BackgroundVitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, hos... more BackgroundVitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, host defense, and inflammation involving host factors and microbiome. Human Vdr gene variation shapes the microbiome and VDR deletion leads to dysbiosis. Low VDR expression and diminished vitamin D/VDR signaling are observed in colon cancer. Nevertheless, how intestinal epithelial VDR is involved in tumorigenesis through gut microbiota remains unknown. We hypothesized that intestinal VDR protects mice against dysbiosis via modulating the JAK/STAT pathway in tumorigenesis. To test our hypothesis, we used an azoxymethane/Dextran Sulfate Sodium-induced cancer model in intestinal VDR conditional knockout (VDRΔIEC) mice, cell cultures, stem-cell derived colonoids, and human colon cancer samples.ResultsVDRΔIEC mice have higher numbers of tumors with location shifted from distal to proximal colon. Fecal microbiota analysis showed that VDR deletion leads to bacterial profile shift from normal to su...
Industrial & Engineering Chemistry Research, 2005
The injection of a gas-liquid spray jet into a fluidized bed of particles is used in many applica... more The injection of a gas-liquid spray jet into a fluidized bed of particles is used in many applications such as fluid catalytic cracking or fluid coking. In such applications uniform contact of the liquid droplets and entrained particles is essential for high yields. The objective of this study is to measure the quality of the solid-liquid mixing when a gas-liquid jet is injected into a fluidized bed of coke particles. A quick method has been developed to determine the local quality of solidliquid mixing on a short time scale. The measuring technique uses temperature to characterize the solid-liquid mixing. Cold ethanol is injected into the fluidized bed via a two-phase spray nozzle and is mixed with the heated fluidized coke particles. An assembly of fast response thermocouples, located downstream of the gas-liquid spray jet, provides instantaneous temperature readings over the liquid spray jet cross section at different axial positions along the length of the jet. In the case of perfect mixing, the temperature should be the same at each radial position. From the variations of the time-averaged temperature, contour plots of the liquid/ solid distribution within the cross-sectional area of the jet are created. This technique is used to compare solid-liquid mixing for two cases: when the spray is introduced as a free jet and when a draft tube is placed downstream of the gas-liquid spray. The use of a draft tube is found to improve liquid/solid mixing. The measurement technique has proven to be a reliable method to determine the liquid/solid distribution in the cross section of the jet. It shows that very good and rapid contact between sprayed droplets and particles can be achieved by using a draft tube mixer.
BackgroundVitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, hos... more BackgroundVitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, host defense, and inflammation involving host factors and microbiome. Human Vdr gene variation shapes the microbiome and VDR deletion leads to dysbiosis. Low VDR expression and diminished vitamin D/VDR signaling are observed in colon cancer. Nevertheless, how intestinal epithelial VDR is involved in tumorigenesis through gut microbiota remains unknown. We hypothesized that intestinal VDR protects mice against dysbiosis via modulating the JAK/STAT pathway in tumorigenesis. To test our hypothesis, we used an azoxymethane/Dextran Sulfate Sodium-induced cancer model in intestinal VDR conditional knockout (VDRΔIEC) mice, cell cultures, stem-cell derived colonoids, and human colon cancer samples.ResultsVDRΔIEC mice have higher numbers of tumors with location shifted from distal to proximal colon. Fecal microbiota analysis showed that VDR deletion leads to bacterial profile shift from normal to su...
Industrial & Engineering Chemistry Research, 2005
The injection of a gas-liquid spray jet into a fluidized bed of particles is used in many applica... more The injection of a gas-liquid spray jet into a fluidized bed of particles is used in many applications such as fluid catalytic cracking or fluid coking. In such applications uniform contact of the liquid droplets and entrained particles is essential for high yields. The objective of this study is to measure the quality of the solid-liquid mixing when a gas-liquid jet is injected into a fluidized bed of coke particles. A quick method has been developed to determine the local quality of solidliquid mixing on a short time scale. The measuring technique uses temperature to characterize the solid-liquid mixing. Cold ethanol is injected into the fluidized bed via a two-phase spray nozzle and is mixed with the heated fluidized coke particles. An assembly of fast response thermocouples, located downstream of the gas-liquid spray jet, provides instantaneous temperature readings over the liquid spray jet cross section at different axial positions along the length of the jet. In the case of perfect mixing, the temperature should be the same at each radial position. From the variations of the time-averaged temperature, contour plots of the liquid/ solid distribution within the cross-sectional area of the jet are created. This technique is used to compare solid-liquid mixing for two cases: when the spray is introduced as a free jet and when a draft tube is placed downstream of the gas-liquid spray. The use of a draft tube is found to improve liquid/solid mixing. The measurement technique has proven to be a reliable method to determine the liquid/solid distribution in the cross section of the jet. It shows that very good and rapid contact between sprayed droplets and particles can be achieved by using a draft tube mixer.
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