Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, Jan 22, 2016
To investigate the role of Sirtuin1 in osteoporosis, Sirtuin1 was determined at the femoral neck ... more To investigate the role of Sirtuin1 in osteoporosis, Sirtuin1 was determined at the femoral neck in female patients undergoing hip operation for fractured hip or osteoarthritis. Reduced Sirtuin1 was found in osteoporotic patients. Pharmacologic activation of Sirtuin1 reduced sclerostin, an inhibitor of bone formation. Activation of Sirtuin1 may be a new direction to generate therapies for osteoporosis. The aim of the study are to investigate the role of Sirtuin1 (Sirt1), an anti-aging factor and a player in age-associated diseases, in osteoporotic hip fractures, and test the hypothesis that Sirt1 is a negative regulator of sclerostin, a bone formation inhibitor, in human femoral bone marrow mesenchymal cells (BM-MSCs). Sirt1 and sclerostin were determined by western blot in bone samples obtained intra-operatively from the inferior medial cortex of the femoral neck (calcar region) in female patients undergoing partial hip replacement for fractured neck of femur (N = 10) or hip replac...
Objectives/Interrogation: Lateral epicondylitis is a tendinopathy of the common extensor origin a... more Objectives/Interrogation: Lateral epicondylitis is a tendinopathy of the common extensor origin at the elbow. When traditional conservative treatment fails, more effective therapies are needed. VergenixTM Soft Tissue Repair Matrix is an injectable gel composed of cross-linked bio-engineered recombinant[for full text, please go to the a.m. URL]
Introduction: Acute hematogenous osteomyelitis (AHO) has been noted mainly in open fractures inju... more Introduction: Acute hematogenous osteomyelitis (AHO) has been noted mainly in open fractures injuring soft tissue immunological defenses and in immuneincompetent patients. Osteomyelitis complicating closed fractures in immunocompetent adult patients is, therefore, a rare clinical entity with scarce literature. Case Report: We report a case of primary Staphylococcus aureus bacterial infection of a closed, humeral shaft fracture occurring in a previously healthy 28-year-old male patient. The patient was involved in a motorcycle accident and was admitted to the surgical ward with a chest drain. While hospitalized, a peak of fever was noted, but no source was found. Diagnosis of the closed fracture infection was noted on primary open reduction and internal fixation (ORIF), and although the patient was treated with antibiotics, local osteomyelitis developed. Treatment including serial debridements utilizing gentamycin beads and an additional ORIF procedure until the full union was achiev...
Classifications of scaphoid fractures associate the angle of the fracture with its stability. To ... more Classifications of scaphoid fractures associate the angle of the fracture with its stability. To examine this assumption, we measured acute scaphoid fracture angles and inclinations in relation to different scaphoid axes, using fracture displacement as an indicator of instability. We examined the effect of using different axes on the measurements of angles. CT scans of 133 scaphoid fractures were classified according to the location of the fractures. Using a three-dimensional computer model, we computed four scaphoid axes. For each fracture, we then measured the fracture angle and the direction of the fracture inclination in relation to each one of the axes. We found a correlation between displacement and the angles of proximal fractures using one of these axes (the surface principal component analysis axis). No such correlations were found for waist fractures, which were the majority of fractures. There were significant differences between the measurements made with different axes....
CASE REPORT Quincke sign manifested on the wrist of a young healthy man. The patient had self-tre... more CASE REPORT Quincke sign manifested on the wrist of a young healthy man. The patient had self-treated with topical antibiotics and steroids for a second-degree burn, but then developed contact dermatitis followed by cellulitis. He presented to the emergency department with a "blinking" effect of the skin lesion. CONCLUSION The "blinking" effect is the result of focal subcutaneous arterial dilatation in the zone of subcutaneous inflammation.
ABSTRACT For the enhancement of population inversion in Cu-halide laser, the potential energy of ... more ABSTRACT For the enhancement of population inversion in Cu-halide laser, the potential energy of metastable state is effectively converted to the quantum transition energy. As a candidate for this aim, Cu-Eu system is proposed. With Cu-Eu system, Cu main lasing and Eu auxiliary lasing are expected simultaneously.
Journal of Physics G: Nuclear and Particle Physics, 2000
The ratio (R), defined as the fractional decrease in the beam signal divided by the fractional de... more The ratio (R), defined as the fractional decrease in the beam signal divided by the fractional decrease in the light monitoring signal, was measured at the GIF-X5 facility for a set of 20 ECAL barrel crystals. The dependence of R on the wavelength of the injected monitoring light and its path-length in the crystals was studied. Measurements of the inter-crystal variation in R are presented for 10 pre-production crystals. Results on the dependence of signal loss on the irradiation profile are given. The use of lead filters, placed between a 137 Cs source and a crystal, to reproduce different longitudinal irradiation profiles has been tested.
Supplemental material, Supplemental_Video for Median Nerve Compression in the Forearm: A Clinical... more Supplemental material, Supplemental_Video for Median Nerve Compression in the Forearm: A Clinical Diagnosis by Madi El-Haj, Wei Ding, Ketan Sharma, Christine Novak, Susan E. Mackinnon and J. Megan M. Patterson in HAND
Supplemental material, sj-docx-1-han-10.1177_1558944720988126 for Radial Nerve Palsy: Nerve Trans... more Supplemental material, sj-docx-1-han-10.1177_1558944720988126 for Radial Nerve Palsy: Nerve Transfer Versus Tendon Transfer to Restore Function by J. Megan M. Patterson, Stephanie A. Russo, Madi El-Haj, Christine B. Novak and Susan E. Mackinnon in HAND
Background: Radial nerve injuries cause profound disability, and a variety of reconstruction opti... more Background: Radial nerve injuries cause profound disability, and a variety of reconstruction options exist. This study aimed to compare outcomes of tendon transfers versus nerve transfers for the management of isolated radial nerve injuries. Methods: A retrospective chart review of 30 patients with isolated radial nerve injuries treated with tendon transfers and 16 patients managed with nerve transfers was performed. Fifteen of the 16 patients treated with nerve transfer had concomitant pronator teres to extensor carpi radialis brevis tendon transfer for wrist extension. Preoperative and postoperative strength data, Disabilities of the Arm, Shoulder, and Hand (DASH) scores, and quality-of-life (QOL) scores were compared before and after surgery and compared between groups. Results: For the nerve transfer group, patients were significantly younger, time from injury to surgery was significantly shorter, and follow-up time was significantly longer. Both groups demonstrated significant ...
Background: Cubital tunnel syndrome has a spectrum of presentations ranging from mild paresthesia... more Background: Cubital tunnel syndrome has a spectrum of presentations ranging from mild paresthesias to debilitating numbness and intrinsic atrophy. Commonly, the classification of severity relies on clinical symptoms and slowing of conduction velocity across the elbow. However, changes in compound muscle action potential (CMAP) amplitude more accurately reflect axonal loss. We hypothesized that CMAP amplitude would better predict functional impairment than conduction velocity alone. Methods: A retrospective cohort of patients who underwent a surgical procedure for cubital tunnel syndrome over a 5year period were included in the study. All patients had electrodiagnostic testing performed at our institution. Clinical and electrodiagnostic variables were recorded. The primary outcome was preoperative functional impairment, defined by grip and key pinch strength ratios. Multivariable regression identified which clinical and electrodiagnostic variables predicted preoperative functional impairment. Results: Eighty-three patients with a mean age of 57 years (75% male) were included in the study. The majority of patients (88%) had abnormal electrodiagnostic studies. Fifty-four percent had reduced CMAP amplitude, and 79% had slowing of conduction velocity across the elbow (recorded from the first dorsal interosseous). On bivariate analysis, older age and longer symptom duration were significantly associated (p < 0.05) with reduced CMAP amplitude and slowing of conduction velocity across the elbow, whereas body mass index (BMI), laterality, a primary surgical procedure compared with revision surgical procedure, Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire scores, and visual analog scale (VAS) scores for pain were not. Multivariable regression analysis demonstrated that reduced first dorsal interosseous CMAP amplitude independently predicted the loss of preoperative grip and key pinch strength and that slowed conduction velocity across the elbow did not. Conclusions: Reduced first dorsal interosseous amplitude predicted preoperative weakness in grip and key pinch strength, and isolated slowing of conduction velocity across the elbow did not. CMAP amplitude is a sensitive indicator of axonal loss and an important marker of the severity of cubital tunnel syndrome. It should be considered when counseling patients with regard to their prognosis and determining the necessity and timing of operative intervention. Level of Evidence: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence. C ubital tunnel syndrome is the second most common compression neuropathy 1,2. It often presents insidiously because the initial symptoms can be intermittent and vague. The sensory symptoms, being limited to the ulnar side of the hand, may not be as bothersome as the critical sensory loss seen in carpal tunnel syndrome. It is therefore not unusual for patients to present with advanced symptoms such as atrophy of the intrinsic muscles and weakness 3. The classic constellation of ulnar compression symptoms is the result of a complex interplay of mechanical and ischemic forces on the ulnar nerve at the cubital tunnel 4,5. Initially, the compressed nerve develops focal areas of demyelination that may Disclosure: There was no source of external funding for this study. The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJS/F182).
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, Jan 22, 2016
To investigate the role of Sirtuin1 in osteoporosis, Sirtuin1 was determined at the femoral neck ... more To investigate the role of Sirtuin1 in osteoporosis, Sirtuin1 was determined at the femoral neck in female patients undergoing hip operation for fractured hip or osteoarthritis. Reduced Sirtuin1 was found in osteoporotic patients. Pharmacologic activation of Sirtuin1 reduced sclerostin, an inhibitor of bone formation. Activation of Sirtuin1 may be a new direction to generate therapies for osteoporosis. The aim of the study are to investigate the role of Sirtuin1 (Sirt1), an anti-aging factor and a player in age-associated diseases, in osteoporotic hip fractures, and test the hypothesis that Sirt1 is a negative regulator of sclerostin, a bone formation inhibitor, in human femoral bone marrow mesenchymal cells (BM-MSCs). Sirt1 and sclerostin were determined by western blot in bone samples obtained intra-operatively from the inferior medial cortex of the femoral neck (calcar region) in female patients undergoing partial hip replacement for fractured neck of femur (N = 10) or hip replac...
Objectives/Interrogation: Lateral epicondylitis is a tendinopathy of the common extensor origin a... more Objectives/Interrogation: Lateral epicondylitis is a tendinopathy of the common extensor origin at the elbow. When traditional conservative treatment fails, more effective therapies are needed. VergenixTM Soft Tissue Repair Matrix is an injectable gel composed of cross-linked bio-engineered recombinant[for full text, please go to the a.m. URL]
Introduction: Acute hematogenous osteomyelitis (AHO) has been noted mainly in open fractures inju... more Introduction: Acute hematogenous osteomyelitis (AHO) has been noted mainly in open fractures injuring soft tissue immunological defenses and in immuneincompetent patients. Osteomyelitis complicating closed fractures in immunocompetent adult patients is, therefore, a rare clinical entity with scarce literature. Case Report: We report a case of primary Staphylococcus aureus bacterial infection of a closed, humeral shaft fracture occurring in a previously healthy 28-year-old male patient. The patient was involved in a motorcycle accident and was admitted to the surgical ward with a chest drain. While hospitalized, a peak of fever was noted, but no source was found. Diagnosis of the closed fracture infection was noted on primary open reduction and internal fixation (ORIF), and although the patient was treated with antibiotics, local osteomyelitis developed. Treatment including serial debridements utilizing gentamycin beads and an additional ORIF procedure until the full union was achiev...
Classifications of scaphoid fractures associate the angle of the fracture with its stability. To ... more Classifications of scaphoid fractures associate the angle of the fracture with its stability. To examine this assumption, we measured acute scaphoid fracture angles and inclinations in relation to different scaphoid axes, using fracture displacement as an indicator of instability. We examined the effect of using different axes on the measurements of angles. CT scans of 133 scaphoid fractures were classified according to the location of the fractures. Using a three-dimensional computer model, we computed four scaphoid axes. For each fracture, we then measured the fracture angle and the direction of the fracture inclination in relation to each one of the axes. We found a correlation between displacement and the angles of proximal fractures using one of these axes (the surface principal component analysis axis). No such correlations were found for waist fractures, which were the majority of fractures. There were significant differences between the measurements made with different axes....
CASE REPORT Quincke sign manifested on the wrist of a young healthy man. The patient had self-tre... more CASE REPORT Quincke sign manifested on the wrist of a young healthy man. The patient had self-treated with topical antibiotics and steroids for a second-degree burn, but then developed contact dermatitis followed by cellulitis. He presented to the emergency department with a "blinking" effect of the skin lesion. CONCLUSION The "blinking" effect is the result of focal subcutaneous arterial dilatation in the zone of subcutaneous inflammation.
ABSTRACT For the enhancement of population inversion in Cu-halide laser, the potential energy of ... more ABSTRACT For the enhancement of population inversion in Cu-halide laser, the potential energy of metastable state is effectively converted to the quantum transition energy. As a candidate for this aim, Cu-Eu system is proposed. With Cu-Eu system, Cu main lasing and Eu auxiliary lasing are expected simultaneously.
Journal of Physics G: Nuclear and Particle Physics, 2000
The ratio (R), defined as the fractional decrease in the beam signal divided by the fractional de... more The ratio (R), defined as the fractional decrease in the beam signal divided by the fractional decrease in the light monitoring signal, was measured at the GIF-X5 facility for a set of 20 ECAL barrel crystals. The dependence of R on the wavelength of the injected monitoring light and its path-length in the crystals was studied. Measurements of the inter-crystal variation in R are presented for 10 pre-production crystals. Results on the dependence of signal loss on the irradiation profile are given. The use of lead filters, placed between a 137 Cs source and a crystal, to reproduce different longitudinal irradiation profiles has been tested.
Supplemental material, Supplemental_Video for Median Nerve Compression in the Forearm: A Clinical... more Supplemental material, Supplemental_Video for Median Nerve Compression in the Forearm: A Clinical Diagnosis by Madi El-Haj, Wei Ding, Ketan Sharma, Christine Novak, Susan E. Mackinnon and J. Megan M. Patterson in HAND
Supplemental material, sj-docx-1-han-10.1177_1558944720988126 for Radial Nerve Palsy: Nerve Trans... more Supplemental material, sj-docx-1-han-10.1177_1558944720988126 for Radial Nerve Palsy: Nerve Transfer Versus Tendon Transfer to Restore Function by J. Megan M. Patterson, Stephanie A. Russo, Madi El-Haj, Christine B. Novak and Susan E. Mackinnon in HAND
Background: Radial nerve injuries cause profound disability, and a variety of reconstruction opti... more Background: Radial nerve injuries cause profound disability, and a variety of reconstruction options exist. This study aimed to compare outcomes of tendon transfers versus nerve transfers for the management of isolated radial nerve injuries. Methods: A retrospective chart review of 30 patients with isolated radial nerve injuries treated with tendon transfers and 16 patients managed with nerve transfers was performed. Fifteen of the 16 patients treated with nerve transfer had concomitant pronator teres to extensor carpi radialis brevis tendon transfer for wrist extension. Preoperative and postoperative strength data, Disabilities of the Arm, Shoulder, and Hand (DASH) scores, and quality-of-life (QOL) scores were compared before and after surgery and compared between groups. Results: For the nerve transfer group, patients were significantly younger, time from injury to surgery was significantly shorter, and follow-up time was significantly longer. Both groups demonstrated significant ...
Background: Cubital tunnel syndrome has a spectrum of presentations ranging from mild paresthesia... more Background: Cubital tunnel syndrome has a spectrum of presentations ranging from mild paresthesias to debilitating numbness and intrinsic atrophy. Commonly, the classification of severity relies on clinical symptoms and slowing of conduction velocity across the elbow. However, changes in compound muscle action potential (CMAP) amplitude more accurately reflect axonal loss. We hypothesized that CMAP amplitude would better predict functional impairment than conduction velocity alone. Methods: A retrospective cohort of patients who underwent a surgical procedure for cubital tunnel syndrome over a 5year period were included in the study. All patients had electrodiagnostic testing performed at our institution. Clinical and electrodiagnostic variables were recorded. The primary outcome was preoperative functional impairment, defined by grip and key pinch strength ratios. Multivariable regression identified which clinical and electrodiagnostic variables predicted preoperative functional impairment. Results: Eighty-three patients with a mean age of 57 years (75% male) were included in the study. The majority of patients (88%) had abnormal electrodiagnostic studies. Fifty-four percent had reduced CMAP amplitude, and 79% had slowing of conduction velocity across the elbow (recorded from the first dorsal interosseous). On bivariate analysis, older age and longer symptom duration were significantly associated (p < 0.05) with reduced CMAP amplitude and slowing of conduction velocity across the elbow, whereas body mass index (BMI), laterality, a primary surgical procedure compared with revision surgical procedure, Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire scores, and visual analog scale (VAS) scores for pain were not. Multivariable regression analysis demonstrated that reduced first dorsal interosseous CMAP amplitude independently predicted the loss of preoperative grip and key pinch strength and that slowed conduction velocity across the elbow did not. Conclusions: Reduced first dorsal interosseous amplitude predicted preoperative weakness in grip and key pinch strength, and isolated slowing of conduction velocity across the elbow did not. CMAP amplitude is a sensitive indicator of axonal loss and an important marker of the severity of cubital tunnel syndrome. It should be considered when counseling patients with regard to their prognosis and determining the necessity and timing of operative intervention. Level of Evidence: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence. C ubital tunnel syndrome is the second most common compression neuropathy 1,2. It often presents insidiously because the initial symptoms can be intermittent and vague. The sensory symptoms, being limited to the ulnar side of the hand, may not be as bothersome as the critical sensory loss seen in carpal tunnel syndrome. It is therefore not unusual for patients to present with advanced symptoms such as atrophy of the intrinsic muscles and weakness 3. The classic constellation of ulnar compression symptoms is the result of a complex interplay of mechanical and ischemic forces on the ulnar nerve at the cubital tunnel 4,5. Initially, the compressed nerve develops focal areas of demyelination that may Disclosure: There was no source of external funding for this study. The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJS/F182).
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