Papers by FRANCISCO GOMEZ
Anales De Medicina Interna, Jun 1, 2001
Clinical & Experimental Allergy, Sep 15, 2015
Background Although specific immunotherapy is the only aetiological treatment for allergic disord... more Background Although specific immunotherapy is the only aetiological treatment for allergic disorders, the underlying mechanisms are not fully understood. Specific immunotherapy induces changes in lymphocyte Th subsets from Th2 to Th1/Treg. Whether differences in immunological patterns underlie patient response to immunotherapy has not yet been established. Objectives We studied the immunological changes occurring during a 1-year period of Dermatophagoides pteronyssinus (DP) immunotherapy and their relation with clinical outcome. Methods We included 34 patients with DP allergy who received subcutaneous specific immunotherapy (SCIT) for 1 year. Following treatment, patients were classified as responders or non-responders. Fourteen allergic subjects who did not receive SCIT were included as controls. Peripheral blood was obtained at 0, 1, 3, 6 and 12 months and cultured with nDer p 1. Phenotypic changes, cytokine production and basophil response were analysed by flow cytometry; transcription factors were measured by mRNA quantification. Serum immunoglobulin levels were also measured. Results After 1 year of SCIT, 82% of cases showed improved symptoms (responders). Although increases in sIgG4 were observed, BAT reactivity was not modified in these patients. Increases in T-BET/FOXP3 as well as nDer p 1-specific Th1/Treg frequencies were also observed, along with a decrease in Th2, Th9 and Th17. These changes corresponded to changes in cytokine levels. Conclusion Patients who respond well to DP-SCIT show immunological differences compared to non-responders. In responders, basal differences include a lower frequency of Th1 and higher frequencies of Th2, Th9 and Th17 cells. After 1 year of treatment, an increased production of sIgG4 was observed in responders, along with a change in Th2 response towards Th1/Treg.
Scientific Reports, 2017
Subcutaneous specific immunotherapy (SCIT) has been shown to modify theDermatophagoides pteroniss... more Subcutaneous specific immunotherapy (SCIT) has been shown to modify theDermatophagoides pteronissinus(DP) allergic response, characterized by generation of Treg cells. However, studies have reported no changes in the proportion of Treg cells after immunotherapy, indicating that the effects may be due to modifications in their regulatory activities. We aimed to determine whether Tregs generated by DP-SCIT can switch the allergic response to tolerant and study the involvement of suppressive cytokines on it. Twenty-four DP-allergic rhinitis patients were recruited, 16 treated with DP-SCIT and 8 untreated. Treg and T effector cells were isolated before and after DP-SCIT, and cocultured in different combinations with α-IL-10, α-TGF-β blocking antibodies and nDer p 1. Treg cells after DP-SCIT increased Th1 and decreased Th2 and Th9 proliferation. Similarly, they increased IL-10 and decreased IL-4 and IL-9-producing cells. α-IL-10 affected the activity of Treg cells obtained after DP-SCIT ...
Revista de Investigación en Psicología, 2014
La parte empírica de este trabajo de investigación incluye los modelos de intervención sistémico ... more La parte empírica de este trabajo de investigación incluye los modelos de intervención sistémico y fenomenológico en el modelo de las constelaciones familiares, así como el modelo de las representaciones sociales. La investigación consiste en aplicar el método de las constelaciones familiares creado por Bert Hellinger a la supervisión clínica. Para ello, se estudiaron catorce casos, presentados por los psicoterapeutas participantes en la misma. Los resultados dan cuenta de los cambios de creencias, convicciones y grados de satisfacción de los participantes en las dinámicas de grupo. En definitiva, la investigación recoge los cambios en las representaciones sociales de los psicoterapeutas investigados, sobre sus problemas y relaciones laborales, como consecuencia de la aplicación del método de las constelaciones familiares.
Journal of Investigational Allergology and Clinical Immunology, 2016
Background: Component-based diagnosis on multiplex platforms is widely used in food allergy but i... more Background: Component-based diagnosis on multiplex platforms is widely used in food allergy but its clinical performance has not been evaluated in nut allergy. Objective: To assess the diagnostic performance of a commercial protein microarray in the determination of specific IgE (sIgE) in peanut, hazelnut, and walnut allergy. Methods: sIgE was measured in 36 peanut-allergic, 36 hazelnut-allergic, and 44 walnut-allergic patients by ISAC 112, and subsequently, sIgE against available components was determined by ImmunoCAP in patients with negative ISAC results. ImmunoCAP was also used to measure sIgE to Ara h 9, Cor a 8, and Jug r 3 in a subgroup of lipid transfer protein (LTP)-sensitized nut-allergic patients (positive skin prick test to LTP-enriched extract). sIgE levels by ImmunoCAP were compared with ISAC ranges. Results: Most peanut-, hazelnut-, and walnut-allergic patients were sensitized to the corresponding nut LTP (Ara h 9, 66.7%; Cor a 8, 80.5%; Jug r 3, 84% respectively). However, ISAC did not detect sIgE in 33.3% of peanut-allergic patients, 13.9% of hazelnut-allergic patients, or 13.6% of walnut-allergic patients. sIgE determination by ImmunoCAP detected sensitization to Ara h 9, Cor a 8, and Jug r 3 in, respectively, 61.5% of peanut-allergic patients, 60% of hazelnut-allergic patients, and 88.3% of walnut-allergic patients with negative ISAC results. In the subgroup of peach LTP-sensitized patients, Ara h 9 sIgE was detected in more cases by ImmunoCAP than by ISAC (94.4% vs 72.2%, P<.05). Similar rates of Cor a 8 and Jug r 3 sensitization were detected by both techniques. Conclusions: The diagnostic performance of ISAC was adequate for hazelnut and walnut allergy but not for peanut allergy. sIgE sensitivity against Ara h 9 in ISAC needs to be improved.
Se aborda brevemente la definición y los aspectos más relevantes del Proceso de Bolonia para la C... more Se aborda brevemente la definición y los aspectos más relevantes del Proceso de Bolonia para la Convergencia Europea de los Estudios Superiores. Favoreciendo la comprensión del Espacio Europeo de Educación Superior en la comunidad escolar de un centro educativo, con niveles de Educación Primaria, Secundaria y Bachillerato, mediante la explicación del Proceso en marcha en su Revista del APA. También se exponen los tres modelos de enseñanza-aprendizaje que han existido hasta los momentos actuales, siendo el tercero de ellos, el de la Convergencia Europea, el que pretende devolver a la sociedad parte de todo lo que recibe de ella. La comparación de las tituaciones actuales y de las futuras, asi como sus tiempos de duración, mediante una tabla, cierran el artículo dando una visión global del Proceso de Bolonia.
Clinical and Translational Allergy, 2015
Pediatric Allergy and Immunology, 2015
BackgroundPeanut allergens are common triggers of food allergy. Analyses of sensitization pattern... more BackgroundPeanut allergens are common triggers of food allergy. Analyses of sensitization patterns, relationships with other allergens, clinical symptoms, and variation with age are needed. We studied sensitization to Ara h 2, Ara h 9, and Pru p 3 in a peanut allergic children/adolescents and the relationship with peach and pollen.MethodsPeanut allergic patients aged between 1 and 20 years old were classified into two groups: A) allergic to peanut only and B) allergic to peach and peanut. The IgE response was measured to Ara h 2, Ara h 9, and Pru p 3.ResultsOf 964 subjects evaluated, 28% were allergic to peanut. From this group, 68% were also sensitized to pollen. Urticaria was the most frequent entity followed by anaphylaxis and OAS. Fifty‐eight percent had Ara h 2‐ and/or Ara h 9‐specific IgE. More than half reported symptoms with peanut alone (Group A) and 35% to peanut and peach (Group B). We observed significant differences in sex, age, onset of symptoms, and sensitization to A...
Anales de medicina interna (Madrid, Spain : 1984), 2001
Journal of Palliative Medicine, 2014
Background: Transfusion is not an exceptional circumstance in palliative cancer patients (PCPs). ... more Background: Transfusion is not an exceptional circumstance in palliative cancer patients (PCPs). This makes it necessary to confront not only medical aspects but also those of infrastructure and ethical issues. On some occasions, literature needs to be consulted to work out the best approach in a patient's particular case. Our aim was to review the literature contained in PubMed and EMBASE so as to find out about the information available on transfusion in PCPs. Methods: A search for literature was carried out in databases PubMed and EMBASE, using ''transfusion,'' ''cancer,'' ''end-of-life care,'' ''terminal care,'' and ''palliative care'' as key words. Publications were classified according to the main topic discussed (clinical, infrastructure, and ethics) and the information included in each article critically assessed. Results: We found 334 articles but only 43 were considered valuable for the present study. Of these 43 articles, 21 deal with clinical topics while 12 deal with infrastructure and 10 with ethical issues. There is an absolute lack of randomized controlled trials or clinical guidelines. Trigger parameters for transfusion are not clearly established. Benefits of the procedure are shortly experienced and remain controversial. Home transfusions are encouraged, but this sole procedure has not been demonstrated to be cost effective. Different cultures, cases, and realities illustrate the diversity of the ethical management of transfusion in PCPs. Discussion: Although transfusion is certainly a common practice in PCPs, there is a relative lack of literature on this topic. Publications are unconnected and hardly any prospective studies have been performed. A large part of the little literature available only concerns descriptive and very general aspects of the issue. As transfusional products and financial and human resources are finite, it would be desirable to establish clear research lines on the different aspects considered (clinical, infrastructure, and ethical) that can help clinicians, nurses, patients, and carers to make a decision.
European Journal of Clinical Nutrition, 2004
Background: Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by inf... more Background: Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by inflammatory lymphocytic infiltration of the salivary glands, leading to dryness of the mouth (xerostomia). It has been postulated that xerostomia is the preceding stage for the development of alterations in taste acuity (dysgeusia) in this type of patients. Objectives: To determine detection and recognition thresholds to the 4 basic tastes (sweet, salty, sour and bitter) in pSS patients and compare them to a control group. To determine if the long-term consumption of chile peppers and spicy Mexican diets had an effect on the taste perception and acuity of the pSS patients. Setting: This study was done in the Department of Food Science and Technology of the Instituto Nacional de Ciencias Médicas y Nutrició n Salvador Zubirán (INCMNSZ), a third-level hospital in Mexico City. Subjects: The patient group consisted of 21 Mexican females (mean7s.d., age: 53.179.8 y) diagnosed with pSS (time of duration of the disease, 8.676.6 y, median 7 y, range 1-25 y) who were recruited at the outpatient service of the Department of Immunology and Rheumatology of the INCMNSZ. The control group consisted of 20 healthy nonsmokers age-matched Mexican women (50.3711.9 y) most of them personnel of the INCMNSZ, and some friends and nonblood relatives to the patients (sisters-in-law) who volunteered to participate in the study. Interventions: Detection and recognition thresholds were determined by the method of least noticeable differences on three occasions during three nonconsecutive days. Saliva production was determined by Saxon's test on two separate occasions. Results: Although saliva production was severely reduced in pSS patients (1.3570.55 ml/2 min, Po0.001) compared to controls (6.2672.41 ml/2 min), all subjects recognized the 4 basic tastes when these were tested at suprathreshold concentrations. The detection thresholds for the sweet, sour and bitter tastes were higher in pSS patients, as well as the recognition thresholds for the salty, sour and bitter tastes. A relationship between time of evolution of the disease and saliva production with individual thresholds could not be established. Conclusions: pSS patients exhibited different degrees of dysgeusia depending on the taste being studied, that is, they were mildly dysgeusic for the sweet and salty tastes and clearly dysgeusic for the sour and bitter tastes. Although both pSS patients and controls had consumed 'typical Mexican diets' their entire lives, our results showed that the consumption of chile peppers and spicy foods did not have any effect on the taste perception and acuity of the pSS patients.
CIRIEC- …, 2008
CIRIEC-España, revista de economía pública, social y cooperativa ISSN: 0213-8093. © 2008 CIRIEC-E... more CIRIEC-España, revista de economía pública, social y cooperativa ISSN: 0213-8093. © 2008 CIRIEC-España www.ciriec.es www.ciriec-revistaeconomia.es ... Sara Fernández de Bobadilla Güemez Profesora Titular de Escuela Universitaria, Doctora Eva Velasco Balmaseda ...
Uploads
Papers by FRANCISCO GOMEZ