Papers by Dr. S. M. Abdur Rahman
Dhaka University Journal of Pharmaceutical Sciences
This study presents the findings of in vivo, in vitro and in silico investigations of the Oroxylu... more This study presents the findings of in vivo, in vitro and in silico investigations of the Oroxylum indicum (L.) Kurz leaf extracts. Various fractions namely chloroform (CF), ethyl acetate (EAF), n-hexane (HF) and aqueous fractions (AF) obtained from the crude extract were subjected to biological investigations. In DPPH based free radical scavenging assay, CF and MF fractions showed potent antioxidant activity with IC50 9.70 g/ml and 10.46 g/ml as compared to IC50 8.56g/ml for the standard ascorbic acid. The CF and HF fractions of O. indicum (L.) Kurz leaves exhibited mild antimicrobial activity. In analgesic activity screening by acetic acid induced writhing method, EAF showed significant writhing inhibition of 68% and 72%, at doses 150 mg/kg and 300 mg/kg, respectively. In tail immersion method, EAF also showed potent analgesic activity with reaction time of 1.816 ± 0.047 and 2.15 ± 0.041 min, after 30 minutes following oral doses of 150 mg/kg and 300 mg/kg, respectively. Molecu...
Dhaka University Journal of Pharmaceutical Sciences
Sugar and sugar derivatives have numerous reported biological activities. Sugar moieties in many ... more Sugar and sugar derivatives have numerous reported biological activities. Sugar moieties in many therapeutically important compounds have influence on their pharmacological activities. Structure activity relationship studies have revealed the importance of sugar moieties in the structure of many clinically used drugs. This review focuses on the major biological activities such as anti-cancer, anti-diabetic, analgesic, anti-inflammatory, antiviral and antimicrobial activities of sugars and their derivatives including modified or synthetic sugar derivatives. The available reported structure activity relationship studies have also been described in this review. Biological investigation of different activities of sugar derivatives proves their suitability as one of the interesting classes of molecules for development of new drugs. Dhaka Univ. J. Pharm. Sci. 20(3): 381-394, 2022 (June) Centennial Special Issue
Indian Journal of Pharmaceutical Education and Research, 2022
Background: A daunting public health issue that mainly affects women is breast cancer. Resistance... more Background: A daunting public health issue that mainly affects women is breast cancer. Resistance to drugs applied in the treatment of this cancer as well as their side effects have made it necessary to look for new therapeutic agents. Objectives: The study is aimed at identification of multi-targeted inhibitors of molecular targets associated with breast cancer. Methods: We investigated fifteen compounds from Bergenia ciliata (haw.) Sternb against four major molecular targets of breast cancer viz; estrogen receptor-α (ER-α), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2/ ERBB2) and epidermal growth factor receptor (EGFR) by docking simulation. Properties describing ADME/T aspects of the potential compounds were also investigated by in silico approach. Results: Among the fifteen compounds investigated, stigmasterol, β-sitosterol, paashaanolactone and afzelechin exhibited more or comparable binding affinity values with the different targets compared to that of native ligands and therefore may be developed as leads for multi-targeted therapy against breast cancer. Conclusion: Considering the molecular docking results and ADME/T analysis, it can be suggested that these compounds can be subjected to further structural modification and in vivo analysis for evaluating the potential of their candidacy as new drugs in the field of treatment and management of breast cancer.
Dhaka University Journal of Pharmaceutical Sciences, 2021
In the present study some substituted benzimidazole derivatives were screened for several biologi... more In the present study some substituted benzimidazole derivatives were screened for several biological activities. The synthesized compounds were subjected to evaluation of central analgesic, anti-inflammatory, cytotoxicity, antimicrobial and antioxidant activities by radiant heat induced tail flicking, carrageenan induced rat paw edema inhibition, brine shrimp lethality bioassay, disc diffusion and DPPH free radical scavenging methods, respectively. Compounds 2a, 2c and 2d elongated the tail flicking time by 58.07-, 51.59- and 76.65%, respectively (p < 0.001) at 50 mg/kg body weight dose compared to the standard morphine (87.17%). Compounds 2b, 2c and 2d showed prominent anti-inflammatory activity at 100 mg/kg body weight dose (% of paw edema inhibition 81.75%, 79.09% and 86.69%, respectively) compared to the standard aceclofenac (87.83%). Among the synthesized benzimidazole derivatives, compounds 1a, 1b, 1c, 2a and 2d exhibited potent cytotoxicity with the IC50 values of 5.47-, 1...
Saudi Pharmaceutical Journal
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Dhaka University Journal of Pharmaceutical Sciences
The present study focuses on the investigation of methanol extracts of roots of three indigenous ... more The present study focuses on the investigation of methanol extracts of roots of three indigenous plants of Bangladesh namely Acacia nilotica, Azadirachta indica and Justicia adhatoda to evaluate their analgesic and hypoglycemic activities in experimental animal model along with in silico modelling of several compounds present in the root extracts of these plants. Analgesic and hypoglycemic activities were evaluated in Swiss albino mice using acetic acid-induced writhing inhibition method and glucose tolerance test, respectively. In silico molecular docking and ADME study was conducted to assess the binding affinity with the target receptors and oral bioavailability of the compounds. The methanol extracts of A. nilotica, J. adhatoda and A. indica roots at a dose of 400 mg/kg body weight reduced the number of writhes by 61.53%, 54.61% and 47.69%, respectively compared to standard diclofenac sodium (70.77% at a dose of 50 mg/kg bw) (p<0.05). A. nilotica and A. indica root extracts s...
Dhaka University Journal of Pharmaceutical Sciences
Three fractions obtained by Kupchan partitioning of 70% methanol extract of leaves of Stevia reba... more Three fractions obtained by Kupchan partitioning of 70% methanol extract of leaves of Stevia rebaudiana with n-hexane, dichloromethane and ethyl acetate designated by HSR, DSR and ESR were investigated for their antioxidant and antimicrobial activities. HSR and ESR exhibited prominent free radical scavenging activity having IC50 value of 11.59 and 10.38 μg/ml compared to standard, ascorbic acid (IC50 value 6.05 μg/ml). HSR and ESR also demonstrated significant antibacterial activity by disc diffusion method on some Gram-positive and Gramnegative bacteria. Among the fractions ESR showed the highest antioxidant and antibacterial activity. No significant antifungal activity was observed for any fraction. Preliminary phytochemical screening of all fractions showed the presence of alkaloids, saponin, flavonoids, tannin, carbohydrate and triterpenoids. Total three compounds have been isolated from ESR fraction among which two known compounds (1-2) were characterized as quercitrin (1) and ...
Dhaka University Journal of Pharmaceutical Sciences
Three fractions obtained by Kupchan partitioning of 70% methanol extract of leaves of Stevia reba... more Three fractions obtained by Kupchan partitioning of 70% methanol extract of leaves of Stevia rebaudiana with n-hexane, dichloromethane and ethyl acetate designated by HSR, DSR and ESR were investigated for their antioxidant and antimicrobial activities. HSR and ESR exhibited prominent free radical scavenging activity having IC50 value of 11.59 and 10.38 μg/ml compared to standard, ascorbic acid (IC50 value 6.05 μg/ml). HSR and ESR also demonstrated significant antibacterial activity by disc diffusion method on some Gram-positive and Gramnegative bacteria. Among the fractions ESR showed the highest antioxidant and antibacterial activity. No significant antifungal activity was observed for any fraction. Preliminary phytochemical screening of all fractions showed the presence of alkaloids, saponin, flavonoids, tannin, carbohydrate and triterpenoids. Total three compounds have been isolated from ESR fraction among which two known compounds (1-2) were characterized as quercitrin (1) and ...
Dhaka University Journal of Pharmaceutical Sciences, 2015
The present study was performed to evaluate the biological activities of metal complexes of indom... more The present study was performed to evaluate the biological activities of metal complexes of indomethacin with cobalt, copper, manganese and zinc. In radiant tail flick method, complexes of indomethacin with cobalt and copper at a dose of 20 mg/kg b.w. showed significant central analgesic activity having 66.09% and 75.45% elongation of time after 30 minutes and complexes of indomethacin with copper at a dose of 20 mg/kg b.w. showed significant central analgesic activity having 62.47% elongation of time after 60 minutes compared to the standard morphine. In this study, indomethacin and its complexes with cobalt, copper and manganese showed mild antimicrobial activity and the indomethacin-manganese complex also displayed highest cytotoxicity with a lowest LC50 1.222 ± 0.21 ?g/ml and indomethacin-cobalt, indomethacin-copper and indomethacin-zinc had significant LC50 of 1.549 ± 0.39 ?g/ml, 1.662 ± 0.17 ?g/ml and 1.903 ± 0.64 ?g/ml, respectively where standard vincristine sulphate had LC5...
Dhaka University Journal of Pharmaceutical Sciences
Three fractions obtained by Kupchan partitioning of 70% methanol extract of leaves of Stevia reba... more Three fractions obtained by Kupchan partitioning of 70% methanol extract of leaves of Stevia rebaudiana with n-hexane, dichloromethane and ethyl acetate designated by HSR, DSR and ESR were investigated for their antioxidant and antimicrobial activities. HSR and ESR exhibited prominent free radical scavenging activity having IC50 value of 11.59 and 10.38 μg/ml compared to standard, ascorbic acid (IC50 value 6.05 μg/ml). HSR and ESR also demonstrated significant antibacterial activity by disc diffusion method on some Gram-positive and Gramnegative bacteria. Among the fractions ESR showed the highest antioxidant and antibacterial activity. No significant antifungal activity was observed for any fraction. Preliminary phytochemical screening of all fractions showed the presence of alkaloids, saponin, flavonoids, tannin, carbohydrate and triterpenoids. Total three compounds have been isolated from ESR fraction among which two known compounds (1-2) were characterized as quercitrin (1) and ...
Indian Journal of Pharmaceutical Sciences
Dhaka University Journal of Pharmaceutical Sciences
The present study describes the synthesis and pharmacological evaluation of a number of substitut... more The present study describes the synthesis and pharmacological evaluation of a number of substituted benzimidazole derivatives designated by 3A-1, 3A-2, 3A-3, 3B-1 and 3B-2 through condensation of different o-aryldiamine compounds with the corresponding aldehyde employing ammonium salt as a catalyst. All the compounds were characterized by IR and 1H NMR spectroscopic analysis. The synthesized benzimidazole derivatives were investigated for analgesic and antioxidant activities using acetic acid-induced writhing inhibition in Swiss albino mice and DPPH free radical scavenging assay, respectively. Compounds 3A-3, 3B-1 and 3B-2 at a dose of 50 mg/kg body weight reduced the number of writhings by 88.24%, 84.03% and 85.71%, respectively (p<0.001) in comparison with standard diclofenac (90.76% inhibition). The derivatives 3A-1, 3A-2, 3A-3 and 3B-2 showed prominent antioxidant activity with IC50 values of 0.038, 0.959, 8.834 and 7.519 μg/ml, respectively in comparison with the standard bu...
Dhaka University Journal of Pharmaceutical Sciences
Comparative peripheral analgesic and antipyretic activities of copper, zinc, cobalt and manganese... more Comparative peripheral analgesic and antipyretic activities of copper, zinc, cobalt and manganese complexes of indomethacin were studied. Peripheral analgesic effect of the complexes was evaluated by following acetic acid-induced writhing inhibition method in mice whereas antipyretic activity was assessed by Brewer’s yeastinduced pyrexia in rat model. At 10- and 20-mg/kg doses, the zinc-indomethacin complex produced significant writhing inhibition (p<0.001) by 67.35% and 77.55% whereas cobalt-indomethacin showed writhing inhibition by 61.22% and 64.63% in a dose dependent manner respectively, which were prominent compared to that of standard indomethacin (61.90% and 72.27% inhibition respectively). Moreover, the zinc-indomethacin complex exerted significant antipyretic activity at both 10- and 20-mg/kg dose by reducing body temperature from 100.38°F to 97.8°F (4th hour) and 100.36°F to 98.21°F (4th hour), respectively that were comparable to standard paracetamol. From this study,...
Dhaka University Journal of Pharmaceutical Sciences
A stability indicating HPLC method was developed and validated for the quantitative determination... more A stability indicating HPLC method was developed and validated for the quantitative determination of fexofenadine hydrochloride. An isocratic separation was achieved using phenomenex (C18) column (250×4.6 mm, 5 μm) with flow rate of 1.0 ml/min and UV detection at 254 nm. The mobile phase consists of 5Mm acetate buffer: acetonitrile (50:50; v/v) with pH 9.4 adjusted with acetic acid. The drug was subjected to oxidative, acidic, basic, neutral, photolytic and thermal degradation. All degradation products were eluted in an overall analytical run time of approximately 40 min with the parent compound fexofenadine hydrochloride at a flow rate of approximately 3.3±0.3 min. The method was linear over the concentration range of 31.5-500 μg/ml (r2 = 0.999) with limit of detection and quantification of 3.5 μg/ml and 10.1 μg/ml, respectively. The method has the requisite accuracy, selective, precision and robustness to assay fexofenadine HCl in tablets.Dhaka Univ. J. Pharm. Sci. 17(1): 43-50, 2...
Toxicology International (Formerly Indian Journal of Toxicology)
Alexandria Journal of Medicine, 2017
Advances in pharmacological sciences, 2016
Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depre... more Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes. Methods. The antinociceptive activity was evaluated by acetic acid-induced writhing method and radiant heat tail-flick method while anxiolytic activity was evaluated by elevated plus maze model. The CNS depressant activity of naproxen metal complexes was assessed using phenobarbitone-induced sleeping time test and the hypoglycemic test was performed using oral glucose tolerance test. Results. Metal complexes significantly (P < 0.001) reduced the number of abdominal muscle contractions induced by 0.7% acetic acid solution in a dose dependent manner. At the dose of 25 mg/kg body weight p.o. copper, cobalt, and zinc complexes exhibited higher antinociceptive activity having 59.15%, 60.56%, and 57.75% of writhing inhibition, respectively, than the parent ligand naproxen (54.93%). In tail-flick test, at both doses of 25 and 5...
天然有機化合物討論会講演要旨集, Sep 1, 2001
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Papers by Dr. S. M. Abdur Rahman