Papers by Francisco Munoz
Metode Revista De Difusion De La Investigacion, 2012
Cuadernos De Realidades Sociales, 1987
Anuario Arqueologico De Andalucia 1986 Vol 2 1987 Isbn 84 86944 02 3 Pags 79 83, 1987
Glycoaldehyde effect on structure and activity of hen lysozyme Pilar Sanchis, Carlos Maya, Bartol... more Glycoaldehyde effect on structure and activity of hen lysozyme Pilar Sanchis, Carlos Maya, Bartolomé Vilanova, Francisco Muñoz, Josefa Donoso, Miquel Adrover Departament de Química, Universitat de les Illes Baleares, Palma de Mallorca, Spain Correspondence: [email protected] Abstract One of the main factors for the complications related to diabetes mellitus is the protein glycation (PG) process, which involves the natural occurring reaction between long-life protein amino groups and glucose. Initially it starts with the formation of a Schiff base that evolves to the final formation of the Advanced Glycation End Products (AGES) [1]. During this process, free radicals and highly reactive carbonyl compounds are also produced, which can further contribute to the post-translational protein modification initiated by the glucose. Glycoaldehyde (GLA) is one of these compounds. In fact, GLA-derived AGEs have been found in foam cells isolated from diabetic individuals [2]. A pressing ques...
Cognitive Brain Research, 2001
Some theoretical perspectives propose a semantic system in which categories are represented in di... more Some theoretical perspectives propose a semantic system in which categories are represented in different brain regions. Others assume that distinctions are based rather on differences in the demands placed by different categories on shared processing systems. In this study semantic categorization processes were investigated using the recognition potential (RP), an event-related brain response that reflects semantic processing, peaks at around 250 ms after stimulus onset and originates in areas subserving perceptual-semantic analyses. Results indicate that the RP shows some degree of sensitivity to categorization processes, but that categories assumed to differ markedly in their processing demands share, to a large extent, a common neural generator. This provides support for the non-categorical view on the organization of the semantic system, though introducing subtle variations, and suggesting the existence of a semantic subsystem specializing in the processing of perceptual-semantic features regardless of the semantic category involved.
Psychophysiology, 2005
Anterior negativities obtained when a grammatical rule is violated may reflect highly automatic f... more Anterior negativities obtained when a grammatical rule is violated may reflect highly automatic first‐pass parsing processes, the detection of a morphosyntactic mismatch, and/or the inability to assign the incoming word to the current phrase structure. However, for some theorists these negativities rather reflect some aspect of working memory processes. Event‐related brain potentials (ERPs) obtained for word category and morphosyntactic violations were directly compared with effects obtained when working memory is particularly demanded (embedding subject‐ or object‐relative clauses), yielding a significant dissociation in terms of topography. Even though, the anterior negativities for grammatical violations vanished when relative clauses were embedded, suggesting that the processes reflected by anterior negativities related to grammatical violations and those related to working memory manipulations, even if different, are placing demands on a common pool of limited resources.
Cognitive Brain Research, 2001
Previous research on open-and closed-class words has revealed the existence of several difference... more Previous research on open-and closed-class words has revealed the existence of several differences in the processing of these types of vocabulary. In this paper the processing of open-and closed-class words was compared by means of an early electrical brain response, recognition potential (RP), which indexes semantic processing and originates from basal extrastriate areas. The effects of word frequency on closed-class words were also investigated. For these purposes, open-and closed-class words, among other stimuli, were presented by means of the rapid stream stimulation procedure. Results showed that there were no significant differences when comparing the RP evoked by open-and closed-class words in the left hemisphere. However, in the right hemisphere this situation changed: the RP evoked by open-and closed-class words did differ. Moreover, there were no differences between the RP evoked by closed-class words and pseudowords. These patterns of results suggest that the semantic processing of closed-class words shares some aspects with the processing of open-class words, despite the existence of some differences. Thus, whereas the semantic processing of open-class words recruits brain areas of both hemispheres, the semantic processing of closed-class words is left-lateralized. A second purpose of this work is to study word-frequency effects on closed-class words. Our results show the insensitivity of closed-class words to word-frequency effects.
2013 11th IEEE International Conference on Industrial Informatics (INDIN), 2013
ABSTRACT In this work we describe a cognitive model to infer the more likely user's state... more ABSTRACT In this work we describe a cognitive model to infer the more likely user's states in data-intensive contexts. Stress, mental fatigue, or even inaptitude, are selected to be inferred by the model based two sources of information: context and psycho-physiological sensors network. As long as a complex, high demanding context will predict those cognitive states that, in turn, will be diagnosed by the set of sensors (EEG and ECG). All these input variables are represented in a probabilistic model in which links are defined based on the literature. The outcome of the model is a probability of being inapt to perform in a suitable way. In case of inaptitude, assistance should be delivered to the user to normalize the current user's state.
Theoretical Chemistry Accounts, 2012
The Journal of Physical Chemistry B, 2005
The indiscriminate use of beta-lactams has considerably diminished their efficiency as a result o... more The indiscriminate use of beta-lactams has considerably diminished their efficiency as a result of bacteria developing effective defense mechanisms against them. Recent pharmaceutical research has led to the synthesis of tricyclic beta-lactam antibiotics known as "tricyclic carbapenems" or "trinems". In this work, we studied the chemical reactivity, an essential property for antibiotic action, of trinems and found it to be similar to that of cephalosporins. Also, we elucidated the interaction pattern for sanfetrinem and 4beta-methoxy trinem and compared it to that for classical beta-lactams. The behavior of both trinems was found to be similar to that of penicillin G toward Staphylococcus aureus PC1, and that of cephalothin and imipenem toward Enterobacter cloacae P99.
The Journal of Physical Chemistry A, 2003
Physica B: Condensed Matter, 2013
The collision dynamics of one Ag or Cu atom impinging on a Au 12 cluster is investigated by means... more The collision dynamics of one Ag or Cu atom impinging on a Au 12 cluster is investigated by means of DFT molecular dynamics. Our results show that the experimentally confirmed 2D to 3D transition of Au 12-Au 13 is mostly preserved by the resulting planar Au 12 Ag and Au 12 Cu minimum energy clusters, which is quite remarkable in view of the excess energy, well larger than the 2D-3D potential barrier height. The process is accompanied by a large sÀd hybridization and charge transfer from Au to Ag or Cu. The dynamics of the collision process mainly yields fusion of projectile and target, however scattering and cluster fragmentation also occur for large energies and large impact parameters. While Ag projectiles favor fragmentation, Cu favors scattering due to its smaller mass. The projectile size does not play a major role in favoring the fragmentation or scattering channels. By comparing our collision results with those obtained by an unbiased minimum energy search of 4483 Au 12 Ag and 4483 Au 12 Cu configurations obtained phenomenologically, we find that there is an extra bonus: without increase of computer time collisions yield the planar lower energy structures that are not feasible to obtain using semi-classical potentials. In fact, we conclude that phenomenological potentials do not even provide adequate seeds for the search of global energy minima for planar structures. Since the fabrication of nanoclusters is mainly achieved by synthesis or laser ablation, the set of local minima configurations we provide here, and their distribution as a function of energy, are more relevant than the global minimum to analyze experimental results obtained at finite temperatures, and is consistent with the dynamical coexistence of 2D and 3D liquid Au clusters conformations obtained previously.
Language and Cognitive Processes, 2003
Event-related potentials (ERPs) were employed to compare word category and verb inflection violat... more Event-related potentials (ERPs) were employed to compare word category and verb inflection violations in Spanish. A similar frontal negativity was found between 250-400 ms for both violation types, suggesting that they equally disrupt initial syntactic analyses. Also, word category violations elicited a negativity at posterior electrodes larger than verb inflection anomalies and correct sentences within this time window, probably reflecting difficulties to semantically analyse phrase structure violations. Finally, a centroparietal positivity in the 500-700 ms interval was found for both error types. Both violations did not differ along the first half of this interval (500-600 ms), but larger effects for verb inflection violations were reported along Requests for reprints should be addressed to José
Uploads
Papers by Francisco Munoz