Papers by Flavio Gomes Guimaraes
Biodiversidade Brasileira - BioBrasil, Jun 10, 2013
Procyon cancrivorus tem ampla distribuicao na America do Sul, sendo encontrada em todos os biomas... more Procyon cancrivorus tem ampla distribuicao na America do Sul, sendo encontrada em todos os biomas brasileiros. E frequentemente registrada, inclusive em areas degradadas, embora seja rara ao longo de grandes regioes e sua dinâmica populacional e distribuicao geografica sejam pouco compreendidas. Desta forma, a especie e classificada como Menos Preocupante (LC). Ha conectividade com as populacoes dos paises vizinhos, porem nao existem informacoes sobre a dinâmica fonte-sumidouro. Assim, a categoria indicada na avaliacao regional nao foi alterada.
RESUMO A questao da realizacao de Exames Supletivos de Educacao de Jovens e Adultos – EJA, por es... more RESUMO A questao da realizacao de Exames Supletivos de Educacao de Jovens e Adultos – EJA, por escolas privadas e a determinacao por parte dos Conselhos Estaduais de Educacao, de que estes instrumentos de avaliacao sejam ofertados, exclusivamente, pelo Poder Publico, e tema recorrente no meio juridico e educacional, culminando com processos na esfera judicial, inclusive com antecipacoes de tutela em favor das escolas privadas por Juizes de primeira instância. Trata-se, portanto, de materia de interesse no campo da Legislacao Educacional, especialmente no que se refere aos exames em apreco, como possibilidades de certificacao dos Ensinos Fundamental e Medio, aos jovens e adultos que nao tiveram o acesso as citadas etapas da Educacao Basica, na idade apropriada e no tempo certo. O presente trabalho tem por objetivo apresentar subsidios a reflexao sobre dois aspectos argumentativos, que tem sido uteis para o norteamento das decisoes em primeira instância, em favor das escolas privadas,...
Journal of Human Growth and Development, 2007
Neste trabalho apresentamos e discutimos uma metodologia de avaliação familiar numa perspectiva d... more Neste trabalho apresentamos e discutimos uma metodologia de avaliação familiar numa perspectiva da Single Session Work, que é baseada numa única intervenção, e se destina ao atendimento de adolescente em conflito com a lei. A avaliação familiar compreendeu os seguintes objetivos: levantar informações psicossociais que possibilitassem uma melhor compreensão das características da clientela atendida; compreender o paradigma familiar, identificando os elementos relacionados à eclosão da crise atual, entendendo por crise o envolvimento do adolescente com a Justiça; estimular as famílias a estabelecerem novos paradigmas, capazes de responder à crise. Acreditamos que esta metodologia pode ser útil no contexto judiciário, com essa população de adolescentes, que cumpre medidas socieducativas e que não apresenta demanda para transformações. Reconhecemos seu potencial de gerar informação, resgatar vínculos parentais, significar o ato delinqüente, por ser uma intervenção crítica pontual e que ...
Paidéia (Ribeirão Preto), 2002
O campo da Terapia Familiar Sistêmica tem demonstrado um interesse crescente pelos processos de c... more O campo da Terapia Familiar Sistêmica tem demonstrado um interesse crescente pelos processos de construção de significado, sobretudo com o desenvolvimento das abordagens pós-modernas. O presente estudo resulta de um interesse por essa nova visão, tendo por objetivo discutir o processo de construção narrativa acerca do adolescente no contexto de terapia familiar. Para isso, descreve-se a evolução do pensamento cibernético chegando a duas vertentes teóricas contemporâneas: Construtivismo e Construcionismo Social. O estudo atenta para a importância das narrativas no contexto de terapia, não só como fonte de compreensão da realidade familiar, mas como uma desencadeadora do processo de mudança.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], 2015
Radiotherapy is one of the main approaches to cure prostate cancer, and its success depends on th... more Radiotherapy is one of the main approaches to cure prostate cancer, and its success depends on the accuracy of dose planning. A complicating factor is the presence of a metallic prosthesis in the femur and pelvis, which is becoming more common in elderly populations. The goal of this work was to perform dose measurements to check the accuracy of radiotherapy treatment planning under these complicated conditions. To accomplish this, a scale phantom of an adult pelvic region was used with alanine dosimeters inserted in the prostate region. This phantom was irradiated according to the planned treatment under the following three conditions: with two metallic prostheses in the region of the femur head, with only one prosthesis, and without any prostheses. The combined relative standard uncertainty of dose measurement by electron spin resonance (ESR)/alanine was 5.05%, whereas the combined relative standard uncertainty of the applied dose was 3.35%, resulting in a combined relative standa...
Revista De Medicina E Saude De Brasilia, Jan 5, 2014
A imunossupressão terapêutica está frequentemente associada ao aparecimento de diversos tipos de ... more A imunossupressão terapêutica está frequentemente associada ao aparecimento de diversos tipos de tumores, incluindo carcinoma vulvar, uma neoplasia rara que geralmente acomete mulheres acima de 65 anos. Os imunossupressores são capazes de inibir a resposta imune celular e, consequentemente, diminuem a ação do sistema imunológico. Assim, as células do sistema imunológico não atuam de maneira adequada para impedir a proliferação celular em casos de infecção prévia por micro-organismos patogênicos. Relatamos o caso de uma paciente com 41 anos, diagnosticada com papilomavírus humano (HPV) genital há 18 anos e submetida a tratamento quimioterápico por cerca de 4 meses devido ao aparecimento de carcinoma epidermoide vulvar recidivado. Vários estudos sugerem que infecções por HPV, principalmente o tipo 16, têm aumentado a incidência desse carcinoma em mulheres jovens.
Radiologia Brasileira, 2014
Objetivo: A oferta de radioterapia de alta tecnologia para população atendida pelo Sistema Único ... more Objetivo: A oferta de radioterapia de alta tecnologia para população atendida pelo Sistema Único de Saúde (SUS) é limitada, por não pertencer ao rol de procedimentos e, muitas vezes, pela capacidade instalada frente à demanda e dificuldade de retenção de recursos humanos especializados. Dessa forma, o acesso à radioterapia de intensidade modulada (IMRT) é restrito a poucos serviços no Brasil. Pretendemos apresentar as características dos primeiros 508 tratamentos de IMRT durante os primeiros anos de instalação da técnica em um hospital universitário. Materiais e Métodos: Foram analisados 508 tratamentos de IMRT, de maio de 2011 a setembro de 2013, que completaram a radioterapia. A técnica empregada foi multilâminas estático. Resultados: De um total de 4.233 pacientes tratados no período, 12,5% realizaram IMRT. As principais indicações foram para crânio, cabeça e pescoço, e próstata. Aproximadamente 30% das radioterapias de crânio e 50% das de próstata foram por IMRT. A toxicidade to...
Radiation Protection Dosimetry, 2014
Journal of Psychopharmacology, 1987
In order to assess the role played by serotonin (5-HT) and noradrenaline in anxiety, four groups ... more In order to assess the role played by serotonin (5-HT) and noradrenaline in anxiety, four groups of healthy volunteers were given 25 mg of the selective inhibitor of 5-HT uptake chlorimipramine, 50 mg of the selective inhibitor of noradrenaline uptake maprotiline, 1 mg of the benzodiazepine anxiolytic lorazepam or placebo, and submitted to a simulated public speaking (SPS) test, consisting of speaking in front of a videocamera. Subjective anxiety was evaluated by the visual analog mood scale (VAMS) of Norris as well as by the state-trait anxiety inventory (STAI) of Spielberger. Chlorimipramine enhanced SPS-induced anxiety, whereas maprotiline and lorazepam reduced anxiety during as well as outside the test period. Mental and physical sedation (VAMS) were increased by either maprotiline or lorazepam. In a scale of bodily symptoms, chlorimipramine tended to increase muscle tension, agitation and palpitation, whereas maprotiline caused lethargy. The rise in blood pressure induced by th...
International Journal of Radiation Oncology*Biology*Physics, 2007
analyzed by Principle Component Analysis (PCA). Scores for factors were used for classification a... more analyzed by Principle Component Analysis (PCA). Scores for factors were used for classification and results were correlated with clinically assessed radiation response. Results: PCA of spectra of 2 nd-fraction-of-radiotherapy tissues gave three clusters corresponding to complete response (CR), partial response (PR) and no response (NR), (Figure 1a). In this analysis we could discriminate no response and partial response conditions but there exists an overlap between complete and partial response conditions. We are also pursued predictive studies using tissues collected after 5 th fraction of EBRT in order to explore better discrimination between PR and CR conditions. The available results so for show good correlation with clinical response (Figure 1b). Conclusions: The findings of the study thus suggest the feasibility of Raman spectroscopic prediction of tumor response to radiotherapy.
BMC Cancer, 2007
Background: Brain metastases (BM) are the most common form of intracranial cancer. The incidence ... more Background: Brain metastases (BM) are the most common form of intracranial cancer. The incidence of BM seems to have increased over the past decade. Recursive partitioning analysis (RPA) of data from three Radiation Therapy Oncology Group (RTOG) trials (1200 patients) has allowed three prognostic groups to be identified. More recently a simplified stratification system that uses the evaluation of three main prognostics factors for radiosurgery in BM was developed. Methods: To analyze the overall survival rate (OS), prognostic factors affecting outcomes and to estimate the potential improvement in OS for patients with BM from breast cancer, stratified by RPA class and brain metastases score (BS-BM). From January 1996 to December 2004, 174 medical records of patients with diagnosis of BM from breast cancer, who received WBRT were analyzed. The surgery followed by WBRT was used in 15.5% of patients and 84.5% of others patients were submitted at WBRT alone; 108 patients (62.1%) received the fractionation schedule of 30 Gy in 10 fractions. Solitary BM was present in 37.9 % of patients. The prognostic factors evaluated for OS were: age, Karnofsky Performance Status (KPS), number of lesions, localization of lesions, neurosurgery, chemotherapy, absence extracranial disease, RPA class, BS-BM and radiation doses and fractionation. Results: The OS in 1, 2 and 3 years was 33.4 %, 16.7%, and 8.8 %, respectively. The RPA class analysis showed strong relation with OS (p < 0.0001). The median survival time by RPA class in months was: class I 11.7, class II 6.2 and class III 3.0. The significant prognostic factors associated with better OS were: higher KPS (p < 0.0001), neurosurgery (P < 0.0001), single metastases (p = 0.003), BS-BM (p < 0.0001), control primary tumor (p = 0.002) and absence of extracranial metastases (p = 0.001). In multivariate analysis, the factors associated positively with OS were: neurosurgery (p < 0.0001), absence of extracranial metastases (p <0.0001) and RPA class I (p < 0.0001). Conclusion: Our data suggests that patients with BM from breast cancer classified as RPA class I may be effectively treated with local resection followed by WBRT, mainly in those patients with single BM, higher KPS and cranial extra disease controlled. RPA class was shown to be the most reliable indicators of survival.
American Journal of Clinical Oncology, 2009
To report the outcomes and toxicity of high dose rate brachytherapy as a boost for localized pros... more To report the outcomes and toxicity of high dose rate brachytherapy as a boost for localized prostate cancer. Between 1997 and 2000, the medical records of 131 patients with prostate adenocarcinoma who were treated with external beam radiation therapy and high dose rate brachytherapy, were retrospectively analyzed. Furthermore, 55% of the patients received neoadjuvant/concurrent or adjuvant androgen deprivation therapy. Patients were stratified into 2 groups. Group 1 included 65 patients with Gleason score 7, pretreatment prostate specific antigen (PSA) between 10 and 20 ng/mL, and clinical stage T2b. Group 2 included 66 patients with Gleason score between 8 and 10, PSA greater than 20 ng/mL, and clinical stage greater than T2b. At a median follow-up of 62.8 months, the 5-year biochemical control (BC) rate, as defined by the American Society for Therapeutic Radiology and Oncology Phoenix Consensus panel statement, was 81% and overall survival was 91%. BC in Groups 1 and 2 were 87% and 71%, respectively. On univariate analysis risk group, pretreatment PSA and age were significant predictors of BC. However, on multivariate analysis only pretreatment PSA was significant. Using the Radiation therapist oncology group criteria, there were 2 (1.5%) cases of grade 3 acute urinary toxicity. Regarding late side effects (n = 5), 4% of patients had grade 3 genitourinary toxicity and no grade 4 complication was observed. External beam radiation therapy and high dose rate brachytherapy for prostate cancer resulted in excellent BC, and overall survival with minimal severe, acute, or late complications.
Brazilian Journal of Microbiology, 2005
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Papers by Flavio Gomes Guimaraes