Depresi merupakan suatu penyakit psikologis yang ditandai dengan menurunnya konsentrasi, anhedoni... more Depresi merupakan suatu penyakit psikologis yang ditandai dengan menurunnya konsentrasi, anhedonia, kelelahan, putus asa, dan tidak berdaya serta rasa ingin bunuh diri. Gangguan depresi merupakan salah satu penyakit dengan penderita terbanyak yaitu 322 juta orang di dunia. Obat antidepresan dengan zat aktif dari bahan alam merupakan obat herbal yang dapat mengurangi efek samping bahan kimia. Salah satu tanaman yang memiliki aktivitas sebagai antidepresan adalah tanaman pare (Momordica charantia L). Bagian tanaman yang digunakan adalah buahnya, karena buah pare mengandung senyawa flavonoid, terpenoid, saponin dan polifenol. Tujuan penelitian ini adalah untuk mengetahui efektivitas buah pare sebagai antidepresan terhadap mencit (Mus Musculus) galur Swiss Webster. Metode yang digunakan untuk uji efektivitas antidepresan adalah TST (Tail Suspension Test) dan FST (Forced Swimming Test) dengan membagi 3 kelompok yaitu hewan uji kelompok 1 diinduksi dengan fluoxetin dengan dosis 20 mg, kelompok 2 diinduksi dengan ekstrak etanol buah pare, serta kelompok 3 merupakan kontrol. Perlakuan FST terhadap hewan uji dilakukan selama 6 menit setelah pemberian dosis terakhir. Durasi pengamatan selama 6 menit, dan diamati waktu imobilitasnya. Dari penelitian ini didapatkan hasil bahwa ekstrak buah pare (Momordica charantia. L) positif mengandung senyawa triterpenoid yang memiliki aktivitas antidepresan dengan pemberian dosis 250mg/kgBB yang dapat dibandingkan dengan obat fluoxetine. Hasil perbandingan antara ekstrak buah pare dengan obat fluoxetine yaitu dengan nilai signifikansi 0.548 menunjukkan bahwa tidak ada perbedaan antara ekstrak buah pare dengan obat fluoxetine.
Cancer is one of the leading causes of human death in the world. One of the therapies given to ca... more Cancer is one of the leading causes of human death in the world. One of the therapies given to cancer patients is chemotherapy, which has cytotoxic effects. One of the plants that has the same effect is berenuk or calabash (Crescentia cujete L.) plant, from the family of Bignoniaceae. This plant contains napthoquinone as one of its cytotoxic chemical compounds and other secondary metabolites such as alkaloids, flavonoids, saponins, tannins, terpenoids, and anthraquinones. The objective of this study is to determine the cytotoxic activity of an ethanolic extract of the fruit of berenuk on Artemia salina Leach larvae. The BSLT (Brine Shrimp Lethality Test) method was used for this study. The powder of berenuk fruit flesh was extracted using ethanol. The obtained solvent was evaporated using a rotary evaporator to obtain a thick extract. The extract was tested on A. salina larvae that had been prepared and the value of mortality was observed. The result of a cytotoxic activity test of an ethanolic extract of berenuk fruit on A. salina larvae had the LC50 value of 529.386 ppm, which is categorized as toxic.
Introduction: Approximately (24.8%) the world's population suffers from anemia and 50% of an anem... more Introduction: Approximately (24.8%) the world's population suffers from anemia and 50% of an anemic case is due to iron deficiency. This study investigated the efficacy of Moringa oleifera L leaves to extract as an iron booster and supplement to help overcome anemia in the community. Methods: It was a randomized, double-blind, placebo-controlled study in anemic women (hemoglobin 8-12g/dL), in which the water extract of moringa leaves was examined as an add-on therapy in the subject treated with ferrous sulfate (200mg/ tablet). Thirty-five women subject of 16-49 years old were divided into 17 of moringa leaves and 18 of control. The extract of moringa leaves of 1400 mg was formulated in capsules and was administrated daily for 3 weeks. Results: The result showed there were significantly increase of mean of hemoglobin (0.794±0.81 g/dL), ferritin (29.378±42.48 ng/mL), MCHC (Mean Corpuscular Haemoglobin Concentration) (2.459±2.86 g/dL), RDW (Red Distribution Wide) (1.4±2.07 %) and decreased of platelets (36529.41±59024.48 /uL). The control groups were significantly increased of mean of the hemoglobin (0.644± 0.83g/dL), erythrocytes (0.475±0.523 Tpt/L), hematocrit (2.189±l4.08 %), MCV (Mean Corpuscular Volume)(4.756±8.91 fL), MCH (2.183±2.47 pg) dan RDW (2.844±2.80%).The hematocrit (3.14±1.47%), MCH (Mean Corpuscular Hemoglobin) (3.495±1.33 pg), MCHC (3.264±0.96 g/dL) values of moringa leaves were significantly higher whereas the platelets count (55251.63±23404/uL) of moringa leaves were significantly lower (p<0.05) than those of control group. Conclusion: It can be concluded that moringa leaves extract could improve iron deficiency anemia in women.
Schizophrenia is a psychiatric disorder characterized by disturbances in thinking processes, perc... more Schizophrenia is a psychiatric disorder characterized by disturbances in thinking processes, perceptions, emotional responses, and social interactions. The therapy commonly used in the treatment of schizophrenia is antipsychotic or psychotropic drugs. The use of psychotropic drugs is the first step in overcoming and following up on mental disorders. The object of this research is several hospitals that treat patients with psychiatric disorders, namely schizophrenia. Where the subjects used in this study were men/women with schizophrenia aged 18 to 60 years in the city of Indramayu who are undergoing treatment at the hospital for the 2020-2022 period. This study aims to describe the use of antipsychotic classes that are used as one of the pharmacological therapies in patients. This research method uses a descriptive quantitative method, while the sample fee used in this study is the slovin calculation formula, with a total population of 875 and a sample of 274 is obtained. The result...
One business that is not yet known and has a good effect on health is the herbal extract of gambi... more One business that is not yet known and has a good effect on health is the herbal extract of gambier, gambir extract herbs can increase health stamina and reduce the effects of smoking on society, this is what makes CV Uncaria Herbal Indonesia (UHI) as a herbal pioneer from gambir extract want to do an analysis that affects brand loyalty in each of its products. This research aims to determine and analyze the influence of social media marketing, e-WOM, brand awareness, and brand image on brand loyalty at Uncaria Herbal Indonesia. The method of this research in this research was a questionnaire filled out by respondents, namely CV UHI customers who are active on social media. A sampling of 150 respondents in this study using the Accidental Sampling method. This study uses descriptive analysis. Based on the results of research using SPSS. Through the results of this research, it can be concluded that there is a positive and significant influence of social media marketing, e-WOM, Brand ...
Cancer is one of the leading causes of human death in the world. One of the therapies given to ca... more Cancer is one of the leading causes of human death in the world. One of the therapies given to cancer patients is chemotherapy, which has cytotoxic effects. One of the plants that has the same effect is berenuk or calabash (Crescentia cujete L.) plant, from the family of Bignoniaceae. This plant contains napthoquinone as one of its cytotoxic chemical compounds and other secondary metabolites such as alkaloids, flavonoids, saponins, tannins, terpenoids, and anthraquinones. The objective of this study is to determine the cytotoxic activity of an ethanolic extract of the fruit of berenuk on Artemia salina Leach larvae. The BSLT (Brine Shrimp Lethality Test) method was used for this study. The powder of berenuk fruit flesh was extracted using ethanol. The obtained solvent was evaporated using a rotary evaporator to obtain a thick extract. The extract was tested on A. salina larvae that had been prepared and the value of mortality was observed. The result of a cytotoxic activity test of an ethanolic extract of berenuk fruit on A. salina larvae had the LC50 value of 529.386 ppm, which is categorized as toxic.
Penyakit Ginjal Kronik (PGK) merupakan masalah kesehatan di seluruh penjuru dunia. PGK menjadi pe... more Penyakit Ginjal Kronik (PGK) merupakan masalah kesehatan di seluruh penjuru dunia. PGK menjadi penyebab menurunnya kualitas hidup penderitanya sekaligus meningkatkan risiko kematian. Penyakit Ginjal Kronik ditandai dengan terjadinya kerusakan ginjal dalam waktu lama dan progresif. Gangguan pada PGK berkaitan dengan kejadian stres oksidatif, yaitu keadaan di mana Reactive Oxygen Species (ROS) terbentuk melebihi pertahanan antioksidan. Kuersetin sebagai bagian keluarga flavonoid diketahui memiliki aktivitas antioksidan. Penelitian sebelumnya mendapatkan bahwa pemberian kuersetin mampu meningkatkan ekspresi protein Nuclear factor related erythroid factor 2 (Nrf2) di dalam nukleus pada tikus yang mengalami PGK. Penelitian ini merupakan penelitian lanjutan untuk mengkonfirmasi apakah peningkatan ekspresi protein Nrf2 di dalam nukleus terjadi pada tahap transkripsi. Metode: Jaringan ginjal tikus Sprague-Dawley dari penelitian terdahulu yang tersimpan pada suhu -80 o C, diukur ekspresi mR...
Indicators in assessing the success of health services and health development programs are the ma... more Indicators in assessing the success of health services and health development programs are the maternal mortality, infant and children under five years old mortality. Comprehensive handling is very important and beginning of nutrition care in pregnancy. Posyandu (Integrated services center for mothers and children under five years) as a form of institution that involves community participation in maternal and toddler health problems is the spearhead for reducing this mortality rate. The cooperation between Puskesmas (Community Health Centers) and Posyandu in public health supervision issues required good communication and clear reporting so that problems arise can be handled quickly Therefore, it takes an application system that can bridge communication between the two institutions in the prevention of maternal and child mortality, nutrition problems, especially malnutrition and stunting in children. The mobile-based application is expected to help public health supervision by integrating the performance of posyandu cadres, midwives and doctors in Kelurahan Pancoran Mas, Depok City.
Depresi merupakan suatu penyakit psikologis yang ditandai dengan menurunnya konsentrasi, anhedoni... more Depresi merupakan suatu penyakit psikologis yang ditandai dengan menurunnya konsentrasi, anhedonia, kelelahan, putus asa, dan tidak berdaya serta rasa ingin bunuh diri. Gangguan depresi merupakan salah satu penyakit dengan penderita terbanyak yaitu 322 juta orang di dunia. Obat antidepresan dengan zat aktif dari bahan alam merupakan obat herbal yang dapat mengurangi efek samping bahan kimia. Salah satu tanaman yang memiliki aktivitas sebagai antidepresan adalah tanaman pare (Momordica charantia L). Bagian tanaman yang digunakan adalah buahnya, karena buah pare mengandung senyawa flavonoid, terpenoid, saponin dan polifenol. Tujuan penelitian ini adalah untuk mengetahui efektivitas buah pare sebagai antidepresan terhadap mencit (Mus Musculus) galur Swiss Webster. Metode yang digunakan untuk uji efektivitas antidepresan adalah TST (Tail Suspension Test) dan FST (Forced Swimming Test) dengan membagi 3 kelompok yaitu hewan uji kelompok 1 diinduksi dengan fluoxetin dengan dosis 20 mg, kelompok 2 diinduksi dengan ekstrak etanol buah pare, serta kelompok 3 merupakan kontrol. Perlakuan FST terhadap hewan uji dilakukan selama 6 menit setelah pemberian dosis terakhir. Durasi pengamatan selama 6 menit, dan diamati waktu imobilitasnya. Dari penelitian ini didapatkan hasil bahwa ekstrak buah pare (Momordica charantia. L) positif mengandung senyawa triterpenoid yang memiliki aktivitas antidepresan dengan pemberian dosis 250mg/kgBB yang dapat dibandingkan dengan obat fluoxetine. Hasil perbandingan antara ekstrak buah pare dengan obat fluoxetine yaitu dengan nilai signifikansi 0.548 menunjukkan bahwa tidak ada perbedaan antara ekstrak buah pare dengan obat fluoxetine.
Cancer is one of the leading causes of human death in the world. One of the therapies given to ca... more Cancer is one of the leading causes of human death in the world. One of the therapies given to cancer patients is chemotherapy, which has cytotoxic effects. One of the plants that has the same effect is berenuk or calabash (Crescentia cujete L.) plant, from the family of Bignoniaceae. This plant contains napthoquinone as one of its cytotoxic chemical compounds and other secondary metabolites such as alkaloids, flavonoids, saponins, tannins, terpenoids, and anthraquinones. The objective of this study is to determine the cytotoxic activity of an ethanolic extract of the fruit of berenuk on Artemia salina Leach larvae. The BSLT (Brine Shrimp Lethality Test) method was used for this study. The powder of berenuk fruit flesh was extracted using ethanol. The obtained solvent was evaporated using a rotary evaporator to obtain a thick extract. The extract was tested on A. salina larvae that had been prepared and the value of mortality was observed. The result of a cytotoxic activity test of an ethanolic extract of berenuk fruit on A. salina larvae had the LC50 value of 529.386 ppm, which is categorized as toxic.
Introduction: Approximately (24.8%) the world's population suffers from anemia and 50% of an anem... more Introduction: Approximately (24.8%) the world's population suffers from anemia and 50% of an anemic case is due to iron deficiency. This study investigated the efficacy of Moringa oleifera L leaves to extract as an iron booster and supplement to help overcome anemia in the community. Methods: It was a randomized, double-blind, placebo-controlled study in anemic women (hemoglobin 8-12g/dL), in which the water extract of moringa leaves was examined as an add-on therapy in the subject treated with ferrous sulfate (200mg/ tablet). Thirty-five women subject of 16-49 years old were divided into 17 of moringa leaves and 18 of control. The extract of moringa leaves of 1400 mg was formulated in capsules and was administrated daily for 3 weeks. Results: The result showed there were significantly increase of mean of hemoglobin (0.794±0.81 g/dL), ferritin (29.378±42.48 ng/mL), MCHC (Mean Corpuscular Haemoglobin Concentration) (2.459±2.86 g/dL), RDW (Red Distribution Wide) (1.4±2.07 %) and decreased of platelets (36529.41±59024.48 /uL). The control groups were significantly increased of mean of the hemoglobin (0.644± 0.83g/dL), erythrocytes (0.475±0.523 Tpt/L), hematocrit (2.189±l4.08 %), MCV (Mean Corpuscular Volume)(4.756±8.91 fL), MCH (2.183±2.47 pg) dan RDW (2.844±2.80%).The hematocrit (3.14±1.47%), MCH (Mean Corpuscular Hemoglobin) (3.495±1.33 pg), MCHC (3.264±0.96 g/dL) values of moringa leaves were significantly higher whereas the platelets count (55251.63±23404/uL) of moringa leaves were significantly lower (p<0.05) than those of control group. Conclusion: It can be concluded that moringa leaves extract could improve iron deficiency anemia in women.
Schizophrenia is a psychiatric disorder characterized by disturbances in thinking processes, perc... more Schizophrenia is a psychiatric disorder characterized by disturbances in thinking processes, perceptions, emotional responses, and social interactions. The therapy commonly used in the treatment of schizophrenia is antipsychotic or psychotropic drugs. The use of psychotropic drugs is the first step in overcoming and following up on mental disorders. The object of this research is several hospitals that treat patients with psychiatric disorders, namely schizophrenia. Where the subjects used in this study were men/women with schizophrenia aged 18 to 60 years in the city of Indramayu who are undergoing treatment at the hospital for the 2020-2022 period. This study aims to describe the use of antipsychotic classes that are used as one of the pharmacological therapies in patients. This research method uses a descriptive quantitative method, while the sample fee used in this study is the slovin calculation formula, with a total population of 875 and a sample of 274 is obtained. The result...
One business that is not yet known and has a good effect on health is the herbal extract of gambi... more One business that is not yet known and has a good effect on health is the herbal extract of gambier, gambir extract herbs can increase health stamina and reduce the effects of smoking on society, this is what makes CV Uncaria Herbal Indonesia (UHI) as a herbal pioneer from gambir extract want to do an analysis that affects brand loyalty in each of its products. This research aims to determine and analyze the influence of social media marketing, e-WOM, brand awareness, and brand image on brand loyalty at Uncaria Herbal Indonesia. The method of this research in this research was a questionnaire filled out by respondents, namely CV UHI customers who are active on social media. A sampling of 150 respondents in this study using the Accidental Sampling method. This study uses descriptive analysis. Based on the results of research using SPSS. Through the results of this research, it can be concluded that there is a positive and significant influence of social media marketing, e-WOM, Brand ...
Cancer is one of the leading causes of human death in the world. One of the therapies given to ca... more Cancer is one of the leading causes of human death in the world. One of the therapies given to cancer patients is chemotherapy, which has cytotoxic effects. One of the plants that has the same effect is berenuk or calabash (Crescentia cujete L.) plant, from the family of Bignoniaceae. This plant contains napthoquinone as one of its cytotoxic chemical compounds and other secondary metabolites such as alkaloids, flavonoids, saponins, tannins, terpenoids, and anthraquinones. The objective of this study is to determine the cytotoxic activity of an ethanolic extract of the fruit of berenuk on Artemia salina Leach larvae. The BSLT (Brine Shrimp Lethality Test) method was used for this study. The powder of berenuk fruit flesh was extracted using ethanol. The obtained solvent was evaporated using a rotary evaporator to obtain a thick extract. The extract was tested on A. salina larvae that had been prepared and the value of mortality was observed. The result of a cytotoxic activity test of an ethanolic extract of berenuk fruit on A. salina larvae had the LC50 value of 529.386 ppm, which is categorized as toxic.
Penyakit Ginjal Kronik (PGK) merupakan masalah kesehatan di seluruh penjuru dunia. PGK menjadi pe... more Penyakit Ginjal Kronik (PGK) merupakan masalah kesehatan di seluruh penjuru dunia. PGK menjadi penyebab menurunnya kualitas hidup penderitanya sekaligus meningkatkan risiko kematian. Penyakit Ginjal Kronik ditandai dengan terjadinya kerusakan ginjal dalam waktu lama dan progresif. Gangguan pada PGK berkaitan dengan kejadian stres oksidatif, yaitu keadaan di mana Reactive Oxygen Species (ROS) terbentuk melebihi pertahanan antioksidan. Kuersetin sebagai bagian keluarga flavonoid diketahui memiliki aktivitas antioksidan. Penelitian sebelumnya mendapatkan bahwa pemberian kuersetin mampu meningkatkan ekspresi protein Nuclear factor related erythroid factor 2 (Nrf2) di dalam nukleus pada tikus yang mengalami PGK. Penelitian ini merupakan penelitian lanjutan untuk mengkonfirmasi apakah peningkatan ekspresi protein Nrf2 di dalam nukleus terjadi pada tahap transkripsi. Metode: Jaringan ginjal tikus Sprague-Dawley dari penelitian terdahulu yang tersimpan pada suhu -80 o C, diukur ekspresi mR...
Indicators in assessing the success of health services and health development programs are the ma... more Indicators in assessing the success of health services and health development programs are the maternal mortality, infant and children under five years old mortality. Comprehensive handling is very important and beginning of nutrition care in pregnancy. Posyandu (Integrated services center for mothers and children under five years) as a form of institution that involves community participation in maternal and toddler health problems is the spearhead for reducing this mortality rate. The cooperation between Puskesmas (Community Health Centers) and Posyandu in public health supervision issues required good communication and clear reporting so that problems arise can be handled quickly Therefore, it takes an application system that can bridge communication between the two institutions in the prevention of maternal and child mortality, nutrition problems, especially malnutrition and stunting in children. The mobile-based application is expected to help public health supervision by integrating the performance of posyandu cadres, midwives and doctors in Kelurahan Pancoran Mas, Depok City.
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