Papers by Dr Sidharth Kaul
Acta hydrochimica et hydrobiologica, 1984
Acta hydrochimica et hydrobiologica, 1983
The mineral content was investigated in t'he bclow-ground biomass. the aboveground biomass and t,... more The mineral content was investigated in t'he bclow-ground biomass. the aboveground biomass and t,he litter of t'he niacrophytes in five wetlands in t,he valley of the river Jehlam. I n different seasons, t,he concent,rations of calcium, magnesium. sodium, potassium, phosphorus ancl nitrogen in the dry matter mere determined. Sodium, phosphorus, pot~assium and calcium showed decreasing concentraions from spring to autumn. The socliuni and nisgnesiuin concentrations showed a n irregula,r trend. ,4s a whole, the incorporated mass of substances per unit of area increases, however. in the course of the period of vegatation for t'he below-ground bioniass as well as the above-ground biomass. Due t,o washing-out, the litter always shows considerably rednred concent,rations.
Social Science Research Network, Oct 29, 2018
Molecular and Cellular Neuroscience, 2004
The cellular mechanisms underlying the neurodegenerative process in Parkinson's disease are not w... more The cellular mechanisms underlying the neurodegenerative process in Parkinson's disease are not well understood. Using RNA interference (RNAi), we demonstrate that caspase-3-dependent proteolytic activation of protein kinase CD (PKCD) contributes to the degenerative process in dopaminergic neurons. The Parkinsonian toxin MPP + activated caspase-3 and proteolytically cleaved PKCD into catalytic and regulatory subunits, resulting in persistent kinase activation in mesencephalic dopaminergic neuronal cells. The caspase-3 inhibitor Z-DEVD-FMK and the caspase-9 inhibitor Z-LEHD-FMK effectively blocked MPP +-induced PKCD proteolytic activation. To characterize the functional role of PKCD activation in MPP +-induced dopaminergic cell death, RNAi-mediated gene knockdown was performed. Among four siRNAs designed against PKCD, two specifically suppressed PKCD expression. The application of siRNA abolished the MPP +-induced PKCD activation, DNA fragmentation, and tyrosine hydroxylase (TH)positive neuronal loss. Together, these results suggest that proteolytic activation of PKCD may be a critical downstream event in the degenerative process of Parkinson's disease.
Internationale Revue der gesamten Hydrobiologie und Hydrographie, 1983
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Papers by Dr Sidharth Kaul