This paper focuses on the implementation of a computational design and robotic fabrication method... more This paper focuses on the implementation of a computational design and robotic fabrication method that integrates the elastic and hygroscopic behavior of wood as active drivers in the design process, using the material's differentiated characteristics as its main capacity. The project builds on previous work by the authors, furthering their research on the formal and performative transfer of such behaviors into informed architectural systems. Wood's fibrous structure, relatively low stiffness and high structural capacity are instrumentalized into self-forming mechanisms through conical elastic deformation, while the same organic makeup and corresponding hygroscopic properties have also been programmed, formally articulated and integrated into a climate responsive architectural system. This research will be presented alongside a full-scale architectural project (Figure 1, Figure 2).
International Journal of Pharmacy and Pharmaceutical Sciences, 2017
Objective: To study microcrystalline cellulose II (MCCII) as new pelletization aid for a high and... more Objective: To study microcrystalline cellulose II (MCCII) as new pelletization aid for a high and low solubility drugs such as verapamil. HCl and carbamazepine, respectively.Methods: Approximately, 30 g of MCCII and drug mixtures were hydrated passed through a # 20 mesh sieved and spheronizated at a frequency of 6 Hz and residence time of 480 s. A microscopy analysis was used to evaluate the shape and size descriptors. Pellets properties such as compressibility, friability, density, flowability and product yield were also evaluated. Drug release properties were tested according to the USP specifications and compared to those of MCCI.Results: The wetting level of the excipients depended on drug loading and drug solubility. Thus, a high drug loading (>50%) rendered pellets having a low yield, flowability and caused a detriment on size descriptors. Likewise, the regular morphology and strength of MCCII-based pellets was highly affected by increasing drug loads. Verapamil. HCl pellet...
iii ivto the commonality of humankind and to those who not forget it v viAcknowledgements I want ... more iii ivto the commonality of humankind and to those who not forget it v viAcknowledgements I want to thank all people that contributed to the successful completion of this work. Primarily and in first place I have to thank Matthias Wolff who not only helped to finish this project but also contributed a great deal that it took off. In Peru I want to thank all colleagues and friends at IMARPE that welcomed me in the first place and helped me ever
International Journal of Pharmacy and Pharmaceutical Sciences, Oct 2, 2017
Objective: To study microcrystalline cellulose II (MCCII) as new pelletization aid using the extr... more Objective: To study microcrystalline cellulose II (MCCII) as new pelletization aid using the extrusion/spheronization technology. Methods: The effect of the spheronization rate and spheronization time was assessed by a response surface design. The shape descriptors and physical properties of pellets were taken as response variables. Approximately, 30 g of MCCII were hydrated, passed through a # 20 mesh sieve and spheronizated at frequencies of 6, 9 and 12 Hz and residence times of 15, 240 and 480 s in 9 experimental runs. In a separate experimental set, moisture levels of 25, 50, 75, 100 and 125% were employed at the optimal operating conditions of 6 Hz and 480 s. A microscopy analysis was used to evaluate the shape descriptors. Pellets properties such as compressibility, friability, porosity, strength, flow rate and mass were also evaluated. Results: Pellets having a small size and a high value of shape descriptors related to morphology were obtained employing a spheronization rate and spheronization time of 6Hz and 480s and 100% wetting level. The spheronization time increased pellet densification but decreased the total porosity. Pellet mass was also favoured by using high spheronization rates. A high moisture level (>100%) rendered pellets having a large size, mass, low porosity and good yield. Conversely, pellet size decreased as sample load increased, whereas porosity and compressibility increased as sample load augmented. Conclusion: MCCII offers the potential for use as an alternative pelletization agent rendering pellets having a good flowability, high mechanical strength and low friability at the optimal operational conditions.
h i g h l i g h t s • Access and instrumentalisation of computational capacities within organic s... more h i g h l i g h t s • Access and instrumentalisation of computational capacities within organic systems. • Formal complexity through singular parametric differentiation in material behaviour. • Environment cognisant architectural systems with climate dependent formal behaviour. • Embedded biomimetic intelligence through material programming.
ABSTRACT Microfabrication via two-photon absorption polymerization is a technique to design compl... more ABSTRACT Microfabrication via two-photon absorption polymerization is a technique to design complex microstructures in a simple and fast way. The applications of such structures range from mechanics to photonics to biology, depending on the dopant material and its specific properties. In this paper, we use two-photon absorption polymerization to fabricate optically active microstructures containing the conductive and luminescent polymer poly(2-methoxy-5-(2′-ethylhexyloxy)-1,4-phenylenevinylene) (MEH-PPV). We verify that MEH-PPV retains its optical activity and is distributed throughout the microstructure after fabrication. The microstructures retain the emission characteristics of MEH-PPV and allow waveguiding of locally excited fluorescence when fabricated on top of low refractive index substrates.
This paper focuses on the implementation of a computational design and robotic fabrication method... more This paper focuses on the implementation of a computational design and robotic fabrication method that integrates the elastic and hygroscopic behavior of wood as active drivers in the design process, using the material's differentiated characteristics as its main capacity. The project builds on previous work by the authors, furthering their research on the formal and performative transfer of such behaviors into informed architectural systems. Wood's fibrous structure, relatively low stiffness and high structural capacity are instrumentalized into self-forming mechanisms through conical elastic deformation, while the same organic makeup and corresponding hygroscopic properties have also been programmed, formally articulated and integrated into a climate responsive architectural system. This research will be presented alongside a full-scale architectural project (Figure 1, Figure 2).
International Journal of Pharmacy and Pharmaceutical Sciences, 2017
Objective: To study microcrystalline cellulose II (MCCII) as new pelletization aid for a high and... more Objective: To study microcrystalline cellulose II (MCCII) as new pelletization aid for a high and low solubility drugs such as verapamil. HCl and carbamazepine, respectively.Methods: Approximately, 30 g of MCCII and drug mixtures were hydrated passed through a # 20 mesh sieved and spheronizated at a frequency of 6 Hz and residence time of 480 s. A microscopy analysis was used to evaluate the shape and size descriptors. Pellets properties such as compressibility, friability, density, flowability and product yield were also evaluated. Drug release properties were tested according to the USP specifications and compared to those of MCCI.Results: The wetting level of the excipients depended on drug loading and drug solubility. Thus, a high drug loading (>50%) rendered pellets having a low yield, flowability and caused a detriment on size descriptors. Likewise, the regular morphology and strength of MCCII-based pellets was highly affected by increasing drug loads. Verapamil. HCl pellet...
iii ivto the commonality of humankind and to those who not forget it v viAcknowledgements I want ... more iii ivto the commonality of humankind and to those who not forget it v viAcknowledgements I want to thank all people that contributed to the successful completion of this work. Primarily and in first place I have to thank Matthias Wolff who not only helped to finish this project but also contributed a great deal that it took off. In Peru I want to thank all colleagues and friends at IMARPE that welcomed me in the first place and helped me ever
International Journal of Pharmacy and Pharmaceutical Sciences, Oct 2, 2017
Objective: To study microcrystalline cellulose II (MCCII) as new pelletization aid using the extr... more Objective: To study microcrystalline cellulose II (MCCII) as new pelletization aid using the extrusion/spheronization technology. Methods: The effect of the spheronization rate and spheronization time was assessed by a response surface design. The shape descriptors and physical properties of pellets were taken as response variables. Approximately, 30 g of MCCII were hydrated, passed through a # 20 mesh sieve and spheronizated at frequencies of 6, 9 and 12 Hz and residence times of 15, 240 and 480 s in 9 experimental runs. In a separate experimental set, moisture levels of 25, 50, 75, 100 and 125% were employed at the optimal operating conditions of 6 Hz and 480 s. A microscopy analysis was used to evaluate the shape descriptors. Pellets properties such as compressibility, friability, porosity, strength, flow rate and mass were also evaluated. Results: Pellets having a small size and a high value of shape descriptors related to morphology were obtained employing a spheronization rate and spheronization time of 6Hz and 480s and 100% wetting level. The spheronization time increased pellet densification but decreased the total porosity. Pellet mass was also favoured by using high spheronization rates. A high moisture level (>100%) rendered pellets having a large size, mass, low porosity and good yield. Conversely, pellet size decreased as sample load increased, whereas porosity and compressibility increased as sample load augmented. Conclusion: MCCII offers the potential for use as an alternative pelletization agent rendering pellets having a good flowability, high mechanical strength and low friability at the optimal operational conditions.
h i g h l i g h t s • Access and instrumentalisation of computational capacities within organic s... more h i g h l i g h t s • Access and instrumentalisation of computational capacities within organic systems. • Formal complexity through singular parametric differentiation in material behaviour. • Environment cognisant architectural systems with climate dependent formal behaviour. • Embedded biomimetic intelligence through material programming.
ABSTRACT Microfabrication via two-photon absorption polymerization is a technique to design compl... more ABSTRACT Microfabrication via two-photon absorption polymerization is a technique to design complex microstructures in a simple and fast way. The applications of such structures range from mechanics to photonics to biology, depending on the dopant material and its specific properties. In this paper, we use two-photon absorption polymerization to fabricate optically active microstructures containing the conductive and luminescent polymer poly(2-methoxy-5-(2′-ethylhexyloxy)-1,4-phenylenevinylene) (MEH-PPV). We verify that MEH-PPV retains its optical activity and is distributed throughout the microstructure after fabrication. The microstructures retain the emission characteristics of MEH-PPV and allow waveguiding of locally excited fluorescence when fabricated on top of low refractive index substrates.
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Papers by David Correa