Papers by Dr. Rajesh Singh Pawar
Journal of Drug Delivery and Therapeutics
The most common problem about conventional dosage form is dysphagia (difficulty in swallowing). S... more The most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach in a conventional dosage form which is oral dispersible tablet. Oral dispersible tablet is also called as mouth dissolving tablet, fast dissolving tablet, or oral disintegrating tablet. Oral dispersible tablet has advantage as it quickly disintegrates into saliva when it is put on the tongue. The faster the drug disintegrates or is dissolved, the faster the absorption and the quicker the therapeutic effect of drug will be attained. The objective of present study was to formulate directly compressible orodispersible tablets of cimetidine with improved solubility and bioavailability by using solid dispersion technique. Cimetidine is a histamine H2-receptor antagonist. It is widely prescribed in active duodenal ulcers, gastric ulcers, Zollinger-Ellison syndrome, gastroesophageal reflux disease and erosive esophagitis. Solid dispersion of cimetidine was prepared b...
The origin of the name resveratrol is reportedly derived from the Latin word 'res' meanin... more The origin of the name resveratrol is reportedly derived from the Latin word 'res' meaning 'which comes from' the plant 'veratrum' and 'ol' indicating the presence of an alcohol moiety. Resveratrol is obtained from plants. The function of resveratrol in plants is thought to be protection since it is produced when the plant is under environmental stress, whether ultraviolet radiation, infection, or insect infestation. Resveratrol's introduction into the dietary supplement market a few years back was based upon the consideration that intake of it and other polyphenol compounds from red wine may contribute to the 'French paradox', the unexpectedly low rate of death from cardiovascular disease in the Mediterranean population, despite a diet that is relatively high in saturated fat. Since then, interest in resveratrol has increased due to research suggesting additional antioxidant, anti-inflammatory, anticancer, antiviral, and anti-aging effect...
Avicenna Journal of Phytomedicine, 2016
Objective: Martynia annua L. (M. annua), (Martyniaccae) has been traditionally used in the treatm... more Objective: Martynia annua L. (M. annua), (Martyniaccae) has been traditionally used in the treatment of epilepsy, sore throat and inflammatory disorders. The leaf paste is used topically on Tuberculosis of the lymphatic glands and wounds of domestic animals. Tephrosia purpurea (T. purpurea), (Fabaceae) has been used traditionally as a remedy for asthma, gonorrhea, rheumatism and ulcers. This study aimed to evaluate the potential wound healing effects of different fractions ofethanol extract of M. annua leaves and aerial parts of T. purpurea. Materials and Methods: Methanol fraction of M. annua (MAF-C) and ethyl acetate fraction of T. purpurea (TPF-A) were evaluated for healing potential in dead-space and burn wound models. An ointment (5% w/w) of MAF-C and TPF-A, pongamol (0.2 and 0.5% w/w) and luteolin (0.2 and 0.5% w/w) was applied topically twice a day. The effects were compared with Povidone Iodine ointment with respect to protein, collagen content, enzymatic assay and histopath...
Herba Polonica, 2012
Plants have traditionally been used as a source of medicine in India by indigenous people of diff... more Plants have traditionally been used as a source of medicine in India by indigenous people of different ethnic groups inhabiting various terrains for the control of various ailments afflicting human and their domestic animals. Recently, focus on plant research has increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems. More than 13,000 plants have been studied during last 5 years. Our review aims to compile data generated through the research activity using modern scientific approaches and innovative scientific tools in last few years. This article represent wound healing activity of various plants found and used traditionally. We have made an attempt to give an insight into different plants of potential wound healing properties which could be beneficial in therapeutic practice.
Background: Ventilago calyculata Tul. (‘kevati’), is found throughout India as climbing shrub. It... more Background: Ventilago calyculata Tul. (‘kevati’), is found throughout India as climbing shrub. It is widely used in various traditional system of medicine. Objective: In the present work pharmacognostical standardization has been developed for the systematic identification of the bark of Ventilago calyculata. Phenols and flavonoids were also quantified. Materials and Methods: Morphological, microscopical and phytochemical studies were performed. Various physicochemical parameters conforming the identity, quality, purity of the bark. The quantity of phenols and flavonoids were estimated. Results: The bark was oval, brownish yellow, bitter with characteristic odour and rough texture. The microscopical studies revealed the presence of cork with brownish contents, crimson inner cork, collenchyma, cellulosic parenchyma with cuboidal calcium oxalate crystals and schlereids. The total ash value, acid insoluble ash value and water soluble ash values of stem bark were found to be 15% w/w, 3....
Journal of Acute Medicine, 2016
Objective: Sida cordifolia Linn. (Hindidkungyi; Sanskritdbala) is a shrub (family Malvaceae) grow... more Objective: Sida cordifolia Linn. (Hindidkungyi; Sanskritdbala) is a shrub (family Malvaceae) grown all over India. In Ayurveda, the crushed leaves of the plant is used for the treatment and dressing of wounds. Traditionally, root juice is also used to promote the healing of wounds. This study was designed to evaluate the wound healing potential of hydrogel of methanolic extract of Sida cordifolia Linn. (MeOHSC) in diabetic rats. Methods: The methanolic extract in the form of hydrogel was applied topically for the management of wounds in fructose-fed streptozotocininduced diabetic rats. The % wound contraction, period of epithelialization, hydroxyproline content, and histopathological examination were evaluated using the excision wound model, and tensile strength was measured using the incision wound model. Results: The results showed that in both models, hydrogel of MeOHSC was found to have significant wound healing activity compared with diabetic wound control in terms of % wound contraction (p < 0.01), period of epithelialization (p < 0.01), and hydroxyproline content (p < 0.01) in the excision model, and tensile strength (p < 0.01) in the incision model. The presence of collagen fibers and stronger growth of epithelial cells were observed in hydrogel of MeOHSC than in the diabetic wound control group. Conclusion: Our findings suggest that hydrogel of MeOHSC has a potential benefit in enhancing the wound healing process in diabetic condition. This is possibly because of the presence of phenolic compounds and confirmation of gallic acid in the extracts.
International Journal of Pharmacy and Pharmaceutical Sciences, 2015
Objective: This study was done for comparative evaluation of different herbal formulations used f... more Objective: This study was done for comparative evaluation of different herbal formulations used for topical delivery of therapeutic agents at the time of injury to accelerate skin repair in the shortest time possible, with minimal pain, discomfort and scarring to the patient during the wound healing process. Methods: Topical application of ointments and gels prepared from the methanolic extract of Aegle marmelos leaves and Mucuna pruriens seeds were formulated and evaluated for its efficacy and safety. General formulation approaches towards achieving optimum physical properties and topical delivery characteristics for an active wound healing dosage form were considered for different herbal formulations. Results: All formulation showed good stability during storage and no major changes observed after carrying out other physiochemical evaluations and during entire storage period. Differences in wound healing were observed between the various treatments and compared to the herbal formulation which has promising effect on the wound healing process. Conclusions: The results obtained were encouraging and gel-based formulations produced better wound healing than emulsifying ointment formulations. The results demonstrated that the tested hydrogel had promising healing effect in skin injuries and it will aid in identifying and targeting the many aspects of the complex wound healing process.
Chinese Medicine, 2011
The present study was undertaken to evaluate in-vitro antioxidant and anthelmintic activity of et... more The present study was undertaken to evaluate in-vitro antioxidant and anthelmintic activity of ethanolic and aqueous extract from whole plant Sida cordifolia Linn (Malvaceae). The antioxidant activities are evaluated by various antioxidant assays like α, α-Diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging, total reducing power, nitric oxide scavenging and hydrogen peroxide scavenging. The various antioxidant activities were compared to standard antioxidants such as ascorbic acid. The antioxidant activity of ethanolic extract is almost quantitatively equivalent to that of the standards used, ascorbic acid. The further anthelmintic activity of whole plant is investigated through using Indian earthworm (Pheretima posthuma) showed that it is one of the most important local medicinal plants both for ritual and ethnomedical practices. Various concentrations of ethanol and aqueous extract (10, 20, 30, 40 mg/ml) of whole plant of Sida cordifolia Linn were tested in the bioassay, which involve determination of time of paralysis of the worms. Albendazole was included as reference standard. The most activity was observed with aqueous extract as compared to standard drug. The results from the above studies indicate that plant Sida cordifolia Linn. possesses potent antioxidant and anthelmintic activity.
Pharmacognosy Communications, 2012
Introduction: The plant Alpinia galanga Linn.(Zingiberaceae) is widely distributed in India. It i... more Introduction: The plant Alpinia galanga Linn.(Zingiberaceae) is widely distributed in India. It is a perennial, aromatic and rhizomatous herb which is traditionally used as a carminative, stomachic, disinfectant, aphrodisiac and for the treatment of inflammation. The objective of present study is to evaluate the immunomodulatory and antioxidant effects of different extracts in a dose-dependent manner. Methods: Immunomodulatory activity was studied by examining T cell proliferation, splenocyte proliferation and by delayed type hypersensitivity reaction measurement. The antioxidant effect was observed by measuring lipid peroxidation (LPO), reduced glutathione (GSH) content and by determination of superoxide dismutase (SOD) and catalase (CAT) activities. Results: The flavonoid fraction of Alpinia galanga Linn. extract significantly stimulated (P <0.001) T cell proliferation and splenocyte proliferation in mice spleen at a dose of 100 mg/kg body weight of mice. The aqueous fraction had a lower stimulatory effect than the flavonoid fraction. The presence of quercetin in the flavonoid fraction was confirmed by chromatographic studies. The antioxidant level of the spleen cells also increased following treatment with the flavonoid fraction. Conclusion: In conclusion the flavonoid fraction of Alpinia galanga Linn. rhizomes have greater immunostimulating effects as well as antioxidant effects in mice.
Pharmacognosy Research, 2014
Objective: Ajuga bracteosa Wall ex Benth (Labiatae) is popularly known in India as "Neelkanthi." ... more Objective: Ajuga bracteosa Wall ex Benth (Labiatae) is popularly known in India as "Neelkanthi." A decoction of the leaves, fl owers, and barks is used in India for the treatment of cancer including diabetes, malaria, and infl ammation etc. The main objective of this study is to investigate the cytotoxic potential of Ajuga bracteosa. Materials and Methods: Successive solvent extraction of Ajuga bracteosa in petroleum ether, methanol, and water extracts was done. These extracts were tested against human breast adenocarcinoma (MCF-7) and larynx carcinoma (Hep-2) tumor cell lines, using the thiazolyl blue test (MTT) assay. Results: The methanolic fraction of Ajuga bracteosa had shown the signifi cant results against MCF-7 and Hep-2 tumor cell lines. The methanolic, petroleum ether and aqueous extract from Ajuga bracteosa, presented an IC50 value at 24 h of 10, 65, 70 μg/ml and 5, 30, 15 μg/ml on MCF-7 and Hep-2 cells, respectively. Steroids compounds namely β-sitosterol and unknown constituents were identifi ed in the most active methanol extract of Ajuga bracteosa wall ex Benth. These known and unknown compounds exhibited cytotoxic potential against MCF-7 and Hep-2 cancer cells. Conclusion: Among all the tested extracts, methanolic extract can be considered as potential sources of anti-cancer compounds. Further studies are necessary for more extensive biological evaluations.
Journal of Ethnopharmacology, 2010
The present study provides a scientific evaluation for the wound healing potential of methanolic ... more The present study provides a scientific evaluation for the wound healing potential of methanolic (MeOH) extract of TDR fruits. Excision and incision wounds were inflicted upon three groups of six rats each. Group I was assigned as control (ointment base), Group II was treated with standard silver sulfadiazine (0.01%) cream. Group III was treated with 5% MeOH extract ointment. The parameters observed were percentage of wound contraction, epithelialization period, hydroxyproline content, tensile strength including histopathological studies. It was noted that the effect produced by the extract ointment showed significant (P&lt;0.01) healing in both the wound models when compared with control group. All parameters such as wound contraction, epithelialization period, hydroxyproline content, tensile strength and histopathological studies showed significant changes when compared to control. The result shows that TDR extract ointment demonstrates wound healing potential in both excision and incision models.
Indian Journal of Pharmacology, 2010
Objective: To evaluate the hypoglycemic activity of various extracts, petroleum ether, chloroform... more Objective: To evaluate the hypoglycemic activity of various extracts, petroleum ether, chloroform and aqueous extract of Cassia occidentalis in normal and alloxan-induced diabetic rats. Materials and Methods: Petroleum ether, chloroform and aqueous extract of whole plant of Cassia occidentalis were orally tested at the dose of 200 mg/kg for hypoglycemic effect in normal and alloxan-induced diabetic rats. In addition, changes in body weight, serum cholesterol, triglyceride and total protein levels, assessed in the ethanol extract-treated diabetic rats, were compared with diabetic control and normal animals. Histopathological observations during 21 days treatment were also evaluated. Results: Aqueous extract of C. occidentalis produced a significant reduction in fasting blood glucose levels in the normal and alloxan-induced diabetic rats. Apart from aqueous extract, petroleum ether extract showed activity from day 14 and chloroform extract showed activity from 7 days. Significant differences were observed in serum lipid profiles (cholesterol and triglyceride), serum protein, and changes in body weight by aqueous extract treated-diabetic animals, when compared with the diabetic control and normal animals. Concurrent histopathological studies of the pancreas of these animals showed comparable regeneration by extract which were earlier necrosed by alloxan. Conclusion: Aqueous extract of C. occidentalis exhibited significant antihyperglycemic activity in normal and alloxan-induced diabetic rats. They also showed improvement in parameters like body weight and serum lipid profiles as well as histopathological studies showed regeneration of β-cells of pancreas and so might be of value in diabetes treatment.
Int J Cur Bio Med Sci., 2011
Fig.2.2 Effect of different extract (400mg/kg) of Ajuga bracteosa on Tail immersion method
British Journal of Pharmaceutical Research, 2016
Aims: This study was designed to elucidate the antioxidant, analgesic and antipyretic activities ... more Aims: This study was designed to elucidate the antioxidant, analgesic and antipyretic activities of the ethanol extract of the stem bark of Dichaetanthera africana.
Planta Medica, 2009
We are excited to present a program featuring a roster of internationally recognized experts and ... more We are excited to present a program featuring a roster of internationally recognized experts and researchers in the field of botanicals. We wish to extend our thanks to our speakers for their willingness to participate in and contribute to the success of the meeting. We invite you to visit the website of the National Center for Natural Products Research at http://www. pharmacy.olemiss.edu/ncnpr to learn more about our research program. Oxford and the Ole Miss campus are a beautiful setting, and we hope you will get to explore them, especially if this is your first time to visit here. If there is anything we can do to make your visit more enjoyable, please contact us.
Journal of Ethnopharmacology, 2006
Tephrosia purpurea is a well-known herb for its hepatoprotective, anticancer, antiulcer, antibact... more Tephrosia purpurea is a well-known herb for its hepatoprotective, anticancer, antiulcer, antibacterial and in healing bleeding piles, etc. The present study was aimed for wound healing potential of ethanolic extract of Tephrosia purpurea (aerial part) in the form of simple ointment using three types of wound models in rats as incision wound, excision wound and dead space wound. The results were comparable to standard drug Fluticasone propionate ointment, in terms of wound contraction, tensile strength, histopathological and biochemical parameters such as hydroxyproline content, protein level, etc. Histopathological study showed significant (P < 0.05) increase in fibroblast cells, collagen fibres and blood vessels formation. All parameters were observed significant (P < 0.05) in comparison to control group.
Uploads
Papers by Dr. Rajesh Singh Pawar