Papers by Doğangün Yüksel
Open journal of clinical & medical case reports, Mar 11, 2024
Molecular imaging and radionuclide therapy, Apr 4, 2024
European Journal of Breast Health
Research Square (Research Square), Dec 7, 2022
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Journal of Labelled Compounds and Radiopharmaceuticals
In this study, quality control parameters such as radiochemical yield, radiochemical purity, and ... more In this study, quality control parameters such as radiochemical yield, radiochemical purity, and in vitro stability of gallium (68Ga)‐prostate‐specific membrane antigen‐11 ([68Ga]Ga‐PSMA11) radiopharmaceutical obtained in a research laboratory with three different synthesis algorithms were evaluated and compared. Gallium (68Ga) chloride precursor to be used in labeling in all three methods was obtained by using ITG brand 68Ge/68Ga generator. The first method for the [68Ga]Ga‐PSMA11 radiopharmaceutical was performed with the automated synthesis module, which is widely used in clinical practice. Its radiochemical yield, quality assurance, and stability met expectations. Radiolabeling success, suitability of quality control parameters, and in vitro stability of [68Ga]Ga‐PSMA11 radiopharmaceutical performed with ANMI kit were examined. The final product showed success in 68Ga‐complexation kinetics. All quality control criteria performed met the expectation for clinical applications. Dir...
iranian journal of nuclear medicine, 2020
Introduction 18F-FDG PET/CT provides very effective results in detecting metastases of breast can... more Introduction 18F-FDG PET/CT provides very effective results in detecting metastases of breast cancer. In our study, we investigated the relationship between maximum standard uptake value (SUVmax) and prognostic pathologic factors in breast cancer cases with isolated bone metastasis and whether there was any difference in terms of prognostic pathologic factors between the group with and without bone metastasis. Methods Between 2013 and 2016, isolated bone metastases (55 female; 56±12 years; 32-87), and non-metastatic (46 female; 55±13 years; 30-81) patients who were referred to department of nuclear medicine and underwent 18F-FDG PET/CT for staging were included in the study. PET/CT images of patients and pathologic prognostic factors were evaluated retrospectively. SUVmax value of the most intense activity from metastatic bone lesions was calculated. Results In the metastatic group, there was no statistically significant relationship between measured SUVmax value of bone metastasis ...
Hellenic journal of nuclear medicine, 2020
OBJECTIVE Acute appendicitis (AA) is a common urgent surgical situation of the gastrointestinal t... more OBJECTIVE Acute appendicitis (AA) is a common urgent surgical situation of the gastrointestinal tract. Gallium-68 (68Ga)-citrate has been recently investigated as a radiopharmaceutical for infection and inflammation imaging. Aim of the study was to determine the effectiveness of 68Ga-citrate positron emission tomography/computed tomography (PET/CT) imaging in rabbits with experimentally induced AA. MATERIALS AND METHODS In the AA group (n=6), the appendices of the rabbits were surgically ligated. The sham group (n=6) was used as control. Gallium-68-citrate was synthesized. All rabbits were imaged using 68Ga-citrate PET/CT at 36th following the establishment of experimental models, and at 36th h, all rabbits were appendectomised. Appendices were examined histopathologically. Blood samples were drawn from all rabbits at the beginning and end of the experimental process. Interleukin-6 (IL-6) and procalcitonin (Pct) levels were measured. Acute appendicitis was confirmed histopathologica...
Differansiye tiroid kanserleri icerisinde follikuler kanser, papiller kansere gore daha sik uzak ... more Differansiye tiroid kanserleri icerisinde follikuler kanser, papiller kansere gore daha sik uzak metastaz yapar. Kutanoz metastaz nadir gorulmektedir ve en sik skalp bolgesinde yerlesmektedir. Total tiroidektomi sonrasi metastatik olgularda I-131 ablasyon/metastaz tedavisi uygulanmaktadir. Bu yazida, 63 yasinda kadin metastatik follikuler tiroid kanseri olgusu sunulmustur. Hastada, I-131 ile radyoiyod tedavisi sonrasi 7. gunde cekilen tum vucut tarama sintigrafisinde mediastinel lenf nodu, akciger ve kemik metastazlari yaninda kranyum posteriorunda skalp derisinde noduler lezyon izlenmis olup, taramaya ek olarak alinan tek foton emisyon tomografisi - bilgisayarli tomografi (SPECT-BT) sayesinde anatomik lokalizasyonu net olarak yapilmistir. Eksizyonel biyopsi sonrasi follikuler kanser metastazi tanisi almistir.
Nuclear Medicine Communications, 2020
Background/aim Especially suitable for PET due to its nuclear physical and radiochemical properti... more Background/aim Especially suitable for PET due to its nuclear physical and radiochemical properties, the positron emitter Gallium-68 (68Ga) occurs by electron capture from Germanium-68 (68Ge). In such a radionuclide generator, the germanium is bound to an insoluble, inert column matrix and forms a secular radioactive balance with 68Ga obtained in the hour. As a result of the limited radiochemical selectivity of the elution process, the eluate obtained is basically contaminated with the main nuclide traces, so that the eluate becomes a mixture of 68Ga and 68Ge radionuclides. Also, the generator eluate contains a number to metal cations that reduce specific radioactivity and can compete with 68Ga. The presence of toxic metal that can be found in the eluate carries the risks of contamination at every step from the production of generators to radiopharmaceutical production. Materials and method In our study, by collecting the eluate of the 68Ge/68Ga generators used with different identities in different centers in Turkey, we report comparative analysis of metal contamination in the generator eluate. The eluates of 68Ge/68Ga generators to five different identities were collected. Eluates were analyzed by inductively coupled plasma–mass spectrometry. Results and Conclusion As a result, each generator contains metallic impurities different from its certificate.
Revista Española de Medicina Nuclear e Imagen Molecular, 2021
OBJECTIVES In this study, we aimed to investigate the correlation between SUVmax of primary tumor... more OBJECTIVES In this study, we aimed to investigate the correlation between SUVmax of primary tumor and prognostic factors/molecular subtype in ductal breast cancer patients. MATERIALS AND METHODS We retrospectively reviewed 150 female patients with pathologically proven invasive ductal breast cancer from January 2015 to October 2019 who underwent 18F-FDG PET/CT for initial staging. Histopathological prognostic features of the primary tumor (histological grade, hormone receptor status, Ki-67 index, vb.) were obtained from the tru-cut biopsy report. In 18F-FDG PET/CT studies, the maximum standardized uptake value (SUVmax) of the primary breast tumor was calculated and compared with the presence of axillary lymphadenopathy and/or distant metastases, histopathological prognostic factors and molecular subtype. RESULTS The high SUVmax of primary breast tumors is significantly correlated with the clinicopathological factors: high tumor size, high histologic grade, high Ki-67 index, axillary lymph node positivity and distant metastasis. SUVmax value was significantly higher in patients with basal subtype than patients with Luminal A subtype (8.14±3.71 and 4.64±2.45, p=0.002). Correlation analysis revealed a low correlation between Ki-67 index and SUVmax (r=0.276, p=0.001) and moderate correlation between tumor size and SUVmax (r=0.470, p=0.001). In multivariate linear regression analysis, Ki-67 index and tumor size had a statistically significant effect on SUVmax values. As these parameters increase, it is seen that it increases SUVmax values (p=0.004, Std Beta: 0.228, 95% CI: 0.010-0.055 and p=0.001, Std Beta: 0.374, 95% CI: 0.55-0.136, respectively). CONCLUSION High SUVmax value is associated with prognotic factors suggesting poor prognosis. Pretreatment 18F-FDG PET/CT can be used as a tool to predict prognosis in breast cancer.
Indian Journal of Nuclear Medicine, 2021
Thoracic aortic aneurysm (TAA) should be treated before the complications with prophylactic surge... more Thoracic aortic aneurysm (TAA) should be treated before the complications with prophylactic surgery. However, important number of ruptures have been occurred below the cut-off size for surgery. In addition, in some cases, who in the cut-off value limit, decision of surgery may sometimes be difficult. 18Fluoro-deoxy-glukose positron emission tomography/computed tomography (18FDG-PET/CT) may useful such situations. We present a case that, TAA in 18FDG-PET/CT in a patient with larynx carcinoma. He had a TAA with near the cut-off value and increased metabolic activity in baseline imaging. After 3 months, SUVmax value increased and elective surgery was performed. We think that aneurysms may be another pathology that 18FDG-PET/CT potentially be useful apart from imaging malignant diseases.
Nuclear Medicine and Molecular Imaging, 2021
Purpose The generator product radionuclide gallium-68(68 Ga) is widely used for PET/CT imaging ag... more Purpose The generator product radionuclide gallium-68(68 Ga) is widely used for PET/CT imaging agents and the 68 Ga-labeled MAA is an attractive alternative to 99m Tc-labeled MAA. Using a commercially available MAA labeling kit for 99m Tc, we presented a reliable synthesis protocol with a highly efficient, organic solvent-free cationic method in GMP conditions in the Scintomics automated synthesis unit. Methods The labeling process was performed by incubating for 7 min at 90°C in the borax vial containing the generator product 68 GaCl 3 MAA-HEPES eluted from the PSH + cartridge with 1.5 mL 5 molar NaCl. Quality control of the final product content was examined, and radiopharmaceutical production was carried out in accordance with GMP guidelines. Results 68 Ga eluted from the generator was obtained in more than 99% radiochemical purity and efficiency. In this case, the labeling efficiency was found to be >99%. When the results of SEM-EDX analysis in the final product were examined, it was determined that most of toxic metals were no appreciable in the product content. Conclusions The radiochemical and chemical purity of the final product allows direct use without purification steps to remove "free 68 Ga" or other toxic compounds.
Clinical Hemorheology and Microcirculation, 2019
BACKGROUND: Although radioiodine theraphy (RAIT) is thought to affect blood cells and oxidative s... more BACKGROUND: Although radioiodine theraphy (RAIT) is thought to affect blood cells and oxidative stress, hemorheological alterations following dose-dependent RAIT remains unknown. OBJECTIVE: The aim of this study was to determine the effects of RAIT on hemorheological and oxidative stress parameters in patients with differentiated thyroid cancers (DTC). METHODS: Totally 31 DTC patients (mean age 46.32 ± 11.15 years) and 26 healthy controls (mean age 50.50 ± 6.22 years) were included. Venous blood samples were collected from each patient before and after treatment (7th day, 1 th month and 6 th month). Erythrocyte aggregation-deformability and oxidative stress parameters were determined. p < 0.05 was considered as statistically significant. RESULTS: Erythrocyte deformability of the patients determined at 16.87 and 30 Pascal were significantly lower than healthy individuals. Erythrocyte aggregation index (AI) of the patients was higher, whereas erythrocyte aggregation half-time (t½) was lower compared to control. Erythrocyte deformability values and AI were not significantly different from the pre-and post-radioiodine treatment groups. There was no statistically significant difference between the oxidative stress parameters before and after the treatment. CONCLUSIONS: Patients were in a worse hemorheological condition compared to healthy individuals. After RAIT, RBC deformability and aggregation were not affected and no significant change in oxidative stress parameters was detected.
The Turkish Journal of Thoracic and Cardiovascular Surgery, 2019
Molecular Imaging and Radionuclide Therapy, 2019
Pamukkale Medical Journal, 2019
Amac: Enfeksiyon tanisinda F-18 FDG ile lokosit isaretleme yaparak PET/BT cihazinda goruntuleme h... more Amac: Enfeksiyon tanisinda F-18 FDG ile lokosit isaretleme yaparak PET/BT cihazinda goruntuleme henuz rutin pratige girmemekle birlikte uzerinde bir suredir calisilmaktadir. Ancak F-18 FDG ile lokositlerin baglanma etkinligi dusuk duzeyde kalmaktadir. Biz calismamizda, enfeksiyon on tanili hastalarda insulin ve glukagon kullaniminin F-18 FDG ile lokosit isaretleme uzerindeki etkisini belirlemeyi amacladik. Gerec ve Yontem: Enfeksiyon on tanisi ile basvuran 7 gonullu calismaya dahil edildi. Gonullulerin aclik kan sekeri 80-120 mg/dl arasinda idi. Gonullulerden alinan 20 ml venoz kandan lokositler izole edildi. Oda isisinda inkube edilen ve 2 mCi F-18 FDG ile isaretlenen 3 grup olusturuldu. Gruplarin birine 10 IU kristalize insulin, ikincisine 0,1 mg glukagon ilave edildi. Son gruba ise herhangi bir sey eklenmedi. Her grup icin elde edilen materyal santrifuj edilerek bagli lokositlerin cokmesi saglandi. Bagli olan ve bagli olmayan komponent aktiviteleri ayri ayri olculerek total aktivite elde edildi. Bagli komponent aktivitesi total aktiviteye bolunerek baglanma yuzdesi hesaplandi. Elde edilen veriler, SPSS 25 .0 ( IBM SPSS Statistics 25 software Armonk, NY: IBM Corp.) paket programiyla analiz edildi. Degiskenlerin ortalama ±standart deviasyon, ortanca (minimum-maksimum) degerleri elde edildi. (p<0,05) degerler istatistiksel olarak anlamli olarak degerlendirildi. Bulgular : F-18 FDG isaretli lokosit baglanma yuzdeleri insulinli, glukagonlu ve hic birsey eklenmeyen gruplarda sirasiyla %31.57 (±%5,9), %30 (±%6,2) ve %27.57 (±%4,3) olarak bulundu. Her 3 grubun baglanma yuzdeleri arasinda istatistiksel acidan anlamli fark saptanmadi (p=0,418). Sonuc : F-18 FDG ile lokosit isaretleme, enfeksiyon tanisinda kullanilmasi mumkun olan bir yontem olup, invitro isaretleme esnasinda insulin ve glukagon kullanimi baglanma etkinligini degistirmemektedir.
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Papers by Doğangün Yüksel