Papers by Fred Ross-Cisneros
Investigative Ophthalmology & Visual Science, 2016
American Journal of Physiology-regulatory Integrative and Comparative Physiology, May 1, 1997
An earlier study showed that norepinephrine (NE) was released in the paraventricular nucleus (PVN... more An earlier study showed that norepinephrine (NE) was released in the paraventricular nucleus (PVN) and posterior hypothalamus (PH) along with increases of mean arterial pressure (MAP) and heart rate (HR) during shaker stress (SS). Here we investigated the possibility that nitric oxide (NO) donors, infused into hypothalamus, could modulate responses to SS. In conscious rats, an injector-microdialysis probe, for direct application of donor and collection of extracellular NE, respectively, was inserted into PVN or PH; MAP and HR were recorded continuously from conscious rats. The NO donor, molsidomine (Mol), infused 5 or 30 min before SS, did not alter baseline values of NE, MAP, or HR, but did attenuate changes elicited by 5 min of SS; methylene blue blocked the effects of Mol. The NO donor, sodium nitroprusside, was much less effective than Mol as a modulator of stress-related effects. The results indicate that MAP, HR, and hypothalamic NE responses to environmental stress, but not baseline values, can be modulated by NO donors in the hypothalamus.
Investigative Ophthalmology & Visual Science, Jul 22, 2019
Investigative Ophthalmology & Visual Science, May 1, 2003
Univ Bologna, Dept Neurol Sci, Bologna, ItalyUniv So Calif, Keck Sch Med, Doheny Eye Inst, Los An... more Univ Bologna, Dept Neurol Sci, Bologna, ItalyUniv So Calif, Keck Sch Med, Doheny Eye Inst, Los Angeles, CA 90033 USAUniv Copenhagen, Dept Clin Biochem, Copenhagen, DenmarkS Orsola Malpighi Univ Hosp, Biomed Ctr Appl Res CRBA, Bologna, ItalyUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilInst Olhos Colatina, Colatina, ES, BrazilUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilWeb of Scienc
Investigative Ophthalmology & Visual Science, Jun 16, 2013
Investigative Ophthalmology & Visual Science, May 14, 2008
Investigative Ophthalmology & Visual Science, Jul 13, 2018
Investigative Ophthalmology & Visual Science, May 10, 2007
Cell Reports, Jul 1, 2022
Investigative Ophthalmology & Visual Science, Jun 16, 2013
Investigative Ophthalmology & Visual Science, May 1, 2004
Journal of Neuro-ophthalmology, Jun 1, 2011
Objective-Alzheimer's disease (AD) is associated with optic nerve degeneration yet the underlying... more Objective-Alzheimer's disease (AD) is associated with optic nerve degeneration yet the underlying pathophysiology of this disease and the optic nerve disorder remains poorly understood. Low density lipoprotein receptor-related protein (LRP) is implicated in the pathogenesis of AD by mediating the transport of amyloid-β (Aβ) out of the brain into the systemic circulation. As a key player in the reaction to central nervous system (CNS) injury, astrocytes associate with LRP in AD. This study investigates the role of LRP and astrocytes in the pathogenesis of AD optic neuropathy. Methods-To investigate the role of LRP and astrocytes in the pathogenesis of AD optic neuropathy, we conducted immunohistochemical (IHC) studies on postmortem optic nerves in AD patients (n = 11) and age-matched controls (n = 10) to examine the presence of LRP. Quantitative analyses using imaging software were used to document the extent of LRP in neural tissues. Axonal integrity was assessed by performing IHC on the subjects' optic nerves with an antibody to neurofilament (NF) protein. Double-immunofluorescence labeling was performed to investigate whether LRP colocalized with astrocytes expressing glial fibrillary acidic protein (GFAP). Results-LRP expression was decreased in AD optic nerves compared to controls (p < 0.001). LRP immunoreactivity was observed in the microvasculature and perivascularly in close proximity to astrocytic processes. Colocalization of LRP in astrocytes of optic nerves was also demonstrated. The presence of optic neuropathy was confirmed in the AD optic nerves by demonstrating greatly reduced immunostaining for NF protein as compared to controls. Conclusion-The reduction of LRP in the AD degenerative optic nerves supports the hypothesis that LRP may play a role in the pathophysiology of AD optic neuropathy.
Investigative Ophthalmology & Visual Science, Sep 26, 2016
Investigative Ophthalmology & Visual Science, May 1, 2006
Investigative Ophthalmology & Visual Science, May 1, 2006
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Papers by Fred Ross-Cisneros