In 2014, the International Endohernia Society (IEHS) published the first international "Guideline... more In 2014, the International Endohernia Society (IEHS) published the first international "Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias." Guidelines reflect the currently best available evidence in diagnostics and therapy and give recommendations to help surgeons to standardize their techniques and to improve their results. However, science is a dynamic field which is continuously developing. Therefore, guidelines require regular updates to keep pace with the evolving literature. Methods For the development of the original guidelines, all relevant literature published up to year 2012 was analyzed using the ranking of the Oxford Centre for Evidence-Based Medicine. For the present update, all of the previous authors were asked to evaluate the literature published during the recent years from 2012 to 2017 and revise their statements and recommendations given in the initial guidelines accordingly. In two Consensus Conferences (October 2017 Beijing, March 2018 Cologne), the updates were presented, discussed, and confirmed. To avoid redundancy, only new statements or recommendations are included in this paper. Therefore, for full understanding both of the guidelines, the original and the current, must be read. In addition, the new developments in repair of abdominal wall hernias like surgical techniques within the abdominal wall, release operations (transversus muscle release, component separation), Botox application, and robot-assisted repair methods were included. Results Due to an increase of the number of patients and further development of surgical techniques, repair of primary and secondary abdominal wall hernias attracts increasing interests of many surgeons. Whereas up to three decades ago hernia-related publications did not exceed 20 per year, currently this number is about 10-fold higher. Recent years are characterized by the advent of new techniques-minimal invasive techniques using robotics and laparoscopy, totally extraperitoneal repairs, novel myofascial release techniques for optimal closure of large defects, and Botox for relaxing the abdominal wall. Furthermore, a concomitant rectus diastasis was recognized as a significant risk factor for recurrence. Despite insufficient evidence with respect to these new techniques, it seemed to us necessary to include them in the update to stimulate surgeons to do research in these fields. Conclusion Guidelines are recommendations based on best available evidence intended to help the surgeon to improve the quality of his daily work. However, science is a continuously evolving process, and as such guidelines should be updated about every 3 years. For a comprehensive reference, however, it is suggested to read both the initial guidelines published in 2014 together with the update. Moreover, the presented update includes also techniques which were not known 3 years before.
Sustainable, capacity-building educational collaborations are essential to address the global bur... more Sustainable, capacity-building educational collaborations are essential to address the global burden of surgical disease. To assess an international, competency-based training paradigm for hernia surgery in underserved countries. In this prospective, observational study performed from November 1, 2013, through October 31, 2015, at 16 hospitals in Brazil, Ecuador, Haiti, Paraguay, and the Dominican Republic, surgeons completed initial training programs in hernia repair, underwent interval proficiency assessments, and were appointed regional trainers. Competency-based evaluations of technical proficiency were performed using the Operative Performance Rating Scale (OPRS). Maintenance of proficiency was evaluated by video assessments 6 months after training. Certified trainees received incentives to document independent surgical outcomes after training. An OPRS score of 3.0 (scale of 1 [poor] to 5 [excellent]) indicated proficiency. Secondary outcomes included initial vs final scores by...
With the technical success of tension-free inguinal herniorrhaphy, chronic groin pain has far sur... more With the technical success of tension-free inguinal herniorrhaphy, chronic groin pain has far surpassed recurrence as the most common long-term complication. To evaluate laparoscopic triple neurectomy of the ilioinguinal, iliohypogastric, and genitofemoral nerve trunks in the retroperitoneal lumbar plexus for treatment of refractory inguinodynia. Prospective study. University hernia center. Twenty consecutive patients with chronic inguinodynia (14 male; mean age, 46 years; all failing pain management; prior neurectomy in 4 patients) and follow-up to 180 days (minimum, 90 days). Groin pain (Numeric Rating Scale score), dermatomal mapping, hernia recurrence, histologic confirmation, and complications. There were no intraoperative complications. All patients had histologic confirmation of neurectomy and clinical confirmation with dermatomal mapping. Mean numeric pain scores were significantly decreased (baseline score, 7.8) on postoperative days 1 (score, 2.9; P < .001), 7 (score, 2...
Document classification is a wide-spread problem with many applications, from organizing search e... more Document classification is a wide-spread problem with many applications, from organizing search engine snippets to spam filtering. We previously described Textpresso, a text-mining system for biological literature, which marks up full text according to a shallow ontology that includes terms of biological interest. This project investigates document classification in the context of biological literature, making use of the Textpresso markup of a corpus of Caenorhabditis elegans literature. We present a two-step text categorization algorithm to classify a corpus of C. elegans papers. Our classification method first uses a support vector machine-trained classifier, followed by a novel, phrase-based clustering algorithm. This clustering step autonomously creates cluster labels that are descriptive and understandable by humans. This clustering engine performed better on a standard test-set (Reuters 21578) compared to previously published results (F-value of 0.55 vs. 0.49), while producing...
The present study investigated the effect of targeted mutations in the DNA-dependent protein kina... more The present study investigated the effect of targeted mutations in the DNA-dependent protein kinase catalytic subunit and phosphorylation domains on the survival of cells in response to different qualities of ionizing radiation. Mutated Chinese hamster ovary V3 cells were exposed to 500 MeV/nucleon initial energy and 200 keV/µm monoenergetic Fe ions; 290 MeV/nucleon initial energy and average 50 keV/µm spread-out Bragg peak C ions; 70 MeV/nucleon initial energy and 1 keV/µm monoenergetic protons; and 0.663 MeV initial energy and 0.3 keV/µm Cs 137 γ radiation. The results demonstrated that sensitivity to high linear energy transfer radiation is increased when both S2056 and T2609 clusters each contain a point mutation or multiple mutations are present in either cluster, whereas the phosphoinositide 3 kinase cluster only requires a single mutation to induce the sensitized phenotype of V3 cells. Additionally, the present study demonstrated that sensitivity to DNA cross-linking damage by cisplatin only requires a single mutation in one of the three clusters and that additional point mutations do not increase cell sensitivity.
Inguinal hernia repair is one of the most common surgeries performed worldwide. With the success ... more Inguinal hernia repair is one of the most common surgeries performed worldwide. With the success of modern hernia repair techniques, recurrence rates have significantly declined, with a lower incidence than the development of chronic postherniorrhaphy inguinal pain (CPIP). The avoidance of CPIP is arguably the most important clinical outcome and has the greatest impact on patient satisfaction, health care utilization, societal cost, and quality of life. The etiology of CPIP is multifactorial, with overlapping neuropathic and nociceptive components contributing to this complex syndrome. Treatment is often challenging, and no definitive treatment algorithm exists. Multidisciplinary management of this complex problem improves outcomes, as treatment must be individualized. Current medical, pharmacologic, interventional, and surgical management strategies are reviewed.
An unfavourable phenomenon is observed: current electronic markets are fragmented and have formed... more An unfavourable phenomenon is observed: current electronic markets are fragmented and have formed a set of autonomously distributed product information islands. This leads to heterogeneity of product information between separated sources and makes difficult on product document interoperation. To resolve the issue and facilitate business document interoperation, this paper proposes a heterogeneous concept mapping approach. By this approach, heterogeneous product documents are transformed from one context to another context without losing any semantic information. This transformation process is supported by a heterogeneous concept transformation algorithm that includes five transformation steps: source-local context transformation, local-common context transformation, commoncommon context transformation, common-local context transformation and local-source context transformation.
This chapter aims at presenting some future trends given in the final results of the INTEROP Netw... more This chapter aims at presenting some future trends given in the final results of the INTEROP Network of Excellence (Chen et al., 2007) that prospect ways to support federation oriented enterprise interoperability. At first, a detailed definition of enterprise interoperability is given and the relevant concepts are structured in an Enterprise interoperability framework. A review will show two early collaborative interoperable platforms developed in the 90's. Then, a review of more recent solutions to establish interoperability, which aim to solve previous shortcomings, is proposed. The study in this chapter focused on ongoing researches for solutions based on the High Level Architecture (HLA) at the technological level because it tends to provide the desired properties. This standard was originally developed for military interoperability of large simulators with real environment. Indeed, the HLA standard has been successfully transposed for enterprise interoperability at the implementation level, reusing modeling and simulation developed through years of experiences in distributed systems to manage causality, confidentiality and interoperability. The presentation of HLA platforms will be followed by a synthetic comparison of the various approaches. The state-of-the-art is concluded by presenting MDA (Model Driven Architecture) methodology which supports the transformation of enterprise models from conceptual level to models for execution or simulation and the emerging MDI (Model Driven Interoperability) methodology. From
Lecture Notes in Business Information Processing, 2009
Interoperability is a key feature for enterprises in today's competitive environment. Fundamental... more Interoperability is a key feature for enterprises in today's competitive environment. Fundamental interoperability problems are however still not well understood. Within the scope of the Framework for Enterprise Interoperability (FEI) originally proposed by INTEROP NoE and now moved to ISO standardization process, this paper tentatively identifies and categorizes a set of interoperability barriers. Barriers to interoperability are defined as incompatibility between two enterprise systems. A list of interoperability barriers is presented and these barriers are then mapped to the FEI and illustrated with examples. The most significant dependencies between barriers are also tentatively defined and presented.
DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage. Unrepaired DSB... more DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage. Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis-processing of DSBs can lead to genomic instability and carcinogenesis. One important pathway in eukaryotic cells responsible for the repair of DSBs is non-homologous end-joining (NHEJ). In this review we will discuss the interesting new insights into the mechanism of the NHEJ pathway and the proteins which mediate this repair process. Furthermore, the general role of NHEJ in promoting genomic stability will be discussed.
2008 IEEE/WIC/ACM International Conference on Web Intelligence and Intelligent Agent Technology, 2008
With an increasing complexity of business processes, self-healing capability is becoming an impor... more With an increasing complexity of business processes, self-healing capability is becoming an important issue in order to support robust service flow execution. In this paper, a dynamic self-healing mechanism is proposed, which can dynamically identify suitable alternatives and replace faulty services such that a service flow can be performed successfully despite of unexpected exceptions. This mechanism explicitly utilizes Semantic Web services for service matching and selection of a composite service in business service flow, and Semantic web services are equipped with rich business rules in a domain-dependent manner. We explore the self-healing mechanism for supporting self-healable service flow execution which is modeled in BPEL4WS. A demo system of self-healing capable Service Flow Execution is built to validate its effectiveness by a concrete scenario, PC manufacturing application.
The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-st... more The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair.
Thin gallium-doped zinc oxide (in GZO the Ga 2 O 3 contents are approximately 3 wt%) films having... more Thin gallium-doped zinc oxide (in GZO the Ga 2 O 3 contents are approximately 3 wt%) films having different ZnO buffer layers were deposited using radio frequency (rf) magnetron sputtering. The use of a grey-based Taguchi method to determine the processing parameters of ZnO buffer layer deposition has been studied by considering multiple performance characteristics. A Taguchi method with an L 9 orthogonal array, signal-to-noise (S/N) ratio, and analysis of variance (ANOVA) is employed to investigate the performance characteristics in the deposition operations. The effect and optimization of ZnO buffer deposition parameters (rf power, sputtering pressure, thickness, and annealing) on the structure, morphology, electrical resistivity, and optical transmittance of the GZO films are studied. Annealing treatment and reduction in thickness resulted in a decrease in root-mean-square (RMS) surface roughness of the ZnO buffer layer. Using the optimal ZnO buffer layer obtained by the application of the grey-based Taguchi method, the electrical resistivity of GZO films was decreased from 2.94 × 10 −3 to 9.44 × 10 −4 cm and the optical transmittance in the visible region was slightly increased from 84.81% to 85.82%.
Sino-US competition, and even conflict, in space seems increasingly likely in light of recent ant... more Sino-US competition, and even conflict, in space seems increasingly likely in light of recent anti-satellite events. Advancing the cause of non-weaponization of space has long been limited by the scope of discussions. This article recommends to the incoming US administration a bargaining strategy that encompasses wider issues, increasing the possibility of circumventing this impasse and achieving improved security for US space systems by forestalling an anti-satellite arms race. Including commercial space and civil space issues in discussions with China on space security, in a type of ''grand bargain'' negotiation, may lead to agreement between the parties on a code of conduct in space. Simultaneously taking certain hedging positions against default may improve the US bargaining position and increase the likelihood of compliance.
It is known in the RAD51/RAD52-dependent DNA repair pathway that RAD51 is a RecA-like protein tha... more It is known in the RAD51/RAD52-dependent DNA repair pathway that RAD51 is a RecA-like protein that has DNA-bindhave been identified in yeast, a novel protein(s) that ing, ATP-binding, and DNA strand-exchange activities, functions with RAD51/RAD52 may also exist in huwhile RAD54 contains regions homologous to DNA helmans. Using a yeast two-hybrid system, we have identiicase. Interactions among RAD52, RAD51, RAD55, and fied a 12-kDa protein that associates with the human RAD57 have been identified (Firmenich et al., 1995; RAD51 and RAD52 proteins. This protein shares sig-Hays et al., 1995; Shinohara et al., 1992; Smith and nificant amino acid homology with the yeast protein Rothstein, 1995). RAD52 and RAD54 are highly ex-SMT3, which functionally associates with the yeast mipressed during yeast meiosis (Cole et al., 1989). Yeast tosis fidelity protein MIF2. It also shares moderate ho-RAD51 and RAD53 also have cell-cycle-dependent exmology with ubiquitin and several other proteins, inpression (Basile et al., 1992; Zheng et al., 1993), and cluding the N-terminus of the RAD23 protein and a RAD53 also participates in cell cycle control (Sanchez ubiquitin cross reacting protein. Therefore, the gene is et al., 1996). tentatively designated UBL1 for ubiquitin-like 1. The In humans, only RAD51 and RAD52 have been re-UBL1 mRNA is expressed in many human tissues, most highly in testis. The UBL1 gene is mapped to chromo-ported (Muris et al., 1994; Shen et al., 1995; Shinohara some 2q32.2-q33, and a related sequence may be loet al., 1993). The human RAD51 protein has activities cated on chromosome 1q23-q25. ᭧ 1996 Academic Press, Inc. similar to those of yeast RAD51, including DNA binding and a specific interaction with RAD52 protein (Benson et al., 1994; Shen et al., 1996a). Also, we have found Sequence data from this article have been deposited with the Gen-Bank/EMBL Data Libraries under Accession No. U38784.
Abstract. The simultaneous cooperation and competition between companies referred to as coopetiti... more Abstract. The simultaneous cooperation and competition between companies referred to as coopetition in the strategy literature is becoming a recurring theme in the business settings. Companies cooperate with their competitors to gain access to supplementary and ...
This review summarizes the recent studies assessing patients with psychogenic nonepileptic seizur... more This review summarizes the recent studies assessing patients with psychogenic nonepileptic seizures and developments in treatment. The misdiagnosis of nonepileptic seizure is costly to patients, the healthcare system, and to society. Patients with nonepileptic seizures are prescribed antiepileptic drugs that do not treat nonepileptic seizures, have multiple laboratory tests performed, and may not receive the necessary mental healthcare that could benefit them.The first step in nonepileptic seizure treatment is proper diagnosis. Video electroencephalography remains the gold standard for nonepileptic seizure diagnosis. Certain seizure types, such as frontal lobe seizures, may mimic nonepileptic seizure semiology. Bedside observations may augment video electroencephalography to establish nonepileptic seizure diagnosis. The methodology in nonepileptic seizure treatment trials is examined, describing the challenges in conducting clinical trials with patients with overlapping neurologic and psychiatric disorders. Finally, realizing that nonepileptic seizures are in a spectrum of somatoform disorders, diagnostic literature is reviewed in other conversion disorders. Nonepileptic seizure patients remain one of the most challenging populations to diagnose and treat in medical practice. Clinical findings and laboratory advances exist that more clearly establish the diagnosis of nonepileptic seizures. With the appropriate diagnosis, neurologists and mental health providers are better equipped to treat the underlying causes of nonepileptic seizures.
In 2014, the International Endohernia Society (IEHS) published the first international "Guideline... more In 2014, the International Endohernia Society (IEHS) published the first international "Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias." Guidelines reflect the currently best available evidence in diagnostics and therapy and give recommendations to help surgeons to standardize their techniques and to improve their results. However, science is a dynamic field which is continuously developing. Therefore, guidelines require regular updates to keep pace with the evolving literature. Methods For the development of the original guidelines, all relevant literature published up to year 2012 was analyzed using the ranking of the Oxford Centre for Evidence-Based Medicine. For the present update, all of the previous authors were asked to evaluate the literature published during the recent years from 2012 to 2017 and revise their statements and recommendations given in the initial guidelines accordingly. In two Consensus Conferences (October 2017 Beijing, March 2018 Cologne), the updates were presented, discussed, and confirmed. To avoid redundancy, only new statements or recommendations are included in this paper. Therefore, for full understanding both of the guidelines, the original and the current, must be read. In addition, the new developments in repair of abdominal wall hernias like surgical techniques within the abdominal wall, release operations (transversus muscle release, component separation), Botox application, and robot-assisted repair methods were included. Results Due to an increase of the number of patients and further development of surgical techniques, repair of primary and secondary abdominal wall hernias attracts increasing interests of many surgeons. Whereas up to three decades ago hernia-related publications did not exceed 20 per year, currently this number is about 10-fold higher. Recent years are characterized by the advent of new techniques-minimal invasive techniques using robotics and laparoscopy, totally extraperitoneal repairs, novel myofascial release techniques for optimal closure of large defects, and Botox for relaxing the abdominal wall. Furthermore, a concomitant rectus diastasis was recognized as a significant risk factor for recurrence. Despite insufficient evidence with respect to these new techniques, it seemed to us necessary to include them in the update to stimulate surgeons to do research in these fields. Conclusion Guidelines are recommendations based on best available evidence intended to help the surgeon to improve the quality of his daily work. However, science is a continuously evolving process, and as such guidelines should be updated about every 3 years. For a comprehensive reference, however, it is suggested to read both the initial guidelines published in 2014 together with the update. Moreover, the presented update includes also techniques which were not known 3 years before.
Sustainable, capacity-building educational collaborations are essential to address the global bur... more Sustainable, capacity-building educational collaborations are essential to address the global burden of surgical disease. To assess an international, competency-based training paradigm for hernia surgery in underserved countries. In this prospective, observational study performed from November 1, 2013, through October 31, 2015, at 16 hospitals in Brazil, Ecuador, Haiti, Paraguay, and the Dominican Republic, surgeons completed initial training programs in hernia repair, underwent interval proficiency assessments, and were appointed regional trainers. Competency-based evaluations of technical proficiency were performed using the Operative Performance Rating Scale (OPRS). Maintenance of proficiency was evaluated by video assessments 6 months after training. Certified trainees received incentives to document independent surgical outcomes after training. An OPRS score of 3.0 (scale of 1 [poor] to 5 [excellent]) indicated proficiency. Secondary outcomes included initial vs final scores by...
With the technical success of tension-free inguinal herniorrhaphy, chronic groin pain has far sur... more With the technical success of tension-free inguinal herniorrhaphy, chronic groin pain has far surpassed recurrence as the most common long-term complication. To evaluate laparoscopic triple neurectomy of the ilioinguinal, iliohypogastric, and genitofemoral nerve trunks in the retroperitoneal lumbar plexus for treatment of refractory inguinodynia. Prospective study. University hernia center. Twenty consecutive patients with chronic inguinodynia (14 male; mean age, 46 years; all failing pain management; prior neurectomy in 4 patients) and follow-up to 180 days (minimum, 90 days). Groin pain (Numeric Rating Scale score), dermatomal mapping, hernia recurrence, histologic confirmation, and complications. There were no intraoperative complications. All patients had histologic confirmation of neurectomy and clinical confirmation with dermatomal mapping. Mean numeric pain scores were significantly decreased (baseline score, 7.8) on postoperative days 1 (score, 2.9; P < .001), 7 (score, 2...
Document classification is a wide-spread problem with many applications, from organizing search e... more Document classification is a wide-spread problem with many applications, from organizing search engine snippets to spam filtering. We previously described Textpresso, a text-mining system for biological literature, which marks up full text according to a shallow ontology that includes terms of biological interest. This project investigates document classification in the context of biological literature, making use of the Textpresso markup of a corpus of Caenorhabditis elegans literature. We present a two-step text categorization algorithm to classify a corpus of C. elegans papers. Our classification method first uses a support vector machine-trained classifier, followed by a novel, phrase-based clustering algorithm. This clustering step autonomously creates cluster labels that are descriptive and understandable by humans. This clustering engine performed better on a standard test-set (Reuters 21578) compared to previously published results (F-value of 0.55 vs. 0.49), while producing...
The present study investigated the effect of targeted mutations in the DNA-dependent protein kina... more The present study investigated the effect of targeted mutations in the DNA-dependent protein kinase catalytic subunit and phosphorylation domains on the survival of cells in response to different qualities of ionizing radiation. Mutated Chinese hamster ovary V3 cells were exposed to 500 MeV/nucleon initial energy and 200 keV/µm monoenergetic Fe ions; 290 MeV/nucleon initial energy and average 50 keV/µm spread-out Bragg peak C ions; 70 MeV/nucleon initial energy and 1 keV/µm monoenergetic protons; and 0.663 MeV initial energy and 0.3 keV/µm Cs 137 γ radiation. The results demonstrated that sensitivity to high linear energy transfer radiation is increased when both S2056 and T2609 clusters each contain a point mutation or multiple mutations are present in either cluster, whereas the phosphoinositide 3 kinase cluster only requires a single mutation to induce the sensitized phenotype of V3 cells. Additionally, the present study demonstrated that sensitivity to DNA cross-linking damage by cisplatin only requires a single mutation in one of the three clusters and that additional point mutations do not increase cell sensitivity.
Inguinal hernia repair is one of the most common surgeries performed worldwide. With the success ... more Inguinal hernia repair is one of the most common surgeries performed worldwide. With the success of modern hernia repair techniques, recurrence rates have significantly declined, with a lower incidence than the development of chronic postherniorrhaphy inguinal pain (CPIP). The avoidance of CPIP is arguably the most important clinical outcome and has the greatest impact on patient satisfaction, health care utilization, societal cost, and quality of life. The etiology of CPIP is multifactorial, with overlapping neuropathic and nociceptive components contributing to this complex syndrome. Treatment is often challenging, and no definitive treatment algorithm exists. Multidisciplinary management of this complex problem improves outcomes, as treatment must be individualized. Current medical, pharmacologic, interventional, and surgical management strategies are reviewed.
An unfavourable phenomenon is observed: current electronic markets are fragmented and have formed... more An unfavourable phenomenon is observed: current electronic markets are fragmented and have formed a set of autonomously distributed product information islands. This leads to heterogeneity of product information between separated sources and makes difficult on product document interoperation. To resolve the issue and facilitate business document interoperation, this paper proposes a heterogeneous concept mapping approach. By this approach, heterogeneous product documents are transformed from one context to another context without losing any semantic information. This transformation process is supported by a heterogeneous concept transformation algorithm that includes five transformation steps: source-local context transformation, local-common context transformation, commoncommon context transformation, common-local context transformation and local-source context transformation.
This chapter aims at presenting some future trends given in the final results of the INTEROP Netw... more This chapter aims at presenting some future trends given in the final results of the INTEROP Network of Excellence (Chen et al., 2007) that prospect ways to support federation oriented enterprise interoperability. At first, a detailed definition of enterprise interoperability is given and the relevant concepts are structured in an Enterprise interoperability framework. A review will show two early collaborative interoperable platforms developed in the 90's. Then, a review of more recent solutions to establish interoperability, which aim to solve previous shortcomings, is proposed. The study in this chapter focused on ongoing researches for solutions based on the High Level Architecture (HLA) at the technological level because it tends to provide the desired properties. This standard was originally developed for military interoperability of large simulators with real environment. Indeed, the HLA standard has been successfully transposed for enterprise interoperability at the implementation level, reusing modeling and simulation developed through years of experiences in distributed systems to manage causality, confidentiality and interoperability. The presentation of HLA platforms will be followed by a synthetic comparison of the various approaches. The state-of-the-art is concluded by presenting MDA (Model Driven Architecture) methodology which supports the transformation of enterprise models from conceptual level to models for execution or simulation and the emerging MDI (Model Driven Interoperability) methodology. From
Lecture Notes in Business Information Processing, 2009
Interoperability is a key feature for enterprises in today's competitive environment. Fundamental... more Interoperability is a key feature for enterprises in today's competitive environment. Fundamental interoperability problems are however still not well understood. Within the scope of the Framework for Enterprise Interoperability (FEI) originally proposed by INTEROP NoE and now moved to ISO standardization process, this paper tentatively identifies and categorizes a set of interoperability barriers. Barriers to interoperability are defined as incompatibility between two enterprise systems. A list of interoperability barriers is presented and these barriers are then mapped to the FEI and illustrated with examples. The most significant dependencies between barriers are also tentatively defined and presented.
DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage. Unrepaired DSB... more DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage. Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis-processing of DSBs can lead to genomic instability and carcinogenesis. One important pathway in eukaryotic cells responsible for the repair of DSBs is non-homologous end-joining (NHEJ). In this review we will discuss the interesting new insights into the mechanism of the NHEJ pathway and the proteins which mediate this repair process. Furthermore, the general role of NHEJ in promoting genomic stability will be discussed.
2008 IEEE/WIC/ACM International Conference on Web Intelligence and Intelligent Agent Technology, 2008
With an increasing complexity of business processes, self-healing capability is becoming an impor... more With an increasing complexity of business processes, self-healing capability is becoming an important issue in order to support robust service flow execution. In this paper, a dynamic self-healing mechanism is proposed, which can dynamically identify suitable alternatives and replace faulty services such that a service flow can be performed successfully despite of unexpected exceptions. This mechanism explicitly utilizes Semantic Web services for service matching and selection of a composite service in business service flow, and Semantic web services are equipped with rich business rules in a domain-dependent manner. We explore the self-healing mechanism for supporting self-healable service flow execution which is modeled in BPEL4WS. A demo system of self-healing capable Service Flow Execution is built to validate its effectiveness by a concrete scenario, PC manufacturing application.
The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-st... more The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair.
Thin gallium-doped zinc oxide (in GZO the Ga 2 O 3 contents are approximately 3 wt%) films having... more Thin gallium-doped zinc oxide (in GZO the Ga 2 O 3 contents are approximately 3 wt%) films having different ZnO buffer layers were deposited using radio frequency (rf) magnetron sputtering. The use of a grey-based Taguchi method to determine the processing parameters of ZnO buffer layer deposition has been studied by considering multiple performance characteristics. A Taguchi method with an L 9 orthogonal array, signal-to-noise (S/N) ratio, and analysis of variance (ANOVA) is employed to investigate the performance characteristics in the deposition operations. The effect and optimization of ZnO buffer deposition parameters (rf power, sputtering pressure, thickness, and annealing) on the structure, morphology, electrical resistivity, and optical transmittance of the GZO films are studied. Annealing treatment and reduction in thickness resulted in a decrease in root-mean-square (RMS) surface roughness of the ZnO buffer layer. Using the optimal ZnO buffer layer obtained by the application of the grey-based Taguchi method, the electrical resistivity of GZO films was decreased from 2.94 × 10 −3 to 9.44 × 10 −4 cm and the optical transmittance in the visible region was slightly increased from 84.81% to 85.82%.
Sino-US competition, and even conflict, in space seems increasingly likely in light of recent ant... more Sino-US competition, and even conflict, in space seems increasingly likely in light of recent anti-satellite events. Advancing the cause of non-weaponization of space has long been limited by the scope of discussions. This article recommends to the incoming US administration a bargaining strategy that encompasses wider issues, increasing the possibility of circumventing this impasse and achieving improved security for US space systems by forestalling an anti-satellite arms race. Including commercial space and civil space issues in discussions with China on space security, in a type of ''grand bargain'' negotiation, may lead to agreement between the parties on a code of conduct in space. Simultaneously taking certain hedging positions against default may improve the US bargaining position and increase the likelihood of compliance.
It is known in the RAD51/RAD52-dependent DNA repair pathway that RAD51 is a RecA-like protein tha... more It is known in the RAD51/RAD52-dependent DNA repair pathway that RAD51 is a RecA-like protein that has DNA-bindhave been identified in yeast, a novel protein(s) that ing, ATP-binding, and DNA strand-exchange activities, functions with RAD51/RAD52 may also exist in huwhile RAD54 contains regions homologous to DNA helmans. Using a yeast two-hybrid system, we have identiicase. Interactions among RAD52, RAD51, RAD55, and fied a 12-kDa protein that associates with the human RAD57 have been identified (Firmenich et al., 1995; RAD51 and RAD52 proteins. This protein shares sig-Hays et al., 1995; Shinohara et al., 1992; Smith and nificant amino acid homology with the yeast protein Rothstein, 1995). RAD52 and RAD54 are highly ex-SMT3, which functionally associates with the yeast mipressed during yeast meiosis (Cole et al., 1989). Yeast tosis fidelity protein MIF2. It also shares moderate ho-RAD51 and RAD53 also have cell-cycle-dependent exmology with ubiquitin and several other proteins, inpression (Basile et al., 1992; Zheng et al., 1993), and cluding the N-terminus of the RAD23 protein and a RAD53 also participates in cell cycle control (Sanchez ubiquitin cross reacting protein. Therefore, the gene is et al., 1996). tentatively designated UBL1 for ubiquitin-like 1. The In humans, only RAD51 and RAD52 have been re-UBL1 mRNA is expressed in many human tissues, most highly in testis. The UBL1 gene is mapped to chromo-ported (Muris et al., 1994; Shen et al., 1995; Shinohara some 2q32.2-q33, and a related sequence may be loet al., 1993). The human RAD51 protein has activities cated on chromosome 1q23-q25. ᭧ 1996 Academic Press, Inc. similar to those of yeast RAD51, including DNA binding and a specific interaction with RAD52 protein (Benson et al., 1994; Shen et al., 1996a). Also, we have found Sequence data from this article have been deposited with the Gen-Bank/EMBL Data Libraries under Accession No. U38784.
Abstract. The simultaneous cooperation and competition between companies referred to as coopetiti... more Abstract. The simultaneous cooperation and competition between companies referred to as coopetition in the strategy literature is becoming a recurring theme in the business settings. Companies cooperate with their competitors to gain access to supplementary and ...
This review summarizes the recent studies assessing patients with psychogenic nonepileptic seizur... more This review summarizes the recent studies assessing patients with psychogenic nonepileptic seizures and developments in treatment. The misdiagnosis of nonepileptic seizure is costly to patients, the healthcare system, and to society. Patients with nonepileptic seizures are prescribed antiepileptic drugs that do not treat nonepileptic seizures, have multiple laboratory tests performed, and may not receive the necessary mental healthcare that could benefit them.The first step in nonepileptic seizure treatment is proper diagnosis. Video electroencephalography remains the gold standard for nonepileptic seizure diagnosis. Certain seizure types, such as frontal lobe seizures, may mimic nonepileptic seizure semiology. Bedside observations may augment video electroencephalography to establish nonepileptic seizure diagnosis. The methodology in nonepileptic seizure treatment trials is examined, describing the challenges in conducting clinical trials with patients with overlapping neurologic and psychiatric disorders. Finally, realizing that nonepileptic seizures are in a spectrum of somatoform disorders, diagnostic literature is reviewed in other conversion disorders. Nonepileptic seizure patients remain one of the most challenging populations to diagnose and treat in medical practice. Clinical findings and laboratory advances exist that more clearly establish the diagnosis of nonepileptic seizures. With the appropriate diagnosis, neurologists and mental health providers are better equipped to treat the underlying causes of nonepileptic seizures.
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Papers by David Chen