Papers by Dragan Djordjevic
Facta Universitatis, Jan 26, 2019
The importance of metabolic syndrome (MetSy) lies in the fact that its components are proven risk... more The importance of metabolic syndrome (MetSy) lies in the fact that its components are proven risk factors for early blood vessel atherosclerosis and thrombosis.Aim of the paper: Our aim was to establish the prevalence of MetSy in patients with arterial hypertension (AH) and its impact on asymptomatic carotid atherosclerosis. The study involved 391 examinees, divided into two groups. The study group consisted of patients with arterial hypertension (n=342; average age, 66.56 ± 09.52; with 51% of female gender). The presence of cardiovascular (CV) risk factors was established for all involved patients, cardiovascular risk score was determined (SCORE risk), laboratory analyses were performed, as well as anthropometric measurements and color Doppler sonography of the great blood vessels of the neck. The patients with AH were divided into two groups according to the presence of MetSy. Metabolic syndrome was confirmed in 198 patients who comprised group I; there were 144 examinees without MetSy and these comprised group II. Those with MetSy had a greater average number of CV risk factors, a higher SCORE risk score, higher body mass index (p<0.0001), and more frequently had diabetes, hyperlipidemia and obesity. The thickness of the intimal medial complex (IMC) of the carotid arteries was significantly greater in the group with MetSy (p<0.0001)-51% of examinees had IMC thickness ≥0.90. The patients with MetSy more commonly had one or more carotid plaques (p=0.03), a higher average number of plaques (p=0.01) and percentage of stenosis (p=0.01). As the most important factors associated with early carotid atherosclerosis, multivariant regression analysis singled out the following (for the model R=0.512. R2=0.262. adjusted R2=0.255. standard error of the estimate = 0.174; p<0.0001): age (coefficiant β=0.331. p<0.0001), number of MetSy components (coefficient β=0.158. p=0.002), level of serum uric acid (coefficient β=0.284; p<0.0001). Our results demonstrated a significant association of MetSy and its components with early atherosclerotic changes in the carotid arteries.
Journal of Hypertension, Jul 1, 2019
The aim of our study was to evaluate the effects of oxidative stress generated by stroke upon ery... more The aim of our study was to evaluate the effects of oxidative stress generated by stroke upon erythrocytes` membrane and plasma and upon antioxidant enzymes in hypertensive patients associated with stroke. Design and method: This study has been done on 80 patients:40 male and 40 female aged between 35-87 years old with arterial hypertension(AHT) associated with stroke from Emergency Universitary Hospital, Cardiology Clinic. Blood was collected by vein puncture from hypertensive and normotensive patients and processed by centrifugation at 3000 g at 4C. Lipid peroxidation in plasma and red blood cell membrane as well as thiol groups and GGT, GST, catalase and superoxid dismutase antioxidant enzymes have been evaluated using standard biochemical techniques. Results: Our data have pointed out that there is less lipid peroxidation in female patients with stroke (p < 0.05) where membrane fl uidity is decreased due to activation of plasma and erythrocyte superoxid dismutase and catalase. The diminished catalase activity can be accounted for as a mechanism of glutathion peroxidase regulation. In male with stroke the low Catalase activity has been associated with an increased level of lipid peroxidation (p < 0.05) both in membrane and plasma, while concentration of cytoplasm thiols was low(p < 0.01)Concentration of free thiols in membrane is signifi cantly increased(p < 0.01)in stroke patients despite the age or gender. Conclusions: Following stroke, there is a modifi cation of antioxidant and detoxifi cation potential of erythrocytes by decreasing their capacity to uptake GSH from plasma but also elimination of GSH conjugates.
European Journal of Heart Failure, Jun 1, 2000
Journal of Hypertension, Jun 1, 2018
Percentage of variance in SBP at a single follow-up that is attributable to intra-individual visi... more Percentage of variance in SBP at a single follow-up that is attributable to intra-individual visit-to-visit variation. The expected inter-individual group variance of SBP values at a single follow-up was estimated as the sum of the following variance components: inter-individual variance in mean SBP, intra-individual visit-to-visit variance in SBP and inter-individual variance in intra-individual visit-to-visit SBP. Observed levels of variance in SBP values at a single follow-up (taken as the average over the first 2 years of follow-up) is compared with expected levels in each of the cohorts based on the above model. The proportion of observed inter-individual group variance of SBP values at a single follow-up which could be attributed to intra-individual variability is estimated as the sum of the latter two variance components divided by the total variance. Measure UK-TIA trial ASCOT trial 1 Atenolol group ASCOT trial 1 Amlodipine group ESPS-1 2 Dutch TIA trial ASCOT trial Atenolol group ASCOT trial Amlodipine group Area under ROC curves (95% CI) for risk of subsequent stroke based on the different BP parameters, separately and in combination, based on BP readings at the first 10 follow-up visits in the UK-TIA trial. Predictive power was maintained after excluding patients with uncontrolled severe hypertension (mean SBP ≥160mmHg). AuROC (95% CI) Model All patients Mean SBP<160mmHg Level parameters Minimum 0.
Srpski Arhiv Za Celokupno Lekarstvo, 2011
Medicina, 2020
Background and objectives: A long-term therapeutic strategy in hypertensive patients equally depe... more Background and objectives: A long-term therapeutic strategy in hypertensive patients equally depends on measured arterial blood pressure values and total determined cardiovascular risk. The aim of the adequate hypertensive patient treatment is both the reduction in arterial blood pressure and the reduction of all preexisting modifiable risk factors, prevention of target organs damage, and adverse cardiovascular events. The aim of this study was to determine independent predictors of cardiovascular events in patients with hypertension and high cardiovascular (CV) risk, and whether the modifiable risk factors could affect long-term prognosis in the studied population. Materials and Methods: This prospective study included 142 hypertensive patients (65% females), mean age 63.1±8 years, with high CV risk. Each participant was followed for 6.2 years. Results: During the follow-up period, the incidence of non-fatal and fatal CV events was 19.7%, CV mortality 7%, and total mortality 9.9%. ...
Journal of Hypertension, 2018
s e245 fi nal visit, myocardial infarction, unstable angina or sudden death within period between... more s e245 fi nal visit, myocardial infarction, unstable angina or sudden death within period between fi rst and second visits) were detected in 11 patients (91% with high or very high total cardiovascular risk). In these patients initially were detected higher fasting (28,5 ± 21,2 mcU/ml vs 15,4 ± 6,2 mcU/ml, p < 0,05) and postprandial (56,0 ± 40,6 mcU/ml vs 21,4 ± 14,6 mcU/ml, p < 0,05) insulin concentration and faster postprandial (88,0 ± 10,2 bpm vs 72,5 ± 8,8 bpm, p < 0,01) and fasting (85,2 ± 13,3 bpm vs 67,7 ± 8,1 bpm, p < 0,01) heart rate than in others. Negative results were detected in 78% of patients with high or very high total cardiovascular risk and heart rate greater than 80 bpm. In the observation period irregular antihypertensive pharmacotherapy was revealed in 70% of patients with negative results and 36% of other participants (p < 0,05). Physical activity reduction was detected in 60% of persons with negative result and 23% of others. Conclusions: Unfavorable prognostic factors in patients with fi rst grade arterial hypertension in real clinical conditions include high or very high total cardiovascular risk, tachycardia, hyperinsulinemia and poor treatment adherence (irregular antihypertensive therapy, low physical activity level).
Journal of Hypertension, 2019
The current American and European guidelines for hypertension treatment lowered BP targets for pa... more The current American and European guidelines for hypertension treatment lowered BP targets for patients with diabetes mellitus (DM) and those with coronary artery disease (CAD) to 130/80 mmHg or less. However, there is a concern that extremely low BP may increase cardiovascular (CV) events in DM patients, especially in those with CAD. Coronary revascularization has become prevalent in diabetic CAD patients. Thus, we investigated the effects of low BP on CV events in diabetic CAD patients after coronary revascularization. Design and method: We sub-analyzed 2,718 DM patients with stable chronic CAD in the CREDO-Kyoto cohort-1, a prospective multi-center registry, enrolling 9,877 CAD patients who underwent the fi rst CABG or PCI. Results: CV death was not affected by low SBP, whereas DBP below 70 mmHg slightly but not signifi cantly increase CV death (Figure). Low SBP and DBP did not affect the incidences of non-fatal myocardial infarction and non-fatal stroke. On multivariate Cox proportional hazard regression analysis, DBP below 70 mmHg was not a signifi cant factor for increasing CV death, while creatinine clearance (hazard ratio [HR] 0.970 [95% confi dence interval; 0.961-0.978], p = 0.000), non-use of statin (HR 2.336 [1.185-4.405], P = 0.014), pulse pressure (HR 1.016 [1.003-1.030], P = 0.015), hypertension (HR 2.420 [1.090-5.373], P = 0.030), and prior myocardial infarction (HR 1.804 [1.037-3.139], P = 0.037) were the independent factors for CV death. Conclusions: In diabetic CAD patients after coronary revascularization, low BP was not a signifi cant factor for increasing CV events. Along with the management of risk factors and comorbidities, strict BP control, e.g. targeting less than 130/80 mmHg, may help improve the prognosis of diabetic CAD patients after revascularization.
Acta Medica Medianae, 2018
Metabolic syndrome (MetS) is a cluster of several risk factors that may indicate worse outcome af... more Metabolic syndrome (MetS) is a cluster of several risk factors that may indicate worse outcome after myocardial infarction with ST segment elevation (STEMI). The aim of this study was to determine the impact of MetS on quality of life among patients with STEMI. A prospective study was performed among all STEMI patients who were treated with primary percutaneous coronary intervention in Clinical Centre of Serbia. During the three-year follow up, the occurrence of new cardiovascular events was followed. After 36 months the valid data were collected for 507 patients. At the end of the follow up, all alive and capable patients completed the Short Form 36 (SF-36) questionnaire. The prevalence of MetS was 42.80%. An increased appearance of new myocardial infarction (p = 0.004), new unexpected revascularizations (p = 0.014) and the increased number of hospitalizations because of heart failure (p = 0.050) were recorded in the group of patients with MetS during a follow-up. Multiple regression analysis revealed that MetS was a predictor for lower scores of: physical functioning (OR 2.684; p < 0.001), role physical functioning (OR 2.121; p = 0.001), bodily pain (OR 2.559; p = 0.005), general health (OR 2.522; p < 0.001) and physical component score (OR 2.516; p < 0.001). Among mental components, MetS was a predictor of lower scores of vitality (OR 1.999; p = 0.002) and mental health (OR 2.142; p = 0.016). Patients with MetS are at high risk for the appearance of new cardiovascular events, and the presence of this syndrome is associated with poorer quality of life after surviving STEMI.
Cardiovascular & hematological disorders drug targets, 2018
The impact of overt diabetes and poor glycemic control on the risk of cardiovascular disease is w... more The impact of overt diabetes and poor glycemic control on the risk of cardiovascular disease is well established. Among patients with type 2 diabetes, several studies demonstrated a significant increase in coronary artery disease-related death and cardiovascular events associated with HbA1c levels of greater than 7% compared with lower levels. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are a novel class of anti-diabetic drugs that lower blood glucose levels through the suppression of renal glucose reabsorption thereby promoting renal glucose excretion. To summarize data on the potential mechanisms of SGLT-2 inhibition that could exert cardiovascular benefits in patients with diabetes mellitus. We conducted an in-depth literature search of SGLT-2 inhibitors and potential cardiovascular benefits and mechanisms that mediate those effects. In diabetes, expression of the SGLT-2 genes is up-regulated and renal threshold increased, resulting in increased glucose reabsorption from g...
Scandinavian journal of clinical and laboratory investigation, Jul 27, 2018
The goal of the present study was to determine the prevalence of hyperuricemia in patients with c... more The goal of the present study was to determine the prevalence of hyperuricemia in patients with coronary artery disease (CAD), within three months after coronary events. Also, we aimed to determine whether the presence of hyperuricemia holds correlation with severe CAD, overall heart functioning and risk factors for CAD. The study included 505 consecutive CAD patients, 385 males and 120 females, aged 60.9 ± 9.6 years, with a mean body mass index (BMI) 28.0 ± 3.7 kg/m. All patients were admitted to specialized cardiovascular rehabilitation within three months post-acute myocardial infarction (AMI) without revascularization (32.6%), percutaneous coronary intervention (PCI) with myocardial infarction (32.1%) and with coronary bypass graft (35.3%). The mean value of serum acidum uricum (SUA) was 345.5 ± 100.3 µmol/L, where 115 (22.8%) patients had asymptomatic hyperuricemia. Patients with asymptomatic hyperuricemia had significantly higher average number of risk factors, lower HDL chole...
Clinical cardiology, 2017
Persistent and adequate treatment of patients with arterial hypertension leads to more favorable ... more Persistent and adequate treatment of patients with arterial hypertension leads to more favorable disease outcome. Aside for the present left ventricular hypertrophy (LVH), there are other non-invasive parameters which can represent additional predictors of unfavorable prognosis in patients with essential arterial hypertension during the 10-year follow-up. A hypertensive group with LVH (124 patients; age 57.0 ± 8.0; 84 males and 40 females) was included in the study and examined noninvasively. Patients used regular medication therapy during the follow-up period. During the 10-year follow-up period, unfavorable outcome was recorded for 40 (32.3%) patients. Patients with unfavorable outcome had higher baseline values of left ventricular mass index (178.9 ± 29.5 g/mvs 165.5 ± 29.5 g/m; P < 0.05) and QTc dispersion (64.1 ± 24.7 ms vs 54.8 ± 19.4 ms; P < 0.05). Frequency of positive Cornell product was higher in the group of patients with unfavorable outcome (35% vs 22.2%; P < 0....
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Journal of Hypertension, 2017
Background and objectives: A long-term therapeutic strategy in hypertensive patients equally depe... more Background and objectives: A long-term therapeutic strategy in hypertensive patients equally depends on measured arterial blood pressure values and total determined cardiovascular risk. The aim of the adequate hypertensive patient treatment is both the reduction in arterial blood pressure and the reduction of all preexisting modifiable risk factors, prevention of target organs damage, and adverse cardiovascular events. The aim of this study was to determine independent predictors of cardiovascular events in patients with hypertension and high cardiovascular (CV) risk, and whether the modifiable risk factors could affect long-term prognosis in the studied population. Materials and Methods: This prospective study included 142 hypertensive patients (65% females), mean age 63.1±8 years, with high CV risk. Each participant was followed for 6.2 years. Results: During the follow-up period, the incidence of non-fatal and fatal CV events was 19.7%, CV mortality 7%, and total mortality 9.9%. Our multivariate analysis showed that plaques in both carotid arteries (p = 0.042), diabetes mellitus (p = 0.042) and cholesterol at the beginning of the study (p = 0.016) were significantly associated with an increased risk of CV events. Patients' age (p = 0.009), intima-media thickness (p = 0.001) and diabetes mellitus (p = 0.042) were significantly associated with an increased risk of CV mortality, and age (p = 0.007) and cholesterol (p = 0.002) were independent variables significantly associated with increased total mortality rates. Conclusions: The results of the present study showed that the main predictors of adverse CV events in high-risk hypertensive patients were years of age, cholesterol levels, diabetes, intima-media thickness, and carotid arteries plaques.
American Journal of Hypertension, 2002
Using digitized M-mode echocardiograms and 75-mg oral glucose tolerance test (OGTT), we evaluated... more Using digitized M-mode echocardiograms and 75-mg oral glucose tolerance test (OGTT), we evaluated the possible influence of post-prandial glycemia on left ventricular (LV) morphology and function in nevertreated, non-obese, non-diabetic hypertensives. We enrolled 89 subjects (49 men, age 45Ϯ11 years) with never-treated hypertension (24h BP Ͼ 135 and/or 85 mmHg), body mass index Ͻ 30 Kg/m2, glycemia at fast Ͻ 110 mg/dl and at 120 min during OGTT Ͻ 140 mg/dl. We measured glucose and insulin at fast, 30,60,90 and 120 min during OGTT, and metabolic clearance rate of glucose,an index of insulin sensitivity. With regard to the LV we evaluated: LV end-diastolic diameter, septal and posterior wall thickness, LV mass index, peak shortening and peak lengthening rate of LV diameter, peak thinning rate of LV posterior wall. Out of the 89 subjects, 31 had LV hypertrophy (LVMi Ͼ 134 g/m2 in men, Ͼ 110 g/m2 in women); LV systolic function was normal (peak shortening rate of LV diameter Ͼ 1.9 sec-1) in all the patients; 25 patients had preclinical LV diastolic dysfunction (peak lengthening rate of LV diameter Ͻ 3.6 sec-1 and/or peak thinning rate of LV posterior wall Ͻ 8.4 cm/sec). The metabolic parameters did not correlate with LV morphologic characteristics, nor with LV systolic function. With regard to diastolic function, peak thinning rate of LV posterior wall was inversely related to glycemia at 120 min (r ϭ-0,20, pϽ0.05) and to glucose MCR (rϭ-0.25, pϽ0.01). From stepwise multiple regression analysis the main independent determinants of peak thinning rate of LV posterior wall (multiple R ϭ 0.31, pϭ0.0092) were glucose MCR (beta ϭ 0.23, pϭ0.02) and LVMi (beta ϭ-0.20, pϭ0.04), whereas post-prandial glycemia did not enter the equation. In conclusion, in never-treated, non-obese, non-diabetic essential hypertensives, post-prandial glycemia is not related to LV remodeling. With regard to LV diastolic function, the influence of post-prandial glycemia is outweighted by insulin sensitivity, that appears to be an independent determinant of LV diastolic function.
American Journal of Hypertension, 2001
EH were also examined plasma (PNE) and urinary norepinephrine (UNE), plasma renin activity (PRA),... more EH were also examined plasma (PNE) and urinary norepinephrine (UNE), plasma renin activity (PRA), plasma aldosterone concentration (PAC) after ingested a diet of 7g salt (NaCl) per day for a week. By multiple regression analysis, TEI index was significantly related to PAC as an independent variable (R 2 ϭ0.40, pϽ0.005) but not to nighttime mean BP, PRA, PNE, and UNE. Since TEI index was significantly related to nighttime mean BP, it was suggested that TEI index would be useful for an index of the severity of hypertensive target organ damage. Moreover, since TEI index was strongly related to PAC rather than BP, PAC might be correlated with both left ventricular systolic and diastolic function.
American Journal of Hypertension, 2003
Metabolic syndrome (MS) carries of a number of risk factors for some patients with cardiovascular... more Metabolic syndrome (MS) carries of a number of risk factors for some patients with cardiovascular (CV) diseases. These risk factors, including isulin resistence, dyslipidermia, hypertension and obesity, increase the risk of the development of DM and multiply the risk of CV diseases. Aim: To prove the presence of MS in patients with hypertension and LVH analysing clinical parametres and to estimate the impact of this syndrome on patient prognosis. Methods: There have been analysed 73 hypertensive patients (43 male patients), avarage age 56.3 Ϯ 8.5 with echo proved LVH (avarage LV mass index 163.5 Ϯ 31,8 g/m 2). Every patient has got the following results echo, ECG, treadmill exercise testing, 24-hour AMBP and 24hour Holter monitoring (analysis of ventricular arrhythmias-VA and heart rate variablility-HRV). MS is defined according to NCEP ATP III. Results: 36 patients (55 Ϯ 8 years) fulfilled the criterion of MS. They had significantly higher glucose level (5.9 Ϯ 1 vs 5.1 Ϯ 0.6. pϽ0.001), lower HDL cholesterol 0.99 Ϯ 0.3 vs 1.2 Ϯ 0.3, pϽ0.009), higher triglycerides (2.8 Ϯ 2 vs. 1.6 Ϯ 0.6, pϽ0.02) and higher BMI (29.6 Ϯ 3.8 vs. 27.8 Ϯ 3, pϽ0.03). LV mass index was also higher in these patients but not statistically significant (165. 5 Ϯ 29 vs. 159.9 Ϯ 34, ns.) This group of patients had more frequent complex VA (19 to 6, pϽ0.001) and significantly lower values of HRV (SDNN-114.1 Ϯ 25 vs. 126.4 Ϯ 21, pϽ0.05; RR interval-809.6 Ϯ 113 vs. 885.7 Ϯ 115, pϽ0.02). After 12 month treatment this group of patients had significantly higher glucose level (5.7Ϯ 1.4 vs. 5 Ϯ 0.7, pϽ0.03), higher double product at physical exercise test (28 Ϯ 5 vs. 25 Ϯ 4, pϽ0.03), lower day SDNN (103.4 Ϯ 27 vs. 116.4 Ϯ 21, pϽ0.05) shorter day and night RR interval (802.4 Ϯ 132 vs. 894 Ϯ 131, pϽ0.007; 918 Ϯ 138 vs. 1026.5 Ϯ 131, pϽ0.04). Significant ST depression has been registered in 8 patients of this group in contrast to 4 patients in the group without metabolic syndrome (ns). After 4 year observation 5 patients in this group had serious cardiovascular incidents (3 CVI-1 death, 2 IM) while in the second group 2 patients (1 IM and 1 PTCA with inbuilt stent)(ns). Conclusion: MS in hypertensive patients with LVH is connected with significantly higher activity of sympathetic nervous system and increased risk of CV incidents.
European Heart Journal, 2013
Background: Hypertension is a potent risk factor for congestive heart failure (CHF). Development ... more Background: Hypertension is a potent risk factor for congestive heart failure (CHF). Development of overt CHF may be preceded by a phase of asymptomatic left venrticular systolic dysfunction. The aim of this study was early detection of alteration in left ventricular systolic function. Methods: 120 hypertensive patients, with preserved ejection fraction (EF), were divided in three groups according LVDD: normal (n=40), abnormal relaxation (Grade I, n=37) and pseudonormal (Grade II, n=43). Left atrial volume index (LAVI), left ventricular mass index (LVMI), left ventricular dimensions and volume inexes (LVEDV/BSA and LVESV/BSA) and EF were estimated by echocardiography. We measured coresponding velocities from tissue Doppler at the level of the septal mitral annulus (Em, Am, Sm), including E/Em and tissue Doppler myocardial performance index (tMPI). The same measurements were repeated after three years. Results: Close correlations were found between Sm and EF (r=0.349; p=0.0009), LVMI (r=-0.222; p=0.015), LVEDV/BSA (r =-0.317; p=0.0004) and LVESV/BSA (r =-0.472; p=0.0005). Levels of LVEDV/BSA (89.3 vs 103.8 vs 101.7; p=0.009), LVESV/BSA (34.0 vs 42.9 vs 44.0; p=0.0004), LVMI (104.3 vs 112.5 vs 123.0; p=0.0004), LAVI (32.0 vs 35.5 vs 44.5; p=0.0001) and MPI (61.7 vs 72.1 vs 76.3; p=0.036) progressively increased from the normal group through LVDD Grade I and II groups. Significantly different values of EF (63 vs 61 vs 59; p=0.003) and Sm (0.074 vs 0.067 vs 0.059; p=0.003) were obtained between groups too, but with progressively decrease from the normal group through LVDD Grade I and II groups. General linear model for repeated measures showed increase of LVEDV/BSA (F=50.009; p<0.001), LVESV/BSA (F=34.258; p<0.001), LVMI (F=27.648; p<0.001), LAVI (F=17.083; p<0.001) and tMPI (F=35.842; p<0.001) during three years, with significant time difference, but withot significant difference between groups, these parameters enarged in all groups almost at the same manner. Sm also significantly changed during three years with significant time difference (F=128.24; p<0.001) and with significant difference between groups (F=4.597; p< 0,012), Sm decrease in all groups, but most expressed in LVDD Grade II group. Conclusion: Left ventriculae EF was not sensitive indicator for the detection of subclinical systolic dysfunction, but decrease of Sm appeared as the first sign of systolic abnormalities following established diastolic dysfunction and was the clear reflection of LV remodeling process. This suggests that Sm may aid in the identification of patients at high risk for development of CHF who need preventive treatment.
Srpski arhiv za celokupno lekarstvo, 2006
INTRODUCTION The cardiovascular changes (vascular structure changes, hypertrophy of the left vent... more INTRODUCTION The cardiovascular changes (vascular structure changes, hypertrophy of the left ventricle) contribute to both the increased cardiovascular morbidity and the mortality of essential hypertension. Therefore, modern treatment strategies should not only target blood pressure (BP) reduction but also normalize cardiovascular structure and function. OBJECTIVE Aim of the study was to determine the effect of the ACE inhibitor Fosinopril on the Intima-media thickness of the common carotid artery and on the left ventricle mass after 9-month treatment of hypertensive patients. METHOD The study included 40 patients with the arterial hypertension and the left ventricle hypertrophy verified by echocardiography. The patients were randomized on A) ACE-inhibitor - Fosinopril and 6) without ACE inhibitor - atenolol, and they were followed up 9 months. The groups were not different by age, sex, and metabolic status. Color Duplex ultrasonography of the carotid arteries was performed by Acuso...
Journal of Hypertension, 2010
, with no independent effect of EF (HR ¼ 0.90/10%, CI ¼ 0.70-1.03, p ¼ 0.11). Conclusion: Evaluat... more , with no independent effect of EF (HR ¼ 0.90/10%, CI ¼ 0.70-1.03, p ¼ 0.11). Conclusion: Evaluation of LV pump performance is influenced by the amount of myocardial muscle pumping blood into the arterial tree. When LV mass is taken into consideration, indices of LV pump performance may be at least as good as ejection-phase indices of LV function for identification of subjects at risk of incident CV events.
Journal of Hypertension, 2004
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Papers by Dragan Djordjevic