Papers by Douglas B Quine
Science News, Feb 8, 1969
AFA Watchbird, 1980
Julius Caesar used Homing Pigeons to carry messages from the remote corners of Europe to home, in... more Julius Caesar used Homing Pigeons to carry messages from the remote corners of Europe to home, in Rome. That was two thousand years ago. Ever since that time, thoughtful people have wondered at these amazing birds, and in the present century, this wonder has manifested itself in some honest scientific study, trying to learn just how they do it. What "super-human powers" do the pigeons possess that enable them to take off in unfamiliar territory, make a few circles, and fly home with remarkable speed? Scientists in Germany, England, Italy, Switzerland and the United States were probing at this question. Then in 1967, Dr. William T. Keeton in the Avian Orientation Research Project, at Cornell University, Ithaca, New York, turned his attention to the question. For many years Cornell had the reputation of having one of the world's leading centers of research in animal behavior - everything from honeybees to monkeys. Keeton was a "natural" - not only because of hi...
Archives of Pathology & Laboratory Medicine, 2019
Context.— Clinical laboratories are obligated to implement Logical Observation Identifier Names a... more Context.— Clinical laboratories are obligated to implement Logical Observation Identifier Names and Codes (LOINC), an informatics standard used to uniquely identify laboratory tests. The historical progress of laboratories in achieving this goal is unknown. Objective.— To evaluate the implementation of LOINC by clinical laboratories with attention to LOINC's adoption, diversity, and correctness over time. Design.— We aggregated data from 130 facilities within the Veterans Health Administration (VA), an early adopter of LOINC, during a 20-year period (1999–2018). To assess the adoption of LOINC, we calculated the annual proportion of tests and results without a LOINC. To assess the diversity of LOINC, we counted the yearly number of distinct LOINCs in active use. To assess the correctness of LOINC over time, we compared the assigned LOINCs to a manually reviewed gold standard for each year. Results.— We reviewed a total of 586 000 tests and 9.162 billion results. LOINC adoption, ...
American Journal of Clinical Pathology
Objectives Surprisingly, laboratory results, the principal output of clinical laboratories, are n... more Objectives Surprisingly, laboratory results, the principal output of clinical laboratories, are not standardized. Thus, laboratories frequently report results with identical meaning in different formats. For example, laboratories report a positive pregnancy test as “+,” “P,” or “Positive.” To assess the feasibility of a widespread implementation of a result standard, we (1) developed a standard result format for common laboratory tests and (2) implemented a feedback system for clinical laboratories to view their unstandardized results. Methods In the largest integrated health care system in America, 130 facilities had the opportunity to collaboratively develop the standard. For 15 weeks, clinical laboratories received a weekly report of their unstandardized results. At the study’s conclusion, laboratories were compared with themselves and their peers by metrics that reflected their unstandardized results. Results We rereviewed 156 million test results and observed a 51% decline in t...
Journal of Neuroscience Methods, 1985
Acta Oto-Laryngologica, 1986
Acetylcholine (Ach) has received strong support as the neurotransmitter at vestibular efferent ne... more Acetylcholine (Ach) has received strong support as the neurotransmitter at vestibular efferent nerve endings. Ach, cholinomimetics and cholinergic antagonists were therefore applied to frog isolated whole labyrinths and isolated semicircular canals. Both spontaneous and evoked single unit and multiple unit activities were recorded from the decentralized posterior semicircular canal afferent nerve. In a manner analogous to efferent nerve stimulation, Ach produced both facilitatory and inhibitory changes in afferent firing rates. The facilitatory effect is likely mediated by muscarinic receptors (i.e. atropine antagonizes it at low concentrations). The facilitatory effect can also be elicited by muscarine and carbachol and it is likely produced presynaptically on the vestibular sensory cell. That is, the effects of Ach are not changed by removal of the efferent neurons but they are absent when afferent transmitter release is blocked. The inhibitory effect is not as well characterized as is the facilitatory effect but it can be blocked by strychnine. The results are consistent with the hypothesis that Ach is the transmitter responsible for both the facilitatory and the inhibitory effects of efferent vestibular nerve stimulation.
L'invention concerne un procede permettant d'acheminer un message electronique (100) d... more L'invention concerne un procede permettant d'acheminer un message electronique (100) d'une adresse electronique defavorisee vers une adresse electronique d'acheminement par l'entremise d'un ordinateur distant (110) d'acheminement de courrier electronique disposant d'une adresse electronique unique. Un utilisateur envoie un courrier electronique a l'ordinateur distant d'acheminement de courrier electronique, lequel analyse l'adresse electronique du message pour determiner s'il existe une adresse electronique defavorisee associee a l'adresse electronique voulue.
The Illinois Natural History Survey is developing algorithms for real-time bird hazard warnings t... more The Illinois Natural History Survey is developing algorithms for real-time bird hazard warnings to aircraft. The algorithms will allow the NEXRAD weather radar to discriminate bird echoes from other echoes and report the presence of birds hazardous to aircraft. R(o) W\ J , where X is wavelength, T is the pulse repetition time, R is the autocorrelation function, and SNR is the system signal-to-noise ratio. The second is called SW2 in CHILL data and 032 in equation (9) Srivastava et al. (1979): 2-X2 iR(2r)
Headache: The Journal of Head and Face Pain
To characterize patient‐reported ideas and concerns about cluster headache, treatment options, an... more To characterize patient‐reported ideas and concerns about cluster headache, treatment options, and management strategies.
Journal of the American Medical Informatics Association
Logical Observation Identifiers Names and Codes (LOINC) is the most widely used controlled vocabu... more Logical Observation Identifiers Names and Codes (LOINC) is the most widely used controlled vocabulary to identify laboratory tests. A given laboratory test can often be reported in more than 1 unit of measure (eg, grams or moles), and LOINC defines unique codes for each unit. Consequently, an identical laboratory test performed by 2 different clinical laboratories may have different LOINC codes. The absence of unit conversions between compatible LOINC codes impedes data aggregation and analysis of laboratory results. To develop such conversions, a computational process was developed to review the LOINC standard for potential conversions, and multiple expert reviewers oversaw and finalized the conversion list. In all, 285 bidirectional conversions were identified, including conversions for routine clinical tests such as sodium, magnesium, and human immunodeficiency virus (HIV). Unit conversions were applied to the aggregation of laboratory test results to demonstrate their usefulness. Diverse informatics projects may benefit from the ability to interconvert compatible results.
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Papers by Douglas B Quine