RESUMEN. Se presentan algunos aspectos generales relacionados a la bioquímica del vanadio y a la ... more RESUMEN. Se presentan algunos aspectos generales relacionados a la bioquímica del vanadio y a la posible esencialidad de este elemento. Luego se discuten las propiedades insulino-miméticas y antitumorales de diversos compuestos de vanadio (IV) y vanadio (V). Finalmente, se hacen algunos comentarios sobre la toxicidad de compuestos de este metal y sobre diferentes agentes quelantes utilizados como antídotos.
denominado Miranda se decidió implementar e el sistema de distribución de medicamentos por Dosis ... more denominado Miranda se decidió implementar e el sistema de distribución de medicamentos por Dosis Unitarias (SDDU), que comenzó a funcionar en el mes de Agosto de 1997. Con el fin de evaluar si existe una optimización en la utilización de los recursos al incorporar a un residente a la sala, se comparó en forma retrospectiva la demanda de medicamentos expresados como el número de unidades/pacientes/día (UPD) durante el mes inmediato anterior a la puesta en marcha del SDDU (Julio de 1997) y la demanda originada en los dos siguientes meses con el SDDU (Agosto y Septiembre). Como consecuencia de la Gestión Farmacéutica se obtuvieron reducciones en el número de unidades en los tres servicios, con respecto al mes de Junio. Los porcentajes de reducción de UPD en Agosto fueron del 14,98% en Clínica Médica Miranda, del 30,89 % en Clínica Médica Hombres y del 37,10% en Clínica Médica Mujeres. (P<0.05). En el mes de Septiembre, las reducciones en UPD fueron del 64,08%, 52,68% y 44,62%, respectivamente (P<O.01). De acuerdo a estos resultados, la presencia del residente ha optimizado el uso racional de medicamentos, mediante la significativa reducción de las unidades solicitadas por los servicios.
The levels of platelet MAO activity increase and the frequency of affective symptoms diminish in ... more The levels of platelet MAO activity increase and the frequency of affective symptoms diminish in the depressed chronic schizophrenics treated with nomifensine. 2. Nomifensine has no inhibitory effect/n vitro on platelet MAO activity in depressed schizophrenic pellets.
EFFECT OF MAO-A AND MAO-B INHIBITORS IN GANGLIA AND NERVE ENDINGS Effect of mao-A and mao-B inhib... more EFFECT OF MAO-A AND MAO-B INHIBITORS IN GANGLIA AND NERVE ENDINGS Effect of mao-A and mao-B inhibitors in ganglia and nerve endings Efecto de los inhibidores de mao-A y B en el ganglio y en los terminales nerviosos FILINGER, E. Clinical Pharmacy. Department of Pharmaceutical Technology. Faculty of Pharmacy and Biochemistry (U.B.A.).
RESUMEN. El presente artículo aborda de una manera introductoria la evolución desde la Farmacia C... more RESUMEN. El presente artículo aborda de una manera introductoria la evolución desde la Farmacia Clínica hasta la Atención Farmacéutica y su aplicación en el ámbito de la Salud Mental. Se explica el papel que el farmacéutico de oficina puede realizar a fin de mejorar la salud y calidad de vida de los pacientes con trastornos psiquiátricos en el ámbito ambulatorio. SUMMARY. "Pharmaceutical Care in Psychiatric Outpatients". This article broaches in an introductory way the evolution from the Clinical Pharmacy to the Pharmaceutical Care and their application in the mental health. It is explained the rol that the pharmacist in a community pharmacy can do with the purpose of the improvement of health and quality of life of psychiatric outpatients.
The release and metabolism of 3H-noradrenaline (3H-NA) produced by d-amphetamine was studied in t... more The release and metabolism of 3H-noradrenaline (3H-NA) produced by d-amphetamine was studied in the superior cervical ganglion of the cat (cell bodies) and in the nictitating membrane (nerve endings). Exposure of the nictitating membrane to 10 microM d-amphetamine, resulted in the release of 5.1% of the total radioactivity. This was mainly collected as 3H-normetanephrine (3H-NMN) and as 3H-NA; 3H-3,4-dihydroxyphenylglycol (3H-DOPEG) did not contribute to the drug-induced outflow of radioactivity. In contrast, exposure of ganglionic cell bodies to 10 microM d-amphetamine for 10 min released only 1.74% of the total tissue radioactivity and 3H-DOPEG represented the most important fraction of the released radioactivity. When ganglia were exposed to 30 microM d-amphetamine, the radioactivity released was 5.2%; the proportion of 3H-NA and 3H-NMN increased and 3H-DOPEG was reduced. These results show that: a) d-amphetamine releases 3H-NA from prelabeled cell bodies and nerve endings; b) the potency of d-amphetamine was higher in nerve terminals than in cell bodies, and c) at low concentrations of d-amphetamine, the metabolism of the released neurotransmitter differed between both parts of the adrenergic neuron.
Publisher Summary This chapter describes the metabolism of endogenous noradrenaline. The metaboli... more Publisher Summary This chapter describes the metabolism of endogenous noradrenaline. The metabolism of noradrenaline is carried out mainly by two enzymes, monoamine oxidase, and catechol- O -methyltransferase. Two additional enzymes are involved in either the reduction or the oxidation of the aldehyde of NA, which is formed through the activity of MAO. These enzymes include aldehyde reductase, which is a MADPH-dependent enzyme and aldehyde dehydrogenase, which is a NAD + -dependent enzyme. It is found that when transmitter release is elicited by nerve stimulation, a significant fraction of the NA released is collected as metabolites. It is found that for the nerve-muscle preparation of the cat nictitating membrane, 3 H-DOPEG is the main fraction in the overflow of 3 H transmitter elicited by nerve stimulation, accounting for approximately 40% of the total radioactivity. Under these experimental conditions, 3 H-NMN accounted for 20% of the total radioactivity released by nerve stimulation. Similar results were obtained in the perfused cat spleen. Under conditions of release elicited by nerve stimulation, the HDOPEG formed results from neuronal re-uptake of the released transmitter and subsequent presynaptic metabolism by MAO and aldehyde reductase.
The two forms of MAO, A and B, are present in the nictitating membrane and superior cervical gang... more The two forms of MAO, A and B, are present in the nictitating membrane and superior cervical ganglion of the cat. 2. The KM for the substrate tyramine differed between both tissues, the affinity of the ganglionar enzyme was almost three times lower than that of the nictitating membrane. 3. The potency of clorgyline to inhibit the form A of MAO, using tyramine as substrate, was lower in ganglia than in the nictitating membrane. 4. Sympathetic denervation decreased type A to a greater extent than type B in the nictitating membrane. 5. In superior cervical ganglion, clorgyline was a more potent inhibitor of noradrenaline metabolism than in the nictitating membrane.
1. Normal, atrophied and denervated submaxillary glands were incubated with [3H]adenine for 1 h. ... more 1. Normal, atrophied and denervated submaxillary glands were incubated with [3H]adenine for 1 h. The accumulation of [3H]adenine, expressed as microCi/g tissue, did not differ significantly when the sympathetically denervated glands were compared with the control group. The radioactivity retained in both control and denervated tissues was also similar. 2. In atrophied glands 3H-accumulation as well as 3H-retention were 2-fold higher than these obtained in controls per unit weight, but 30% lower when expressed per gland. 3. The spontaneous efflux of radioactivity, expressed as fractional release, from normal, atrophied and denervated glands prelabelled with [3H]adenine was similar. 4. The outflow of radioactivity was enhanced by exposure of the tissues to 60 mM K+ during 2.5 min. 5. In all three groups, the purine release induced by K+ was the same. 6. Phentolamine 3.1 microM enhanced the K+-induced release of [3H]purine compounds in control and atrophied glands but not in denervated glands. 7. Propranolol 0.3 microM produced no changes among the three experimental groups. 8. Atropine 1 microM and phentolamine 3.1 microM plus atropine 1 microM did not modify the release of tritiated purine compounds in control and denervated glands. 9. Our results cannot discriminate between neuronal or non-neuronal elements as the source of purines released by depolarization but suggest that classical pharmacological tools such as phentolamine and atropine may affect purine metabolism in a complex fashion.
General Pharmacology-the Vascular System, Sep 1, 1994
A~tract-1. The reserpine-like agent, Ro 4-1284 (2-hydroxy-2ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,... more A~tract-1. The reserpine-like agent, Ro 4-1284 (2-hydroxy-2ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-1 lb-[H]benzo (a)quinolizine) releases [3H]noradrenaline ([3H]NA) from prelabelled superior cervical ganglion (cell bodies) and nictitating membrane (nerve endings) of the cat. 2. The potency of Ro 4-1284 29.0/~M was higher in the cell bodies than in the nerve endings. 3. In both tissues, exposure to the reserpine-like agent Ro 4-1284 induced a selective increase in the spontaneous outflow of [3H]DOPEG, while the [3H]OMDA metabolites to the release induced by Ro 4-1284 was very small. 4. The desamination is the preferential way of the metabolic inactivation of the [3H]NA released by the reserpine-like agent in both parts of the noradrenergic neuron.
RESUMEN. Las drogas utilizadas para medios de contraste se han empleado rutinariamente para urogr... more RESUMEN. Las drogas utilizadas para medios de contraste se han empleado rutinariamente para urogramas excretores, Tomografía Axial Computada (TAC) y angiografía en los últimos treinta años. Si bien son drogas relativamente seguras, las reacciones adversas a medios de contraste (RAMc) ocurren y llevan muchas veces a importantes consecuencias en el paciente y en el sistema de salud. Para prevenir reacciones adversas es necesario fijar estrategias de selección de su uso basadas en el perfil del paciente. El papel del farmacéutico es desarrollar medidas de prevención y selección para el uso de contrastes radiológicos, así como la provisión y control de estos fármacos usados para diagnóstico. SUMMARY. "The Role of the Pharmacist in the Use of Radiologic Contrast Materials". Drugs employed as contrast media have been routinely used for excretory urography, CT and angiography in the last 30 years. Though they are relatively safe drugs, adverse reactions can be expected and many times led to important consequences in patients and in the health system. In order to prevent these adverse reactions, it is necessary to establish selection criteria for their use based on the patient's profile. The pharmacy's role is to the develop prevention and selection criteria in the use of radiological contrast media, as much as the provision and control of these drugs used for diagnosis.
RESUMEN. Se analizan las diferencias entre los inhibidores de la bomba de protones y de los antih... more RESUMEN. Se analizan las diferencias entre los inhibidores de la bomba de protones y de los antihistamínicos H2. Se consideraron la farmacología, la farmacocinética, sus usos en las distintas patologías gastrointestinales y la administración y dosis en el adulto, así como también las dosis pediátricas y geriátricas, los efectos adversos, contraindicaciones e interacciones de los siguientes grupos de fármacos: 1) Cimetidina, Ranitidina, Famotidina y Nizatidina y 2) Omeprazol, Lansoprazol, Pantoprazol y Rabeprazol. Además se incluye un estudio farmacoeconómico de ambos grupos de fármacos de acción gastrointestinal. SUMMARY. "Drugs used for the Control of Gastric Acidity and the Treatrnent of Peptic Ulcer". Differences between H+/K+ ATPase inhibitors and histamine H2-receptor antagonists were was analyzed, including pharmacokiiietic uses in differeiit gastrointestinal pathologies, the administration and adult dosage , as well as bdiatric aiid geriatric dosages, adverse reactions. precautions and dmg interactions of the following groups of drugs: 1) Cimetidine, Ranitidine, Famotidine and Nizatidine, and 11) Omeprazole, Lansoprazole, Pantoprazole and Rabeprazole. Additionally, a pharmaeconomic study of both groups of gastrointestinal dmgs has been included.
de 2001. Los talleres aportaron nuevos conceptos para el trabajo diario de los asistentes. El cur... more de 2001. Los talleres aportaron nuevos conceptos para el trabajo diario de los asistentes. El curso fue útil para la identificación, prevención y resolución de problemas relacionados con los medicamentos. Los temas se eligieron en base a las áreas de más consultas y donde se detectaban mayor número de errores tanto en la administración como en la prescripción. Se desarrollaron los siguientes temas: generalidades de las vías de administración y de los vasodilatadores, antibióticos, antiinflamatorios, analgésicos, antiulcerosos y farmacovigilancia. SUMMARY. "Training in Drug Administration". With the aim to resolve problems inherent to drug administration, a Course of "Drug Administration" was carried out in the University Hospital "Hospital de Clínicas José de San Martín" in November 2001. The different workshops contributed to new concepts for the daily work of the assistants. The course was useful for the identification, prevention and resolution of problems related to drugs. The topics were chosen based on the areas with the most consultations and where the major number of errors were detected both in the administration and in the prescription. The following subjects were developed: basic knowledge of the routes of administration and of vasodilators, antibiotics, anti-inflammatories, analgesics, antiulcerous and pharmacovigilance.
RESUMEN. Se presentan algunos aspectos generales relacionados a la bioquímica del vanadio y a la ... more RESUMEN. Se presentan algunos aspectos generales relacionados a la bioquímica del vanadio y a la posible esencialidad de este elemento. Luego se discuten las propiedades insulino-miméticas y antitumorales de diversos compuestos de vanadio (IV) y vanadio (V). Finalmente, se hacen algunos comentarios sobre la toxicidad de compuestos de este metal y sobre diferentes agentes quelantes utilizados como antídotos.
denominado Miranda se decidió implementar e el sistema de distribución de medicamentos por Dosis ... more denominado Miranda se decidió implementar e el sistema de distribución de medicamentos por Dosis Unitarias (SDDU), que comenzó a funcionar en el mes de Agosto de 1997. Con el fin de evaluar si existe una optimización en la utilización de los recursos al incorporar a un residente a la sala, se comparó en forma retrospectiva la demanda de medicamentos expresados como el número de unidades/pacientes/día (UPD) durante el mes inmediato anterior a la puesta en marcha del SDDU (Julio de 1997) y la demanda originada en los dos siguientes meses con el SDDU (Agosto y Septiembre). Como consecuencia de la Gestión Farmacéutica se obtuvieron reducciones en el número de unidades en los tres servicios, con respecto al mes de Junio. Los porcentajes de reducción de UPD en Agosto fueron del 14,98% en Clínica Médica Miranda, del 30,89 % en Clínica Médica Hombres y del 37,10% en Clínica Médica Mujeres. (P<0.05). En el mes de Septiembre, las reducciones en UPD fueron del 64,08%, 52,68% y 44,62%, respectivamente (P<O.01). De acuerdo a estos resultados, la presencia del residente ha optimizado el uso racional de medicamentos, mediante la significativa reducción de las unidades solicitadas por los servicios.
The levels of platelet MAO activity increase and the frequency of affective symptoms diminish in ... more The levels of platelet MAO activity increase and the frequency of affective symptoms diminish in the depressed chronic schizophrenics treated with nomifensine. 2. Nomifensine has no inhibitory effect/n vitro on platelet MAO activity in depressed schizophrenic pellets.
EFFECT OF MAO-A AND MAO-B INHIBITORS IN GANGLIA AND NERVE ENDINGS Effect of mao-A and mao-B inhib... more EFFECT OF MAO-A AND MAO-B INHIBITORS IN GANGLIA AND NERVE ENDINGS Effect of mao-A and mao-B inhibitors in ganglia and nerve endings Efecto de los inhibidores de mao-A y B en el ganglio y en los terminales nerviosos FILINGER, E. Clinical Pharmacy. Department of Pharmaceutical Technology. Faculty of Pharmacy and Biochemistry (U.B.A.).
RESUMEN. El presente artículo aborda de una manera introductoria la evolución desde la Farmacia C... more RESUMEN. El presente artículo aborda de una manera introductoria la evolución desde la Farmacia Clínica hasta la Atención Farmacéutica y su aplicación en el ámbito de la Salud Mental. Se explica el papel que el farmacéutico de oficina puede realizar a fin de mejorar la salud y calidad de vida de los pacientes con trastornos psiquiátricos en el ámbito ambulatorio. SUMMARY. "Pharmaceutical Care in Psychiatric Outpatients". This article broaches in an introductory way the evolution from the Clinical Pharmacy to the Pharmaceutical Care and their application in the mental health. It is explained the rol that the pharmacist in a community pharmacy can do with the purpose of the improvement of health and quality of life of psychiatric outpatients.
The release and metabolism of 3H-noradrenaline (3H-NA) produced by d-amphetamine was studied in t... more The release and metabolism of 3H-noradrenaline (3H-NA) produced by d-amphetamine was studied in the superior cervical ganglion of the cat (cell bodies) and in the nictitating membrane (nerve endings). Exposure of the nictitating membrane to 10 microM d-amphetamine, resulted in the release of 5.1% of the total radioactivity. This was mainly collected as 3H-normetanephrine (3H-NMN) and as 3H-NA; 3H-3,4-dihydroxyphenylglycol (3H-DOPEG) did not contribute to the drug-induced outflow of radioactivity. In contrast, exposure of ganglionic cell bodies to 10 microM d-amphetamine for 10 min released only 1.74% of the total tissue radioactivity and 3H-DOPEG represented the most important fraction of the released radioactivity. When ganglia were exposed to 30 microM d-amphetamine, the radioactivity released was 5.2%; the proportion of 3H-NA and 3H-NMN increased and 3H-DOPEG was reduced. These results show that: a) d-amphetamine releases 3H-NA from prelabeled cell bodies and nerve endings; b) the potency of d-amphetamine was higher in nerve terminals than in cell bodies, and c) at low concentrations of d-amphetamine, the metabolism of the released neurotransmitter differed between both parts of the adrenergic neuron.
Publisher Summary This chapter describes the metabolism of endogenous noradrenaline. The metaboli... more Publisher Summary This chapter describes the metabolism of endogenous noradrenaline. The metabolism of noradrenaline is carried out mainly by two enzymes, monoamine oxidase, and catechol- O -methyltransferase. Two additional enzymes are involved in either the reduction or the oxidation of the aldehyde of NA, which is formed through the activity of MAO. These enzymes include aldehyde reductase, which is a MADPH-dependent enzyme and aldehyde dehydrogenase, which is a NAD + -dependent enzyme. It is found that when transmitter release is elicited by nerve stimulation, a significant fraction of the NA released is collected as metabolites. It is found that for the nerve-muscle preparation of the cat nictitating membrane, 3 H-DOPEG is the main fraction in the overflow of 3 H transmitter elicited by nerve stimulation, accounting for approximately 40% of the total radioactivity. Under these experimental conditions, 3 H-NMN accounted for 20% of the total radioactivity released by nerve stimulation. Similar results were obtained in the perfused cat spleen. Under conditions of release elicited by nerve stimulation, the HDOPEG formed results from neuronal re-uptake of the released transmitter and subsequent presynaptic metabolism by MAO and aldehyde reductase.
The two forms of MAO, A and B, are present in the nictitating membrane and superior cervical gang... more The two forms of MAO, A and B, are present in the nictitating membrane and superior cervical ganglion of the cat. 2. The KM for the substrate tyramine differed between both tissues, the affinity of the ganglionar enzyme was almost three times lower than that of the nictitating membrane. 3. The potency of clorgyline to inhibit the form A of MAO, using tyramine as substrate, was lower in ganglia than in the nictitating membrane. 4. Sympathetic denervation decreased type A to a greater extent than type B in the nictitating membrane. 5. In superior cervical ganglion, clorgyline was a more potent inhibitor of noradrenaline metabolism than in the nictitating membrane.
1. Normal, atrophied and denervated submaxillary glands were incubated with [3H]adenine for 1 h. ... more 1. Normal, atrophied and denervated submaxillary glands were incubated with [3H]adenine for 1 h. The accumulation of [3H]adenine, expressed as microCi/g tissue, did not differ significantly when the sympathetically denervated glands were compared with the control group. The radioactivity retained in both control and denervated tissues was also similar. 2. In atrophied glands 3H-accumulation as well as 3H-retention were 2-fold higher than these obtained in controls per unit weight, but 30% lower when expressed per gland. 3. The spontaneous efflux of radioactivity, expressed as fractional release, from normal, atrophied and denervated glands prelabelled with [3H]adenine was similar. 4. The outflow of radioactivity was enhanced by exposure of the tissues to 60 mM K+ during 2.5 min. 5. In all three groups, the purine release induced by K+ was the same. 6. Phentolamine 3.1 microM enhanced the K+-induced release of [3H]purine compounds in control and atrophied glands but not in denervated glands. 7. Propranolol 0.3 microM produced no changes among the three experimental groups. 8. Atropine 1 microM and phentolamine 3.1 microM plus atropine 1 microM did not modify the release of tritiated purine compounds in control and denervated glands. 9. Our results cannot discriminate between neuronal or non-neuronal elements as the source of purines released by depolarization but suggest that classical pharmacological tools such as phentolamine and atropine may affect purine metabolism in a complex fashion.
General Pharmacology-the Vascular System, Sep 1, 1994
A~tract-1. The reserpine-like agent, Ro 4-1284 (2-hydroxy-2ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,... more A~tract-1. The reserpine-like agent, Ro 4-1284 (2-hydroxy-2ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-1 lb-[H]benzo (a)quinolizine) releases [3H]noradrenaline ([3H]NA) from prelabelled superior cervical ganglion (cell bodies) and nictitating membrane (nerve endings) of the cat. 2. The potency of Ro 4-1284 29.0/~M was higher in the cell bodies than in the nerve endings. 3. In both tissues, exposure to the reserpine-like agent Ro 4-1284 induced a selective increase in the spontaneous outflow of [3H]DOPEG, while the [3H]OMDA metabolites to the release induced by Ro 4-1284 was very small. 4. The desamination is the preferential way of the metabolic inactivation of the [3H]NA released by the reserpine-like agent in both parts of the noradrenergic neuron.
RESUMEN. Las drogas utilizadas para medios de contraste se han empleado rutinariamente para urogr... more RESUMEN. Las drogas utilizadas para medios de contraste se han empleado rutinariamente para urogramas excretores, Tomografía Axial Computada (TAC) y angiografía en los últimos treinta años. Si bien son drogas relativamente seguras, las reacciones adversas a medios de contraste (RAMc) ocurren y llevan muchas veces a importantes consecuencias en el paciente y en el sistema de salud. Para prevenir reacciones adversas es necesario fijar estrategias de selección de su uso basadas en el perfil del paciente. El papel del farmacéutico es desarrollar medidas de prevención y selección para el uso de contrastes radiológicos, así como la provisión y control de estos fármacos usados para diagnóstico. SUMMARY. "The Role of the Pharmacist in the Use of Radiologic Contrast Materials". Drugs employed as contrast media have been routinely used for excretory urography, CT and angiography in the last 30 years. Though they are relatively safe drugs, adverse reactions can be expected and many times led to important consequences in patients and in the health system. In order to prevent these adverse reactions, it is necessary to establish selection criteria for their use based on the patient's profile. The pharmacy's role is to the develop prevention and selection criteria in the use of radiological contrast media, as much as the provision and control of these drugs used for diagnosis.
RESUMEN. Se analizan las diferencias entre los inhibidores de la bomba de protones y de los antih... more RESUMEN. Se analizan las diferencias entre los inhibidores de la bomba de protones y de los antihistamínicos H2. Se consideraron la farmacología, la farmacocinética, sus usos en las distintas patologías gastrointestinales y la administración y dosis en el adulto, así como también las dosis pediátricas y geriátricas, los efectos adversos, contraindicaciones e interacciones de los siguientes grupos de fármacos: 1) Cimetidina, Ranitidina, Famotidina y Nizatidina y 2) Omeprazol, Lansoprazol, Pantoprazol y Rabeprazol. Además se incluye un estudio farmacoeconómico de ambos grupos de fármacos de acción gastrointestinal. SUMMARY. "Drugs used for the Control of Gastric Acidity and the Treatrnent of Peptic Ulcer". Differences between H+/K+ ATPase inhibitors and histamine H2-receptor antagonists were was analyzed, including pharmacokiiietic uses in differeiit gastrointestinal pathologies, the administration and adult dosage , as well as bdiatric aiid geriatric dosages, adverse reactions. precautions and dmg interactions of the following groups of drugs: 1) Cimetidine, Ranitidine, Famotidine and Nizatidine, and 11) Omeprazole, Lansoprazole, Pantoprazole and Rabeprazole. Additionally, a pharmaeconomic study of both groups of gastrointestinal dmgs has been included.
de 2001. Los talleres aportaron nuevos conceptos para el trabajo diario de los asistentes. El cur... more de 2001. Los talleres aportaron nuevos conceptos para el trabajo diario de los asistentes. El curso fue útil para la identificación, prevención y resolución de problemas relacionados con los medicamentos. Los temas se eligieron en base a las áreas de más consultas y donde se detectaban mayor número de errores tanto en la administración como en la prescripción. Se desarrollaron los siguientes temas: generalidades de las vías de administración y de los vasodilatadores, antibióticos, antiinflamatorios, analgésicos, antiulcerosos y farmacovigilancia. SUMMARY. "Training in Drug Administration". With the aim to resolve problems inherent to drug administration, a Course of "Drug Administration" was carried out in the University Hospital "Hospital de Clínicas José de San Martín" in November 2001. The different workshops contributed to new concepts for the daily work of the assistants. The course was useful for the identification, prevention and resolution of problems related to drugs. The topics were chosen based on the areas with the most consultations and where the major number of errors were detected both in the administration and in the prescription. The following subjects were developed: basic knowledge of the routes of administration and of vasodilators, antibiotics, anti-inflammatories, analgesics, antiulcerous and pharmacovigilance.
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