Papers by Dr Harun Hudari
Human immunodeficiency virus (HIV) is a retrovirus type virus that infects cells of the human imm... more Human immunodeficiency virus (HIV) is a retrovirus type virus that infects cells of the human immune system (especially CD4 positive T-cells and major components of the cellular immune system), and interferes with their function. This viral infection results in a continuous decline in the immune system, which will result in immune deficiency. People who are immune deficient/immunodeficiency become more susceptible to various types of infections.
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya
Rapid increasing cases of Monkeypox infections in countries around the world, forcing medical pro... more Rapid increasing cases of Monkeypox infections in countries around the world, forcing medical professionals to be prepared to prevent it becoming the next global pandemic. We conducted the study to determine knowledge, attitude, and perception of doctors regarding preparedness for 2022 human monkeypox infection. This cross-sectional design research was conducted on 2-5 of August 2022, by circulating an online survey link to all internal medicine residents at the medical faculty of Universitas Sriwijaya, Dr. Mohammad Hoesin hospital Palembang Indonesia. The survey contained questions about the respondent's characteristics, knowledge, attitudes and perceptions about Monkeypox infection. A total of 75 residents agreed and completed the survey and were analyzed, with a mean age of 31 years, and 49 men (65.3%). Respondents’ knowledge of monkeypox is not very good. Almost all respondents knew that monkeypox was transmitted by direct contact, but only 53.4% knew that monkeypox was not ...
The Eurasian Journal of Medicine
Objective: The global case fatality rate of coronavirus disease 2019 is 2.16% as announced by the... more Objective: The global case fatality rate of coronavirus disease 2019 is 2.16% as announced by the World Health Organization. In Indonesia, according to the Ministry of Health, the number is even higher, reaching a 2.8% case fatality rate. D-dimer levels were found to affect coronavirus disease 2019 patient' s survival in several studies. The study aimed to determine whether the amount of D-dimer predicted survival in coronavirus disease 2019 patients. Materials and Methods: This research was performed in a retrospective cohort design and used survival analysis. From March 1, 2020, to August 31, 2020, the samples were collected from polymerase chain reaction-confirmed coronavirus disease 2019 patients at Mohammad Hoesin General Hospital in Palembang, South Sumatera, Indonesia. We used electronic medical records to obtain demographic (age and gender), coexisting condition, laboratory (coagulation and hematologic test), and outcome (non-survivors or survivors) data. The chi-square and Mann-Whitney tests were used to evaluate the results. The Kaplan-Meier method and the Mantel-Haenszel log-rank test were used to examine D-dimer levels and patient outcomes. Youden index was calculated to determine the optimal cutoff value of D-dimer. Results: There were 52 non-survivors and 235 survivors among the 287 patients who met the inclusion criterion. Non-survivors had D-dimer levels of more than 1.49 mg/L in 82.69% of cases. Males had lower cutoff compared to females (>1.49 mg/L vs. >2.2 mg/L). The researchers discovered a highly significant correlation between D-dimer levels and coronavirus disease 2019 mortality (P = .001). The c-index analysis showed that D-dimer (0.79, 95% CI: 0.73-0.83) ability for mortality prediction was the second-best compared with other laboratory markers. Conclusion: D-dimer can be used as a predictor of coronavirus disease 2019 in-hospital mortality for early identification of coagulopathy.
Bioscientia Medicina : Journal of Biomedicine and Translational Research
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndro... more The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The clinical manifestation of COVID-19 is broad, ranging from an asymptomatic carrier state to severe disease leading to the death penalty. There is also emerging evidence that kidneys are affected early in COVID-19. Proteinuria and haematuria have been reported in 44% and 26.7% on admission, respectively. This literature review shows clinical manifestations of acute kidney injury (AKI) in a patient with COVID-19 infection. Literature reviews are carried out on various sources found on Google Scholar and Pubmed to search for articles, journal research, case reports, systematic reviews, meta-analyses, and textbooks. Various studies demonstrate the possibility of coronavirus infecting the kidney with several mechanisms such as cytokine storm syndrome (CSS), direct viral infection, and imbalance of renin-angiotensin-aldosterone (RAAS). Haematuria and protein...
Sriwijaya Journal of Medicine
HIV-AIDS mengakibatkan penurunan sistem imun tubuh dan terjadinya inflamasi yang berpengaruh pada... more HIV-AIDS mengakibatkan penurunan sistem imun tubuh dan terjadinya inflamasi yang berpengaruh pada kualitas hidup pasien. Kadar IL-10 dapat dikaitkan juga sebagai respon terhadap adanya inflamasi yang akan mempengaruhi kualitas hidup pasien HIV-AIDS. Penelitian ini bertujuan mengukur kadar IL-10 serum pasien, menentukan kualitas hidup pasien berdasarkan skor WHOQOL dan menganalisis korelasi kadar IL-10 serum dengan kualitas hidup pasien HIV-AIDS. Desain penelitian ini adalah potong lintang dengan rancangan uji korelasi, dilakukan pada Juni-Oktober 2020 di RSMH Palembang dengan subjek penelitian pasien yang didiagnosis HIV-AIDS dalam pengobatan rutin di Poliklinik Tropik dan Infeksi Penyakit Dalam RSMH Palembang. Sampel diperoleh dengan metode consecutive sampling pasien yang mengkonsumsi obat anti retroviral (ARV) dan berusia ≥ 18 tahun. Seluruh pengolahan dan analisis data dalam penelitian ini dengan menggunakan Program SPSS versi 22 for Windows.Dari sampel sebanyak 32 pasien didapa...
Journal of Medicine, 2021
Objective: To determine NAC oral administration’s effect on changes in IL-10 levels and total lym... more Objective: To determine NAC oral administration’s effect on changes in IL-10 levels and total lymphocyte count (TLC) in patients with HIV/AIDS in Dr Mohammad Hoesin Hospital, Palembang. Material and Methods: This study was a double-blind, randomized clinical trial. A total of 32 HIV/AIDS patients undergoing ARV treatment were randomly divided into two groups: the placebo and NAC groups. In the placebo group, patients were given capsules containing lactose at a dose of 3x1 capsules/ day, while the NAC group, were given NAC at a dose of 3x200 mg/day. Each group was treated for 12 weeks. Results: NAC administration significantly reduced IL-10 levels P= 0.038 but could not significantly increase TLC after treatment P= 0.376. However, TLC on the NAC group remained higher when compared with TLC on the placebo group. Conclusion: NAC administration significantly reduced levels of IL-10 and increased TLC; therefore, NAC has potential effects of increasing the effectiveness of antiretroviral ...
International Journal of Infectious Diseases, 2022
Purpose Coronavirus infectious disease 2019 (COVID-19) had been infecting the world including hea... more Purpose Coronavirus infectious disease 2019 (COVID-19) had been infecting the world including healthcare personnel (HCP), but many survivors still experienced symptoms although had recovered with negative PCR results. This study aimed to identify post-COVID-19 syndrome among HCP in our hospital. Methods & Materials We conducted a cross-sectional study, asking HCP, surviving COVID-19 from April 2020 until February 2021, confirmed by twice negative PCR SARS CoV-2, and still working at the hospital at the time the research was conducted, to fill in an online questionnaire asking questions about symptoms related to post COVID-19 syndrome. Results Total study participants who completed the questionnaire were 164, 106 (65%) of them were women, consisted of 21 (13%) specialists, 52 (32%) residents, and 91 (55%) nurses. The average age was 37 (26 – 69) years old. When they experienced COVID-19, 60 (37%) participants were in asymptomatic, 76 (46%) mild, 26 (16%) moderate, and 2 (1%) severe-critical condition. Among participants, 78 (48%) still had symptoms by the time the survey was conducted, 61 (78.2%) were women, and these symptoms were still experienced in 41 (53%) survivors who had recovered more than 3 months. Fatigue was the most common symptom reported (55, 71%), followed by cough (15, 19%), joint pain (12, 15%), headache (10, 13%), muscle pain (9, 12%), breathing difficulty (7,9%), anosmia (5, 6%), bitter tongue (4, 5%). Conclusion Post-COVID-19 syndrome was quite common in HCP and this might cause the inability to work, treat, and care for patients optimally. Particular attention should be paid to this condition.
International Journal of Infectious Diseases, 2020
Journal of Information & Knowledge Management, 2021
World Health Organization (WHO) has declared the novel corona virus (COVID-19) as a pandemic due ... more World Health Organization (WHO) has declared the novel corona virus (COVID-19) as a pandemic due to its high transmission and the rapid spread of the COVID-19. Along these lines, there is a need for more research about risk factors that can affect the spread of COVID-19 and its fatality. Therefore, this study aims to analyze risk factors in patients who died from COVID-19 at the Mohammad Hoesin Hospital in Palembang, South Sumatra, Indonesia. This study used a cross-sectional approach. The data were collected from all patients who died with suspected, probable, and confirmed status until September 2020 Data on death due to COVID-19 were collected with suspect, probable, and confirmed status. The results showed that comorbidity became the most dominant factor (62.1%) with (OR Adj) 3.780 (1.000 – 3.168) after controlling for contact history with confirmed cases and sex. There were differences in the mean age and length of stay in patients with confirmed COVID-19 and not. Prevention o...
Penyakit HIV/AIDS merupakan suatu penyakit infeksi yang masih terus menjadi masalah besar bagi ma... more Penyakit HIV/AIDS merupakan suatu penyakit infeksi yang masih terus menjadi masalah besar bagi masyarakat global. Hasil estimasi dan proyeksi jumlah orang dengan HIV/AIDS di Indonesia pada tahun 2018 sebanyak 640.000 orang dan prevalensi secara nasional pada orang dewasa sebesar 0,4%. Berbagai macam bentuk infeksi yang disebabkan oleh HIV, salah satunya ditandai dengan turunnya jumlah sel limfosit T CD4 + dan juga penurunan kadar IFN-γ yang dapat menyebabkan percepatan replikasi virus hingga terjadi kegagalan sistem imun. N-asetilsistein (NAC) merupakan varian dari asam amino L-sistein yang merupakan sumber dari golongan sulfhydryl (SH) dan diubah dalam tubuh menjadi metabolit yang mampu menstimulasi sintesis gluthatione (GSH), menginduksi detoksifikasi dan bertindak secara langsung sebagai pemakan radikal bebas juga merupakan antioksidan diharapkan dapat memperbaiki kondisi tersebut. Penelitian ini bertujuan untuk mengetahui efek pemberian NAC terhadap perubahan kadar IFN-γ pada penderita HIV/AIDS di RSUP dr. Mohammad Hoesin Palembang. Penelitian ini merupakan uji klinik acak tersamar ganda. Sampel yang digunakan dalam penelitian ini sebanyak 32 pasien HIV/AIDS yang menjalani pengobatan ARV di RSUP dr. Mohammad Hoesin Palembang dibagi secara acak ke dalam 2 kelompok, yaitu kelompok Plasebo dan NAC. Pada kelompok Plasebo, pasien diberi kapsul yang berisi laktosa dengan dosis 3x1 kapsul/hari, sedangkan kelompok NAC, diberi NAC dengan dosis 3x 200 mg/hari. Setiap kelompok diberi perlakuan sama selama 12 minggu. Darah pasien diambil sebelum dan setelah perlakuan untuk diperiksa kadar IFN-γ. Hasil penelitian menunjukkan bahwa kelompok uji yang diberikan NAC maupun placebo tidak menunjukkan perubahan kadar IFN-γ yang bermakna setelah 12 minggu perlakuan(p>0,05). Kesimpulan penelitian, pemberian NAC tidak mempengaruhi kadar IFN-γ pada penderita HIV/AIDS yang menjalani pengobatan ARV.
International Journal of Infectious Diseases, 2020
Background: Neurosyphilis could develop at any time in the course of syphilis; with an annual inc... more Background: Neurosyphilis could develop at any time in the course of syphilis; with an annual incidence of 0.7 per 100,000 men. Homosexual and HIV were risk factors. Here we report an unusual case of neurosyphilis in non-HIV patient with complicated pulmonary involvement. Case description: A fifty-six-year-old promiscuity, heterosexual man, active smoker presented with a three-month history of pruritic maculopapular rashes on his body associated with lowgrade fever, and a two-week history of productive cough with dyspnea. On physical examination, he was tachypnea, with crackles on the base of the right lung. There was plaque hyperpigmentation on his malar area and multiple maculopapular, erythematous lesions on his trunk, extremities including palms of the hands, and scrotal area. No ulcer was found on his penis. Laboratory results revealed leukocytosis (19.9 × 10 3 /l), non-reactive HIV test, with high titer of serum VDRL (1/8) and TPHA (1/1280). Chest X-ray showed infiltrate on right perihilar area. Patient was diagnosed as pneumonia with secondary syphilis. The patient was treated with a single dose of benzathine penicillin G 2.4 million units intramuscular and azithromycin 500 mg tablet OD. During observation, he had altered mental status, generalized tonic seizure, high-grade fever with respiratory distress. He had Argyll Robertson pupil, left central facial and hypoglossal nerve paralysis, and positive meningeal signs, with normal brain CT scan result, non-reactive CSF-VDRL and TPHA, with high leucocyte (17 cells/l) and protein (54 mg/dl). He was diagnosed neurosyphilis with hospital-acquired pneumonia and treated with ceftriaxone and vancomycin, 2 g OD and 750 mg OD intravenous, respectively. The patient showed no significant improvement and unfortunately, he progressed to death caused by multiple organ dysfunctions due to septic shock. Discussion: There is no single, highly sensitive and specific diagnostic test exists for neurosyphilis. The diagnosis of neurosyphilis is based on clinical findings and the results of serologic tests and CSF examination. The CSF-VDRL has sensitivity 30-70%, non-reactive test does not exclude neurosyphilis. Neurosyphilis in a patient without HIV infection could be diagnosed by a high WBC or protein in CSF with symptoms or signs of neurosyphilis even with non-reactive CSF-VDRL. Conclusion: Neurosyphilis could be considered even with a non-reactive CSF-VDRL result in non-HIV patient.
Bioscientia Medicina : Journal of Biomedicine and Translational Research, 2021
Introduction. Human Immunodeficiency Virus (HIV) infection has been a concerning health problem w... more Introduction. Human Immunodeficiency Virus (HIV) infection has been a concerning health problem worldwide. It causes reduction in body immune system and inflammation that can affect its clinical profile. Undergoing ARV therapy patients causes intestine microbiota dysbiosis and translocation that lead to imperfect absorbtion of fatty acid. One way to control microbiota dysbiosis is by controlling the nutritional factor, especially with omega-3. However, different regions upstands different custom in fish consumption especially those of which are rich in omega-3. The purpose of this research is to compare omega-3 serum level between HIV-AIDS patients and healthy population, as well as analyzing the correlation of omega-3 serum level with of HIV-AIDS patient clinical profile.Methods. The research will be applying observational analytic study using comparative study approach which will be performed in Tropical Infection Internal Medicine polyclinic and Medical Check-Up Polyclinic in RSM...
Jurnal Kedokteran dan Kesehatan Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 2021
The COVID-19 pandemic that attacks the world has made the attention of all medical personnel focu... more The COVID-19 pandemic that attacks the world has made the attention of all medical personnel focused on this disease. The clinical picture is similar to other infectious diseases such as malaria, dengue, influenza, etc., which often leads to misdiagnosis. We report the case of a man, 31 years old, with a history of travel and complaints of high fever persisting for more than 7 days. On physical examination, the temperature was 39-40 C, others were within normal limits. Initial platelet count was 69 x 103/µL, leukocytes was 15.52 x 109/L, CRP was 96 mg/L. The blood smear found Plasmodium falciparum, and PCR SARS-CoV-2 was positive. Chest X-ray showed pneumonia. Dihydroartemisinin-piperaquine and primaquine therapies were administered for malaria, as well as favipiravir, azithromycin, and other symptomatic therapy for COVID-19. Platelets decreased to 38 x 103/µL while D-dimer level increased (> 20 mg/L). Anticoagulant was delayed. On monitoring after therapy, the platelets returned...
Journal of Drug Delivery and Therapeutics, 2020
Aims: to determine the effect of NAC administration on hematological abnormalities in HIV/AIDS pa... more Aims: to determine the effect of NAC administration on hematological abnormalities in HIV/AIDS patients who are undergoing ARV treatment. Method: This was a pilot study using a double blind randomized clinical trial. A total of 32 subjects who met the inclusion and exclusion criteria were divided into 2 groups, namely placebo and NAC. Subjects in the NAC group were given NAC at a dose of 3x200 mg/day, while the placebo group was given lactose at a dose of 3x200 mg/day. Each group was given treatment for 12 weeks. Before and after treatment, subjects were examined for hematologic parameters. Results: Most of subjects had normal hematological features. NAC administration did not have a significant effect on the mean levels of Hb, Ht, number of erythrocytes, leukocytes and platelets (p> 0.05). However, NAC administration can reduce the degree of anemia and improve the condition of thrombocytopenia, leukopenia and lymphopenia. Conclusion: NAC administration can reduce hematological ...
Journal of Physics: Conference Series, 2019
Histoplasma capsulatum is a dimorphic fungus which can cause infection usually in immunocompromis... more Histoplasma capsulatum is a dimorphic fungus which can cause infection usually in immunocompromised patients. An immunocompetent patient can be affected if he got chronic exposure to soil contaminated with birds or bats guano. We are reporting a case of a 54 years old man, working as trashman at open-air landfill, presented to hospital, with persistent fever and abdominal pain. The patient also complained of enlargement of submandibular lymph nodes. The abdominal ultrasound and CT-scan showed bilateral adrenal masses. Biopsy per laparoscopy of adrenal mass, and aspiration cytology of lymphadenopathy were performed and the results of cyto and histopathology examinations were Histoplasma capsulatum infection. The patient was planned for itraconazole 200 mg bid for 12-24 months. After 6 months of therapy, the patient had no more complains and the lymph nodes have shrinked significantly.
Bioscientia Medicina : Journal of Biomedicine and Translational Research
Background: Hepatitis C is an inflammatory disease of the liver caused by infection with the hep... more Background: Hepatitis C is an inflammatory disease of the liver caused by infection with the hepatitis C virus (HCV). Inflammatory markers are significant in assessing the course of an infectious or inflammatory disease. One of them is the neutrophil-lymphocyte ratio (NLR) and the amount of HCV RNA viral load, which combines neutrophils as an active inflammatory component and lymphocytes as a regulatory and protective component in a single parameter. Research on the relationship between NLR and HCV RNA in HIV patients coinfected with HCV is still limited. This study aimed to determine the relationship between NLR and HCV RNA in HIV-HCV coinfected patients who received DAA therapy and went to the outpatient polyclinic at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: Analytic observational study. A total of 38 research subjects participated in this study. Observation of NLR was carried out using hematology analyzer, and observation of HCV RNA levels was carrie...
Introduction. Vitamin D plays a role in health overall, but hypovitaminosis D stilloccurs through... more Introduction. Vitamin D plays a role in health overall, but hypovitaminosis D stilloccurs throughout the world. HIV/AIDS patients are prone to suffer fromhypovitaminosis D because of the infection itself and the side effects of antiretroviraltherapy. Various effort have been tried to improve the immune status of HIV/AIDSpatients, one of them is by adding vitamin D. Vitamin D acts as an antiinflammatoryso that it can prevent apoptosis of CD4 T cells and increase CD4 cell count.Methods. This is a randomized control trial add on a study that aims to determinethe effect of vitamin D to increase in CD4 counts of HIV / AIDS patients who havereceived antiretroviral drugs. Subjects were HIV / AIDS patients who had receivedantiretroviral drugs. A total of 20 subjects were divided randomly into two groups;one group received vitamin D (calcitriol 0.5 mcg per day) for eight weeks, and theother group that received a placebo. Each group was measured of CD4 cell countbefore and after treatment. Re...
Journal of Hypertension, 2015
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Papers by Dr Harun Hudari