Proceedings of the National Academy of Sciences, 2022
Significance A major challenge in studying intention reading is high motor variability. Analyses ... more Significance A major challenge in studying intention reading is high motor variability. Analyses conducted across trials provide insights into what happens on average; however, they may obscure how individual observers read intention information in individual movements. We combined motion tracking, psychophysics, and computational analyses to examine intention reading in autism spectrum disorders (ASDs) with single-trial resolution. Results revealed that a sizeable fraction of ASD observers can identify intention-informative variations in ASD (but not in typically developing) movement kinematics, but they are nonetheless unable to extract the encoded intention information. This approach not only enhances our basic understanding of mind reading in ASD but also provides potential avenues for the rational design of training procedures to improve the reading of others’ actions.
BackgroundThe GluN2B subunit ofN-methyl-d-aspartate receptors is crucially involved in the physio... more BackgroundThe GluN2B subunit ofN-methyl-d-aspartate receptors is crucially involved in the physiology of the prefrontal cortex during working memory (WM). Consistently, genetic variants in the GluN2B coding gene (GRIN2B) have been associated with cognitive phenotypes. However, it is unclear howGRIN2Bgenetic variation affects gene expression and prefrontal cognitive processing. Using a composite score, we tested the combined effect ofGRIN2Bvariants on prefrontal activity during WM performance in healthy subjects.MethodWe computed a composite score to combine the effects of single nucleotide polymorphisms on post-mortem prefrontalGRIN2BmRNA expression. We then computed the composite score in independent samples of healthy participants in a peripheral blood expression study (n= 46), in a WM behavioural study (n= 116) and in a WM functional magnetic resonance imaging study (n= 122).ResultsFive polymorphisms were associated withGRIN2Bexpression: rs2160517, rs219931, rs11055792, rs1783396...
Proceedings of the National Academy of Sciences, 2022
Significance A major challenge in studying intention reading is high motor variability. Analyses ... more Significance A major challenge in studying intention reading is high motor variability. Analyses conducted across trials provide insights into what happens on average; however, they may obscure how individual observers read intention information in individual movements. We combined motion tracking, psychophysics, and computational analyses to examine intention reading in autism spectrum disorders (ASDs) with single-trial resolution. Results revealed that a sizeable fraction of ASD observers can identify intention-informative variations in ASD (but not in typically developing) movement kinematics, but they are nonetheless unable to extract the encoded intention information. This approach not only enhances our basic understanding of mind reading in ASD but also provides potential avenues for the rational design of training procedures to improve the reading of others’ actions.
BackgroundThe GluN2B subunit ofN-methyl-d-aspartate receptors is crucially involved in the physio... more BackgroundThe GluN2B subunit ofN-methyl-d-aspartate receptors is crucially involved in the physiology of the prefrontal cortex during working memory (WM). Consistently, genetic variants in the GluN2B coding gene (GRIN2B) have been associated with cognitive phenotypes. However, it is unclear howGRIN2Bgenetic variation affects gene expression and prefrontal cognitive processing. Using a composite score, we tested the combined effect ofGRIN2Bvariants on prefrontal activity during WM performance in healthy subjects.MethodWe computed a composite score to combine the effects of single nucleotide polymorphisms on post-mortem prefrontalGRIN2BmRNA expression. We then computed the composite score in independent samples of healthy participants in a peripheral blood expression study (n= 46), in a WM behavioural study (n= 116) and in a WM functional magnetic resonance imaging study (n= 122).ResultsFive polymorphisms were associated withGRIN2Bexpression: rs2160517, rs219931, rs11055792, rs1783396...
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Papers by Dalila Albergo