Papers by GABRIEL SEBASTIAN MENDOZA CONTRERAS
Nefrologia, 2009
Nephrogenic systemic fibrosis (NSF) was first recognized as a unique entity in 1997 and subsequen... more Nephrogenic systemic fibrosis (NSF) was first recognized as a unique entity in 1997 and subsequently defined in the literature in 2000 as a novel fibrosing disorder occurring in the setting of renal disease. Prevention, early recognition and treatment are essential to limiting its impact. The most important risk factors for developing NSF are chronic or significant acute kidney disease (especially dialysis dependent patients) and the administration of gadolinium (GD3) containing contrast agents, agents that cause NSF by releasing free gadolinium (GD3) into tissues based on their pharmacokinetics. International commissions in drug control and medicinal products recommend to avoid gadolinium based contrast agents in patients with GFR < 30 ml/minute/1.73 m(2). Unfortunately there is lack of universally effective therapy at this time and the literature is based on case reports and small case series. Recommendations to guide the use of gadolinium based contrast agents in patients with underlying kidney disease should be individualized and considered in consultation with the ordering physician, radiologist and nephrologist.
Journal of the American Society of Nephrology, 2002
ABSTRACT. The preoperative impairment of renal function is associated with the need for postopera... more ABSTRACT. The preoperative impairment of renal function is associated with the need for postoperative renal replacement therapy (RRT) in patients undergoing liver transplantation. The principal goal of this investigation was to identify other factors apparent before or during transplant that were independently associated with the need for RRT in the early posttransplant period. A total of 260 consecutive adult patients who received a primary liver transplant were studied. Twenty-eight patients required early RRT (RRT initiated within 1 wk of transplant); 23 for control of volume overload. Preoperative blood urea nitrogen (odds ratio [95% CI], 1.52 [1.15 to 2.01] per 10 mg/dl), serum creatinine (1.91 [1.06 to 3.44] per 1 mg/dl), and urine output (0.12 [0.03 to 0.44] L/d) were independently predictive of the need for early RRT and in combination formed a parsimonious model that discriminated well (area under the receiver operating characteristic curve, 0.877) and had excellent fit (P ...
Journal of Hypertension, 2020
,m , for the SPRINT Research Group See editorial comment on page 1462 Background: Patients with s... more ,m , for the SPRINT Research Group See editorial comment on page 1462 Background: Patients with stage 1 systolic hypertension have increased risk of cardiovascular disease (CVD) events. Methods: Using Cox models, we assess the effect of targeting an intensive SBP goal of less than 120 mmHg compared with standard SBP goal of less than 140 mmHg on the risk of CVD events in adults with stage 1 systolic hypertension with diabetes mellitus enrolled in Action to Control Cardiovascular Risk in Diabetes Blood Pressure trial (ACCORD BP) (n ¼ 1901) and without diabetes mellitus enrolled in Systolic Blood Pressure Intervention Trial (SPRINT) (n ¼ 3484) that used identical SBP goal interventions. Outcomes: In ACCORD BP, the primary composite CVD outcome was the first occurrence of myocardial infarction, stroke, or CVD mortality. In SPRINT, the primary composite CVD outcome was the first occurrence of myocardial infarction, other acute coronary syndrome, stroke, heart failure, or CVD mortality. Results: In SPRINT, targeting an intensive SBP goal significantly reduced the risk of the primary CVD outcome [hazard ratio 0.75 (95% confidence interval, 0.58-0.98); events 1.78 vs. 2.37%/year]. In ACCORD BP, the relationships of SBP goal with the primary CVD outcome was modified by the glycemia goal intervention (interaction P ¼ 0.039). In the standard glycemia subgroup (A1c target 7-7.9%), intensive SBP goal significantly reduced the risk of the primary CVD outcome [hazard ratio 0.61 (0.40-0.94); events 1.63 vs. 2.56%/year]. In the intensive glycemia subgroup (A1c target <6%), the risk of the primary CVD outcome was not significantly different between groups [hazard ratio 1.20 (0.76-1.89); events 1.91 vs. 1.60%/year]. Conclusion: Targeting an intensive SBP goal significantly reduced the risk of CVD events in patients with stage 1 systolic hypertension without diabetes and with diabetes on standard glycemia goal.
Journal of clinical hypertension (Greenwich, Conn.), Jan 14, 2016
The Systolic Blood Pressure Intervention Trial (SPRINT) tested whether a systolic blood pressure ... more The Systolic Blood Pressure Intervention Trial (SPRINT) tested whether a systolic blood pressure (SBP) value <120 mm Hg reduces adverse clinical outcomes compared with the goal of <140 mm Hg. Here the authors describe the baseline characteristics of Hispanic participants in SPRINT. Nondiabetic hypertensive patients 50 years and older with SBP 130-180 mm Hg taking zero to four blood pressure (BP) medications were enrolled from the mainland United States and Puerto Rico. Cross-sectional, bivariate analysis was employed comparing sociodemographic and clinical factors in Hispanics vs non-Hispanics. Multivariable logistic regression models restricted to Hispanics were used to identify factors associated with achieved BP control (SBP <140 mm Hg and diastolic BP…
American journal of kidney diseases : the official journal of the National Kidney Foundation, Jan 20, 2016
Unlike the case with creatinine, conditions affecting the non-glomerular filtration rate (GFR) de... more Unlike the case with creatinine, conditions affecting the non-glomerular filtration rate (GFR) determinants of low-molecular-weight serum proteins, β-trace protein (BTP), β2-microglobulin (B2M), and cystatin C, are not well characterized. Pooled cross-sectional analysis of 3 studies. 3,156 persons with chronic kidney disease from the MDRD (Modification of Diet in Renal Disease) Study, AASK (African American Study of Kidney Disease and Hypertension), and CRIC (Chronic Renal Insufficiency Cohort) Study. Demographic and clinical factors hypothesized to be associated with non-GFR determinants of the filtration markers, selected from literature review and physiologic and clinical considerations. Serum creatinine, BTP, B2M, and cystatin C levels. In multivariable-adjusted errors-in-variables regression models that included adjustment for measured GFR (mGFR) and mGFR measurement error, creatinine level had stronger associations with male sex, black race, and higher urine creatinine excreti...
Nueva Revista De Politica Cultura Y Arte, 2009
Lateral Revista De Cultura, 2001
Lateral Revista De Cultura, 2002
New England Journal of Medicine, Mar 4, 2004
Lateral Revista De Cultura, 2002
Lateral Revista De Cultura, 2002
Nuestro Tiempo, 2007
Corria el ano 1963 cuando Bob Dylan publico su segundo album, The Freewheelin? Bob Dylan, que con... more Corria el ano 1963 cuando Bob Dylan publico su segundo album, The Freewheelin? Bob Dylan, que contenia la famosa ?Blowin? in the Wind?, cancion que le lanzo al estrellato y le postulo rapidamente como el gran profeta del movimiento pacifista. Sus preguntas retoricas encadenadas se convirtieron en el himno de la revolucion juvenil de los anos sesenta: ??Cuanto tiempo tienen que volar las balas de canon antes de que sean prohibidas para siempre? ?Cuantas muertes se aceptaran, hasta que se sepa que ya ha muerto demasiada gente? La respuesta, amigo mio, esta flotando en el viento?, decia la voz desgarrada de Dylan. Su tercer disco, The Times They Are A-Changin? (1964), que seguia abundando en la cancion protesta, le consolido como un musico de prestigio y fama internacional.
Lateral Revista De Cultura, 2002
Circulation, Nov 22, 2011
Nuestro Tiempo, 2008
Durante los ultimos meses, diversas voces han llamado al boicot de los juegos olimpicos de Pekin.... more Durante los ultimos meses, diversas voces han llamado al boicot de los juegos olimpicos de Pekin. El motivo: la dificil conviencia del regimen chino con los derechos humanos, sobre todo a raiz de los sucesos del Tibet. Pero no es la primera vez que se intenta boicotear una gran cita olimpica ni tampoco es novedoso que un regimen autoritario pretenda convertir un evento deportivo en una plataforma para la propaganda. En Berlin 1936 la situacion fue muy semejante.
Lateral Revista De Cultura, 2002
Nueva Revista De Politica Cultura Y Arte, 2009
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Papers by GABRIEL SEBASTIAN MENDOZA CONTRERAS