Papers by Denis Sarigiannis
ISEE Conference Abstracts
Environmental health perspectives, Sep 19, 2013
ISEE Conference Abstracts, 2020
ISEE Conference Abstracts, 2020
ISEE Conference Abstracts, 2021
ISEE Conference Abstracts, 2021
BACKGROUND AND AIM: Phthalates and their substitute Hexamoll® DINCH® are a group of plasticisers ... more BACKGROUND AND AIM: Phthalates and their substitute Hexamoll® DINCH® are a group of plasticisers with a production volume of millions of tons per year found in daily use products. There is a societ...
When do you have enough data to act? An arduous question that environmental and occupational prof... more When do you have enough data to act? An arduous question that environmental and occupational professionals have struggled with for decades. Science at best offers partial knowledge and information surrounded with (statistical) uncertainties. Such partial knowledge often leads to policies being postponed till more information becomes available. But when is enough data enough? Occupational exposure to diesel motor exhaust (DME) has long been suspected to be a human carcinogen. The first case-control studies on DME and lung cancer were published in the mid-eighties, followed by several cohort studies conducted in the early part of this century. Based on the accumulating evidence a working group of the International Agency for Research on Cancer (IARC) declared DME as a known carcinogen in 2012. Why did it take 25 years to come to this decision? And what has happened after this decision as national or regional limit values for controlling occupational exposure to diesel exhaust are still rare? KEYNOTE 2 From car to coronary: The cardiovascular effects of nanoparticles in vehicle exhaust
Negative pregnancy occurrence and outcome (such as pre-eclampsia, preterm birth and small-for-ges... more Negative pregnancy occurrence and outcome (such as pre-eclampsia, preterm birth and small-for-gestational-age) are associated with air pollution (among others, exposure to ozone and vehicle exhaust...
Background Application of pesticides on crops has important and wide-ranging impacts on health. T... more Background Application of pesticides on crops has important and wide-ranging impacts on health. The major factors influencing emissions from pesticides are pesticide dosages, crop typology, areas c...
International Journal of Molecular Sciences, 2020
Exposure to chemical substances that can produce endocrine disrupting effects represents one of t... more Exposure to chemical substances that can produce endocrine disrupting effects represents one of the most critical public health threats nowadays. In line with the regulatory framework implemented within the European Union (EU) to reduce the levels of endocrine disruptors (EDs) for consumers, new and effective methods for ED testing are needed. The OBERON project will build an integrated testing strategy (ITS) to detect ED-related metabolic disorders by developing, improving and validating a battery of test systems. It will be based on the concept of an integrated approach for testing and assessment (IATA). OBERON will combine (1) experimental methods (in vitro, e.g., using 2D and 3D human-derived cells and tissues, and in vivo, i.e., using zebrafish at different stages), (2) high throughput omics technologies, (3) epidemiology and human biomonitoring studies and (4) advanced computational models (in silico and systems biology) on functional endpoints related to metabolism. Such inte...
Toxicology Letters, 2018
This study aimed to evaluate the response of HepaRG cells after co-exposure to phthalates and hea... more This study aimed to evaluate the response of HepaRG cells after co-exposure to phthalates and heavy metals, using a high-dimensional biology paradigm (HDB). Liver is the main metabolism site for the majority of xenobiotics. For this reason, the HepaRG cell line was used as an in vitro model, and cells were exposed to two characteristic mixtures of phthalates and heavy metals containing phthalates (DEHP, DiNP, BBzP) and metals (lead, methylmercury, total mercury) in a concentration-dependent manner. The applied chemical mixtures were selected as the most abundant pollutants in the REPRO_PL and PHIME cohorts, which were studied using the exposome-wide approach in the frame of the EU project HEALS. These studies investigated the environmental causation of neurodevelopmental disorders in neonates and across Europe. The INTEGRA computational platform was used for the calculation of the effective concentrations of the chemicals in the liver through extrapolation from human biomonitoring data and this dose (and a ten-times higher one) was applied to the hepatocyte model. Multi-omics analysis was performed to reveal the genes, proteins, and metabolites affected by the exposure to these chemical mixtures. By extension, we could detect the perturbed metabolic pathways. The generated data were analyzed using advanced bioinformatic tools following the HEALS connectivity paradigm for multi-omics pathway analysis. Co-mapped transcriptomics and proteomics data showed that co-exposure to phthalates and heavy metals leads to perturbations of the urea cycle due to differential expression levels of arginase-1 and-2, argininosuccinate synthase, carbamoyl-phosphate synthase, ornithine carbamoyltransferase, and argininosuccinate lyase. Joint pathway analysis of proteomics and metabolomics data revealed that the detected proteins and metabolites, choline phosphate cytidylyltransferase A, phospholipase D3, group XIIA secretory phospholipase A2, α-phosphatidylcholine, and the a 1,2-diacyl-sn-glycero-3-phosphocholine, are responsible for the homeostasis of the metabolic pathways phosphatidylcholine biosynthesis I, and phospholipases metabolism. The urea, phosphatidylcholine biosynthesis I and phospholipase metabolic pathways are of particular interest since they have been identified also in human samples from the REPRO_PL and PHIME cohorts using untargeted metabolomics analysis and have been associated with impaired psychomotor development in
Environmental Research, 2019
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Science of The Total Environment, 2017
Underground rail reduces health impact attributed to PM x in cities. • Changes in traffic composi... more Underground rail reduces health impact attributed to PM x in cities. • Changes in traffic composition reduce health impacts attributed to NO 2 and C 6 H 6. • Monetary savings from PM 10 and PM 2.5 exposure correspond to 60 and 49 million Euro. • Monetary savings from NO 2 and C 6 H 6 exposure correspond to 41 and 1 million Euro. • 3-4% reduction in mortality and morbidity from green transport policies.
Remote Sensing of Clouds and the Atmosphere IX, 2004
Our recent work has demonstrated the feasibility of using satellite-derived data to draw quantita... more Our recent work has demonstrated the feasibility of using satellite-derived data to draw quantitative maps of particulate loading within the planetary boundary layer. Our method, when used in conjunction with atmospheric dispersion models and ground data, can provide a comprehensive estimate of tropospheric pollution from particulate matter. Information filtering techniques are used to reduce the error of the information fusion
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Papers by Denis Sarigiannis