Papers by Dr. Madhusmruti Khandai
Environmental Science and Pollution Research, Mar 24, 2023
Social Science Research Network, 2022
Disaster Medicine and Public Health Preparedness
India has already passed through 2 waves of the coronavirus disease (COVID-19) pandemic losing ma... more India has already passed through 2 waves of the coronavirus disease (COVID-19) pandemic losing many lives. The reason for losing lives may be due to the unpreparedness of the health care system of India for this unprecedented pandemic. To assess the government’s preparedness, an institutional-based cross-sectional prospective survey was conducted among the adult population of selected states in India. A self-administered 30-item questionnaire divided into 5 sections (demography of the participants, steps to create awareness, prevent spread of infection, handle the emergency, and prognosis) was distributed online through Google Forms. The responses were collected in an Excel file. SPSS software was used to perform the descriptive statistics and analysis of variance (ANOVA). Nearly a quarter of the participants “strongly disagree”/“disagree” about the government’s preparedness for the third wave. Considering their perception, it cannot be assured that the government is well prepared t...
Archives of Pharmacy Practice
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Recent developments in nanotechnology and process chemistry have expanded the scope of nanostruct... more Recent developments in nanotechnology and process chemistry have expanded the scope of nanostructures to the biomedical field. The ability of nanostructures to precisely deliver drugs to the target site not only reduces the amount of drug needed but also reduces systemic adverse effects. Carbon nanostructures gained traction in pharmaceutical technology in the last decade due to their high stability, ease of synthesis, tunable surface chemistry, and biocompatibility. Fullerene, nanotubes, nanodiamonds, nanodots, and nanoribbons are among the major carbon nanostructures that have been extensively studied for applications in tissue engineering, biosensing, bioimaging, theranostics, drug delivery, and gene therapy. Due to the fluorescent properties of functionalized nanostructures, they have been extensively studied for use as probes in cellular imaging. Moreover, these nanostructures are promising candidates for delivering drugs to the brain, bones, and deep-seated tumors. Still, rese...
Current Reviews in Clinical and Experimental Pharmacology
Background: Parkinson's disease is the second most common neurological ailment. It is also kn... more Background: Parkinson's disease is the second most common neurological ailment. It is also known that it affects practically all other brain components, although only gradually. Animal models are mostly used to test the efficacy of treatment against a specific enzyme and to aid in the creation of a new drug dose. Objective: The purpose of this review paper is to highlight in vivo Parkinson's disease screening approaches, as well as the mechanism of action of each drug involved in Parkinson's disease development, and discuss the limitations of each model. In addition, also sheds light on Parkinson's disease genetic models. Method: The data for the publication was gathered from databases such as PubMed, Bentham Science, Elsevier, Springer Nature, Wiley, and Research Gate after a thorough examination of diverse research findings linked to Parkinson’s disease and its screening models. Result: Each chemical or drug has a unique mechanism for causing disease, whether it...
International Journal of Green Pharmacy, 2008
In the present study, the effects of a natural superdisintegrant vis-a-vis isolated mucilage of P... more In the present study, the effects of a natural superdisintegrant vis-a-vis isolated mucilage of Plantago ovata and synthetic superdisintegrants like sodium starch glycolate (SSG) and croscarmellose sodium (Ac-di-sol) were compared in the formulations of fast dissolving tablets (FDT). FDTs of aceclofenac (model drug) were prepared by direct compression method using microcrystalline cellulose as direct compressible vehicle. Th ose tablets were evaluated for weight variation, hardness, disintegration time, drug content, friability and dissolution. Swelling index was also investigated with an aim to compare the swelling property of mucilage of Plantago ovata with SSG and Ac-di-sol. Among all the super disintegrants, Plantago ovata mucilage showed the highest swelling index. Hence, the present study revealed that this natural superdisintegrant (Plantago ovata mucilage) showed better disintegrating property than the most widely used synthetic super disintegrants like SSG and Ac-di-sol in the formulations of FDTs. Key words: Fast dissolving drug delivery, Plantago ovata mucilage, swelling index, sodium starch glycolate, croscarmellose sodium
Acta Pharmaceutica, 2009
Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC... more Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of the tablets were studied. Applying an exponential equation, it was found that the kinetics of soluble drug release followed anomalous non-Fickian diffusion transport whereas insoluble drug showed zero-order release. SEM study showed pore formation on the tablet surface that differed depending on drug solubility. t-Test pointed to a significant difference in amount of both drugs released due to the difference in solubili...
Acta Pharmaceutica, 2010
Preparation,in vitroandin vivoevaluation of algino-pectinate bioadhesive microspheres: An investi... more Preparation,in vitroandin vivoevaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysisIonotropic gelation was used to entrap aceclofenac into algino-pectinate bioadhesive microspheres as a potential drug carrier for the oral delivery of this anti-inflammatory drug. Microspheres were investigatedin vitrofor possible sustained drug release and their usein vivoas a gastroprotective system for aceclofenac. Polymer concentration and polymer/drug ratio were analyzed for their influence on microsphere properties. The microspheres exhibited good bioadhesive property and showed high drug entrapment efficiency. Drug release profiles exhibited faster release of aceclofenac from alginate microspheres whereas algino-pectinate microspheres showed prolonged release. Dunnet's multiple comparison analysis suggested a significant difference in percent inhibition of paw edema when the optimized formulation was compared ...
Powder Technology, 2014
The objective behind this study is to ameliorate the flowability, compressibility and tableting p... more The objective behind this study is to ameliorate the flowability, compressibility and tableting properties of aceclofenac by developing a prolonged release microparticulate system using an algino-carbopol polymeric blend. Prepared microspheres were subjected to various physico-chemical studies along with in vitro drug release studies to optimize the concentration of the polymeric blend required to sustain the drug release for 12 h. Optimize formulation was further subjected to different flowability and compressibility studies to observe the impact of microspheres on improvements of flow properties. All the microsphere formulations exhibited good entrapment efficiency and showed prolonged drug release. SEM study revealed that the microspheres were almost spherical in shape with rough outer surface containing small pores. The findings of micromeritic studies suggested that the flowability and compressibility properties of the pure drug were significantly improved by the microsphere formulation. Heckel analysis also suggested that the microspheres exhibited better plasticity and die filling behavior as compared to pure drug. The tablets containing optimized microspheric formulation showed better handling properties than pure drug and no significant difference in drug release when compared with the marketed product. So the present study concluded that encapsulation of aceclofenac into microparticulate system not only enhanced its flowability, compressibility and tableting properties but also simultaneously helped to improve the patient compliance by sustaining the drug release for a prolonged period of time to manage pain and its symptoms.
Current Drug Delivery, 2012
The aim of this present research work was to prepare and evaluate alginate microspheres of aceclo... more The aim of this present research work was to prepare and evaluate alginate microspheres of aceclofenac by ionic gelation method for targeting the drug release in intestinal region and decrease distinct tissue protection in the stomach. This method offers to prepare microspheres which are important in controlling the release rate and the absorption of aceclofenac from the intestinal region. Variation in polymer concentration was studied systemically for their influence on the encapsulation efficacy, particle size and in vitro drug release. The enteric nature of the microspheres showed very less amount of drug released in acidic medium. The mucoadhesion property was strongly dependent on the pH of the medium and the polymer concentration in the formulations. In vitro drug release study proposed a mixed drug release mechanism, partially involving the sphere matrix disintegration and drug diffusion of the microspheres. Holm-Sidak multiple comparison analysis suggested a significant difference in measured t50% values among all the microsphere formulations. In vivo studies revealed that the anti-inflammatory effect induced by the aceclofenac loaded alginate microspheres was significantly high and prolonged than that induced by the pure aceclofenac. So, this aceclofenac loaded alginate microspheres exhibited promising properties to improve the patient compliance by controlling and prolonging the systemic absorption of aceclofenac along with a distinct tissue protection in the stomach.
The aim of the study is to formulate paracetamol suspensions and evaluate their sedimentation sta... more The aim of the study is to formulate paracetamol suspensions and evaluate their sedimentation stability in a rapid way by employing near infrared transmission measurements. The mucilage extracted from Plantago ovata seeds was also used as one of the suspending agents. The mucilage is a natural suspending agent that can be used as an effective alternative for traditional suspending agents. Stability studies of suspensions are very important to enable the patient to receive the intended amount of the drug(s) in the dose administered. Physical stability of paracetamol suspensions was studied in terms of sedimentation stability in a rapid way employing infrared extinction profiles by using the instrument Separation analyzer (LUMiReader ®) in the present work. The LUMiReader ® instantaneously measures the extinction profiles of the transmitted light across the entire length of a suspension sample employing STEP-Technology (Space-and Time-resolved Extinction Profiles Technology). Paraceta...
The aim of the present work was to develop sustain release matrix formulation of Propranolol hydr... more The aim of the present work was to develop sustain release matrix formulation of Propranolol hydrochloride and investigate the effects of both hydrophilic and hydrophobic polymers on in-vitro drug release. Matrix tablets were prepared by direct compression method using different concentration of Hydroxypropylmethylcellulose (HPMC) and Ethyl Cellulose (EC). Prepared formulations were subjected to various studies like hardness, friability, thickness, % drug content, weight variation, dynamics of water uptake and erosion etc. Tablets were subjected to In-Vitro drug release in 0.1 N HCl (pH 1.2) for first 2 hours followed by phosphate buffer (pH 6.8) for remaining hours. In-vitro drug release data were fitting to Higuchi and Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release. It was observed that combination of both the polymers exhibited the best release profile and able to sustain the drug release for prolong period of time. Swelling ...
Suspensions are one of the most important and popular dosage forms. A large number of drugs are ... more Suspensions are one of the most important and popular dosage forms. A large number of drugs are formulated in the form of suspensions and are available commercially. Stability studies of suspensions are very important to enable the patient to receive the intended amount of the medicine(s) in the dose administered. Physical stability of ampicillin suspensions was studied in terms of sedimentation stability in a rapid way employing infrared extinction profiles by using the instrument Separation analyzer (LUMiReader®) in the present work. The LUMiReader® instantaneously measures the extinction profiles of the transmitted light across the entire length of a suspension sample employing STEP-Technology (Space- and Time-resolved Extinction Profiles Technology). Ampicillin trihydrate suspensions were formulated with different suspending agents like methylcellulose (MC), hydroxypropyl methylcellulose (HPMC), sodium carboxymethylcellulose (SCMC) and mucilage of Plantago ovata (POM) and thei...
The present investigation was aimed to isolate, characterize and establish a natural polymer obta... more The present investigation was aimed to isolate, characterize and establish a natural polymer obtained from partially ripe and fresh fruits of Dillenia indica and its utility to deliver losartan potassium in a sustained manner from microspheric macromolecular dosage form. All the microspheres were prepared by ionotropic gelation technique and investigated for various physico-chemical parameters along with in-vitro drug release studies to optimize the concentration of algino-Dillenia polymeric blend required to develop twice daily sustained release dosage form of losartan potassium. The functional characteristic studies and rheological behavior analysis suggested that extracted polysaccharide can be used as a viscosity modifying agent as well as sustain release ingredient. All the microsphere formulations exhibited excellent mucoadhesion properties and site-specific drug release. In-vitro studies revealed that the optimum concentration of algino-Dillenia polymeric blend is suitable to...
The aim of the study is to formulate paracetamol su spensions and evaluate their sedimentation st... more The aim of the study is to formulate paracetamol su spensions and evaluate their sedimentation stabilit y in a rapid way by employing near infrared transmission measure ments. The mucilage extracted from Plantago ovata s eed was also used as one of the suspending agents. The muci lage is a natural suspending agent that can be used as an effective alternative for traditional suspending ag ents. Stability studies of suspensions are very imp ortant to enable the patient to receive the intended amount of the d rug(s) in the dose administered. Physical stability of paracetamol suspensions was studied in terms of sedimentation s tability in a rapid way employing infrared extincti on profiles by using the instrument Separation analyzer (LUMiReade r) in the present work. The LUMiReader ® instantaneously measures the extinction profiles of the transmitted light across the entire length of a suspension sam ple employing STEP-Technology (Spaceand Time-resolved Extinctio n Profiles Technology)....
Micro-particulate drug delivery of aceclofenac was prepared by gelation technique using a blend o... more Micro-particulate drug delivery of aceclofenac was prepared by gelation technique using a blend of sod ium alginate and sericin as release retardant. The formulations were investigated for various evaluation parameters like particle size, flow behavior, swelling properties, surface m orphology study by SEM and in vitro drug release et c. All the formulations showed good flow behavior as compared to the pure drug. It was observed that by increasin g the polymer concentration the drug release of all the f ormulations were gradually decreased. The drug rele ase mechanism showed that all the formulations followed zero order kinetics followed by case-II diffusion. SEM study revealed that the spheres were almost spherical in shape with rough outer surface. Ex- vivo mucoadhesion study depicts that when the polymer concentration was inc reased the mucoadhesion nature was also increased. FTIR study showed that the major peaks of pure drug were almost intact in the formulation. So, it was con...
Current Drug Delivery, Mar 10, 2015
The aim of the present research work is to develop carbo-protein polymeric complex based sustain ... more The aim of the present research work is to develop carbo-protein polymeric complex based sustain release microspheres of losartan potassium and investigate the ability of this dosage form to improve the flowability, compressibility and tableting properties of losartan potassium. The influence of silk sericin, alginate and its blend on various physicochemical parameters and in vitro drug release pattern were studied to optimize the concentration of polymeric blend required for 12 h. sustain release. Optimized batch was subjected to different flowability, compressibility and tableting properties studies to observe the effects of carbo-protein microspheres on flow properties. Results indicated that the concentration of sericin was found to be the main influential factor for prolonged drug release. Different micromeritic studies revealed that the poor flowability and compressibility properties of pure losartan potassium were significantly improved by this algino-sericin microspheric dosage form. Research findings also revealed that plasticity, die filling behavior and tableting properties of the pure drug were significantly improved by this microsphere formulation. So these prospective results concluded that carbo-protein polymeric microspheres helps to sustain the drug release for prolong hours as well as improve the flowability, compressibility and tableting properties of losartan potassium.
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Papers by Dr. Madhusmruti Khandai