Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2001
1800'lü yýllarda kadýn popülasyonunun ortalama yaþam beklentisi 38 yýl civarýndaydý. Ancak günümü... more 1800'lü yýllarda kadýn popülasyonunun ortalama yaþam beklentisi 38 yýl civarýndaydý. Ancak günümüzde ise batýlý ülkelerde bu 74-76 yýla ulaþtý. Dolayýsýyla menopoz sonrasý bir kadýnýn önünde 25-30 yýllýk bir yaþam süresi vardýr. Sonuç olarak postmenopozal döneme gelip over yetmezliði ile karþýlaþan kadýnlarýn sayýsý da
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1998
Bu çalışmanın amacı yüksek riskli gebeliklerde umbi likal arter doppler ile perinatal prognoz ara... more Bu çalışmanın amacı yüksek riskli gebeliklerde umbi likal arter doppler ile perinatal prognoz arası ilişkinin araştırılmasıdır.
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1993
In this study serum progesterone (P) levels on hu man chorionic gonadotropin (hCG) administration... more In this study serum progesterone (P) levels on hu man chorionic gonadotropin (hCG) administration day in in vitro fertilization (IVF) cycles with gonadotropin-releasing hormone agonist (GnRH-a) suppression were inves tigated whether an elevated P level had an adverse af fect on oocyte quality and fertilization of oocytes. Seven ty-eight cycles treated with GnRH-a (Buserelin) begun in the luteal phase of the prior menstrual cycle and conti nued until the day of hCG were studied. In 30 cycles P was < 1.5 ng/ml and in 48 cycles P > 1.5 ng/ml. Cycles with high P levels had significantly high estradiol (E2) levels on the day of hCG (p<0.01). The mean number of mature oocytes per cycle, the fertilization and cleavage rate and the number of embryos was significantly low and the mean number of postmature oocytes was significant ly high when the P level over 1.5 ng/ml on the hCG day (p<0.05). In conclusion, the IVF cycles suppressed with GnRH-a; the fertilization, cleavage rate and oocyte quali ty is better when the P level lower than 1.5 ng/ml on the hCG day.
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2001
Placenta previa has been one of the great concerns in obstetric practice as it is associated with... more Placenta previa has been one of the great concerns in obstetric practice as it is associated with considerable perinatal morbidity (1). Patients with placenta previa, usually experience third trimester vaginal bleeding resulting from the lower uterine segment thinning (2,3). Bleeding is painless in most instances without an apparent causative factor such as preterm uterine activity. Disruption of the placental implantation site has been argued as a main reason for bleeding. Management of patients with symptomatic placenta previa mainly targets a reduction of maternal bleeding and prevention of preterm birth and thus, the overall maternal and fetal morbidity decreases. Recently a conservative approach has gained popularity among obstetricians as it provides reduction of fetal morbidity without enhancing maternal morbidity. Although tocolytic therapy may be considered in the management of symptomatic placenta previa, close patient monitoring and fetal assessment are still the mainstays of therapy. In the present study, retrospective data analysis of patients with placenta previa presenting with vaginal bleeding and preterm uterine contractions was done. Materials and Methods Patient charts of eighty-five women suffering from placenta previa with initial episode of vaginal bleeding who were admitted to Dr. Zekai Tahir Burak Women's Hospital between January 1, 1994 and December 31, 1995 were reviewed. Patients enrolled into the study had uterine irritability or regular moderate to strong contractions docu
JPMA. The Journal of the Pakistan Medical Association, 1993
One hundred and twenty five patients with polycystic ovaries on ultrasonography and 17 controls w... more One hundred and twenty five patients with polycystic ovaries on ultrasonography and 17 controls with normal ovaries on ultrasound and regular ovulary cycles underwent clinical and endocrine evaluation. Of 125 ultrasound-diagnosed polycystic ovary patients (PCO) 49.6% complained about hirsutism, 55.2% had menstrual disturbances (46.4% oligomenorrhea, 8.8% amenorrhea), 23.2% had normal but irregular cycles and 50.4% had infertility. PCO patients had significantly higher mean serum LH, testosterone, androstenedione and DHEAS levels and higher mean ovarian volume compared with the control group. Sixty seven percent of PCO patients had enlarged ovaries and significantly higher mean serum LH, testosterone, androstenedione and DHEAS levels, compared with the PCO patients who had ovarian volume within normal range. There was a significant positive correlation between ovarian volume and serum LH, testosterone, androstenedione, DHEAS levels. Hirsutism, oligomenorrhea, irregular cycles were eq...
JPMA. The Journal of the Pakistan Medical Association, 1993
Twenty patients with ultrasound diagnosed polycystic ovaries and high luteinizing hormone levels ... more Twenty patients with ultrasound diagnosed polycystic ovaries and high luteinizing hormone levels who failed to respond to clomiphene citrate were given tamoxifen to induce ovulation. Tamoxifen 20 mg daily (group 1, n = 10) and 40 mg daily (group 2, n = 10) was given for 5 consecutive days from the third to seventh day of the cycle. Treatment was monitored by serial ultrasound scans and assessment of serum estradiol. Human chorionic gonadotrophin (hCG) was administered when at least one follicle was > 16mm and serum estradiol level was > 300 pg/ml per follicle. Ovulation was confirmed with detection of the follicular rupture ultrasonographically 2 days after hCG and midluteal progesterone levels. The ovulation rate achieved in group 2 patients was significantly higher (p = 0.01) than group 1. Three pregnancies were achieved in group 2 patients while there was no pregnancy in group 1. The only side effect was ovarian cyst formation in one patient in group 1. As a result, tamoxif...
International Journal of Gynecology & Obstetrics, 1995
The data suggest that CA 125 levels may be a reliable indicator for monitoring the efficacy of Gn... more The data suggest that CA 125 levels may be a reliable indicator for monitoring the efficacy of GnRH agonist treatment of endometriosis, but its predictor value of recurrence is low.
Comparison of intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IV... more Comparison of intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF) in patients with non-male factor infertility.
Preterm prematür membran rüptürü (PPROM) tanısıyla konservatif tedavi planlanan gebelerde feto-ma... more Preterm prematür membran rüptürü (PPROM) tanısıyla konservatif tedavi planlanan gebelerde feto-maternal enfeksiyonun erken tahmininde ucuz ve noninvazif bir yöntem olarak seri nonstress test (NST) takibinin güvenilirliğinin incelenmesi.
Objective: The effects of various hormone replacement therapies on bone mineral density after 2 y... more Objective: The effects of various hormone replacement therapies on bone mineral density after 2 years of treatment were evaluated in this study. Methods: A total of 138 patients treated with either conjugated equine estrogen or transdermal 17-(3 e stra d io l alone or in com bination with medroxyprogesterone acetate or dydrogesterone had bone mineral density measurements of the first four lumbar vertebrae by using a Dual X-ray Hologic 1000 quantitative digital radiography densitometer. Results: After 2 years of treatment, a significant increase in spinal bone mineral density was found in all groups. No significant differences were found among 6 treatment groups. Conclusion: There were no differences between estrogen replacement therapies and combined hormone replacement therapies. Progesterone did not have any additional effect on bone mineral density.
European Journal of Obstetrics & Gynecology and Reproductive Biology, Oct 1, 1995
Atrial natriuretic peptide (ANP) is a family of peptides secreted by the heart, affecting the car... more Atrial natriuretic peptide (ANP) is a family of peptides secreted by the heart, affecting the cardiovascular, renal and endocrine systems. This study questions previous research findings regarding elevated ANP levels, despite vasoconstriction and hypovolemia, in preeclamptic patients. Seventeen patients with preeclampsia, 5 with superimposed preeclampsia with chronic hypertension and 17 normotensive pregnant women were compared with respect to plasma ANP levels. Seventeen non-pregnant women were taken as the control group. All the women, except the ones with superimposed preeclampsia, were age matched and in their third trimester. ANP levels in the non-pregnant women (6.9 +/- 0.7 pg/ml) were not different from those in the normotensive pregnant women (6.4 +/- 0.7 pg/ml). ANP levels were significantly higher in women with preeclampsia (10.8 +/- 1.8 pg/ml) or superimposed preeclampsia (9.7 +/- 1.4 pg/ml) than in normotensive pregnant women and normal non-pregnant women (P &lt; 0.05). According to the literature, there is a volume depletion in preeclamptic women. However, this wasn&#39;t demonstrated in our study group. ANP levels in preeclamptic women were found to be higher than those in normotensive pregnant women. The etiology still remains obscure.
Objective: The purpose of this retrospective study was to compare 2 different methods of luteal p... more Objective: The purpose of this retrospective study was to compare 2 different methods of luteal phase support in in vitro fertilization patients after embryo transfer. Methods: In 101 embryo transferred cycles 35 of the patients were given hCG supplemental (starting the day before embryo transfer 1500 III every 3 days for 6 times), 54 of them were given progesterone in oil (50 mg/day, IM injection, 20 days) randomly, except when E2 levels exceeded 3000 pg/ml. We had 9 pregnancies in hCG group, 10 with progesterone group. R e su lts: The comparison of results showed no significant difference between the 2 groups. Of the 9 patients who used hCG 6 aborted, of the 10 pregnant patients in progesterone group, 4 aborted. Conclusion: There was no difference from pregnancy rate point of view, but hCG group had a trend to abort more frequently (Fischer's exact test, p=0.06).
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1992
Infertilité kliniğimize değişik endikasyonlarla laparoskopik tetkik için yatırılan ve birlikte öv... more Infertilité kliniğimize değişik endikasyonlarla laparoskopik tetkik için yatırılan ve birlikte över kisti bulunan bir grup hastada, laparoskopi yoluyla kist aspirasyonu yapıldı. Makroskopik olarak benign, uni latéral, unilokuler, düzgün duvarlı, mobil, laparaskop ışığında transluminasyon veren ve 8 cm 'den daha kü çük olan bu kistlerde aspirasyonun laparotomiye ge rek kalmadan yeterli iyileşmeyi sağladığı ve nüks gö rülmediği tespit edilmekle beraber, histopatolojik tanı nın konulamamasından dolayı, tek başına bu işlemin tatminkâr olmadığı sonucuna varıldı.
... 13:35) Türk doktora büyük onur. ... 2. The Effect Of Buserelin On Plasma Lipid And Lipoprotei... more ... 13:35) Türk doktora büyük onur. ... 2. The Effect Of Buserelin On Plasma Lipid And Lipoprotein Concentration During Treatment Of Endometriosis Nedim ÇİÇEK a , Turhan ÇAĞLAR a , Gülnur ÖZAKŞİT a , Perran MÖRÖY a , Ali HABERAL b , Sertaç BATIOĞLU a , Oya GÖKMEN a a ...
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1992
Kronik pelvik ağrı jinekolojide en sık rastlanılan şikayetlerden biridir. Patolojik, fizyolojik v... more Kronik pelvik ağrı jinekolojide en sık rastlanılan şikayetlerden biridir. Patolojik, fizyolojik veya psikolojik orijinli olabilen bu tablonun değerlendirilmesi her za man kolay değildir ve sonuçlar hem doktor hem hasta için can sıkıcı olabilir (1). Fizik muayenede çoğunlukla
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2001
1800'lü yýllarda kadýn popülasyonunun ortalama yaþam beklentisi 38 yýl civarýndaydý. Ancak günümü... more 1800'lü yýllarda kadýn popülasyonunun ortalama yaþam beklentisi 38 yýl civarýndaydý. Ancak günümüzde ise batýlý ülkelerde bu 74-76 yýla ulaþtý. Dolayýsýyla menopoz sonrasý bir kadýnýn önünde 25-30 yýllýk bir yaþam süresi vardýr. Sonuç olarak postmenopozal döneme gelip over yetmezliði ile karþýlaþan kadýnlarýn sayýsý da
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1998
Bu çalışmanın amacı yüksek riskli gebeliklerde umbi likal arter doppler ile perinatal prognoz ara... more Bu çalışmanın amacı yüksek riskli gebeliklerde umbi likal arter doppler ile perinatal prognoz arası ilişkinin araştırılmasıdır.
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1993
In this study serum progesterone (P) levels on hu man chorionic gonadotropin (hCG) administration... more In this study serum progesterone (P) levels on hu man chorionic gonadotropin (hCG) administration day in in vitro fertilization (IVF) cycles with gonadotropin-releasing hormone agonist (GnRH-a) suppression were inves tigated whether an elevated P level had an adverse af fect on oocyte quality and fertilization of oocytes. Seven ty-eight cycles treated with GnRH-a (Buserelin) begun in the luteal phase of the prior menstrual cycle and conti nued until the day of hCG were studied. In 30 cycles P was < 1.5 ng/ml and in 48 cycles P > 1.5 ng/ml. Cycles with high P levels had significantly high estradiol (E2) levels on the day of hCG (p<0.01). The mean number of mature oocytes per cycle, the fertilization and cleavage rate and the number of embryos was significantly low and the mean number of postmature oocytes was significant ly high when the P level over 1.5 ng/ml on the hCG day (p<0.05). In conclusion, the IVF cycles suppressed with GnRH-a; the fertilization, cleavage rate and oocyte quali ty is better when the P level lower than 1.5 ng/ml on the hCG day.
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2001
Placenta previa has been one of the great concerns in obstetric practice as it is associated with... more Placenta previa has been one of the great concerns in obstetric practice as it is associated with considerable perinatal morbidity (1). Patients with placenta previa, usually experience third trimester vaginal bleeding resulting from the lower uterine segment thinning (2,3). Bleeding is painless in most instances without an apparent causative factor such as preterm uterine activity. Disruption of the placental implantation site has been argued as a main reason for bleeding. Management of patients with symptomatic placenta previa mainly targets a reduction of maternal bleeding and prevention of preterm birth and thus, the overall maternal and fetal morbidity decreases. Recently a conservative approach has gained popularity among obstetricians as it provides reduction of fetal morbidity without enhancing maternal morbidity. Although tocolytic therapy may be considered in the management of symptomatic placenta previa, close patient monitoring and fetal assessment are still the mainstays of therapy. In the present study, retrospective data analysis of patients with placenta previa presenting with vaginal bleeding and preterm uterine contractions was done. Materials and Methods Patient charts of eighty-five women suffering from placenta previa with initial episode of vaginal bleeding who were admitted to Dr. Zekai Tahir Burak Women's Hospital between January 1, 1994 and December 31, 1995 were reviewed. Patients enrolled into the study had uterine irritability or regular moderate to strong contractions docu
JPMA. The Journal of the Pakistan Medical Association, 1993
One hundred and twenty five patients with polycystic ovaries on ultrasonography and 17 controls w... more One hundred and twenty five patients with polycystic ovaries on ultrasonography and 17 controls with normal ovaries on ultrasound and regular ovulary cycles underwent clinical and endocrine evaluation. Of 125 ultrasound-diagnosed polycystic ovary patients (PCO) 49.6% complained about hirsutism, 55.2% had menstrual disturbances (46.4% oligomenorrhea, 8.8% amenorrhea), 23.2% had normal but irregular cycles and 50.4% had infertility. PCO patients had significantly higher mean serum LH, testosterone, androstenedione and DHEAS levels and higher mean ovarian volume compared with the control group. Sixty seven percent of PCO patients had enlarged ovaries and significantly higher mean serum LH, testosterone, androstenedione and DHEAS levels, compared with the PCO patients who had ovarian volume within normal range. There was a significant positive correlation between ovarian volume and serum LH, testosterone, androstenedione, DHEAS levels. Hirsutism, oligomenorrhea, irregular cycles were eq...
JPMA. The Journal of the Pakistan Medical Association, 1993
Twenty patients with ultrasound diagnosed polycystic ovaries and high luteinizing hormone levels ... more Twenty patients with ultrasound diagnosed polycystic ovaries and high luteinizing hormone levels who failed to respond to clomiphene citrate were given tamoxifen to induce ovulation. Tamoxifen 20 mg daily (group 1, n = 10) and 40 mg daily (group 2, n = 10) was given for 5 consecutive days from the third to seventh day of the cycle. Treatment was monitored by serial ultrasound scans and assessment of serum estradiol. Human chorionic gonadotrophin (hCG) was administered when at least one follicle was > 16mm and serum estradiol level was > 300 pg/ml per follicle. Ovulation was confirmed with detection of the follicular rupture ultrasonographically 2 days after hCG and midluteal progesterone levels. The ovulation rate achieved in group 2 patients was significantly higher (p = 0.01) than group 1. Three pregnancies were achieved in group 2 patients while there was no pregnancy in group 1. The only side effect was ovarian cyst formation in one patient in group 1. As a result, tamoxif...
International Journal of Gynecology & Obstetrics, 1995
The data suggest that CA 125 levels may be a reliable indicator for monitoring the efficacy of Gn... more The data suggest that CA 125 levels may be a reliable indicator for monitoring the efficacy of GnRH agonist treatment of endometriosis, but its predictor value of recurrence is low.
Comparison of intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IV... more Comparison of intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF) in patients with non-male factor infertility.
Preterm prematür membran rüptürü (PPROM) tanısıyla konservatif tedavi planlanan gebelerde feto-ma... more Preterm prematür membran rüptürü (PPROM) tanısıyla konservatif tedavi planlanan gebelerde feto-maternal enfeksiyonun erken tahmininde ucuz ve noninvazif bir yöntem olarak seri nonstress test (NST) takibinin güvenilirliğinin incelenmesi.
Objective: The effects of various hormone replacement therapies on bone mineral density after 2 y... more Objective: The effects of various hormone replacement therapies on bone mineral density after 2 years of treatment were evaluated in this study. Methods: A total of 138 patients treated with either conjugated equine estrogen or transdermal 17-(3 e stra d io l alone or in com bination with medroxyprogesterone acetate or dydrogesterone had bone mineral density measurements of the first four lumbar vertebrae by using a Dual X-ray Hologic 1000 quantitative digital radiography densitometer. Results: After 2 years of treatment, a significant increase in spinal bone mineral density was found in all groups. No significant differences were found among 6 treatment groups. Conclusion: There were no differences between estrogen replacement therapies and combined hormone replacement therapies. Progesterone did not have any additional effect on bone mineral density.
European Journal of Obstetrics & Gynecology and Reproductive Biology, Oct 1, 1995
Atrial natriuretic peptide (ANP) is a family of peptides secreted by the heart, affecting the car... more Atrial natriuretic peptide (ANP) is a family of peptides secreted by the heart, affecting the cardiovascular, renal and endocrine systems. This study questions previous research findings regarding elevated ANP levels, despite vasoconstriction and hypovolemia, in preeclamptic patients. Seventeen patients with preeclampsia, 5 with superimposed preeclampsia with chronic hypertension and 17 normotensive pregnant women were compared with respect to plasma ANP levels. Seventeen non-pregnant women were taken as the control group. All the women, except the ones with superimposed preeclampsia, were age matched and in their third trimester. ANP levels in the non-pregnant women (6.9 +/- 0.7 pg/ml) were not different from those in the normotensive pregnant women (6.4 +/- 0.7 pg/ml). ANP levels were significantly higher in women with preeclampsia (10.8 +/- 1.8 pg/ml) or superimposed preeclampsia (9.7 +/- 1.4 pg/ml) than in normotensive pregnant women and normal non-pregnant women (P &lt; 0.05). According to the literature, there is a volume depletion in preeclamptic women. However, this wasn&#39;t demonstrated in our study group. ANP levels in preeclamptic women were found to be higher than those in normotensive pregnant women. The etiology still remains obscure.
Objective: The purpose of this retrospective study was to compare 2 different methods of luteal p... more Objective: The purpose of this retrospective study was to compare 2 different methods of luteal phase support in in vitro fertilization patients after embryo transfer. Methods: In 101 embryo transferred cycles 35 of the patients were given hCG supplemental (starting the day before embryo transfer 1500 III every 3 days for 6 times), 54 of them were given progesterone in oil (50 mg/day, IM injection, 20 days) randomly, except when E2 levels exceeded 3000 pg/ml. We had 9 pregnancies in hCG group, 10 with progesterone group. R e su lts: The comparison of results showed no significant difference between the 2 groups. Of the 9 patients who used hCG 6 aborted, of the 10 pregnant patients in progesterone group, 4 aborted. Conclusion: There was no difference from pregnancy rate point of view, but hCG group had a trend to abort more frequently (Fischer's exact test, p=0.06).
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1992
Infertilité kliniğimize değişik endikasyonlarla laparoskopik tetkik için yatırılan ve birlikte öv... more Infertilité kliniğimize değişik endikasyonlarla laparoskopik tetkik için yatırılan ve birlikte över kisti bulunan bir grup hastada, laparoskopi yoluyla kist aspirasyonu yapıldı. Makroskopik olarak benign, uni latéral, unilokuler, düzgün duvarlı, mobil, laparaskop ışığında transluminasyon veren ve 8 cm 'den daha kü çük olan bu kistlerde aspirasyonun laparotomiye ge rek kalmadan yeterli iyileşmeyi sağladığı ve nüks gö rülmediği tespit edilmekle beraber, histopatolojik tanı nın konulamamasından dolayı, tek başına bu işlemin tatminkâr olmadığı sonucuna varıldı.
... 13:35) Türk doktora büyük onur. ... 2. The Effect Of Buserelin On Plasma Lipid And Lipoprotei... more ... 13:35) Türk doktora büyük onur. ... 2. The Effect Of Buserelin On Plasma Lipid And Lipoprotein Concentration During Treatment Of Endometriosis Nedim ÇİÇEK a , Turhan ÇAĞLAR a , Gülnur ÖZAKŞİT a , Perran MÖRÖY a , Ali HABERAL b , Sertaç BATIOĞLU a , Oya GÖKMEN a a ...
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1992
Kronik pelvik ağrı jinekolojide en sık rastlanılan şikayetlerden biridir. Patolojik, fizyolojik v... more Kronik pelvik ağrı jinekolojide en sık rastlanılan şikayetlerden biridir. Patolojik, fizyolojik veya psikolojik orijinli olabilen bu tablonun değerlendirilmesi her za man kolay değildir ve sonuçlar hem doktor hem hasta için can sıkıcı olabilir (1). Fizik muayenede çoğunlukla
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