Metachromatic leukodystrophy (MLD) is an autosomal recessive degenerative disorder of myelin meta... more Metachromatic leukodystrophy (MLD) is an autosomal recessive degenerative disorder of myelin metabolism. We report three cases of children diagnosed with MLD within a 15-month period. A 2-year-old girl, a 5-yearold boy, and an 11-year-old girl were diagnosed with MLD based on history, physical, examination, electrophysiology studies, biochemical analysis, and imaging studies. In spite of their varied ages and clinical presentations, the salient features of the MRI studies were remarkably similar.
A new pseudotumorouslesion found in the adrenal cortex of six infants with Beckwith- Wiedemann sy... more A new pseudotumorouslesion found in the adrenal cortex of six infants with Beckwith- Wiedemann syndrome is described. These cystic masses were discovered either pre- natally by using sonography or early in the neonatal period as palpable flank masses. Imaging studies, including sonography and CT, could not confidently exclude malig- nancy. After the masses were removed surgically, histologic examination showed them
Medulloblastomas are malignant neoplasms composed of undifferentiated, small, round cells with hi... more Medulloblastomas are malignant neoplasms composed of undifferentiated, small, round cells with high nuclear-to-cytoplasmic ratio. These tumors account for 30±40 % of posterior fossa tumors in children. We present a case of medulloblastoma with increased signal intensity on diffusion-weighted echoplanar MRI. We theorize that the densely cellular nature of medulloblastoma and the high nuclear-to-cytoplasmic ratio of this tumor restrict diffusion of water, causing increased signal on diffusion-weighted MRI.
Objective: To identify maternal beliefs and practices about child feeding that are associated wit... more Objective: To identify maternal beliefs and practices about child feeding that are associated with the development of childhood obesity.
A 10-yr-old boy presented with fulminant hepatic failure. Technetium-99m sulfur colloid images sh... more A 10-yr-old boy presented with fulminant hepatic failure. Technetium-99m sulfur colloid images showed absent reticuloendothelial function in the liver. A [99mTc]-disofenin hepatobiliary scan visualized liver parenchyma and biliary excretion. Disparate appearance of the liver may be seen in other hepatic diseases, but should be remembered as a possible pattern in Wilson's disease.
When a cystic structure in the posterior fossa increases in size, the accompanying increase in pr... more When a cystic structure in the posterior fossa increases in size, the accompanying increase in pressure may cause it to herniate upward through the tentorial hiatus. In our experience this happens most commonly with a dilated trapped fourth ventricle secondary to infection or intraventricular hemorrhage. However, herniation of an arachnoid cyst or a Dandy-Walker malformation through the tentorium may also occur. When herniation occurs, the cystic structure assumes a "keyhole" configuration, indicating that it is trapped and that surgical intervention is necessary. Five cases are presented that illustrate this point, including two patients with dilatation of the fourth ventricle secondary to hemorrhage, two patients with Dandy-Walker malformation, and one patient with an arachnoid cyst.
The authors explain the basic principles of this exciting new modality and focus on the special c... more The authors explain the basic principles of this exciting new modality and focus on the special considerations of its use in children, its clinical applications, digital subtraction and radiation exposure, and digital fluorography and radiography.
In view of the continuing technologic advancements in the development and availability of diagnos... more In view of the continuing technologic advancements in the development and availability of diagnostic imaging modalities, it is appropriate to assess periodically the currently accepted approaches to the evaluation of renal masses in children. The roles, advantages, and disadvantages of plain film, intravenous urography, ultrasonography, radionuclide scintigraphy, computed tomography, angiography, and magnetic resonance imaging in the approach to the evaluation of renal masses in children are discussed. An integrated imaging approach that provides the most accurate and necessary information for diagnosis and treatment is recommended.
The use of CT in the pediatric age group has been steadily increasing since the introduction of t... more The use of CT in the pediatric age group has been steadily increasing since the introduction of the newer generations of scanners with improved resolution and faster scan times. Though the clinical impact of CT of the chest has been less dramatic than that of the head and abdomen, the role of CT is rapidly evolving. CT of the chest has proven to be of great value in the evaluation of the mediastinum and in the detection of metastatic disease. The role of CT of the chest is expanding and further applications are to be expected.
Journal of The American Academy of Dermatology, 1989
Multicentric reticulohistiocytosis affecting a 13-year-old boy induced a sclerosing change of the... more Multicentric reticulohistiocytosis affecting a 13-year-old boy induced a sclerosing change of the leg. The cellular infiltrate comprising activated T lymphocytes and macrophages and human lymphocyte antigen (HLA)-DR expression by keratinocytes in lesional skin all suggest the involvement of cellular immune reactions. We administered systemic cyclosporine but could not obtain a favorable effect without a concomitant low dosage of prednisone.
A 12-year-old boy presented with the classic CT and MRI findings of medulloblastoma and the unusu... more A 12-year-old boy presented with the classic CT and MRI findings of medulloblastoma and the unusual finding of increased signal on diffusion MRI. The small-cell histology of medulloblastoma may account for the increased signal seen on diffusion MRI. Diffusion MRI with echoplanar technique may be useful in evaluation of these tumors and metastatic disease.
Thirty-five consecutive patients with the clinical diagnosis of fenestral otosclerosis were evalu... more Thirty-five consecutive patients with the clinical diagnosis of fenestral otosclerosis were evaluated with high-resolution computed tomography (CT). Twenty-six were diagnosed as having this disorder by CT evidence of abnormal bony excrescences at or adjacent to the oval window. The diagnosis was made upon examination of 1.5-mm-thick targeted sections obtained at 0.5-mm intervals in the axial projection. Coronal sections were also included. Sections were also evaluated for evidence of plaque formation elsewhere in the lateral wall of the labyrinth and for surgical obstacles such as an abnormally wide cochlear aqueduct, a high jugular vein, and a dehiscent facial nerve. It is concluded that fenestral otosclerosis may be accurately diagnosed with proper CT techniques.
Computed tomography (CT) was used to study 25 patients with congenital conductive hearing loss an... more Computed tomography (CT) was used to study 25 patients with congenital conductive hearing loss and normal external auditory canals. Deformities were subdivided according to ossicular, fenestral, and cholesteatomatous origin. Isolated ossicular deformities were found in 14 patients (five bilateral), cholesteatoma in eight, oval-window nondevelopment (with ossicular deformity) in one, and normal studies in two (congenital stapes fixation at the level of the annular ligament). Ossicular deformities may be subdivided into incudostapedial disconnections into incudostapedial disconnections (most common), malleoincudal fixations, and stapes fixations. Most are due to developmental anomaly of the first or second branchial arch. The stapes has a dual origin (second arch and otic capsule). A cholesteatoma is defined as congenital only if there is no history of otitis and the tympanic membrane is intact. In this series, six were in the middle ear proper, and two were within the attic beyond otoscopic view. Their CT appearance, with one exception, was essentially identical to that of acquired lesions.
While conventional angiography has been used to demonstrate cerebrovascular occlusive disease in ... more While conventional angiography has been used to demonstrate cerebrovascular occlusive disease in the past, digital subtraction angiography (DSA) is capable of showing progressive vascular involvement with ease, simplicity, and extremely low morbidity, making it particularly well suited for children and outpatients either alone or coordinated with computed tomography. The authors discuss the usefulness and advantages of DSA as demonstrated in 7 infants and children with hemiplegia, 4 of whom had sickle-cell disease.
Metachromatic leukodystrophy (MLD) is an autosomal recessive degenerative disorder of myelin meta... more Metachromatic leukodystrophy (MLD) is an autosomal recessive degenerative disorder of myelin metabolism. We report three cases of children diagnosed with MLD within a 15-month period. A 2-year-old girl, a 5-yearold boy, and an 11-year-old girl were diagnosed with MLD based on history, physical, examination, electrophysiology studies, biochemical analysis, and imaging studies. In spite of their varied ages and clinical presentations, the salient features of the MRI studies were remarkably similar.
A new pseudotumorouslesion found in the adrenal cortex of six infants with Beckwith- Wiedemann sy... more A new pseudotumorouslesion found in the adrenal cortex of six infants with Beckwith- Wiedemann syndrome is described. These cystic masses were discovered either pre- natally by using sonography or early in the neonatal period as palpable flank masses. Imaging studies, including sonography and CT, could not confidently exclude malig- nancy. After the masses were removed surgically, histologic examination showed them
Medulloblastomas are malignant neoplasms composed of undifferentiated, small, round cells with hi... more Medulloblastomas are malignant neoplasms composed of undifferentiated, small, round cells with high nuclear-to-cytoplasmic ratio. These tumors account for 30±40 % of posterior fossa tumors in children. We present a case of medulloblastoma with increased signal intensity on diffusion-weighted echoplanar MRI. We theorize that the densely cellular nature of medulloblastoma and the high nuclear-to-cytoplasmic ratio of this tumor restrict diffusion of water, causing increased signal on diffusion-weighted MRI.
Objective: To identify maternal beliefs and practices about child feeding that are associated wit... more Objective: To identify maternal beliefs and practices about child feeding that are associated with the development of childhood obesity.
A 10-yr-old boy presented with fulminant hepatic failure. Technetium-99m sulfur colloid images sh... more A 10-yr-old boy presented with fulminant hepatic failure. Technetium-99m sulfur colloid images showed absent reticuloendothelial function in the liver. A [99mTc]-disofenin hepatobiliary scan visualized liver parenchyma and biliary excretion. Disparate appearance of the liver may be seen in other hepatic diseases, but should be remembered as a possible pattern in Wilson's disease.
When a cystic structure in the posterior fossa increases in size, the accompanying increase in pr... more When a cystic structure in the posterior fossa increases in size, the accompanying increase in pressure may cause it to herniate upward through the tentorial hiatus. In our experience this happens most commonly with a dilated trapped fourth ventricle secondary to infection or intraventricular hemorrhage. However, herniation of an arachnoid cyst or a Dandy-Walker malformation through the tentorium may also occur. When herniation occurs, the cystic structure assumes a "keyhole" configuration, indicating that it is trapped and that surgical intervention is necessary. Five cases are presented that illustrate this point, including two patients with dilatation of the fourth ventricle secondary to hemorrhage, two patients with Dandy-Walker malformation, and one patient with an arachnoid cyst.
The authors explain the basic principles of this exciting new modality and focus on the special c... more The authors explain the basic principles of this exciting new modality and focus on the special considerations of its use in children, its clinical applications, digital subtraction and radiation exposure, and digital fluorography and radiography.
In view of the continuing technologic advancements in the development and availability of diagnos... more In view of the continuing technologic advancements in the development and availability of diagnostic imaging modalities, it is appropriate to assess periodically the currently accepted approaches to the evaluation of renal masses in children. The roles, advantages, and disadvantages of plain film, intravenous urography, ultrasonography, radionuclide scintigraphy, computed tomography, angiography, and magnetic resonance imaging in the approach to the evaluation of renal masses in children are discussed. An integrated imaging approach that provides the most accurate and necessary information for diagnosis and treatment is recommended.
The use of CT in the pediatric age group has been steadily increasing since the introduction of t... more The use of CT in the pediatric age group has been steadily increasing since the introduction of the newer generations of scanners with improved resolution and faster scan times. Though the clinical impact of CT of the chest has been less dramatic than that of the head and abdomen, the role of CT is rapidly evolving. CT of the chest has proven to be of great value in the evaluation of the mediastinum and in the detection of metastatic disease. The role of CT of the chest is expanding and further applications are to be expected.
Journal of The American Academy of Dermatology, 1989
Multicentric reticulohistiocytosis affecting a 13-year-old boy induced a sclerosing change of the... more Multicentric reticulohistiocytosis affecting a 13-year-old boy induced a sclerosing change of the leg. The cellular infiltrate comprising activated T lymphocytes and macrophages and human lymphocyte antigen (HLA)-DR expression by keratinocytes in lesional skin all suggest the involvement of cellular immune reactions. We administered systemic cyclosporine but could not obtain a favorable effect without a concomitant low dosage of prednisone.
A 12-year-old boy presented with the classic CT and MRI findings of medulloblastoma and the unusu... more A 12-year-old boy presented with the classic CT and MRI findings of medulloblastoma and the unusual finding of increased signal on diffusion MRI. The small-cell histology of medulloblastoma may account for the increased signal seen on diffusion MRI. Diffusion MRI with echoplanar technique may be useful in evaluation of these tumors and metastatic disease.
Thirty-five consecutive patients with the clinical diagnosis of fenestral otosclerosis were evalu... more Thirty-five consecutive patients with the clinical diagnosis of fenestral otosclerosis were evaluated with high-resolution computed tomography (CT). Twenty-six were diagnosed as having this disorder by CT evidence of abnormal bony excrescences at or adjacent to the oval window. The diagnosis was made upon examination of 1.5-mm-thick targeted sections obtained at 0.5-mm intervals in the axial projection. Coronal sections were also included. Sections were also evaluated for evidence of plaque formation elsewhere in the lateral wall of the labyrinth and for surgical obstacles such as an abnormally wide cochlear aqueduct, a high jugular vein, and a dehiscent facial nerve. It is concluded that fenestral otosclerosis may be accurately diagnosed with proper CT techniques.
Computed tomography (CT) was used to study 25 patients with congenital conductive hearing loss an... more Computed tomography (CT) was used to study 25 patients with congenital conductive hearing loss and normal external auditory canals. Deformities were subdivided according to ossicular, fenestral, and cholesteatomatous origin. Isolated ossicular deformities were found in 14 patients (five bilateral), cholesteatoma in eight, oval-window nondevelopment (with ossicular deformity) in one, and normal studies in two (congenital stapes fixation at the level of the annular ligament). Ossicular deformities may be subdivided into incudostapedial disconnections into incudostapedial disconnections (most common), malleoincudal fixations, and stapes fixations. Most are due to developmental anomaly of the first or second branchial arch. The stapes has a dual origin (second arch and otic capsule). A cholesteatoma is defined as congenital only if there is no history of otitis and the tympanic membrane is intact. In this series, six were in the middle ear proper, and two were within the attic beyond otoscopic view. Their CT appearance, with one exception, was essentially identical to that of acquired lesions.
While conventional angiography has been used to demonstrate cerebrovascular occlusive disease in ... more While conventional angiography has been used to demonstrate cerebrovascular occlusive disease in the past, digital subtraction angiography (DSA) is capable of showing progressive vascular involvement with ease, simplicity, and extremely low morbidity, making it particularly well suited for children and outpatients either alone or coordinated with computed tomography. The authors discuss the usefulness and advantages of DSA as demonstrated in 7 infants and children with hemiplegia, 4 of whom had sickle-cell disease.
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Papers by Eric Faerber