Papers by GILBERTO SANT ANA SILVA
aedemo.es
Page 1. Investigación y Marketing - Nº 80 Dirección holística de la satisfacción y fidelidad del ... more Page 1. Investigación y Marketing - Nº 80 Dirección holística de la satisfacción y fidelidad del cliente (CCM) 30 Dirección holística de la satisfacción y fidelidad del cliente El Customer Care Management (CCM) Muchas empresas ...
Galicia Clínica, 2014
A Síndrome de Erasmus designa a associação entre Esclerose Sistémica e exposição à silica, com ou... more A Síndrome de Erasmus designa a associação entre Esclerose Sistémica e exposição à silica, com ou sem silicose. Não existe nenhuma particularidade clínica, radiológica ou histológica distintiva, além da justaposição sindrómica dos estigmas das duas doenças. A pneumoconiose provocada pela sílica pode evoluir para Esclerose Sistémica. O mecanismo parece envolver a resposta inflamatória provocada pela exposição à sílica. Visto ser uma doença potencialmente fatal e não existir um tratamento efetivo, a prevenção primária e reconhecimento precoce são muito importantes. Apresentamos o caso de um doente exposto à sílica que desenvolveu Esclerose Sistémica.
Revista Brasileira De Otorrinolaringologia, 2003
The Faseb Journal, Apr 1, 2007
PloS one, 2016
The limited capacity of the human brain to process the full extent of visual information reaching... more The limited capacity of the human brain to process the full extent of visual information reaching the visual cortex requires the recruitment of mechanisms of information selection through attention. Neurofibromatosis type-1 (NF1) is a neurodevelopmental disease often exhibiting attentional deficits and learning disabilities, and is considered to model similar impairments common in other neurodevelopmental disorders such as autism. In a previous study, we found that patients with NF1 are more prone to miss targets under overt attention conditions. This finding was interpreted as a result of increased occipito-parietal alpha oscillations. In the present study, we used electroencephalography (EEG) to study alpha power modulations and the performance of patients with NF1 in a covert attention task. Covert attention was required in order to perceive changes (target offset) of a peripherally presented stimulus. Interestingly, alpha oscillations were found to undergo greater desynchronizat...
Ciência Rural, 1995
Fourteen protein systems coded by 15 structural loci were typed by horizontal electrophoresis to ... more Fourteen protein systems coded by 15 structural loci were typed by horizontal electrophoresis to determine possible associations betweem the protein phenotypes and productive traits in Landrace (N=109), Largo White (N= 116) and Duroe (N=57) pigs, reared in Southern Brazil. Signiticant associations between protein phenotypes and production traits were detected. The most consistent interaction were observed between two protein systems (phosphogluconate dehydrogenase - Pgd and Hemopexin -Hpx) and at least one of the four performance variables considered. In Duroc breed, the Pgd phenotypes were associated with daily weight gain (P < 0.01), feed conversion ratio (P < 0.01) and selection index (P < 0.001), while in Landrace significant associations were observed only with feed convertion ratio (P < 0.05). The Hpx phenotypes were associated with daily weight gain (P < 0.05) and backfat thickness (P < 0.05) in Large White and with this last variable (P < 0.01) and selec...
Lecture Notes in Computer Science, 2003
This paper describes a stemming technique that depends principally on a target language&#x27;... more This paper describes a stemming technique that depends principally on a target language&#x27;s lexicon, organised as an automaton of word strings. The clear distinction between the lexicon and the procedure itself allows the stemmer to be customised for any language ...
Biotecnología Aplicada, 2011
... Genetic distance values used to estimate sequence homology between the three species were cal... more ... Genetic distance values used to estimate sequence homology between the three species were calculated with MEGA 4.0 [26], using Kimura's 2-parameter ... 7. Pesole G, Gissi C, De Chirico A, Saccone C. Nucleotide substitution rate of mammalian mitochondrial genomes. ...
Chirality, 2012
This work describes the atropisomeric relationships of 3-methyl-5-(3-methyl-5-phenyl-1H-pyrazol-1... more This work describes the atropisomeric relationships of 3-methyl-5-(3-methyl-5-phenyl-1H-pyrazol-1-yl)-1-phenyl-1H-pyrazol-4-amine (2d), which belongs to series 4-aminobipyrazole derivatives designed as anti-inflammatory agents. The (1)H nuclear magnetic resonance spectra obtained in the presence of a chiral lanthanide shift salt associated to chiral high-performance liquid chromatography analysis, X-ray diffraction, and molecular modeling tools confirmed that ortho bis-functionalized bipyrazole 2d exists as a mixture of aR,aS-atropisomers. These results provide useful information to understand the pharmacological profile of this derivative and of other 4-aminobipyrazole analogs.
Bioorganic & Medicinal Chemistry, 2004
In this study we describe a new comparative molecular field analysis (CoMFA) model of dihydroquin... more In this study we describe a new comparative molecular field analysis (CoMFA) model of dihydroquinazolinone and tetrasubstituted imidazole compounds with p38 MAPK inhibitory activity. A series of 51 (a training set of 40 and a test set of 11) dihydroquinazolinone [Bioorg. Med. Chem. Lett. 2003, 13, 277.] and tetrasubstituted imidazole [J. Med. Chem. 1999, 42, 2180.] derivatives known as p38 mitogen-activated protein kinase (p38 MAPK) selective inhibitors was studied by quantitative structure-activity relationship (3D-QSAR) analysis using comparative molecular field analysis. The 3D-QSAR models were generated and evaluated by a scheme that combines a genetic algorithm (GA) optimization with partial least squares (PLS) regression and by crossvalidation using the leave-one-out technique. The model was able to efficiently predict the activities of the compounds of the test set, suggesting that it can be used for the planning of new p38 MAPK inhibitor candidates useful to treat chronic inflammatory states.
Revista Mexicana de …, 1994
Revista Mexicana de Ciencias Geológicas, volumen 11, número 1, 1994, p. 53-61 Universidad Naciona... more Revista Mexicana de Ciencias Geológicas, volumen 11, número 1, 1994, p. 53-61 Universidad Nacional Autónoma de México, Instituto de Geología, México DF 53 RIESGO DE ACUMULACIÓN DE Cd, Pb, Cr у Co EN TRES SERIES DE SUELOS DEL DR03, ESTADO DE HIDALGO, ...
Revista Mexicana de …, 2000
DISPERSIÓN DE Ni y Cr EN SEDIMENTOS Y SUELOS SUPERFICIALES ... DERIVADOS DE PIROXENITAS, SERPENTI... more DISPERSIÓN DE Ni y Cr EN SEDIMENTOS Y SUELOS SUPERFICIALES ... DERIVADOS DE PIROXENITAS, SERPENTINITAS Y BASALTOS DE LA ... CUENCA SAN JUAN DE OTATES, ESTADO DE GUANAJUATO, MÉXICO ... Gilberto Hernández-Silva1, Gregorio ...
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Papers by GILBERTO SANT ANA SILVA