Papers by Enrique López-Torres
Clínica e Investigación en Ginecología y Obstetricia, Jun 1, 2007
Clínica e Investigación en Ginecología y Obstetricia, 2002
Clínica e Investigación en Ginecología y Obstetricia, Jun 1, 2007
Clínica e Investigación en Ginecología y Obstetricia, Feb 1, 2007
Clínica e Investigación en Ginecología y Obstetricia, Aug 1, 2007
Gastroenterología y Hepatología, 2002
ABSTRACT
World Journal of Gastroenterology, 2006
Clínica e Investigación en Ginecología y Obstetricia, 2003
Clínica e Investigación en Ginecología y Obstetricia, 2003
Summary In this article we talk about Sjogren syndrome, an autoimmune disease of unknown aetiolog... more Summary In this article we talk about Sjogren syndrome, an autoimmune disease of unknown aetiology, which has a diverse clinical presentation with no specific treatment, only symptomatic. We present the case of a pregnant woman with this disease diagnosed in childhood. She had a pregnancy that progressed without important complications, and the pre-existing clinical state was not exacerbated by pregnancy. The disease did not influence the development of the pregnancy.
Clínica e Investigación en Ginecología y Obstetricia, 2002
The Pharmacogenomics Journal, 2012
Journal of Hepatology, 2004
Han sido ampliamente estudiadas los beneficios terapeuticos del aceite de oliva (disminucion en l... more Han sido ampliamente estudiadas los beneficios terapeuticos del aceite de oliva (disminucion en la oxidacion de las LDL-colesterol, aumento de la HDL-colesterol y su relacion positiva con la enfermedad vascular). Algunos de los principales compuestos de este aceite son los compuestos fenolicos, entre los que se destaca el hidroxitirosol por su gran potencia antioxidante y por su posible empleo como neuroprotector. Una de las caracteristicas del mismo esta en su polaridad que condiciona su baja solubilidad en lipidos y por tanto su baja concentracion en el aceite de oliva. El presente trabajo evalua desde un punto de vista farmacologico las propiedades antixoidantes en un modelo experimental de anoxia-reoxigenacon, explorando las principales vias bioquimicas relacionadas con el dano tisular isquemico a nivel cerebral, del hidroxitirosol (HT), y dos de sus esteres, que aumentarian su liposolubilidad; acetato y oleato de hidroxitirosilo. Para ello se emplearon 10 grupos de 8 ratas mach...
Mujer de 70 años sin alergias medicamentosas conocidas, hipertensa de larga evolución y con síndr... more Mujer de 70 años sin alergias medicamentosas conocidas, hipertensa de larga evolución y con síndrome ansioso-depresivo, que desde hacía años recibía tratamiento con enalapril para control de su presión arterial y zolpidem por problemas de insomnio.
Medicina clínica, Jan 10, 2003
Drug Metabolism and Drug Interactions, 2014
Drug-induced liver enzyme abnormalities may indicate hepatic injury. Antipsychotic drugs also may... more Drug-induced liver enzyme abnormalities may indicate hepatic injury. Antipsychotic drugs also may cause increase in the liver enzymes and serum bilirubin levels. The present report evaluates the case of a patient with risperidone-associated hepatocellular damage. A 19-year-old Caucasian man was admitted to the Department of Psychiatry with paranoid schizophrenia and risperidone was administered in a gradually increasing dose up to 8 mg/day. After 3 weeks of treatment, he experienced asthenia and weight loss. The level of aspartate aminotransferase was 283 IU/L (normal: <30 IU/L), and the alanine aminotransferase level was 778 IU/L (normal: <36 IU/L). Treatment with risperidone was immediately discontinued. Six days after drug withdrawal, the alanine aminotransferase level fell more than 50%, and a complete return to normalcy was seen within 2 months. In the present case, a possible causal association between risperidone and hepatocellular damage has been observed due to the temporal relationship between the administration of the drug and the onset of hepatic abnormalities, and a following rapid recovery after stopping the drug. As the hepatic damage could be related to the plasma concentration of risperidone which is highly influenced by the hepatic enzyme CYP2D6, the patient was genotyped for CYP2D6. He was classified as homozygous wild type for CYP2D6. The risk for developing hepatotoxicity during risperidone therapy cannot be supported by the patient CYP2D6 genotype. In clinical practice, it may be recommended to obtain baseline liver function tests before starting risperidone and regular screening for liver enzyme changes during therapy.
Journal of Clinical Psychopharmacology, 2008
The figures represent the correlation coefficients and the P values for each comparison.
European Journal of Gastroenterology & Hepatology, 2005
nchez de la Cuesta a Objective To explore the effect of intravenous Nacetylcysteine (NAC) on the ... more nchez de la Cuesta a Objective To explore the effect of intravenous Nacetylcysteine (NAC) on the prothrombin time (PT) in patients with paracetamol overdose and a persistent normal liver profile. Materials and methods This retrospective case series study examined all admissions with a diagnosis of paracetamol poisoning in a tertiary hospital between 1989 and 2002. Patients were included if they had received NAC infusion, had no biochemical evidence of liver damage, and had more than two measurements of PT. Patients who had also ingested other drugs were excluded. Results Of 65 admissions with paracetamol poisoning, 18 patients (10 men) met the inclusion criteria. The median age was 29 years, and the median quantity of paracetamol ingested was 186 mg/kg. The mean number of PT measurements per patient was 4.8. The baseline PT (as a percentage) 8.6 h after paracetamol ingestion was 89.6%. During NAC infusion the PT fell in all patients (range, 4.8-53.4% relative to baseline; P < 0.0001) at 14 h. The PT was less than 60% in 28% of the patients. Eight hours after the initiation of NAC there was a 16% fall in PT (range, 4.3-34%; P < 0.0001). At the end of NAC infusion all PTs returned to values close to baseline. Nine patients were hospitalized. Conclusions In patients with paracetamol overdose without evidence of liver damage a marked decrease in PT often occurs, which seems to be due to the overload of NAC infused at the beginning of treatment. This particular feature should be noted in clinical practice guidelines as a potentially misleading indicator of the development of severe liver dysfunction.
American Journal of Psychiatry, 2004
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Papers by Enrique López-Torres