Methods of processing ocular fluid specimens, mainly from vitreous surgery, are described. Cytopr... more Methods of processing ocular fluid specimens, mainly from vitreous surgery, are described. Cytopreparatory techniques using Millipore filtration and Papanicolaou staining for cytology, celloidin bags for cell blocks, air-dried and wet smears and electron microscopy are discussed regarding the details of the methods and their role in the pathologic diagnosis of eye disease. Methods of evaluating tissue scrapings from the cornea and conjunctiva are also reviewed.
A closed colony of semi-free-ranging rhesus monkeys maintained in isolation since 1938 by the Car... more A closed colony of semi-free-ranging rhesus monkeys maintained in isolation since 1938 by the Caribbean Primate Research Center (CPRC) is being studied as a model for age related macular drusen. Of examined colony animals 57*7% of the monkeys and 47*3% of their eyes have drusen. The prevalence and severity of drusen are linearly related to increasing age and are significantly higher in specific maternal lineages (matrilines). An electrophysiological estimate indicates loss of function associated with drusen. Prevalence of drusen in CPRC females is almost twice that of males, while the prevalence among CPRC animals in general appears to be several times that of monkeys from continental US facilities. Evidence suggests that the frequency of endstage lesions is also similar to that in human populations. The CPRC matriline monkeys appear to provide the best model yet reported for human age related macular drusen.
A 22-year-old homosexual man had persistent systemic lymphadenopathy and a three-week history of ... more A 22-year-old homosexual man had persistent systemic lymphadenopathy and a three-week history of rapid swelling and induration of his right upper eyelid. Acquired immune deficiency leading to the development of lymphoma was suspected. A biopsy specimen of the mass revealed Burkitt's lymphoma and treatment with systemic chemotherapy and radiation therapy resulted in remission. A significant number of patients with acquired immune deficiency are developing Burkitt's lymphoma. The three separate syndromes of acquired immune deficiency and their associated ophthalmic manifestations are discussed.
Methods of processing ocular fluid specimens, mainly from vitreous surgery, are described. Cytopr... more Methods of processing ocular fluid specimens, mainly from vitreous surgery, are described. Cytopreparatory techniques using Millipore filtration and Papanicolaou staining for cytology, celloidin bags for cell blocks, air-dried and wet smears and electron microscopy are discussed regarding the details of the methods and their role in the pathologic diagnosis of eye disease. Methods of evaluating tissue scrapings from the cornea and conjunctiva are also reviewed.
A closed colony of semi-free-ranging rhesus monkeys maintained in isolation since 1938 by the Car... more A closed colony of semi-free-ranging rhesus monkeys maintained in isolation since 1938 by the Caribbean Primate Research Center (CPRC) is being studied as a model for age related macular drusen. Of examined colony animals 57*7% of the monkeys and 47*3% of their eyes have drusen. The prevalence and severity of drusen are linearly related to increasing age and are significantly higher in specific maternal lineages (matrilines). An electrophysiological estimate indicates loss of function associated with drusen. Prevalence of drusen in CPRC females is almost twice that of males, while the prevalence among CPRC animals in general appears to be several times that of monkeys from continental US facilities. Evidence suggests that the frequency of endstage lesions is also similar to that in human populations. The CPRC matriline monkeys appear to provide the best model yet reported for human age related macular drusen.
A 22-year-old homosexual man had persistent systemic lymphadenopathy and a three-week history of ... more A 22-year-old homosexual man had persistent systemic lymphadenopathy and a three-week history of rapid swelling and induration of his right upper eyelid. Acquired immune deficiency leading to the development of lymphoma was suspected. A biopsy specimen of the mass revealed Burkitt's lymphoma and treatment with systemic chemotherapy and radiation therapy resulted in remission. A significant number of patients with acquired immune deficiency are developing Burkitt's lymphoma. The three separate syndromes of acquired immune deficiency and their associated ophthalmic manifestations are discussed.
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Papers by Harry Engel