Papers by Ernst Rietschel
HNO-Nachrichten, Feb 1, 2021
Wie führt man die SARS-CoV-2-Impfungen mit möglichst minimalem Risiko für allergische Reak tionen... more Wie führt man die SARS-CoV-2-Impfungen mit möglichst minimalem Risiko für allergische Reak tionen durch? Tatsächlich können die aktuellen mRNA-Impfstoffe selbst bei Allergikern meist ohne Weiteres verabreicht werden. Der folgende Beitrag legt dar, wann ein erhöhtes Risiko für schwere Anaphylaxien besteht und gibt praktische Tipps für die sichere Durchführung der Impfung.
Mmw-fortschritte Der Medizin, 2021
Wie führt man die SARS-CoV-2-Impfungen mit möglichst minimalem Risiko für allergische Reaktionen ... more Wie führt man die SARS-CoV-2-Impfungen mit möglichst minimalem Risiko für allergische Reaktionen durch? Tatsächlich können die aktuellen mRNA-Impfstoffe selbst bei Allergikern meist ohne Weiteres verabreicht werden. Der folgende Beitrag legt dar, wann ein erhöhtes Risiko für schwere Anaphylaxien besteht und gibt praktische Tipps für die sichere Durchführung der Impfung. Univ.-Prof. Dr. med. Margitta Worm Allergologie und Immunologie, Klinik für Dermatologie und Allergologie, Charité-Universitätsmedizin Berlin © Ridofranz / Getty Images / iStock (Symbolbild mit Fotomodellen) Alle impfende Personen sollten anaphylaktische Reak tionen erkennen und managen können.
Allergo journal international, Nov 20, 2020
European Respiratory Journal
BackgroundComprehensive studies investigated the role of T-cells in asthma which led to personali... more BackgroundComprehensive studies investigated the role of T-cells in asthma which led to personalised treatment options targeting severe eosinophilic asthma. However, little is known about the contribution of B-cells to this chronic inflammatory disease. In this study we investigated the contribution of various B-cell populations to specific clinical features in asthma.MethodsIn the All Age Asthma Cohort (ALLIANCE), a subgroup of 154 adult asthma patients and 28 healthy controls were included for B-cell characterisation by flow cytometry. Questionnaires, lung function measurements, blood differential counts and allergy testing of participants were analysed together with comprehensive data on B-cells using association studies and multivariate linear models.ResultsPatients with severe asthma showed decreased immature B-cell populations while memory B-cells were significantly increased compared with both mild–moderate asthma patients and healthy controls. Furthermore, increased frequenc...
BMC Pulmonary Medicine
Background Transforming Growth Factor-β1 (TGF-β1) is a genetic modifier in patients with cystic f... more Background Transforming Growth Factor-β1 (TGF-β1) is a genetic modifier in patients with cystic fibrosis (CF). Several single nucleotide polymorphisms (SNPs) of TGF-β1 are associated with neutrophilic inflammation, lung fibrosis and loss of pulmonary function. Aim The aim of this study was to assess the relationship between genetic TGF-β1 polymorphisms and pulmonary disease progression in CF patients. Furthermore, the effect of TGF-β1 polymorphisms on inflammatory cytokines in sputum was investigated. Methods 56 CF-patients and 62 controls were genotyped for three relevant SNPs in their TGF-β1 sequence using the SNaPshot® technique. Individual “slopes” in forced expiratory volume in 1 s (FEV1) for all patients were calculated by using documented lung function values of the previous five years. The status of Pseudomonas aeruginosa (Pa) infection was determined. Sputum concentrations of the protease elastase, the serine protease inhibitor elafin and the cytokines IL-1β, IL-8, IL-6, TN...
Allergo Journal, 2021
Johannes Ring1, KiRsten BeyeR2, andReas BiRcheR3, tilo BiedeRmann1, matthias FischeR4, thomas Fuc... more Johannes Ring1, KiRsten BeyeR2, andReas BiRcheR3, tilo BiedeRmann1, matthias FischeR4, thomas Fuchs5, axel R. helleR6, FloRian hoFFmann7, isidoR hutteggeR8, thilo JaKoB9, ludgeR KlimeK10, matthias V. Kopp11, claudia KugleR1, laRs lange12, oliVeR pFaaR13, eRnst Rietschel14, FRanzisKa RuëFF15, saBine schnadt16, Roland seiFeRt17, BRitta stöcKeR18, Regina tReudleR19, chRistian VogelBeRg20, thomas WeRFel21, maRgitta WoRm22, helmut sitteR23, Knut BRocKoW1
Repetitorium Kinder- und Jugendmedizin, 2019
Allergologie, 2009
The further increase of allergies in industrialised countries demands evidence-based measures of ... more The further increase of allergies in industrialised countries demands evidence-based measures of primary prevention. The recommendations as published in the Guideline of 2004 were updated and consented on the basis of a systematic literature search. Evidence was searched for the period February 2003 -May 2008 in the electronic databases Cochrane and MEDLINE as well as in reference lists of recent reviews and by contacting experts. The retrieved citations were screened for relevance first by title and abstract in a second step as full paper. Levels of evidence were assigned to each included study and the methodological quality of the studies was assessed as high or low. Finally, the revised recommendations were formally consented (nominal group process) by representatives of relevant societies and organisations including a self-help group. Of originally 4.556 hits, 217 studies (4 Cochrane Reviews, 14 Metaanalyses, 19 RCTs, 115 cohort- and 35 case-control studies) were included and cr...
Pneumologie, 2018
ZusammenfassungMukoviszidose (Cystic Fibrosis, CF) ist die häufigste, autosomal-rezessiv vererbte... more ZusammenfassungMukoviszidose (Cystic Fibrosis, CF) ist die häufigste, autosomal-rezessiv vererbte Multisystemerkrankung. In Deutschland sind ca. 8000 Menschen betroffen. Die Erkrankung wird durch Mutationen im Cystic Fibrosis Transmembrane Conductance Regulator (CFTR-) Gen verursacht; diese führen zu einer Fehlfunktion des Chloridkanals CFTR. Dadurch kommt es in den Atemwegen zu einer unzureichenden Hydrierung des epithelialen Flüssigkeitsfilms und somit zu einer chronischen Inflammation. Rezidivierende Infektionen der Atemwege sowie pulmonale Exazerbationen der Lunge führen im Verlauf zu zunehmender Inflammation, pulmonaler Fibrose und fortschreitender Lungendestruktion bis hin zur respiratorischen Globalinsuffizienz, die für über 90 % der Mortalität verantwortlich ist. Das Ziel der medikamentösen Therapie ist die pulmonale Inflammation und v. a. die Infektion der Atemwege zu reduzieren. Der Kolonisation und chronischen Infektion mit Pseudomonas aeruginosa (Pa) kommt die größte Bed...
Allergologie select, 2017
Clinical and Translational Allergy, 2016
Introduction: Bullous lesions are common skin lesions particularly in childhood. Drug reactions, ... more Introduction: Bullous lesions are common skin lesions particularly in childhood. Drug reactions, burns, insect bites, mosquito bites, skin diseases, autoimmune bullous dermatoses and bacterial infections are the most common etiologies. Herein, we report two children who have solitary mastocytoma presented with variable bullous lesions. Case 1: A 3-year old boy admitted to our outpatient department suffering from red, periodically vesicular and bullous lesions on his back of neck since birth. His medical history revealed that he had four attacks characterized by flushing, perioral paleness, and hypotension. The lesion became swollen and itchy when it was rubbed vigorously (positive Darier's sign). Physical examination revealed a bullous lesion (2 × 3 cm) in his dorsal neck region. Laboratory investigations including CBC, liver and kidney function tests and serum electrolytes were within normal limits. Histopathologic examination of a punch biopsy specimen revealed solitary mastocytoma and the patient is under regular antihistamine treatment. Case 2: A 3-month old boy admitted with complaints of oval, erythematous and periodically changing bullous lesions in his proximal of right ankle since birth. His medical history revealed that the lesion became bullous and itchy when his mother rubbed it vigorously. Physical examination revealed a bullous lesion (1 × 1 cm) in his left foot. Laboratory investigations for possible etiologic factors were within normal limits. Histopathologic examination of a punch biopsy specimen revealed solitary mastocytoma. The patient is uneventfully under regular follow up. Conclusion: Solitary mastocytomas should be considered in the differential diagnosis of periodically varying bullous reactions in children. Consent to publish Written informed consent for publication of this clinical details and/or clinical images was obtained from the patient/parent/guardian/relative of the patient. A copy of the consent form is available for review by the Editor of this journal.
Journal of Antimicrobial Chemotherapy, 2015
We evaluated the pharmacokinetics, safety and tolerability of two different continuous treatment ... more We evaluated the pharmacokinetics, safety and tolerability of two different continuous treatment regimens of tobramycin inhalation solution (TIS) in 29 cystic fibrosis (CF) patients chronically infected with Pseudomonas aeruginosa. Patients and methods: In this randomized, multicentre, open-label, two-period crossover study, TIS (300 mg/5 mL) was administered via PARI eFlow w rapid once daily and twice daily each for 8 weeks. Serum pharmacokinetics of these two regimens was analysed. Tobramycin levels were determined before the morning dose and at 30, 60 and 90 min after the end of nebulization in the middle and at the end of each 8 week cycle. At these timepoints, trough and peak serum tobramycin concentrations (C max , mg/L) as well as the area under the curve for 0-90 min of tobramycin (AUC 0-90min) were assessed in order to evaluate the risk of systemic toxicity. Safety parameters and forced expiratory volume in 1 s (FEV 1) were assessed. Results: For once-daily treatment, tobramycin levels were 10% higher after 8 weeks compared with 4 weeks (AUC 0-90min ratio ¼ 1.096, 90% CI ¼ 0.860-1.396, P ¼ 0.5237). For twice-daily treatment, tobramycin levels after 8 weeks showed a 40% decrease compared with 4 weeks (AUC 0-90min ratio ¼ 0.608, 90% CI ¼ 0.461-0.802, P ¼ 0.0055). The AUC 0-90min ratio at 8 weeks (once daily versus twice daily) did not differ significantly (AUC 0-90min ratio¼0.749, 90% CI¼0.514-1.092, P¼0.2009). The mean FEV 1 did not differ markedly compared between treatment periods or with baseline. No audiological or nephrotoxic side effects were noted.
European Respiratory Journal, Sep 1, 2012
Body: Background: Common single nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) are... more Body: Background: Common single nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) are associated with asthma and atopy, but very little is known about the relevance of SNPs in TLR regulatory and downstream signaling pathway molecules. Objective: To systematically analyze the association between SNPs in TLR signaling pathway genes and childhood asthma and atopy. Methods: Common SNPs present in TLR signaling pathway were retrieved from HapMap database and LD analyses were performed to determine tagging SNPs. Association of 375 tagging SNPs with asthma were analysed in a genome wide association (GWA) dataset consisting of 651 asthmatics and 652 controls. SNPs were genotyped by
European Respiratory Journal, Sep 1, 2012
Body: Introduction: Asthma affects boys at a 2:1 ratio during childhood while females are affecte... more Body: Introduction: Asthma affects boys at a 2:1 ratio during childhood while females are affected by asthma twice as often compared to males after puberty. Aims and objectives: This study investigates if and how genetic factors contribute to gender differences in asthma susceptibility. Methods: A GWAS dataset based on the MAGICS/ISAAC II study population (651 cases; 652 controls; 57% males; mean [± SD] age
European Respiratory Journal, Sep 1, 2012
Body: Background: Recently, three genome wide association studies (GWAS) demonstrated FCER1A, the... more Body: Background: Recently, three genome wide association studies (GWAS) demonstrated FCER1A, the gene encoding the α-subunit of the high-affinity IgE receptor, to be a major susceptibility locus for total serum IgE. The top association signal differed between the two studies from the general population and one study based on an asthma case-control design. Objective: To investigate if different FCER1A single-nucleotide polymorphisms (SNPs) are associated with total serum IgE in the general population and asthmatics. Methods: Nineteen SNPs were studied in FCER1A based on a detailed literature search and a tagging approach. SNPs were genotyped by the Illumina HumanHap300Chip (6) or MALDI-TOF-MS (13) in at least 1303 children (651 asthmatics) derived from the German ISAAC-and MAGIC studies. Results: Similarly to two population-based GWAS the peak association with total serum IgE was observed for SNPs rs2427837, rs2251746 and rs2511211 (mean r 2 >0.8), with the lowest p-value of 4.37*10-6. The same 3 SNPs showed the strongest association in non-asthmatics (lowest p=0.0003). While these SNPs were also associated with total serum IgE in asthmatics (lowest p=0.003), additional SNPs (rs3845625, rs7522607 and rs2427829) demonstrated associations with total serum IgE in asthmatics only (lowest p=0.01). SNPs rs2427837, rs2511211, rs3845625 and rs2427829 were also associated with atopic asthma (lowest p=0.02). Conclusions: These data suggest that SNPs in FCER1A specifically influence IgE levels in asthmatics on top of genetic determinants of "basal" IgE levels also present in FCER1A as previously identified by GWAS. Thus, FCER1A variants and IgE-related mechanisms could be involved in specific asthma phenotypes. These authors contributed equally.
Allergy, 2015
Structured educational programmes for patients at risk for anaphylaxis have not yet been establis... more Structured educational programmes for patients at risk for anaphylaxis have not yet been established. Patients and caregivers often lack adequate skills in managing the disease. To investigate effects of structured patient education intervention on knowledge, emergency management skills and psychological parameters in patients with previous episodes of anaphylaxis and caregivers of affected children 95 caregivers (11 male, 84 female, mean age 37 years) of affected children and 98 patients (32 male, 66 female, mean age 47.5 years) were randomly assigned to an intervention (IG) or control group (CG) in a multicentre randomized controlled trial. The IG received two 3-h schooling modules of group education; the CG received standard auto-injector training only. Knowledge of anaphylaxis and emergency management competence in a validated training anaphylaxis situation as main outcome measures as well as secondary psychological parameters were assessed at baseline and 3 months after interve...
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Papers by Ernst Rietschel