapidly developing quality tool for radiotherapy.
Alessia Gasparini onderzocht de Grüneisenparameter, de experimentele maat voor de verhouding van ... more Alessia Gasparini onderzocht de Grüneisenparameter, de experimentele maat voor de verhouding van de coëfficiënt van de thermische uitzetting en de soortgelijke warmte, voor magnetische kwantum kritische punten. Dit deed ze zowel voor een antiferromagnetische (AFM) als ferromagnetische (FM) grondtoestand. Ze bestudeerde daarnaast de thermische eigenschappen van diverse preparaten in detail.
Optics and Lasers in Engineering, 2007
We report on the characterization of periodically poled lithium niobate structures grown by the o... more We report on the characterization of periodically poled lithium niobate structures grown by the off-center Czochralski technique with periods ranging between 2 and 10 mm. The domains distribution along the crystal was inspected by a profilometer scan after etching the structures and carrying a suitable data processing. The second harmonic generation efficiency was predicted by numerically integrating the governing equations through to a recently proposed nonlinear bidirectional beam propagation method. The numerical analysis pointed out the feasibility of the backward second harmonic generation in the sample with the shortest domain period. The predicted second harmonic generation efficiency was finally corrected considering the phase shifts induced in the second harmonic wave by the presence of different sized domains.
Physica Medica, Feb 1, 2022
Supplementary Figure S4. 53BP1 pathway inactivation induces drug resistance in KB1P-G3 tumor cell... more Supplementary Figure S4. 53BP1 pathway inactivation induces drug resistance in KB1P-G3 tumor cells. Related to Figure 2.
The defect in homologous recombination (HR) found in BRCA1-associated cancers can be therapeutica... more The defect in homologous recombination (HR) found in BRCA1-associated cancers can be therapeutically exploited by treatment with DNA-damaging agents and PARP inhibitors. We and others previously reported that BRCA1-deficient tumors are initially hypersensitive to the inhibition of topoisomerase I/II and PARP, but acquire drug resistance through restoration of HR activity by the loss of end-resection antagonists of the 53BP1/RIF1/REV7/Shieldin/CST pathway. Here, we identify radiotherapy as an acquired vulnerability of 53BP1;BRCA1-deficient cells in vitro and in vivo. In contrast to the radioresistance caused by HR restoration through BRCA1 reconstitution, HR restoration by 53BP1 pathway inactivation further increases radiosensitivity. This highlights the relevance of this pathway for the repair of radiotherapy-induced damage. Moreover, our data show that BRCA1-mutated tumors that acquire drug resistance due to BRCA1-independent HR restoration can be targeted by radiotherapy.Significance:These findings uncover radiosensitivity as a novel, therapeutically viable vulnerability of BRCA1-deficient mouse mammary cells that have acquired drug resistance due to the loss of the 53BP1 pathway.
Supplementary Figure S3. Trp53bp1, Rif1 and Rev7 can be knocked out in KB1P-G3 tumor cells. Relat... more Supplementary Figure S3. Trp53bp1, Rif1 and Rev7 can be knocked out in KB1P-G3 tumor cells. Related to Figure 2.
Supplementary Figure S4. 53BP1 pathway inactivation induces drug resistance in KB1P-G3 tumor cell... more Supplementary Figure S4. 53BP1 pathway inactivation induces drug resistance in KB1P-G3 tumor cells. Related to Figure 2.
Supplementary Figure S5. Radiosensitization of BRCA1 deficient cells by 53BP1 depletion is depend... more Supplementary Figure S5. Radiosensitization of BRCA1 deficient cells by 53BP1 depletion is dependent on DNA-PK. Related to Figure 2.
The defect in homologous recombination (HR) found in BRCA1-associated cancers can be therapeutica... more The defect in homologous recombination (HR) found in BRCA1-associated cancers can be therapeutically exploited by treatment with DNA-damaging agents and PARP inhibitors. We and others previously reported that BRCA1-deficient tumors are initially hypersensitive to the inhibition of topoisomerase I/II and PARP, but acquire drug resistance through restoration of HR activity by the loss of end-resection antagonists of the 53BP1/RIF1/REV7/Shieldin/CST pathway. Here, we identify radiotherapy as an acquired vulnerability of 53BP1;BRCA1-deficient cells in vitro and in vivo. In contrast to the radioresistance caused by HR restoration through BRCA1 reconstitution, HR restoration by 53BP1 pathway inactivation further increases radiosensitivity. This highlights the relevance of this pathway for the repair of radiotherapy-induced damage. Moreover, our data show that BRCA1-mutated tumors that acquire drug resistance due to BRCA1-independent HR restoration can be targeted by radiotherapy.Significa...
Supplementary Figure S1. KB1P-RR tumors have an activated DNA damage response. Related to Figure 1.
Supplementary Figure S2. 53BP1 and RAD51 profiling of KB1P-N and KB1P-RR tumors. Related to Figur... more Supplementary Figure S2. 53BP1 and RAD51 profiling of KB1P-N and KB1P-RR tumors. Related to Figure 1.
Supplementary Figure S6. Acquired inactivation of 53BP1 in KB1PM5 tumor-derived cell lines enhanc... more Supplementary Figure S6. Acquired inactivation of 53BP1 in KB1PM5 tumor-derived cell lines enhances radiosensitivity. Related to Figure 2.
IHC scoring for 53BP1-positive cells. Related to Fig. 4D.
Supplementary Figure S3. Trp53bp1, Rif1 and Rev7 can be knocked out in KB1P-G3 tumor cells. Relat... more Supplementary Figure S3. Trp53bp1, Rif1 and Rev7 can be knocked out in KB1P-G3 tumor cells. Related to Figure 2.
Journal of Instrumentation, Sep 1, 2022
This work relates to the study and characterization of the response function of an X-ray spectrom... more This work relates to the study and characterization of the response function of an X-ray spectrometry system. The intrinsic efficiency of a Si(Li) detector has been simulated with the Monte Carlo codes MCNP and GEANT4 in the photon energy range of 2.6-59.5 keV. After finding it necessary to take a radiograph of the detector inside its cryostat to learn the correct dimensions, agreement within 10% between the simulations and experimental measurements with several point-like sources and PIXE results was obtained.
Uploads
Papers by Alessia Gasparini