Papers by Dr. Carolyn Fedler
Continuing Medical Education, 2006
When the clinical suspicion is strong (e.g. in a patient who exhibits overt symptoms and signs of... more When the clinical suspicion is strong (e.g. in a patient who exhibits overt symptoms and signs of hyperthyroidism), thyroid function tests are helpful in confirming the diagnosis. However, situations may occur where clinicians receive ‘abnormal’ test results that appear to be discordant with the clinical findings, and which also occur in the absence of a clearly definable thyroid disease. Such test results may be misinterpreted, the unfortunate outcome being that inappropriate management may be instituted.
A process for making flexible circuits wherein the etching of a polymeric film is accomplished by... more A process for making flexible circuits wherein the etching of a polymeric film is accomplished by dissolving portions thereof with concentrated aqueous base using an aqueous processible crosslinked photoresist as a mask, comprising the steps of laminating the resist on a polymeric film, exposing a pattern into the resist, developing the resist with a dilute aqueous solution until desired image is obtained, etching portions of the polymeric film not covered by the crosslinked resist with a concentrated base at a temperature of from about 50 DEG C. to about 120 DEG C., and then stripping the resist off the polymeric film.
Therapeutic Drug Monitoring, 1999
The use of phenytoin has increased among the rural black population in South Africa, many of whom... more The use of phenytoin has increased among the rural black population in South Africa, many of whom have albumin concentrations below the accepted reference range of 35-50 g/L, related to a combination of malnutrition and late-presenting renal and hepatic disease. Because albumin concentration has a major effect on the proportion of free phenytoin in the extracellular fluid, we instituted a study of the extent of hypoalbuminemia and of the difference between "total" phenytoin (measured by immunoassay), and "corrected" phenytoin (calculated using the Sheiner-Tozer equation, which is based on a mean albumin of 40 g/L). The differences were significant (higher than 20%) in 37% of patients and led us to propose that in populations in which there is a high proportion of patients who are hypoalbuminemic, it is corrected rather than total phenytoin that should be the value reported.
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Papers by Dr. Carolyn Fedler