Archives of Cardiovascular Diseases Supplements, 2014
In both AT2R-/-and IL-17-/-mice diameter expansion did not occur whereas T cells and myeloid cell... more In both AT2R-/-and IL-17-/-mice diameter expansion did not occur whereas T cells and myeloid cells accumulation around the HF artery was not affected. IL-17 infusion (5ng/h, Alzet osmotic minipump) to nude mice and to AT2R-/-mice restored HF remodeling to control level. In order to confirm the role of AT2R in flowmediated remodeling in another vascular territory, neovascularization was examined using an ischemic skin flap model in AT2R-/-mice. As in mesenteric arteries, the absence of AT2R prevented diameter expansion in the arteries feeding the skin flap. Conclusion: we demonstrate for the first time the involvement of lymphocytes T cells polarization into TH17 by angiotensin II type 2 receptor in flowmediated outward remodeling of resistance arteries.
Archives of Cardiovascular Diseases Supplements, 2014
In both AT2R-/-and IL-17-/-mice diameter expansion did not occur whereas T cells and myeloid cell... more In both AT2R-/-and IL-17-/-mice diameter expansion did not occur whereas T cells and myeloid cells accumulation around the HF artery was not affected. IL-17 infusion (5ng/h, Alzet osmotic minipump) to nude mice and to AT2R-/-mice restored HF remodeling to control level. In order to confirm the role of AT2R in flowmediated remodeling in another vascular territory, neovascularization was examined using an ischemic skin flap model in AT2R-/-mice. As in mesenteric arteries, the absence of AT2R prevented diameter expansion in the arteries feeding the skin flap. Conclusion: we demonstrate for the first time the involvement of lymphocytes T cells polarization into TH17 by angiotensin II type 2 receptor in flowmediated outward remodeling of resistance arteries.
Uploads
Papers by Fouad Fadel